Incidental Mutation 'R9514:Triobp'
| ID |
718410 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9514 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 78877378 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 1637
(R1637C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109687]
[ENSMUST00000109689]
[ENSMUST00000109690]
[ENSMUST00000130663]
[ENSMUST00000144151]
[ENSMUST00000229270]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109687
AA Change: R250C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105309
Gene: ENSMUSG00000033088
AA Change: R250C
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
coiled coil region
|
339 |
377 |
N/A |
INTRINSIC |
|
coiled coil region
|
401 |
463 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109689
AA Change: R1591C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
AA Change: R1591C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109690
AA Change: R1637C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
AA Change: R1637C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000122988
Gene: ENSMUSG00000033088
AA Change: R245C
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144151
|
| SMART Domains |
Protein: ENSMUSP00000116765
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
1 |
92 |
1.04e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229270
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810065E05Rik |
T |
C |
11: 58,312,533 (GRCm39) |
S4P |
probably benign |
Het |
| 2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
| Acsl6 |
A |
G |
11: 54,225,880 (GRCm39) |
N307D |
probably benign |
Het |
| Atxn1 |
A |
G |
13: 45,721,433 (GRCm39) |
V154A |
probably benign |
Het |
| Bltp3a |
A |
G |
17: 28,112,414 (GRCm39) |
D1201G |
probably damaging |
Het |
| Cacna2d4 |
T |
C |
6: 119,213,611 (GRCm39) |
L10S |
probably benign |
Het |
| Cd33 |
A |
T |
7: 43,182,150 (GRCm39) |
H98Q |
probably benign |
Het |
| Cebpz |
A |
T |
17: 79,239,684 (GRCm39) |
M579K |
probably benign |
Het |
| Cenpk |
T |
G |
13: 104,370,682 (GRCm39) |
C103G |
probably benign |
Het |
| Cep97 |
T |
A |
16: 55,726,093 (GRCm39) |
Q670L |
probably benign |
Het |
| Cfap65 |
C |
T |
1: 74,945,468 (GRCm39) |
|
probably null |
Het |
| Cir1 |
A |
G |
2: 73,142,781 (GRCm39) |
S18P |
probably damaging |
Het |
| Coprs |
T |
C |
8: 13,935,081 (GRCm39) |
Y158C |
probably damaging |
Het |
| Creld1 |
T |
C |
6: 113,469,765 (GRCm39) |
F389S |
probably damaging |
Het |
| Dimt1 |
T |
C |
13: 107,093,636 (GRCm39) |
I276T |
possibly damaging |
Het |
| Dok1 |
T |
C |
6: 83,009,972 (GRCm39) |
K46E |
probably damaging |
Het |
| Dsp |
T |
A |
13: 38,371,781 (GRCm39) |
C911S |
probably benign |
Het |
| Egr3 |
A |
G |
14: 70,314,978 (GRCm39) |
I29V |
probably benign |
Het |
| Fam186a |
A |
G |
15: 99,844,766 (GRCm39) |
S493P |
unknown |
Het |
| Fam83a |
G |
A |
15: 57,849,765 (GRCm39) |
G103D |
possibly damaging |
Het |
| Fat2 |
T |
A |
11: 55,175,808 (GRCm39) |
Q1635L |
probably damaging |
Het |
| Figla |
A |
C |
6: 85,997,689 (GRCm39) |
H139P |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,262,115 (GRCm39) |
K551E |
probably damaging |
Het |
| Galr2 |
A |
G |
11: 116,174,452 (GRCm39) |
T361A |
probably benign |
Het |
| Gart |
A |
T |
16: 91,427,596 (GRCm39) |
S467R |
probably benign |
Het |
| Ggps1 |
T |
C |
13: 14,229,742 (GRCm39) |
K45R |
probably benign |
Het |
| Ghsr |
G |
C |
3: 27,426,630 (GRCm39) |
V229L |
possibly damaging |
Het |
| H2ac21 |
A |
G |
3: 96,127,401 (GRCm39) |
E57G |
probably damaging |
Het |
| Hectd2 |
A |
T |
19: 36,582,689 (GRCm39) |
H473L |
possibly damaging |
Het |
| Hic2 |
T |
C |
16: 17,076,293 (GRCm39) |
V374A |
possibly damaging |
Het |
| Hivep2 |
T |
A |
10: 14,005,523 (GRCm39) |
I707N |
probably benign |
Het |
| Il17rc |
T |
C |
6: 113,449,741 (GRCm39) |
S116P |
probably damaging |
Het |
| Krt34 |
A |
T |
11: 99,929,226 (GRCm39) |
I328N |
probably damaging |
Het |
| Krt79 |
G |
A |
15: 101,840,288 (GRCm39) |
R303C |
probably damaging |
Het |
| Lama2 |
T |
C |
10: 27,100,015 (GRCm39) |
E830G |
probably benign |
Het |
| Lamb2 |
C |
T |
9: 108,358,006 (GRCm39) |
T149I |
probably damaging |
Het |
| Mau2 |
T |
C |
8: 70,480,153 (GRCm39) |
Y318C |
probably damaging |
Het |
| Mier2 |
T |
C |
10: 79,377,496 (GRCm39) |
S486G |
probably benign |
Het |
| Mllt10 |
A |
G |
2: 18,164,322 (GRCm39) |
D284G |
probably damaging |
Het |
| Nbea |
A |
T |
3: 55,937,366 (GRCm39) |
S748R |
probably damaging |
Het |
| Ncoa6 |
A |
G |
2: 155,248,133 (GRCm39) |
S1724P |
probably benign |
Het |
| Nipal4 |
T |
A |
11: 46,052,922 (GRCm39) |
|
probably null |
Het |
| Nlrc4 |
G |
C |
17: 74,753,736 (GRCm39) |
L216V |
probably benign |
Het |
| Ogfr |
A |
G |
2: 180,235,417 (GRCm39) |
M164V |
possibly damaging |
Het |
| Or1o4 |
G |
T |
17: 37,591,386 (GRCm39) |
|
probably benign |
Het |
| Or4b12 |
G |
A |
2: 90,096,709 (GRCm39) |
Q22* |
probably null |
Het |
| Pcdha12 |
G |
T |
18: 37,155,526 (GRCm39) |
W748C |
probably damaging |
Het |
| Pkd1l3 |
T |
C |
8: 110,395,849 (GRCm39) |
V2083A |
probably damaging |
Het |
| Plin3 |
C |
A |
17: 56,587,824 (GRCm39) |
G297V |
probably benign |
Het |
| Prex1 |
C |
T |
2: 166,419,896 (GRCm39) |
R1260Q |
possibly damaging |
Het |
| Prpf38b |
A |
G |
3: 108,818,619 (GRCm39) |
V47A |
probably benign |
Het |
| Ptch1 |
T |
C |
13: 63,675,071 (GRCm39) |
T851A |
probably benign |
Het |
| Ptk7 |
T |
A |
17: 46,887,744 (GRCm39) |
I563F |
possibly damaging |
Het |
| Ptprm |
A |
G |
17: 67,116,466 (GRCm39) |
Y938H |
probably damaging |
Het |
| R3hcc1l |
G |
A |
19: 42,507,203 (GRCm39) |
|
probably benign |
Het |
| Rapgef6 |
T |
C |
11: 54,443,684 (GRCm39) |
V89A |
probably benign |
Het |
| Sh2b1 |
CTC |
CTCCGCCACGGGGACCAGTTC |
7: 126,066,770 (GRCm39) |
|
probably benign |
Het |
| Sh2b1 |
AGCTCAGCCACGGGGACC |
AGCTCAGCCACGGGGACCCGCTCAGCCACGGGGACC |
7: 126,066,750 (GRCm39) |
|
probably benign |
Het |
| Sh2b1 |
ACCAGCTC |
ACCAGCTCAGCCACGGGGGCCAGCTC |
7: 126,066,765 (GRCm39) |
|
probably benign |
Het |
| Slain1 |
T |
A |
14: 103,932,748 (GRCm39) |
V444E |
probably damaging |
Het |
| Slc10a5 |
T |
A |
3: 10,400,532 (GRCm39) |
I43F |
possibly damaging |
Het |
| Smarca2 |
T |
C |
19: 26,659,452 (GRCm39) |
F914S |
possibly damaging |
Het |
| Smarca5 |
A |
C |
8: 81,428,840 (GRCm39) |
L1003V |
probably damaging |
Het |
| Spata18 |
A |
T |
5: 73,829,840 (GRCm39) |
I332F |
|
Het |
| Spata31d1e |
A |
G |
13: 59,890,806 (GRCm39) |
V338A |
probably damaging |
Het |
| Stard9 |
C |
G |
2: 120,534,564 (GRCm39) |
P3607R |
probably damaging |
Het |
| Tbx19 |
A |
G |
1: 164,966,546 (GRCm39) |
S443P |
unknown |
Het |
| Tktl2 |
C |
G |
8: 66,965,840 (GRCm39) |
A466G |
probably damaging |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tmem129 |
A |
G |
5: 33,815,122 (GRCm39) |
V17A |
probably benign |
Het |
| Tom1l2 |
T |
C |
11: 60,153,486 (GRCm39) |
T164A |
probably damaging |
Het |
| Tor1aip1 |
T |
A |
1: 155,906,177 (GRCm39) |
D205V |
probably damaging |
Het |
| Tpp2 |
T |
A |
1: 44,017,648 (GRCm39) |
S751T |
probably benign |
Het |
| Trim11 |
G |
T |
11: 58,878,477 (GRCm39) |
A251S |
unknown |
Het |
| Trim33 |
T |
C |
3: 103,239,074 (GRCm39) |
V684A |
probably benign |
Het |
| Trpm3 |
A |
G |
19: 22,960,040 (GRCm39) |
N1225S |
probably benign |
Het |
| Usp21 |
T |
C |
1: 171,112,503 (GRCm39) |
Y300C |
probably damaging |
Het |
| Usp32 |
T |
C |
11: 84,913,560 (GRCm39) |
T924A |
probably damaging |
Het |
| Vmn1r198 |
A |
T |
13: 22,539,015 (GRCm39) |
H167L |
possibly damaging |
Het |
| Vmn2r23 |
A |
G |
6: 123,689,672 (GRCm39) |
T183A |
probably benign |
Het |
| Zc3h8 |
T |
C |
2: 128,773,223 (GRCm39) |
Y213C |
probably damaging |
Het |
| Zcchc17 |
A |
T |
4: 130,232,337 (GRCm39) |
D55E |
probably benign |
Het |
| Zfp408 |
A |
T |
2: 91,478,368 (GRCm39) |
W26R |
probably damaging |
Het |
| Zfp937 |
G |
T |
2: 150,080,890 (GRCm39) |
A307S |
possibly damaging |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0276:Triobp
|
UTSW |
15 |
78,857,876 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1510:Triobp
|
UTSW |
15 |
78,887,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2051:Triobp
|
UTSW |
15 |
78,888,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2351:Triobp
|
UTSW |
15 |
78,888,780 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Triobp
|
UTSW |
15 |
78,878,591 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCAGAAGAGCTCCCTGAAGATAG -3'
(R):5'- AGTGGCACTCGCTTGTTCTC -3'
Sequencing Primer
(F):5'- CGGACAGGCTCTGAGGTTATC -3'
(R):5'- ACTCGCTTGTTCTCCCGCAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation