Incidental Mutation 'R9509:Vmn2r72'
ID 718002
Institutional Source Beutler Lab
Gene Symbol Vmn2r72
Ensembl Gene ENSMUSG00000051877
Gene Name vomeronasal 2, receptor 72
Synonyms Vmn2r72-ps, EG244114
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock # R9509 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 85737784-85754981 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85754867 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 39 (I39L)
Ref Sequence ENSEMBL: ENSMUSP00000133014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063425]
AlphaFold D3Z4N8
Predicted Effect probably benign
Transcript: ENSMUST00000063425
AA Change: I39L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: I39L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 82 469 2.3e-28 PFAM
Pfam:NCD3G 512 564 1.2e-18 PFAM
Pfam:7tm_3 594 832 4e-53 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik TTCCTCCTCCTCCTCCTCCTCC TTCCTCCTCCTCCTCCTCC 3: 138,065,834 probably benign Het
2310035C23Rik A G 1: 105,686,979 E216G probably damaging Het
4932415D10Rik A T 10: 82,296,395 N260K probably benign Het
5830411N06Rik T A 7: 140,299,731 Y1093* probably null Het
Acan C T 7: 79,091,020 P378L probably damaging Het
Akap6 A G 12: 53,142,238 D2145G probably damaging Het
Akap9 A T 5: 4,046,349 D2408V probably benign Het
Apol10a C A 15: 77,488,768 Y201* probably null Het
Arhgef4 T C 1: 34,723,691 I676T unknown Het
Capn13 T C 17: 73,337,451 H361R probably benign Het
Ccdc88a G A 11: 29,464,143 V894I probably benign Het
Chd4 T A 6: 125,122,522 L1655Q possibly damaging Het
Chil1 G A 1: 134,188,675 E307K probably damaging Het
Dhfr T A 13: 92,368,231 I139N probably damaging Het
Dock8 A G 19: 25,095,621 S422G probably benign Het
Dspp C A 5: 104,177,791 D673E unknown Het
Dst G T 1: 33,908,384 W38L possibly damaging Het
Dynlt1b A T 17: 6,435,016 E26D probably benign Het
Dysf A T 6: 84,210,797 Y2059F probably damaging Het
Efcab5 G A 11: 77,104,151 S1198F possibly damaging Het
Erp44 T C 4: 48,208,750 I237V probably benign Het
Exosc2 G A 2: 31,674,743 V107I probably benign Het
Fat2 A G 11: 55,309,887 V787A possibly damaging Het
Fbn2 C G 18: 58,114,478 G448A probably benign Het
Fbxw21 A G 9: 109,148,149 V164A possibly damaging Het
Gabpa G A 16: 84,852,507 V201I possibly damaging Het
Gm12253 G A 11: 58,439,945 V177M probably benign Het
Il2rb C A 15: 78,490,216 W84L probably damaging Het
Kank4 T A 4: 98,774,867 T695S possibly damaging Het
Klhl29 T C 12: 5,140,629 Q122R probably damaging Het
L3mbtl1 A G 2: 162,967,383 E670G probably damaging Het
Lifr A G 15: 7,159,474 Y112C probably damaging Het
Lins1 C T 7: 66,708,371 Q85* probably null Het
Lpcat1 T A 13: 73,494,832 V175E probably damaging Het
Mdm1 T C 10: 118,146,825 S122P probably damaging Het
Mtfmt C T 9: 65,435,865 R18C probably benign Het
Mylk4 T C 13: 32,720,560 N197S probably benign Het
Neurl4 T A 11: 69,902,145 L83* probably null Het
Nlrc3 T C 16: 3,964,816 D259G probably damaging Het
Nsf A T 11: 103,863,248 D487E probably benign Het
Olfr138 A G 17: 38,275,390 I206M probably benign Het
Olfr1385 A G 11: 49,494,649 I39V probably benign Het
Olfr469 T A 7: 107,823,233 T79S probably benign Het
Palb2 T A 7: 122,128,176 K157M probably damaging Het
Pbrm1 T C 14: 31,084,957 S1114P probably damaging Het
Pdia6 T A 12: 17,280,988 M364K probably damaging Het
Pf4 G T 5: 90,773,189 G83W probably damaging Het
Pibf1 T C 14: 99,101,285 M79T probably benign Het
Polr3b T G 10: 84,631,786 Y77D probably damaging Het
Pomt2 T A 12: 87,138,028 H208L possibly damaging Het
