Incidental Mutation 'R9518:Or11h7'
ID 718729
Institutional Source Beutler Lab
Gene Symbol Or11h7
Ensembl Gene ENSMUSG00000058188
Gene Name olfactory receptor family 11 subfamily H member 7
Synonyms MOR106-12, Olfr746, GA_x6K02T2PMLR-6372116-6373060
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R9518 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50890696-50891640 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50891101 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 136 (M136L)
Ref Sequence ENSEMBL: ENSMUSP00000151399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080616] [ENSMUST00000218546]
AlphaFold E9Q840
Predicted Effect probably damaging
Transcript: ENSMUST00000080616
AA Change: M136L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000079451
Gene: ENSMUSG00000058188
AA Change: M136L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-52 PFAM
Pfam:7tm_1 41 290 2.8e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000218546
AA Change: M136L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf2 T C 5: 24,771,560 (GRCm39) T556A possibly damaging Het
B230104I21Rik G T 4: 154,434,004 (GRCm39) E63* probably null Het
Brd10 A T 19: 29,731,541 (GRCm39) H490Q possibly damaging Het
Brpf1 A G 6: 113,286,795 (GRCm39) K8E possibly damaging Het
Cacna1i G A 15: 80,271,978 (GRCm39) G1582D probably damaging Het
Ccdc162 T A 10: 41,465,572 (GRCm39) D1428V probably damaging Het
Ccdc178 G A 18: 22,278,516 (GRCm39) T69I possibly damaging Het
Ccdc62 T A 5: 124,089,288 (GRCm39) L309I possibly damaging Het
Ces5a T C 8: 94,257,430 (GRCm39) N125S probably damaging Het
Cps1 G T 1: 67,259,662 (GRCm39) V1335L probably damaging Het
Desi2 A G 1: 178,015,492 (GRCm39) N4S probably benign Het
Dlx6 C A 6: 6,863,406 (GRCm39) D9E probably damaging Het
Dnah12 A C 14: 26,495,713 (GRCm39) D198A probably damaging Het
Dnah8 CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT 17: 30,979,841 (GRCm39) probably null Het
Dpp8 T C 9: 64,981,866 (GRCm39) M716T possibly damaging Het
Dvl3 T A 16: 20,335,961 (GRCm39) I6N possibly damaging Het
Egflam A G 15: 7,319,263 (GRCm39) probably null Het
Eprs1 A T 1: 185,111,763 (GRCm39) M258L probably benign Het
Etnk1 A T 6: 143,149,144 (GRCm39) M352L probably benign Het
Fam124a A C 14: 62,824,947 (GRCm39) D147A probably damaging Het
Fstl4 A G 11: 53,056,647 (GRCm39) D468G possibly damaging Het
Grm8 T A 6: 27,429,469 (GRCm39) Q475L probably benign Het
Kel T C 6: 41,679,334 (GRCm39) E143G probably damaging Het
Kif21a A G 15: 90,840,676 (GRCm39) Y1147H probably damaging Het
Kndc1 A G 7: 139,519,827 (GRCm39) K1729E probably damaging Het
Map4k1 G A 7: 28,693,496 (GRCm39) R433H probably benign Het
Mettl14 T C 3: 123,167,687 (GRCm39) I224V probably benign Het
Mgat5b A G 11: 116,869,299 (GRCm39) N614S probably benign Het
Mlh3 C T 12: 85,313,004 (GRCm39) V1061I probably benign Het
Mtcl3 T A 10: 29,022,748 (GRCm39) C32S probably benign Het
Myo1h T C 5: 114,497,588 (GRCm39) V27A probably damaging Het
Naip5 A T 13: 100,358,367 (GRCm39) H956Q probably benign Het
Or13p3 A G 4: 118,567,120 (GRCm39) N172S probably damaging Het
Pcdh7 A T 5: 58,070,513 (GRCm39) T1064S possibly damaging Het
Peg3 T C 7: 6,714,280 (GRCm39) E314G probably benign Het
Perm1 TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT 4: 156,302,525 (GRCm39) probably benign Het
Pgr A T 9: 8,922,645 (GRCm39) D605V probably damaging Het
Prdm2 T C 4: 142,860,579 (GRCm39) S904G possibly damaging Het
Prpf8 T C 11: 75,394,486 (GRCm39) I1807T possibly damaging Het
Serpinb3c T A 1: 107,200,468 (GRCm39) Q225L probably damaging Het
Strn3 A C 12: 51,696,956 (GRCm39) D258E probably damaging Het
Tent2 A G 13: 93,320,612 (GRCm39) I147T probably benign Het
Tgm2 C T 2: 157,985,049 (GRCm39) R19H probably benign Het
Themis T A 10: 28,544,748 (GRCm39) probably null Het
Trim28 C T 7: 12,764,445 (GRCm39) P753S probably damaging Het
Vac14 C T 8: 111,442,070 (GRCm39) Q683* probably null Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Zfp541 T C 7: 15,813,036 (GRCm39) I563T possibly damaging Het
Other mutations in Or11h7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03288:Or11h7 APN 14 50,890,832 (GRCm39) missense possibly damaging 0.78
IGL03333:Or11h7 APN 14 50,890,855 (GRCm39) nonsense probably null
R0217:Or11h7 UTSW 14 50,891,552 (GRCm39) missense probably damaging 1.00
R0621:Or11h7 UTSW 14 50,891,419 (GRCm39) missense possibly damaging 0.91
R1656:Or11h7 UTSW 14 50,891,465 (GRCm39) missense probably benign 0.16
R1975:Or11h7 UTSW 14 50,890,821 (GRCm39) missense probably damaging 1.00
R4281:Or11h7 UTSW 14 50,891,029 (GRCm39) missense probably benign 0.18
R5763:Or11h7 UTSW 14 50,891,525 (GRCm39) missense possibly damaging 0.84
R6236:Or11h7 UTSW 14 50,891,257 (GRCm39) missense probably damaging 1.00
R6612:Or11h7 UTSW 14 50,891,090 (GRCm39) missense probably damaging 1.00
R7112:Or11h7 UTSW 14 50,891,583 (GRCm39) missense probably benign 0.03
R7125:Or11h7 UTSW 14 50,891,041 (GRCm39) missense possibly damaging 0.92
R7221:Or11h7 UTSW 14 50,891,528 (GRCm39) missense probably damaging 0.99
R7810:Or11h7 UTSW 14 50,891,450 (GRCm39) missense probably benign 0.43
R7881:Or11h7 UTSW 14 50,890,904 (GRCm39) missense probably damaging 1.00
R8002:Or11h7 UTSW 14 50,891,314 (GRCm39) missense probably damaging 0.99
R8681:Or11h7 UTSW 14 50,890,801 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAACATGCTGGTCAACTCTC -3'
(R):5'- GCTCCAAGGCATAAGATCCAAG -3'

Sequencing Primer
(F):5'- GGTCAACTCTCTTTCCAAAACTAAG -3'
(R):5'- TCCAAGGATGTACAAACCAGTG -3'
Posted On 2022-07-18