Incidental Mutation 'R9520:Vmn2r11'
| ID |
718809 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r11
|
| Ensembl Gene |
ENSMUSG00000091450 |
| Gene Name |
vomeronasal 2, receptor 11 |
| Synonyms |
EG384219 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R9520 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109201455 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 350
(T350A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
| AlphaFold |
E9Q4X4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164875
AA Change: T350A
PolyPhen 2
Score 0.348 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: T350A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
|
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
|
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
T |
C |
5: 124,228,176 (GRCm39) |
T22A |
possibly damaging |
Het |
| Ackr3 |
T |
A |
1: 90,141,971 (GRCm39) |
Y143* |
probably null |
Het |
| Actn1 |
A |
T |
12: 80,240,417 (GRCm39) |
D223E |
probably damaging |
Het |
| Apcdd1 |
C |
T |
18: 63,083,190 (GRCm39) |
T340I |
possibly damaging |
Het |
| B4galnt1 |
G |
A |
10: 127,006,580 (GRCm39) |
E375K |
probably damaging |
Het |
| Cacna1b |
A |
T |
2: 24,651,799 (GRCm39) |
S127T |
probably damaging |
Het |
| Cbr3 |
A |
G |
16: 93,487,318 (GRCm39) |
D167G |
probably benign |
Het |
| Cdcp1 |
A |
T |
9: 123,012,736 (GRCm39) |
N270K |
possibly damaging |
Het |
| Cep131 |
A |
G |
11: 119,968,157 (GRCm39) |
V128A |
probably benign |
Het |
| Cfhr4 |
A |
G |
1: 139,682,135 (GRCm39) |
S154P |
probably damaging |
Het |
| Chek1 |
T |
C |
9: 36,625,121 (GRCm39) |
E320G |
probably benign |
Het |
| Cit |
T |
A |
5: 116,079,954 (GRCm39) |
L755* |
probably null |
Het |
| Clstn2 |
A |
T |
9: 97,414,763 (GRCm39) |
L377Q |
probably damaging |
Het |
| Cpne9 |
A |
T |
6: 113,281,413 (GRCm39) |
D498V |
probably damaging |
Het |
| Csad |
A |
G |
15: 102,097,102 (GRCm39) |
M1T |
probably null |
Het |
| Csmd3 |
A |
G |
15: 47,561,608 (GRCm39) |
F1323L |
|
Het |
| Dennd2c |
A |
T |
3: 103,044,484 (GRCm39) |
Q355L |
probably benign |
Het |
| Fbxw10 |
G |
A |
11: 62,750,842 (GRCm39) |
S475N |
possibly damaging |
Het |
| Foxi3 |
A |
G |
6: 70,937,676 (GRCm39) |
S303G |
probably damaging |
Het |
| Glra1 |
G |
C |
11: 55,405,897 (GRCm39) |
F372L |
probably benign |
Het |
| Gm19410 |
A |
G |
8: 36,262,637 (GRCm39) |
E858G |
probably benign |
Het |
| Gm7168 |
T |
A |
17: 14,169,506 (GRCm39) |
V291D |
probably benign |
Het |
| Gpr15lg |
T |
A |
14: 36,829,343 (GRCm39) |
T47S |
possibly damaging |
Het |
| Grin2b |
T |
C |
6: 135,710,399 (GRCm39) |
Y1049C |
probably damaging |
Het |
| Grm2 |
A |
G |
9: 106,525,230 (GRCm39) |
L24P |
|
Het |
| Guca1a |
T |
A |
17: 47,711,335 (GRCm39) |
I4F |
probably benign |
Het |
| H6pd |
T |
C |
4: 150,080,375 (GRCm39) |
I157V |
possibly damaging |
Het |
| Hectd3 |
T |
A |
4: 116,857,882 (GRCm39) |
M605K |
probably damaging |
Het |
| Hsf2 |
T |
A |
10: 57,371,996 (GRCm39) |
N32K |
probably damaging |
Het |
| Hspa1l |
T |
A |
17: 35,196,972 (GRCm39) |
V337D |
probably damaging |
Het |
| Iigp1 |
A |
T |
18: 60,523,451 (GRCm39) |
T190S |
probably benign |
Het |
| Iqgap1 |
T |
C |
7: 80,393,869 (GRCm39) |
R622G |