Pprc1 A T 19: 46,063,399 K456M unknown Het
Rasgef1a A T 6: 118,084,430 K119* probably null Het
Rbbp6 T A 7: 122,998,568 Y701N unknown Het
Reln A T 5: 22,344,200 V70E possibly damaging Het
Rgs17 T C 10: 5,862,576 N41S probably benign Het
Rhbdf1 A T 11: 32,215,055 I106N possibly damaging Het
Robo1 T A 16: 72,962,279 N393K probably damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,579,920 probably benign Het
Scnn1a A T 6: 125,342,641 D495V probably damaging Het
Serpinf2 G A 11: 75,438,069 P45L probably benign Het
Setdb1 A C 3: 95,354,589 I122S possibly damaging Het
Slc4a9 A T 18: 36,535,390 M701L probably damaging Het
Supv3l1 T C 10: 62,429,632 T710A probably benign Het
Syne1 A T 10: 5,348,927 probably null Het
Tenm3 A T 8: 48,313,257 Y743* probably null Het
Tgm2 A T 2: 158,127,290 Y388* probably null Het
Tmem55a T A 4: 14,892,485 C116* probably null Het
Tor3a A G 1: 156,655,929 S308P possibly damaging Het
Trim12a T C 7: 104,304,344 K187E probably benign Het
Trpc1 C T 9: 95,743,196 probably null Het
Uaca C T 9: 60,872,216 T1295M possibly damaging Het
Ush2a T A 1: 188,916,243 Y4682N probably damaging Het
Vldlr A G 19: 27,244,287 N684S probably benign Het
Vps13b A T 15: 35,841,311 M2496L possibly damaging Het
Zbtb5 C T 4: 44,994,332 V351M probably damaging Het
Zeb2 T A 2: 44,997,864 T394S possibly damaging Het
Zfp352 A G 4: 90,224,706 E361G probably damaging Het
Zfp54 C A 17: 21,434,367 Y374* probably null Het
Zfp869 C A 8: 69,706,946 G326W probably damaging Het
Zfyve28 C T 5: 34,197,548 A806T probably benign Het
Other mutations in Vmn2r72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00931:Vmn2r72 APN 7 85749646 missense probably benign 0.01
IGL01019:Vmn2r72 APN 7 85738334 missense probably benign 0.26
IGL01445:Vmn2r72 APN 7 85749646 missense probably benign 0.06
IGL02076:Vmn2r72 APN 7 85738367 missense probably damaging 1.00
IGL02082:Vmn2r72 APN 7 85738166 missense probably benign 0.00
IGL02086:Vmn2r72 APN 7 85738166 missense probably benign 0.00
IGL02089:Vmn2r72 APN 7 85738166 missense probably benign 0.00
IGL02125:Vmn2r72 APN 7 85750711 missense probably benign 0.00
IGL02146:Vmn2r72 APN 7 85737962 missense probably damaging 1.00
IGL02272:Vmn2r72 APN 7 85750693 missense probably benign
IGL02514:Vmn2r72 APN 7 85738699 missense possibly damaging 0.90
IGL02662:Vmn2r72 APN 7 85738183 missense probably benign 0.26
IGL02697:Vmn2r72 APN 7 85738671 missense probably benign 0.36
IGL02733:Vmn2r72 APN 7 85751813 missense probably benign 0.05
IGL03070:Vmn2r72 APN 7 85752041 splice site probably benign
IGL03150:Vmn2r72 APN 7 85751176 missense probably damaging 1.00
IGL03159:Vmn2r72 APN 7 85754954 missense probably benign 0.05
IGL03333:Vmn2r72 APN 7 85750867 missense probably benign 0.10
R0081:Vmn2r72 UTSW 7 85751836 missense probably benign 0.01
R0090:Vmn2r72 UTSW 7 85754876 missense probably benign
R0655:Vmn2r72 UTSW 7 85738111 nonsense probably null
R0778:Vmn2r72 UTSW 7 85749739 missense probably benign 0.00
R1169:Vmn2r72 UTSW 7 85751309 missense probably benign 0.01
R1172:Vmn2r72 UTSW 7 85751944 missense probably damaging 1.00
R1173:Vmn2r72 UTSW 7 85751944 missense probably damaging 1.00
R1175:Vmn2r72 UTSW 7 85751944 missense probably damaging 1.00
R1248:Vmn2r72 UTSW 7 85749188 missense probably benign 0.02
R1302:Vmn2r72 UTSW 7 85738257 missense probably damaging 1.00
R1506:Vmn2r72 UTSW 7 85749211 missense probably benign
R1632:Vmn2r72 UTSW 7 85751792 missense probably benign 0.13
R1775:Vmn2r72 UTSW 7 85738170 missense probably benign 0.01
R1962:Vmn2r72 UTSW 7 85749161 missense probably benign 0.00
R2201:Vmn2r72 UTSW 7 85738236 missense probably benign 0.12
R2290:Vmn2r72 UTSW 7 85738341 missense probably damaging 1.00
R2327:Vmn2r72 UTSW 7 85738256 missense probably damaging 1.00
R2424:Vmn2r72 UTSW 7 85750953 missense probably damaging 1.00
R2655:Vmn2r72 UTSW 7 85751269 missense possibly damaging 0.95
R2860:Vmn2r72 UTSW 7 85750836 missense probably damaging 0.99
R2861:Vmn2r72 UTSW 7 85750836 missense probably damaging 0.99
R2862:Vmn2r72 UTSW 7 85750836 missense probably damaging 0.99
R3009:Vmn2r72 UTSW 7 85749642 missense probably benign 0.00
R3797:Vmn2r72 UTSW 7 85738077 missense probably benign 0.44
R3798:Vmn2r72 UTSW 7 85738077 missense probably benign 0.44
R3902:Vmn2r72 UTSW 7 85749735 missense possibly damaging 0.52
R3959:Vmn2r72 UTSW 7 85751131 missense probably benign 0.36
R3974:Vmn2r72 UTSW 7 85749809 missense probably damaging 1.00
R4399:Vmn2r72 UTSW 7 85738500 missense probably damaging 1.00
R4421:Vmn2r72 UTSW 7 85738500 missense probably damaging 1.00
R4426:Vmn2r72 UTSW 7 85737828 nonsense probably null
R4522:Vmn2r72 UTSW 7 85751926 missense probably benign 0.44
R4523:Vmn2r72 UTSW 7 85751926 missense probably benign 0.44
R4533:Vmn2r72 UTSW 7 85751926 missense probably benign 0.44
R4691:Vmn2r72 UTSW 7 85737911 nonsense probably null
R4781:Vmn2r72 UTSW 7 85737861 missense probably benign 0.14
R4863:Vmn2r72 UTSW 7 85750598 missense possibly damaging 0.91
R4952:Vmn2r72 UTSW 7 85751109 missense probably benign
R4991:Vmn2r72 UTSW 7 85751130 missense probably damaging 0.99
R4995:Vmn2r72 UTSW 7 85738485 missense probably damaging 1.00
R5095:Vmn2r72 UTSW 7 85737853 missense probably damaging 0.98
R5174:Vmn2r72 UTSW 7 85737840 missense probably benign 0.00
R5276:Vmn2r72 UTSW 7 85738254 missense possibly damaging 0.90
R5395:Vmn2r72 UTSW 7 85750897 missense possibly damaging 0.71
R5560:Vmn2r72 UTSW 7 85751942 missense probably damaging 0.96
R5933:Vmn2r72 UTSW 7 85737850 missense probably benign 0.05
R6033:Vmn2r72 UTSW 7 85737929 missense probably damaging 1.00
R6033:Vmn2r72 UTSW 7 85737929 missense probably damaging 1.00
R6354:Vmn2r72 UTSW 7 85750539 critical splice donor site probably null
R6362:Vmn2r72 UTSW 7 85751174 missense probably damaging 1.00
R6594:Vmn2r72 UTSW 7 85749684 missense probably benign 0.32
R6794:Vmn2r72 UTSW 7 85737996 missense probably damaging 1.00
R7113:Vmn2r72 UTSW 7 85749803 splice site probably null
R7189:Vmn2r72 UTSW 7 85754917 missense probably benign 0.36
R7266:Vmn2r72 UTSW 7 85738274 nonsense probably null
R7323:Vmn2r72 UTSW 7 85750563 missense probably benign
R7426:Vmn2r72 UTSW 7 85751140 missense probably benign
R7606:Vmn2r72 UTSW 7 85751154 missense possibly damaging 0.91
R7651:Vmn2r72 UTSW 7 85751938 missense probably damaging 1.00
R7688:Vmn2r72 UTSW 7 85754890 missense probably benign 0.32
R7753:Vmn2r72 UTSW 7 85750626 missense probably damaging 1.00
R7843:Vmn2r72 UTSW 7 85749630 missense probably benign 0.01
R8157:Vmn2r72 UTSW 7 85751233 missense probably benign 0.09
R8254:Vmn2r72 UTSW 7 85751019 missense probably damaging 1.00
R8389:Vmn2r72 UTSW 7 85751960 missense probably damaging 0.99
R8444:Vmn2r72 UTSW 7 85738175 missense probably benign
R8989:Vmn2r72 UTSW 7 85754926 missense probably benign 0.10
R9015:Vmn2r72 UTSW 7 85749180 missense probably benign 0.01
R9080:Vmn2r72 UTSW 7 85738256 missense probably damaging 1.00
R9269:Vmn2r72 UTSW 7 85751203 missense probably benign 0.03
R9317:Vmn2r72 UTSW 7 85754814 missense probably benign 0.04
Z1176:Vmn2r72 UTSW 7 85749191 missense probably damaging 0.99
Predicted Primers
Posted On 2022-07-18