Incidental Mutation 'R9513:Tasor'
ID |
718325 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tasor
|
Ensembl Gene |
ENSMUSG00000040651 |
Gene Name |
transcription activation suppressor |
Synonyms |
D14Abb1e, Fam208a, 4933409E02Rik, MommeD6 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R9513 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
14 |
Chromosomal Location |
27150791-27205512 bp(+) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
T to A
at 27186271 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Stop codon
at position 823
(C823*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000022450
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022450]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably null
Transcript: ENSMUST00000022450
AA Change: C823*
|
SMART Domains |
Protein: ENSMUSP00000022450 Gene: ENSMUSG00000040651 AA Change: C823*
Domain | Start | End | E-Value | Type |
low complexity region
|
20 |
27 |
N/A |
INTRINSIC |
low complexity region
|
42 |
61 |
N/A |
INTRINSIC |
low complexity region
|
74 |
88 |
N/A |
INTRINSIC |
Pfam:DUF3715
|
153 |
314 |
1.5e-55 |
PFAM |
low complexity region
|
442 |
457 |
N/A |
INTRINSIC |
low complexity region
|
1087 |
1102 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for ENU mutations are not viable past gastrulation. [provided by MGI curators]
|
Allele List at MGI |
All alleles(26) : Gene trapped(26) |
Other mutations in this stock |
Total: 85 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
Accsl |
T |
C |
2: 93,699,498 (GRCm39) |
|
probably benign |
Het |
Adgrv1 |
T |
A |
13: 81,530,472 (GRCm39) |
K5867N |
possibly damaging |
Het |
Adh1 |
T |
A |
3: 137,988,571 (GRCm39) |
Y181* |
probably null |
Het |
Agbl2 |
T |
C |
2: 90,631,458 (GRCm39) |
V272A |
possibly damaging |
Het |
Akap13 |
T |
C |
7: 75,354,275 (GRCm39) |
Y80H |
probably benign |
Het |
Amotl1 |
A |
T |
9: 14,526,063 (GRCm39) |
S6T |
probably benign |
Het |
Bicd1 |
T |
A |
6: 149,414,391 (GRCm39) |
V368E |
probably damaging |
Het |
Brinp2 |
G |
A |
1: 158,074,273 (GRCm39) |
T616I |
probably damaging |
Het |
C1rl |
T |
A |
6: 124,485,802 (GRCm39) |
V391E |
probably damaging |
Het |
Cacna1e |
T |
A |
1: 154,318,033 (GRCm39) |
I1450F |
probably damaging |
Het |
Camk2a |
A |
G |
18: 61,088,607 (GRCm39) |
|
probably null |
Het |
Ccdc125 |
A |
G |
13: 100,826,875 (GRCm39) |
E244G |
probably benign |
Het |
Cdh23 |
C |
T |
10: 60,166,995 (GRCm39) |
A1884T |
probably damaging |
Het |
Clcn1 |
T |
C |
6: 42,282,462 (GRCm39) |
I510T |
probably damaging |
Het |
Copb1 |
A |
T |
7: 113,831,432 (GRCm39) |
V572D |
probably benign |
Het |
Ctf1 |
AGCAAC |
A |
7: 127,316,180 (GRCm39) |
|
probably null |
Het |
Dnhd1 |
T |
A |
7: 105,354,179 (GRCm39) |
L3053Q |
probably damaging |
Het |
Ephb4 |
T |
A |
5: 137,361,564 (GRCm39) |
H531Q |
possibly damaging |
Het |
Fgl2 |
T |
A |
5: 21,580,790 (GRCm39) |
C377* |
probably null |
Het |
Frmd4a |
T |
C |
2: 4,608,711 (GRCm39) |
F860L |
probably damaging |
Het |
Gbp9 |
T |
C |
5: 105,229,091 (GRCm39) |
N519D |
probably benign |
Het |
Gm1110 |
A |
G |
9: 26,795,083 (GRCm39) |
S468P |
possibly damaging |
Het |
Gm4847 |
A |
T |
1: 166,462,541 (GRCm39) |
D316E |
probably damaging |
Het |
Gnas |
T |
C |
2: 174,185,089 (GRCm39) |
Y916H |
probably damaging |
Het |
Hectd1 |
T |
C |
12: 51,816,079 (GRCm39) |
D1336G |
possibly damaging |
Het |
Herc2 |
G |
T |
7: 55,762,848 (GRCm39) |
G859V |
probably damaging |
Het |
Hydin |
G |
A |
8: 111,322,114 (GRCm39) |
D4589N |
probably damaging |
Het |
Itfg1 |
A |
T |
8: 86,490,875 (GRCm39) |
N351K |
possibly damaging |
Het |
Kcnd3 |
G |
A |
3: 105,572,863 (GRCm39) |
|
probably null |
Het |
Krt77 |
A |
T |
15: 101,769,779 (GRCm39) |
Y364N |
probably damaging |
Het |
Lcn4 |
C |
T |
2: 26,560,613 (GRCm39) |
|
probably null |
Het |
Lrrn1 |
T |
A |
6: 107,545,505 (GRCm39) |
H434Q |
probably benign |
Het |
Lrrtm2 |
A |
G |
18: 35,346,687 (GRCm39) |
I205T |
probably damaging |
Het |
Mepce |
G |
C |
5: 137,783,759 (GRCm39) |
P189R |
probably damaging |
Het |
Mfap1a |
T |
C |
2: 121,330,084 (GRCm39) |
K221E |
probably benign |
Het |
Myo7a |
A |
G |
7: 97,746,818 (GRCm39) |
|
probably null |
Het |
Ncbp3 |
T |
C |
11: 72,938,727 (GRCm39) |
M1T |
probably null |
Het |
Nck1 |
A |
T |
9: 100,379,369 (GRCm39) |
M294K |
probably benign |
Het |
Nr2f2 |
A |
T |
7: 70,010,056 (GRCm39) |
W8R |
probably damaging |
Het |
Or12e10 |
T |
A |
2: 87,640,187 (GRCm39) |
S8T |
possibly damaging |
Het |
Or1e20-ps1 |
T |
A |
11: 73,324,818 (GRCm39) |
Q78L |
unknown |
Het |
Or4c12b |
A |
T |
2: 89,647,553 (GRCm39) |
R288S |
probably damaging |
Het |
Or6ae1 |
T |
A |
7: 139,742,822 (GRCm39) |
I14F |
possibly damaging |
Het |
Or7e169 |
A |
G |
9: 19,757,816 (GRCm39) |
L33P |
possibly damaging |
Het |
Or8g18 |
T |
C |
9: 39,149,625 (GRCm39) |
T32A |
probably benign |
Het |
Or8j3c |
A |
T |
2: 86,253,707 (GRCm39) |
F104L |
probably damaging |
Het |
Pcdha1 |
A |
G |
18: 37,065,286 (GRCm39) |
K650R |
probably benign |
Het |
Pgm1 |
T |
A |
4: 99,841,242 (GRCm39) |
I532N |
probably damaging |
Het |
Pik3c2a |
T |
A |
7: 115,939,321 (GRCm39) |
K1672N |
probably benign |
Het |
Pou3f1 |
G |
A |
4: 124,552,835 (GRCm39) |
G446S |
probably benign |
Het |
Ppm1j |
T |
C |
3: 104,693,134 (GRCm39) |
I497T |
probably damaging |
Het |
Pprc1 |
C |
T |
19: 46,056,500 (GRCm39) |
Q1202* |
probably null |
Het |
Pramel30 |
T |
A |
4: 144,059,678 (GRCm39) |
I463N |
possibly damaging |
Het |
Prdm15 |
T |
C |
16: 97,607,704 (GRCm39) |
N713S |
probably damaging |
Het |
Ptprb |
A |
G |
10: 116,138,142 (GRCm39) |
T62A |
probably benign |
Het |
Rabl2 |
T |
A |
15: 89,474,631 (GRCm39) |
|
probably null |
Het |
Ranbp3l |
A |
T |
15: 9,037,176 (GRCm39) |
R149* |
probably null |
Het |
Resf1 |
T |
A |
6: 149,229,793 (GRCm39) |
Y946* |
probably null |
Het |
Rfx4 |
T |
A |
10: 84,674,050 (GRCm39) |
M1K |
probably null |
Het |
Ripk4 |
G |
T |
16: 97,547,098 (GRCm39) |
S388* |
probably null |
Het |
Rnft1 |
T |
G |
11: 86,377,065 (GRCm39) |
I43R |
possibly damaging |
Het |
Setbp1 |
A |
T |
18: 78,899,781 (GRCm39) |
F1295L |
probably damaging |
Het |
Sez6 |
A |
G |
11: 77,865,409 (GRCm39) |
D682G |
probably damaging |
Het |
Slc1a1 |
T |
C |
19: 28,812,734 (GRCm39) |
|
probably null |
Het |
Slc7a5 |
G |
T |
8: 122,613,616 (GRCm39) |
T312K |
probably benign |
Het |
Slco4c1 |
A |
T |
1: 96,799,643 (GRCm39) |
N64K |
probably benign |
Het |
Spata13 |
C |
T |
14: 60,929,849 (GRCm39) |
T469I |
probably benign |
Het |
Stxbp5 |
T |
A |
10: 9,687,754 (GRCm39) |
N440I |
probably benign |
Het |
Tas2r114 |
T |
A |
6: 131,666,746 (GRCm39) |
Q94L |
probably benign |
Het |
Tfr2 |
A |
G |
5: 137,575,769 (GRCm39) |
D295G |
possibly damaging |
Het |
Thap7 |
A |
G |
16: 17,348,152 (GRCm39) |
Y60H |
probably damaging |
Het |
Tjap1 |
G |
T |
17: 46,569,733 (GRCm39) |
P409H |
probably damaging |
Het |
Tmtc4 |
G |
A |
14: 123,209,204 (GRCm39) |
A147V |
probably benign |
Het |
Tpp2 |
T |
A |
1: 44,017,648 (GRCm39) |
S751T |
probably benign |
Het |
Tpra1 |
T |
C |
6: 88,887,221 (GRCm39) |
V193A |
probably benign |
Het |
Trafd1 |
T |
C |
5: 121,516,837 (GRCm39) |
N122S |
possibly damaging |
Het |
Vmn1r151 |
T |
A |
7: 22,199,096 (GRCm39) |
D3V |
probably benign |
Het |
Wdr20rt |
A |
G |
12: 65,272,825 (GRCm39) |
Y96C |
probably damaging |
Het |
Zfp507 |
A |
G |
7: 35,475,573 (GRCm39) |
V880A |
probably benign |
Het |
Zfp598 |
A |
G |
17: 24,896,568 (GRCm39) |
D215G |
probably damaging |
Het |
Zfp7 |
T |
C |
15: 76,775,484 (GRCm39) |
S509P |
probably damaging |
Het |
Zfp738 |
A |
T |
13: 67,817,635 (GRCm39) |
C785* |
probably null |
Het |
Zfp985 |
C |
T |
4: 147,667,999 (GRCm39) |
T289I |
probably damaging |
Het |
Zkscan6 |
T |
A |
11: 65,712,795 (GRCm39) |
Y243N |
probably damaging |
Het |
|
Other mutations in Tasor |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00093:Tasor
|
APN |
14 |
27,170,163 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00467:Tasor
|
APN |
14 |
27,170,121 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01071:Tasor
|
APN |
14 |
27,164,579 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01351:Tasor
|
APN |
14 |
27,186,258 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01375:Tasor
|
APN |
14 |
27,162,120 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01509:Tasor
|
APN |
14 |
27,181,731 (GRCm39) |
splice site |
probably benign |
|
IGL02342:Tasor
|
APN |
14 |
27,198,624 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL03105:Tasor
|
APN |
14 |
27,164,509 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03131:Tasor
|
APN |
14 |
27,183,136 (GRCm39) |
nonsense |
probably null |
|
IGL03248:Tasor
|
APN |
14 |
27,198,649 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03383:Tasor
|
APN |
14 |
27,163,918 (GRCm39) |
missense |
possibly damaging |
0.93 |
balsam
|
UTSW |
14 |
27,183,107 (GRCm39) |
missense |
probably benign |
0.01 |
santa_rosa
|
UTSW |
14 |
27,198,658 (GRCm39) |
splice site |
probably null |
|
D4043:Tasor
|
UTSW |
14 |
27,193,949 (GRCm39) |
missense |
probably benign |
0.07 |
R0147:Tasor
|
UTSW |
14 |
27,193,725 (GRCm39) |
missense |
probably benign |
0.23 |
R0512:Tasor
|
UTSW |
14 |
27,168,363 (GRCm39) |
missense |
probably damaging |
1.00 |
R0589:Tasor
|
UTSW |
14 |
27,183,107 (GRCm39) |
missense |
probably benign |
0.01 |
R0609:Tasor
|
UTSW |
14 |
27,183,707 (GRCm39) |
missense |
probably benign |
0.09 |
R0798:Tasor
|
UTSW |
14 |
27,198,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R1107:Tasor
|
UTSW |
14 |
27,201,680 (GRCm39) |
nonsense |
probably null |
|
R1205:Tasor
|
UTSW |
14 |
27,183,275 (GRCm39) |
missense |
probably damaging |
1.00 |
R1376:Tasor
|
UTSW |
14 |
27,151,338 (GRCm39) |
missense |
probably benign |
0.00 |
R1376:Tasor
|
UTSW |
14 |
27,151,338 (GRCm39) |
missense |
probably benign |
0.00 |
R1441:Tasor
|
UTSW |
14 |
27,186,217 (GRCm39) |
nonsense |
probably null |
|
R1493:Tasor
|
UTSW |
14 |
27,171,926 (GRCm39) |
missense |
probably damaging |
1.00 |
R1527:Tasor
|
UTSW |
14 |
27,202,050 (GRCm39) |
critical splice donor site |
probably null |
|
R1729:Tasor
|
UTSW |
14 |
27,201,590 (GRCm39) |
missense |
probably damaging |
1.00 |
R1752:Tasor
|
UTSW |
14 |
27,193,885 (GRCm39) |
nonsense |
probably null |
|
R1960:Tasor
|
UTSW |
14 |
27,201,746 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1960:Tasor
|
UTSW |
14 |
27,160,621 (GRCm39) |
missense |
probably damaging |
1.00 |
R1965:Tasor
|
UTSW |
14 |
27,164,511 (GRCm39) |
missense |
probably damaging |
1.00 |
R2074:Tasor
|
UTSW |
14 |
27,183,170 (GRCm39) |
missense |
probably benign |
0.03 |
R2107:Tasor
|
UTSW |
14 |
27,183,744 (GRCm39) |
critical splice donor site |
probably null |
|
R2130:Tasor
|
UTSW |
14 |
27,198,571 (GRCm39) |
missense |
possibly damaging |
0.74 |
R2130:Tasor
|
UTSW |
14 |
27,168,345 (GRCm39) |
missense |
probably damaging |
1.00 |
R2131:Tasor
|
UTSW |
14 |
27,198,571 (GRCm39) |
missense |
possibly damaging |
0.74 |
R2133:Tasor
|
UTSW |
14 |
27,198,571 (GRCm39) |
missense |
possibly damaging |
0.74 |
R2140:Tasor
|
UTSW |
14 |
27,201,992 (GRCm39) |
missense |
probably damaging |
1.00 |
R2184:Tasor
|
UTSW |
14 |
27,188,141 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2279:Tasor
|
UTSW |
14 |
27,164,452 (GRCm39) |
missense |
probably damaging |
1.00 |
R3979:Tasor
|
UTSW |
14 |
27,199,087 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4113:Tasor
|
UTSW |
14 |
27,181,918 (GRCm39) |
nonsense |
probably null |
|
R4434:Tasor
|
UTSW |
14 |
27,171,818 (GRCm39) |
critical splice donor site |
probably null |
|
R4562:Tasor
|
UTSW |
14 |
27,188,265 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4568:Tasor
|
UTSW |
14 |
27,198,658 (GRCm39) |
splice site |
probably null |
|
R4754:Tasor
|
UTSW |
14 |
27,183,052 (GRCm39) |
missense |
probably benign |
|
R4980:Tasor
|
UTSW |
14 |
27,183,382 (GRCm39) |
missense |
probably benign |
0.39 |
R4993:Tasor
|
UTSW |
14 |
27,151,071 (GRCm39) |
missense |
possibly damaging |
0.88 |
R5200:Tasor
|
UTSW |
14 |
27,151,183 (GRCm39) |
missense |
probably benign |
0.41 |
R5316:Tasor
|
UTSW |
14 |
27,193,992 (GRCm39) |
missense |
possibly damaging |
0.52 |
R5599:Tasor
|
UTSW |
14 |
27,201,886 (GRCm39) |
missense |
probably benign |
0.01 |
R5678:Tasor
|
UTSW |
14 |
27,151,080 (GRCm39) |
small insertion |
probably benign |
|
R5680:Tasor
|
UTSW |
14 |
27,151,080 (GRCm39) |
small insertion |
probably benign |
|
R5887:Tasor
|
UTSW |
14 |
27,188,254 (GRCm39) |
nonsense |
probably null |
|
R6181:Tasor
|
UTSW |
14 |
27,194,235 (GRCm39) |
missense |
probably benign |
0.01 |
R6556:Tasor
|
UTSW |
14 |
27,151,215 (GRCm39) |
missense |
probably benign |
|
R6603:Tasor
|
UTSW |
14 |
27,168,343 (GRCm39) |
missense |
probably damaging |
1.00 |
R6829:Tasor
|
UTSW |
14 |
27,164,438 (GRCm39) |
missense |
possibly damaging |
0.90 |
R6864:Tasor
|
UTSW |
14 |
27,183,115 (GRCm39) |
missense |
probably damaging |
0.96 |
R6919:Tasor
|
UTSW |
14 |
27,171,758 (GRCm39) |
nonsense |
probably null |
|
R7046:Tasor
|
UTSW |
14 |
27,194,392 (GRCm39) |
missense |
probably damaging |
1.00 |
R7057:Tasor
|
UTSW |
14 |
27,183,608 (GRCm39) |
missense |
probably damaging |
0.97 |
R7064:Tasor
|
UTSW |
14 |
27,194,288 (GRCm39) |
missense |
probably benign |
0.09 |
R7290:Tasor
|
UTSW |
14 |
27,160,610 (GRCm39) |
missense |
probably damaging |
1.00 |
R7303:Tasor
|
UTSW |
14 |
27,193,809 (GRCm39) |
missense |
probably damaging |
1.00 |
R7439:Tasor
|
UTSW |
14 |
27,193,602 (GRCm39) |
missense |
probably damaging |
1.00 |
R7524:Tasor
|
UTSW |
14 |
27,188,160 (GRCm39) |
missense |
probably damaging |
0.99 |
R7580:Tasor
|
UTSW |
14 |
27,188,243 (GRCm39) |
missense |
probably benign |
0.29 |
R7726:Tasor
|
UTSW |
14 |
27,169,454 (GRCm39) |
missense |
probably damaging |
0.99 |
R7771:Tasor
|
UTSW |
14 |
27,189,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R7782:Tasor
|
UTSW |
14 |
27,193,901 (GRCm39) |
missense |
probably benign |
0.07 |
R7795:Tasor
|
UTSW |
14 |
27,203,340 (GRCm39) |
missense |
|
|
R7835:Tasor
|
UTSW |
14 |
27,198,600 (GRCm39) |
missense |
probably damaging |
1.00 |
R7954:Tasor
|
UTSW |
14 |
27,169,481 (GRCm39) |
critical splice donor site |
probably null |
|
R7981:Tasor
|
UTSW |
14 |
27,168,373 (GRCm39) |
missense |
possibly damaging |
0.49 |
R8101:Tasor
|
UTSW |
14 |
27,164,438 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8160:Tasor
|
UTSW |
14 |
27,171,913 (GRCm39) |
missense |
probably damaging |
1.00 |
R8307:Tasor
|
UTSW |
14 |
27,193,622 (GRCm39) |
missense |
probably damaging |
1.00 |
R8913:Tasor
|
UTSW |
14 |
27,188,145 (GRCm39) |
missense |
probably damaging |
1.00 |
R9070:Tasor
|
UTSW |
14 |
27,194,484 (GRCm39) |
missense |
probably benign |
0.14 |
R9219:Tasor
|
UTSW |
14 |
27,186,344 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9420:Tasor
|
UTSW |
14 |
27,163,927 (GRCm39) |
missense |
probably damaging |
0.99 |
R9562:Tasor
|
UTSW |
14 |
27,201,766 (GRCm39) |
critical splice donor site |
probably null |
|
R9565:Tasor
|
UTSW |
14 |
27,201,766 (GRCm39) |
critical splice donor site |
probably null |
|
R9627:Tasor
|
UTSW |
14 |
27,194,123 (GRCm39) |
missense |
probably benign |
|
X0002:Tasor
|
UTSW |
14 |
27,194,063 (GRCm39) |
missense |
possibly damaging |
0.90 |
Z1176:Tasor
|
UTSW |
14 |
27,199,105 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Tasor
|
UTSW |
14 |
27,151,165 (GRCm39) |
missense |
probably damaging |
0.97 |
Z1177:Tasor
|
UTSW |
14 |
27,170,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCCTAACTTGAGAGTGCAGC -3'
(R):5'- CCTCTTGAGGACACACAATAGC -3'
Sequencing Primer
(F):5'- GGGACATCCACAAGCTTTATAATTGG -3'
(R):5'- TCTTGAGGACACACAATAGCTAGTAG -3'
|
Posted On |
2022-07-18 |