probably benign |
Het |
| Lce1a1 |
A |
T |
3: 92,554,109 (GRCm39) |
C122S |
unknown |
Het |
| Lrfn4 |
C |
T |
19: 4,664,237 (GRCm39) |
R99H |
probably damaging |
Het |
| Lsm1 |
T |
A |
8: 26,283,744 (GRCm39) |
V52E |
possibly damaging |
Het |
| Malrd1 |
G |
A |
2: 16,079,631 (GRCm39) |
V1783I |
unknown |
Het |
| Mast4 |
T |
C |
13: 102,925,532 (GRCm39) |
K464R |
probably damaging |
Het |
| Mpdz |
T |
C |
4: 81,304,555 (GRCm39) |
D115G |
probably benign |
Het |
| Mtmr3 |
A |
T |
11: 4,441,131 (GRCm39) |
H507Q |
probably damaging |
Het |
| Mycbp2 |
T |
A |
14: 103,497,705 (GRCm39) |
M956L |
probably benign |
Het |
| Myo3b |
A |
G |
2: 70,062,753 (GRCm39) |
T346A |
possibly damaging |
Het |
| Ndrg2 |
T |
C |
14: 52,146,381 (GRCm39) |
I140V |
probably benign |
Het |
| Nsf |
A |
G |
11: 103,804,709 (GRCm39) |
L144P |
probably damaging |
Het |
| Or2a25 |
T |
C |
6: 42,889,051 (GRCm39) |
V198A |
probably damaging |
Het |
| Or8d2b |
C |
T |
9: 38,789,039 (GRCm39) |
T189I |
probably benign |
Het |
| Pck1 |
G |
A |
2: 172,997,854 (GRCm39) |
V308M |
probably damaging |
Het |
| Phip |
C |
T |
9: 82,753,437 (GRCm39) |
R1769K |
possibly damaging |
Het |
| Plekhg1 |
T |
A |
10: 3,906,822 (GRCm39) |
C635S |
|
Het |
| Ppp4r4 |
A |
G |
12: 103,500,378 (GRCm39) |
I58V |
probably benign |
Het |
| Prkacb |
T |
C |
3: 146,456,289 (GRCm39) |
Y170C |
probably damaging |
Het |
| Rnf145 |
A |
T |
11: 44,452,336 (GRCm39) |
E438D |
possibly damaging |
Het |
| Rnf207 |
T |
C |
4: 152,396,234 (GRCm39) |
Y510C |
probably damaging |
Het |
| Rph3a |
C |
T |
5: 121,101,903 (GRCm39) |
C111Y |
probably damaging |
Het |
| Scaf8 |
C |
T |
17: 3,248,285 (GRCm39) |
R1203W |
probably damaging |
Het |
| Sec23a |
T |
G |
12: 59,031,974 (GRCm39) |
I448L |
probably benign |
Het |
| Slc22a27 |
T |
C |
19: 7,843,227 (GRCm39) |
Y492C |
possibly damaging |
Het |
| Supv3l1 |
T |
C |
10: 62,268,181 (GRCm39) |
K555E |
probably damaging |
Het |
| Tdrd3 |
T |
C |
14: 87,724,696 (GRCm39) |
S372P |
probably damaging |
Het |
| Tgm1 |
A |
G |
14: 55,942,296 (GRCm39) |
F685S |
probably damaging |
Het |
| Usp48 |
G |
A |
4: 137,340,996 (GRCm39) |
G332E |
probably benign |
Het |
| Vmn2r25 |
A |
T |
6: 123,830,066 (GRCm39) |
Y28* |
probably null |
Het |
| Vmn2r85 |
T |
A |
10: 130,254,993 (GRCm39) |
I564L |
probably benign |
Het |
| Wdr26 |
G |
T |
1: 181,036,587 (GRCm39) |
T183K |
probably benign |
Het |
| Yjefn3 |
A |
T |
8: 70,341,969 (GRCm39) |
Y97N |
probably damaging |
Het |
| Zbtb38 |
A |
T |
9: 96,568,104 (GRCm39) |
D993E |
probably damaging |
Het |
| Zbtb45 |
T |
C |
7: 12,742,012 (GRCm39) |
Q82R |
probably damaging |
Het |
| Zdhhc8 |
A |
G |
16: 18,045,044 (GRCm39) |
V254A |
probably benign |
Het |
| Zfp648 |
A |
G |
1: 154,081,221 (GRCm39) |
D460G |
probably benign |
Het |
| Zfp760 |
T |
G |
17: 21,941,036 (GRCm39) |
N70K |
probably benign |
Het |
|
| Other mutations in Vmn2r11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
|
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTACTGCCATTTGCTGAGATTC -3'
(R):5'- TCCCTAGAAGTCAGCTTTAGAAGG -3'
Sequencing Primer
(F):5'- TGTGGGCCACAGCATACACAG -3'
(R):5'- GCTTTAGAAGGTGGGAAGATTTAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation