Incidental Mutation 'R9507:Tnfrsf10b'
ID 717897
Institutional Source Beutler Lab
Gene Symbol Tnfrsf10b
Ensembl Gene ENSMUSG00000022074
Gene Name tumor necrosis factor receptor superfamily, member 10b
Synonyms Killer/Dr5, DR5, Trail Receptor, Ly98, KILLER, TRICK2A, TRAIL-R2, TRICKB, TRAILR2, TRICK2B
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R9507 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 70004921-70021860 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70015221 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 233 (D233G)
Ref Sequence ENSEMBL: ENSMUSP00000022663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022663]
AlphaFold Q9QZM4
Predicted Effect probably benign
Transcript: ENSMUST00000022663
AA Change: D233G

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000022663
Gene: ENSMUSG00000022074
AA Change: D233G

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
transmembrane domain 32 54 N/A INTRINSIC
TNFR 88 129 3.17e-7 SMART
TNFR 131 169 4.73e-6 SMART
transmembrane domain 182 201 N/A INTRINSIC
low complexity region 236 247 N/A INTRINSIC
DEATH 262 356 7e-18 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009A15Rik A G 19: 8,866,587 (GRCm39) T47A probably damaging Het
Acsm2 A T 7: 119,179,939 (GRCm39) I386F probably benign Het
Actn4 A T 7: 28,606,397 (GRCm39) D305E probably benign Het
Anln A G 9: 22,274,136 (GRCm39) V567A probably damaging Het
Arhgap35 A G 7: 16,297,343 (GRCm39) I574T probably benign Het
Baz1b C A 5: 135,233,971 (GRCm39) S166Y probably damaging Het
Ccdc191 T C 16: 43,764,192 (GRCm39) L551P probably damaging Het
Cdk5rap2 T C 4: 70,210,110 (GRCm39) T713A probably benign Het
Cep290 C A 10: 100,330,785 (GRCm39) A155E possibly damaging Het
Chst8 G A 7: 34,447,496 (GRCm39) Q41* probably null Het
Cyp2j6 C A 4: 96,406,344 (GRCm39) E476* probably null Het
Des T C 1: 75,343,434 (GRCm39) V439A probably benign Het
Dimt1 A G 13: 107,093,656 (GRCm39) T283A probably benign Het
Dmxl1 T A 18: 50,024,567 (GRCm39) V1747D possibly damaging Het
Fhod1 G A 8: 106,064,694 (GRCm39) R137* probably null Het
Gab2 A T 7: 96,953,448 (GRCm39) D608V probably damaging Het
Gdpd1 T C 11: 86,950,264 (GRCm39) D103G possibly damaging Het
Hspa5 T C 2: 34,664,610 (GRCm39) S355P probably benign Het
Ide A T 19: 37,265,536 (GRCm39) F619L Het
Ifrd1 A C 12: 40,267,225 (GRCm39) D70E probably benign Het
Il18r1 T A 1: 40,513,884 (GRCm39) V30E probably damaging Het
Itpr3 G A 17: 27,337,651 (GRCm39) probably benign Het
Kcng1 A G 2: 168,111,152 (GRCm39) L4S probably damaging Het
Lrfn4 A G 19: 4,664,357 (GRCm39) F59S probably damaging Het
Lrrc15 T C 16: 30,092,829 (GRCm39) D170G probably damaging Het
Mettl21e T A 1: 44,245,536 (GRCm39) M237L probably benign Het
Myh1 A G 11: 67,102,049 (GRCm39) K810E probably benign Het
Nbea T C 3: 55,573,011 (GRCm39) D2524G probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nutm2 A T 13: 50,621,455 (GRCm39) T7S probably benign Het
Or10g3b A T 14: 52,586,678 (GRCm39) L275H probably damaging Het
Or2a5 G T 6: 42,873,835 (GRCm39) C150F probably benign Het
Or2t49 T C 11: 58,392,576 (GRCm39) T275A possibly damaging Het
Or51q1 T G 7: 103,629,198 (GRCm39) F266L probably damaging Het
Or6k2 T A 1: 173,986,552 (GRCm39) I71K possibly damaging Het
Or7a39 A G 10: 78,715,597 (GRCm39) H197R probably benign Het
Pate4 A G 9: 35,519,538 (GRCm39) S51P probably damaging Het
Rbm19 T C 5: 120,265,232 (GRCm39) probably null Het
Rnf139 A G 15: 58,770,664 (GRCm39) K230E probably damaging Het
Rpia G A 6: 70,754,377 (GRCm39) Q134* probably null Het
Rsf1 GC GCGGCGGCGCC 7: 97,229,141 (GRCm39) probably benign Het
Sbk2 G A 7: 4,960,277 (GRCm39) P298S possibly damaging Het
Scrt1 A G 15: 76,403,292 (GRCm39) S233P unknown Het
Sh2b1 CGGGGACCAGCTC CGGGGACCAGCTCAGCCAAGGGGACCAGCTC 7: 126,066,760 (GRCm39) probably benign Het
Sppl2c T A 11: 104,078,153 (GRCm39) Y318N probably benign Het
St6galnac4 G A 2: 32,485,739 (GRCm39) W215* probably null Het
Stxbp6 A G 12: 45,066,360 (GRCm39) L15P probably benign Het
Tmem104 T C 11: 115,091,699 (GRCm39) L74P probably damaging Het
Trmt11 A C 10: 30,434,938 (GRCm39) Y369* probably null Het
Tusc1 T A 4: 93,223,245 (GRCm39) H138L probably benign Het
Ush2a T A 1: 188,596,937 (GRCm39) Y3892* probably null Het
Xirp2 A T 2: 67,344,280 (GRCm39) I2174F possibly damaging Het
Zfp947 C T 17: 22,364,582 (GRCm39) G364D probably benign Het
Other mutations in Tnfrsf10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02525:Tnfrsf10b APN 14 70,019,825 (GRCm39) missense probably damaging 1.00
R0650:Tnfrsf10b UTSW 14 70,013,625 (GRCm39) missense probably damaging 0.98
R2102:Tnfrsf10b UTSW 14 70,013,546 (GRCm39) missense probably benign 0.42
R3870:Tnfrsf10b UTSW 14 70,010,905 (GRCm39) missense probably benign 0.03
R4840:Tnfrsf10b UTSW 14 70,013,608 (GRCm39) missense probably damaging 0.98
R6111:Tnfrsf10b UTSW 14 70,020,007 (GRCm39) missense possibly damaging 0.53
R6351:Tnfrsf10b UTSW 14 70,010,850 (GRCm39) missense probably damaging 1.00
R7853:Tnfrsf10b UTSW 14 70,005,239 (GRCm39) missense unknown
R8857:Tnfrsf10b UTSW 14 70,012,543 (GRCm39) missense probably benign
R9001:Tnfrsf10b UTSW 14 70,015,250 (GRCm39) missense possibly damaging 0.90
R9410:Tnfrsf10b UTSW 14 70,010,849 (GRCm39) missense probably damaging 1.00
R9447:Tnfrsf10b UTSW 14 70,013,608 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CTAAGCAAGAATGGCCCCTC -3'
(R):5'- GAGATGATGTACCCTCCTTCCTG -3'

Sequencing Primer
(F):5'- CCTAACCTTGTTAGTGTTGGAAC -3'
(R):5'- AGTTCTAGGGGATCCAATGACCTC -3'
Posted On 2022-07-18