Incidental Mutation 'R9513:Tpp2'
| ID |
718257 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.607)
|
| Stock # |
R9513 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 44017648 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 751
(S751T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
[ENSMUST00000190207]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087933
AA Change: S751T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: S751T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188313
AA Change: S751T
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: S751T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: S751T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: S751T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190207
|
| SMART Domains |
Protein: ENSMUSP00000140313
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
86 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
87 |
281 |
3e-19 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
| Accsl |
T |
C |
2: 93,699,498 (GRCm39) |
|
probably benign |
Het |
| Adgrv1 |
T |
A |
13: 81,530,472 (GRCm39) |
K5867N |
possibly damaging |
Het |
| Adh1 |
T |
A |
3: 137,988,571 (GRCm39) |
Y181* |
probably null |
Het |
| Agbl2 |
T |
C |
2: 90,631,458 (GRCm39) |
V272A |
possibly damaging |
Het |
| Akap13 |
T |
C |
7: 75,354,275 (GRCm39) |
Y80H |
probably benign |
Het |
| Amotl1 |
A |
T |
9: 14,526,063 (GRCm39) |
S6T |
probably benign |
Het |
| Bicd1 |
T |
A |
6: 149,414,391 (GRCm39) |
V368E |
probably damaging |
Het |
| Brinp2 |
G |
A |
1: 158,074,273 (GRCm39) |
T616I |
probably damaging |
Het |
| C1rl |
T |
A |
6: 124,485,802 (GRCm39) |
V391E |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,318,033 (GRCm39) |
I1450F |
probably damaging |
Het |
| Camk2a |
A |
G |
18: 61,088,607 (GRCm39) |
|
probably null |
Het |
| Ccdc125 |
A |
G |
13: 100,826,875 (GRCm39) |
E244G |
probably benign |
Het |
| Cdh23 |
C |
T |
10: 60,166,995 (GRCm39) |
A1884T |
probably damaging |
Het |
| Clcn1 |
T |
C |
6: 42,282,462 (GRCm39) |
I510T |
probably damaging |
Het |
| Copb1 |
A |
T |
7: 113,831,432 (GRCm39) |
V572D |
probably benign |
Het |
| Ctf1 |
AGCAAC |
A |
7: 127,316,180 (GRCm39) |
|
probably null |
Het |
| Dnhd1 |
T |
A |
7: 105,354,179 (GRCm39) |
L3053Q |
probably damaging |
Het |
| Ephb4 |
T |
A |
5: 137,361,564 (GRCm39) |
H531Q |
possibly damaging |
Het |
| Fgl2 |
T |
A |
5: 21,580,790 (GRCm39) |
C377* |
probably null |
Het |
| Frmd4a |
T |
C |
2: 4,608,711 (GRCm39) |
F860L |
probably damaging |
Het |
| Gbp9 |
T |
C |
5: 105,229,091 (GRCm39) |
N519D |
probably benign |
Het |
| Gm1110 |
A |
G |
9: 26,795,083 (GRCm39) |
S468P |
possibly damaging |
Het |
| Gm4847 |
A |
T |
1: 166,462,541 (GRCm39) |
D316E |
probably damaging |
Het |
| Gnas |
T |
C |
2: 174,185,089 (GRCm39) |
Y916H |
probably damaging |
Het |
| Hectd1 |
T |
C |
12: 51,816,079 (GRCm39) |
D1336G |
possibly damaging |
Het |
| Herc2 |
G |
T |
7: 55,762,848 (GRCm39) |
G859V |
probably damaging |
Het |
| Hydin |
G |
A |
8: 111,322,114 (GRCm39) |
D4589N |
probably damaging |
Het |
| Itfg1 |
A |
T |
8: 86,490,875 (GRCm39) |
N351K |
possibly damaging |
Het |
| Kcnd3 |
G |
A |
3: 105,572,863 (GRCm39) |
|
probably null |
Het |
| Krt77 |
A |
T |
15: 101,769,779 (GRCm39) |
Y364N |
probably damaging |
Het |
| Lcn4 |
C |
T |
2: 26,560,613 (GRCm39) |
|
probably null |
Het |
| Lrrn1 |
T |
A |
6: 107,545,505 (GRCm39) |
H434Q |
probably benign |
Het |
| Lrrtm2 |
A |
G |
18: 35,346,687 (GRCm39) |
I205T |
probably damaging |
Het |
| Mepce |
G |
C |
5: 137,783,759 (GRCm39) |
P189R |
probably damaging |
Het |
| Mfap1a |
T |
C |
2: 121,330,084 (GRCm39) |
K221E |
probably benign |
Het |
| Myo7a |
A |
G |
7: 97,746,818 (GRCm39) |
|
probably null |
Het |
| Ncbp3 |
T |
C |
11: 72,938,727 (GRCm39) |
M1T |
probably null |
Het |
| Nck1 |
A |
T |
9: 100,379,369 (GRCm39) |
M294K |
probably benign |
Het |
| Nr2f2 |
A |
T |
7: 70,010,056 (GRCm39) |
W8R |
probably damaging |
Het |
| Or12e10 |
T |
A |
2: 87,640,187 (GRCm39) |
S8T |
possibly damaging |
Het |
| Or1e20-ps1 |
T |
A |
11: 73,324,818 (GRCm39) |
Q78L |
unknown |
Het |
| Or4c12b |
A |
T |
2: 89,647,553 (GRCm39) |
R288S |
probably damaging |
Het |
| Or6ae1 |
T |
A |
7: 139,742,822 (GRCm39) |
I14F |
possibly damaging |
Het |
| Or7e169 |
A |
G |
9: 19,757,816 (GRCm39) |
L33P |
possibly damaging |
Het |
| Or8g18 |
T |
C |
9: 39,149,625 (GRCm39) |
T32A |
probably benign |
Het |
| Or8j3c |
A |
T |
2: 86,253,707 (GRCm39) |
F104L |
probably damaging |
Het |
| Pcdha1 |
A |
G |
18: 37,065,286 (GRCm39) |
K650R |
probably benign |
Het |
| Pgm1 |
T |
A |
4: 99,841,242 (GRCm39) |
I532N |
probably damaging |
Het |
| Pik3c2a |
T |
A |
7: 115,939,321 (GRCm39) |
K1672N |
probably benign |
Het |
| Pou3f1 |
G |
A |
4: 124,552,835 (GRCm39) |
G446S |
probably benign |
Het |
| Ppm1j |
T |
C |
3: 104,693,134 (GRCm39) |
I497T |
probably damaging |
Het |
| Pprc1 |
C |
T |
19: 46,056,500 (GRCm39) |
Q1202* |
probably null |
Het |
| Pramel30 |
T |
A |
4: 144,059,678 (GRCm39) |
I463N |
possibly damaging |
Het |
| Prdm15 |
T |
C |
16: 97,607,704 (GRCm39) |
N713S |
probably damaging |
Het |
| Ptprb |
A |
G |
10: 116,138,142 (GRCm39) |
T62A |
probably benign |
Het |
| Rabl2 |
T |
A |
15: 89,474,631 (GRCm39) |
|
probably null |
Het |
| Ranbp3l |
A |
T |
15: 9,037,176 (GRCm39) |
R149* |
probably null |
Het |
| Resf1 |
T |
A |
6: 149,229,793 (GRCm39) |
Y946* |
probably null |
Het |
| Rfx4 |
T |
A |
10: 84,674,050 (GRCm39) |
M1K |
probably null |
Het |
| Ripk4 |
G |
T |
16: 97,547,098 (GRCm39) |
S388* |
probably null |
Het |
| Rnft1 |
T |
G |
11: 86,377,065 (GRCm39) |
I43R |
possibly damaging |
Het |
| Setbp1 |
A |
T |
18: 78,899,781 (GRCm39) |
F1295L |
probably damaging |
Het |
| Sez6 |
A |
G |
11: 77,865,409 (GRCm39) |
D682G |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,812,734 (GRCm39) |
|
probably null |
Het |
| Slc7a5 |
G |
T |
8: 122,613,616 (GRCm39) |
T312K |
probably benign |
Het |
| Slco4c1 |
A |
T |
1: 96,799,643 (GRCm39) |
N64K |
probably benign |
Het |
| Spata13 |
C |
T |
14: 60,929,849 (GRCm39) |
T469I |
probably benign |
Het |
| Stxbp5 |
T |
A |
10: 9,687,754 (GRCm39) |
N440I |
probably benign |
Het |
| Tas2r114 |
T |
A |
6: 131,666,746 (GRCm39) |
Q94L |
probably benign |
Het |
| Tasor |
T |
A |
14: 27,186,271 (GRCm39) |
C823* |
probably null |
Het |
| Tfr2 |
A |
G |
5: 137,575,769 (GRCm39) |
D295G |
possibly damaging |
Het |
| Thap7 |
A |
G |
16: 17,348,152 (GRCm39) |
Y60H |
probably damaging |
Het |
| Tjap1 |
G |
T |
17: 46,569,733 (GRCm39) |
P409H |
probably damaging |
Het |
| Tmtc4 |
G |
A |
14: 123,209,204 (GRCm39) |
A147V |
probably benign |
Het |
| Tpra1 |
T |
C |
6: 88,887,221 (GRCm39) |
V193A |
probably benign |
Het |
| Trafd1 |
T |
C |
5: 121,516,837 (GRCm39) |
N122S |
possibly damaging |
Het |
| Vmn1r151 |
T |
A |
7: 22,199,096 (GRCm39) |
D3V |
probably benign |
Het |
| Wdr20rt |
A |
G |
12: 65,272,825 (GRCm39) |
Y96C |
probably damaging |
Het |
| Zfp507 |
A |
G |
7: 35,475,573 (GRCm39) |
V880A |
probably benign |
Het |
| Zfp598 |
A |
G |
17: 24,896,568 (GRCm39) |
D215G |
probably damaging |
Het |
| Zfp7 |
T |
C |
15: 76,775,484 (GRCm39) |
S509P |
probably damaging |
Het |
| Zfp738 |
A |
T |
13: 67,817,635 (GRCm39) |
C785* |
probably null |
Het |
| Zfp985 |
C |
T |
4: 147,667,999 (GRCm39) |
T289I |
probably damaging |
Het |
| Zkscan6 |
T |
A |
11: 65,712,795 (GRCm39) |
Y243N |
probably damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTACAACAGAGCTTAGGATACTC -3'
(R):5'- TGATTCCTTCAGATGCATGCTAC -3'
Sequencing Primer
(F):5'- AATTATGTTTAAATTGGGTCCTAGGG -3'
(R):5'- TTCCTTCAGATGCATGCTACAAAAC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation