Mutagenetix > Incidental Mutation

Incidental Mutation 'R9509:Or2y1'

718023

Institutional Source

Beutler Lab

Gene Symbol

Or2y1

Ensembl Gene

ENSMUSG00000059729

Gene Name

olfactory receptor family 2 subfamily Y member 1

Synonyms

Olfr1385, Olfr1549-ps1, MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, MOR256-41P

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R9509 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

49385362-49386291 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 49385476 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 39 (I39V)

Ref Sequence

ENSEMBL: ENSMUSP00000150035 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071807] [ENSMUST00000214948]

AlphaFold

Q7TQT1

Predicted Effect

probably benign
Transcript: ENSMUST00000071807
AA Change: I39V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071710
Gene: ENSMUSG00000059729
AA Change: I39V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	2.1e-46	PFAM
Pfam:7TM_GPCR_Srsx	35	214	9.5e-6	PFAM
Pfam:7tm_1	41	289	2.8e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214948
AA Change: I39V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	TTCCTCCTCCTCCTCCTCCTCC	TTCCTCCTCCTCCTCCTCC	3: 137,771,595 (GRCm39)		probably benign	Het
Acan	C	T	7: 78,740,768 (GRCm39)	P378L	probably damaging	Het
Akap6	A	G	12: 53,189,021 (GRCm39)	D2145G	probably damaging	Het
Akap9	A	T	5: 4,096,349 (GRCm39)	D2408V	probably benign	Het
Apol10a	C	A	15: 77,372,968 (GRCm39)	Y201*	probably null	Het
Arhgef4	T	C	1: 34,762,772 (GRCm39)	I676T	unknown	Het
Capn13	T	C	17: 73,644,446 (GRCm39)	H361R	probably benign	Het
Ccdc88a	G	A	11: 29,414,143 (GRCm39)	V894I	probably benign	Het
Chd4	T	A	6: 125,099,485 (GRCm39)	L1655Q	possibly damaging	Het
Chi3l1	G	A	1: 134,116,413 (GRCm39)	E307K	probably damaging	Het
Dhfr	T	A	13: 92,504,739 (GRCm39)	I139N	probably damaging	Het
Dock8	A	G	19: 25,072,985 (GRCm39)	S422G	probably benign	Het
Dspp	C	A	5: 104,325,657 (GRCm39)	D673E	unknown	Het
Dst	G	T	1: 33,947,465 (GRCm39)	W38L	possibly damaging	Het
Dynlt1b	A	T	17: 6,702,415 (GRCm39)	E26D	probably benign	Het
Dysf	A	T	6: 84,187,779 (GRCm39)	Y2059F	probably damaging	Het
Efcab5	G	A	11: 76,994,977 (GRCm39)	S1198F	possibly damaging	Het
Erp44	T	C	4: 48,208,750 (GRCm39)	I237V	probably benign	Het
Exosc2	G	A	2: 31,564,755 (GRCm39)	V107I	probably benign	Het
Fat2	A	G	11: 55,200,713 (GRCm39)	V787A	possibly damaging	Het
Fbn2	C	G	18: 58,247,550 (GRCm39)	G448A	probably benign	Het
Fbxw21	A	G	9: 108,977,217 (GRCm39)	V164A	possibly damaging	Het
Gabpa	G	A	16: 84,649,395 (GRCm39)	V201I	possibly damaging	Het
Gm12253	G	A	11: 58,330,771 (GRCm39)	V177M	probably benign	Het
Il2rb	C	A	15: 78,374,416 (GRCm39)	W84L	probably damaging	Het
Kank4	T	A	4: 98,663,104 (GRCm39)	T695S	possibly damaging	Het
Klhl29	T	C	12: 5,190,629 (GRCm39)	Q122R	probably damaging	Het
L3mbtl1	A	G	2: 162,809,303 (GRCm39)	E670G	probably damaging	Het
Lifr	A	G	15: 7,188,955 (GRCm39)	Y112C	probably damaging	Het
Lins1	C	T	7: 66,358,119 (GRCm39)	Q85*	probably null	Het
Lpcat1	T	A	13: 73,642,951 (GRCm39)	V175E	probably damaging	Het
Mdm1	T	C	10: 117,982,730 (GRCm39)	S122P	probably damaging	Het
Mtfmt	C	T	9: 65,343,147 (GRCm39)	R18C	probably benign	Het
Mylk4	T	C	13: 32,904,543 (GRCm39)	N197S	probably benign	Het
Neurl4	T	A	11: 69,792,971 (GRCm39)	L83*	probably null	Het
Nlrc3	T	C	16: 3,782,680 (GRCm39)	D259G	probably damaging	Het
Nsf	A	T	11: 103,754,074 (GRCm39)	D487E	probably benign	Het
Or2n1e	A	G	17: 38,586,281 (GRCm39)	I206M	probably benign	Het
Or5p50	T	A	7: 107,422,440 (GRCm39)	T79S	probably benign	Het
Palb2	T	A	7: 121,727,399 (GRCm39)	K157M	probably damaging	Het
Pbrm1	T	C	14: 30,806,914 (GRCm39)	S1114P	probably damaging	Het
Pdia6	T	A	12: 17,330,989 (GRCm39)	M364K	probably damaging	Het
Pf4	G	T	5: 90,921,048 (GRCm39)	G83W	probably damaging	Het
Pibf1	T	C	14: 99,338,721 (GRCm39)	M79T	probably benign	Het
Pip4p2	T	A	4: 14,892,485 (GRCm39)	C116*	probably null	Het
Polr3b	T	G	10: 84,467,650 (GRCm39)	Y77D	probably damaging	Het
Pomt2	T	A	12: 87,184,802 (GRCm39)	H208L	possibly damaging	Het
Pprc1	A	T	19: 46,051,838 (GRCm39)	K456M	unknown	Het
Rasgef1a	A	T	6: 118,061,391 (GRCm39)	K119*	probably null	Het
Rbbp6	T	A	7: 122,597,791 (GRCm39)	Y701N	unknown	Het
Relch	A	G	1: 105,614,704 (GRCm39)	E216G	probably damaging	Het
Reln	A	T	5: 22,549,198 (GRCm39)	V70E	possibly damaging	Het
Rgs17	T	C	10: 5,812,576 (GRCm39)	N41S	probably benign	Het
Rhbdf1	A	T	11: 32,165,055 (GRCm39)	I106N	possibly damaging	Het
Robo1	T	A	16: 72,759,167 (GRCm39)	N393K	probably damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,229,127 (GRCm39)		probably benign	Het
Scart2	T	A	7: 139,879,644 (GRCm39)	Y1093*	probably null	Het
Scnn1a	A	T	6: 125,319,604 (GRCm39)	D495V	probably damaging	Het
Serpinf2	G	A	11: 75,328,895 (GRCm39)	P45L	probably benign	Het
Setdb1	A	C	3: 95,261,900 (GRCm39)	I122S	possibly damaging	Het
Slc4a9	A	T	18: 36,668,443 (GRCm39)	M701L	probably damaging	Het
Spata31h1	A	T	10: 82,132,229 (GRCm39)	N260K	probably benign	Het
Supv3l1	T	C	10: 62,265,411 (GRCm39)	T710A	probably benign	Het
Syne1	A	T	10: 5,298,927 (GRCm39)		probably null	Het
Tenm3	A	T	8: 48,766,292 (GRCm39)	Y743*	probably null	Het
Tgm2	A	T	2: 157,969,210 (GRCm39)	Y388*	probably null	Het
Tor3a	A	G	1: 156,483,499 (GRCm39)	S308P	possibly damaging	Het
Trim12a	T	C	7: 103,953,551 (GRCm39)	K187E	probably benign	Het
Trpc1	C	T	9: 95,625,249 (GRCm39)		probably null	Het
Uaca	C	T	9: 60,779,498 (GRCm39)	T1295M	possibly damaging	Het
Ush2a	T	A	1: 188,648,440 (GRCm39)	Y4682N	probably damaging	Het
Vldlr	A	G	19: 27,221,687 (GRCm39)	N684S	probably benign	Het
Vmn2r72	T	A	7: 85,404,075 (GRCm39)	I39L	probably benign	Het
Vps13b	A	T	15: 35,841,457 (GRCm39)	M2496L	possibly damaging	Het
Zbtb5	C	T	4: 44,994,332 (GRCm39)	V351M	probably damaging	Het
Zeb2	T	A	2: 44,887,876 (GRCm39)	T394S	possibly damaging	Het
Zfp352	A	G	4: 90,112,943 (GRCm39)	E361G	probably damaging	Het
Zfp54	C	A	17: 21,654,629 (GRCm39)	Y374*	probably null	Het
Zfp869	C	A	8: 70,159,596 (GRCm39)	G326W	probably damaging	Het
Zfyve28	C	T	5: 34,354,892 (GRCm39)	A806T	probably benign	Het

Other mutations in Or2y1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01722:Or2y1	APN	11	49,385,793 (GRCm39)	missense	probably damaging	0.99
IGL02098:Or2y1	APN	11	49,386,224 (GRCm39)	missense	probably damaging	1.00
IGL03206:Or2y1	APN	11	49,385,536 (GRCm39)	missense	probably benign	0.05
IGL03402:Or2y1	APN	11	49,385,873 (GRCm39)	missense	probably benign
R0412:Or2y1	UTSW	11	49,385,594 (GRCm39)	missense	probably damaging	1.00
R1263:Or2y1	UTSW	11	49,385,848 (GRCm39)	missense	probably benign
R1371:Or2y1	UTSW	11	49,385,650 (GRCm39)	missense	probably damaging	1.00
R1488:Or2y1	UTSW	11	49,385,945 (GRCm39)	missense	probably benign	0.07
R1835:Or2y1	UTSW	11	49,385,497 (GRCm39)	missense	probably damaging	1.00
R1923:Or2y1	UTSW	11	49,386,131 (GRCm39)	missense	probably damaging	0.97
R2290:Or2y1	UTSW	11	49,385,857 (GRCm39)	missense	probably benign
R3738:Or2y1	UTSW	11	49,386,287 (GRCm39)	missense	possibly damaging	0.56
R3739:Or2y1	UTSW	11	49,386,287 (GRCm39)	missense	possibly damaging	0.56
R4034:Or2y1	UTSW	11	49,386,287 (GRCm39)	missense	possibly damaging	0.56
R4193:Or2y1	UTSW	11	49,386,134 (GRCm39)	missense	probably damaging	1.00
R4406:Or2y1	UTSW	11	49,385,744 (GRCm39)	missense	probably benign	0.01
R5239:Or2y1	UTSW	11	49,385,555 (GRCm39)	missense	possibly damaging	0.93
R6713:Or2y1	UTSW	11	49,385,784 (GRCm39)	missense	probably damaging	1.00
R6861:Or2y1	UTSW	11	49,385,632 (GRCm39)	missense	probably benign	0.00
R7916:Or2y1	UTSW	11	49,385,543 (GRCm39)	missense	probably benign
R8712:Or2y1	UTSW	11	49,385,671 (GRCm39)	missense	probably benign
R9624:Or2y1	UTSW	11	49,385,834 (GRCm39)	missense	possibly damaging	0.94
R9793:Or2y1	UTSW	11	49,385,882 (GRCm39)	missense	probably damaging	1.00
R9795:Or2y1	UTSW	11	49,385,882 (GRCm39)	missense	probably damaging	1.00
Z1176:Or2y1	UTSW	11	49,385,894 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAATCAAAGGGCCTGGTTCAG -3'
(R):5'- ATGAAAAGCTGGGCCACAC -3'

Sequencing Primer
(F):5'- CTGGTTCAGGAAATCCAGTTAAG -3'
(R):5'- CACACCCTCCATAGCTGATG -3'

Posted On

2022-07-18