Mutagenetix > Incidental Mutation

Incidental Mutation 'R9519:Or51a10'

718765

Institutional Source

Beutler Lab

Gene Symbol

Or51a10

Ensembl Gene

ENSMUSG00000049797

Gene Name

olfactory receptor family 51 subfamily A member 10

Synonyms

MOR13-6, GA_x6K02T2PBJ9-6784380-6783436, Olfr642

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R9519 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

103698615-103699559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 103698636 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 308 (M308I)

Ref Sequence

ENSEMBL: ENSMUSP00000148961 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]

AlphaFold

Q924X8

Predicted Effect

probably benign
Transcript: ENSMUST00000052660
AA Change: M308I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: M308I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	8.5e-119	PFAM
Pfam:7TM_GPCR_Srsx	37	309	1.7e-7	PFAM
Pfam:7tm_1	43	294	4.1e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000074064

SMART Domains

Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	2.6e-124	PFAM
Pfam:7TM_GPCR_Srsx	37	255	3.1e-7	PFAM
Pfam:7tm_1	43	294	3.2e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138055

SMART Domains

Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

Domain	Start	End	E-Value	Type
transmembrane domain	29	51	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000214299
AA Change: M308I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	C	5: 77,030,572 (GRCm39)	E676G	probably benign	Het
Aatk	G	A	11: 119,912,309 (GRCm39)		probably benign	Het
Abcc1	T	C	16: 14,207,681 (GRCm39)	V20A	probably benign	Het
Abcc3	A	G	11: 94,264,805 (GRCm39)	V181A	possibly damaging	Het
Alkbh2	T	C	5: 114,265,794 (GRCm39)	K3E	probably benign	Het
Aox1	A	C	1: 58,373,926 (GRCm39)	K862N	probably damaging	Het
Arap1	G	A	7: 101,043,946 (GRCm39)		probably benign	Het
Arid2	A	G	15: 96,186,948 (GRCm39)	N67D	possibly damaging	Het
Atxn1l	C	T	8: 110,458,688 (GRCm39)	V525M	probably damaging	Het
Bcan	C	G	3: 87,902,964 (GRCm39)	E271D	probably damaging	Het
Bcan	T	C	3: 87,902,968 (GRCm39)	E270G	probably benign	Het
Bcan	C	A	3: 87,902,967 (GRCm39)	E270D	probably damaging	Het
Cadps	T	C	14: 12,546,290 (GRCm38)	H522R	possibly damaging	Het
Dll3	A	G	7: 27,995,764 (GRCm39)	S346P	probably damaging	Het
Epha3	T	A	16: 63,472,668 (GRCm39)	T406S	possibly damaging	Het
Far1	A	G	7: 113,150,559 (GRCm39)	R296G	probably benign	Het
Flot1	T	G	17: 36,136,363 (GRCm39)	V172G	possibly damaging	Het
Gm973	A	G	1: 59,580,611 (GRCm39)	M165V	probably benign	Het
Golm1	T	C	13: 59,792,914 (GRCm39)	H197R	probably benign	Het
Gpr85	T	C	6: 13,836,998 (GRCm39)		probably benign	Het
Herc1	A	G	9: 66,307,356 (GRCm39)	K1017E	probably damaging	Het
Inpp5f	A	C	7: 128,278,515 (GRCm39)	D435A	possibly damaging	Het
Jmjd1c	A	G	10: 66,993,798 (GRCm39)	D93G	possibly damaging	Het
Kcnn4	T	A	7: 24,081,941 (GRCm39)	V363E	probably damaging	Het
Kif9	A	G	9: 110,350,344 (GRCm39)	D745G	probably damaging	Het
Lipm	T	C	19: 34,090,392 (GRCm39)	M191T	probably benign	Het
Ltbp1	C	T	17: 75,692,190 (GRCm39)	R1603C	probably damaging	Het
Ms4a13	C	G	19: 11,147,332 (GRCm39)	S194T	unknown	Het
Muc16	A	T	9: 18,498,216 (GRCm39)	I6577N	probably benign	Het
Nfatc2	T	C	2: 168,412,678 (GRCm39)	T336A	probably benign	Het
Nlrp9c	T	A	7: 26,085,302 (GRCm39)	K92N	possibly damaging	Het
Or1p1b	A	T	11: 74,130,827 (GRCm39)	T146S	probably benign	Het
Parp16	T	A	9: 65,137,222 (GRCm39)	Y149*	probably null	Het
Pdgfra	A	T	5: 75,337,350 (GRCm39)	T463S	probably benign	Het
Peg3	T	C	7: 6,714,394 (GRCm39)	E276G	probably benign	Het
Prom1	A	G	5: 44,213,403 (GRCm39)	V110A	possibly damaging	Het
Ptprq	T	C	10: 107,520,961 (GRCm39)	Y737C	probably damaging	Het
Rsf1	G	GACGGCGGCC	7: 97,229,116 (GRCm39)		probably benign	Het
Sds	T	A	5: 120,619,610 (GRCm39)	L173Q	probably damaging	Het
Shank1	G	A	7: 43,962,342 (GRCm39)	S71N	unknown	Het
Slc8a3	A	T	12: 81,362,326 (GRCm39)	D164E	probably benign	Het
Slc9c1	A	T	16: 45,395,770 (GRCm39)	N607I	probably damaging	Het
Smarce1	A	T	11: 99,104,933 (GRCm39)	I248K	probably benign	Het
Smg7	G	T	1: 152,735,196 (GRCm39)	T213K	probably damaging	Het
Snrnp70	C	T	7: 45,036,875 (GRCm39)	D90N	probably benign	Het
Snx20	A	G	8: 89,354,400 (GRCm39)	V110A	possibly damaging	Het
Snx25	A	G	8: 46,486,783 (GRCm39)	V986A	probably damaging	Het
Soat1	T	C	1: 156,259,779 (GRCm39)	K521E	probably benign	Het
Speg	C	T	1: 75,392,380 (GRCm39)	T1679M	probably damaging	Het
Stoml3	T	A	3: 53,405,402 (GRCm39)	F28I	probably benign	Het
Sult1d1	A	T	5: 87,704,721 (GRCm39)	M256K	probably damaging	Het
Tiam1	T	C	16: 89,608,822 (GRCm39)	E1064G	probably benign	Het
Vwa1	G	A	4: 155,857,336 (GRCm39)	P154L	probably damaging	Het
Zfp790	C	A	7: 29,522,567 (GRCm39)	H3N	unknown	Het

Other mutations in Or51a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01457:Or51a10	APN	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
IGL01933:Or51a10	APN	7	103,699,021 (GRCm39)	missense	probably damaging	1.00
IGL01980:Or51a10	APN	7	103,699,300 (GRCm39)	missense	probably benign	0.21
IGL02161:Or51a10	APN	7	103,698,797 (GRCm39)	missense	possibly damaging	0.66
IGL02639:Or51a10	APN	7	103,698,988 (GRCm39)	missense	probably damaging	0.99
I2289:Or51a10	UTSW	7	103,698,961 (GRCm39)	missense	probably damaging	1.00
R0418:Or51a10	UTSW	7	103,698,979 (GRCm39)	missense	probably benign	0.00
R1647:Or51a10	UTSW	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
R1648:Or51a10	UTSW	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
R1701:Or51a10	UTSW	7	103,699,402 (GRCm39)	missense	possibly damaging	0.95
R2142:Or51a10	UTSW	7	103,699,507 (GRCm39)	missense	probably damaging	1.00
R2165:Or51a10	UTSW	7	103,698,845 (GRCm39)	missense	probably benign	0.22
R2655:Or51a10	UTSW	7	103,698,638 (GRCm39)	missense	probably benign	0.03
R6216:Or51a10	UTSW	7	103,698,902 (GRCm39)	missense	probably damaging	1.00
R6759:Or51a10	UTSW	7	103,699,334 (GRCm39)	missense	probably damaging	1.00
R6925:Or51a10	UTSW	7	103,698,947 (GRCm39)	missense	probably benign	0.16
R7243:Or51a10	UTSW	7	103,698,962 (GRCm39)	missense	probably damaging	1.00
R7684:Or51a10	UTSW	7	103,698,667 (GRCm39)	missense	probably damaging	0.99
R7699:Or51a10	UTSW	7	103,699,800 (GRCm39)	start gained	probably benign
R8316:Or51a10	UTSW	7	103,698,829 (GRCm39)	missense	probably damaging	1.00
R8458:Or51a10	UTSW	7	103,698,875 (GRCm39)	missense	possibly damaging	0.93
R8836:Or51a10	UTSW	7	103,699,055 (GRCm39)	missense	probably benign	0.07
R9161:Or51a10	UTSW	7	103,699,725 (GRCm39)	start gained	probably benign
Z1176:Or51a10	UTSW	7	103,699,480 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CTAGGCTGTATCTTACATGCAACAC -3'
(R):5'- TTGCCTCCAGGGAAGAAAGG -3'

Sequencing Primer
(F):5'- CAACATACACAACATCTATGTGTGTG -3'
(R):5'- GGCTTAAGACACTCAACACATGTG -3'

Posted On

2022-07-18