Incidental Mutation 'R9522:Moxd2'
ID 718946
Institutional Source Beutler Lab
Gene Symbol Moxd2
Ensembl Gene ENSMUSG00000029885
Gene Name monooxygenase, DBH-like 2
Synonyms Dbhl1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R9522 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 40855728-40864428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 40857375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 462 (I462F)
Ref Sequence ENSEMBL: ENSMUSP00000031937 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031937]
AlphaFold Q7TT41
Predicted Effect probably benign
Transcript: ENSMUST00000031937
AA Change: I462F

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000031937
Gene: ENSMUSG00000029885
AA Change: I462F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
DoH 66 156 1.43e-12 SMART
Pfam:Cu2_monooxygen 192 316 8.3e-39 PFAM
Pfam:Cu2_monoox_C 336 493 1.8e-37 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A T 7: 119,847,368 (GRCm39) Y744F probably null Het
Adam17 C A 12: 21,395,693 (GRCm39) V277F probably damaging Het
Adcy8 C T 15: 64,792,560 (GRCm39) C132Y probably damaging Het
Adgrf3 G A 5: 30,404,482 (GRCm39) P318L possibly damaging Het
Ahcyl1 A T 3: 107,579,398 (GRCm39) I212N probably damaging Het
Allc A T 12: 28,620,653 (GRCm39) F33I probably damaging Het
Arhgap32 A G 9: 32,027,450 (GRCm39) T7A probably benign Het
Bbs4 A G 9: 59,260,691 (GRCm39) probably null Het
Btbd1 G T 7: 81,479,081 (GRCm39) P20H unknown Het
Cass4 A G 2: 172,269,348 (GRCm39) I477V possibly damaging Het
Cep83 A G 10: 94,586,184 (GRCm39) E362G probably damaging Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Cimip2c A T 5: 30,623,467 (GRCm39) S5C probably damaging Het
Cntnap5b A G 1: 100,412,347 (GRCm39) D896G probably benign Het
Crocc2 T C 1: 93,117,429 (GRCm39) V305A probably benign Het
Cse1l G A 2: 166,776,673 (GRCm39) V495I probably benign Het
Ctsj A T 13: 61,152,257 (GRCm39) Y36* probably null Het
Ctss T G 3: 95,454,109 (GRCm39) D220E probably benign Het
Ctu1 T C 7: 43,324,900 (GRCm39) L113P probably benign Het
Cyp2d40 G A 15: 82,648,274 (GRCm39) A13V possibly damaging Het
Dhrs4 A T 14: 55,716,219 (GRCm39) probably benign Het
Dlgap4 G T 2: 156,546,514 (GRCm39) R394L possibly damaging Het
Dpysl5 C A 5: 30,935,399 (GRCm39) Y167* probably null Het
E4f1 C T 17: 24,666,096 (GRCm39) G234D probably damaging Het
Eif3g G T 9: 20,809,451 (GRCm39) T27N probably benign Het
Eif3g T A 9: 20,809,452 (GRCm39) T27S probably benign Het
Fcrl2 A G 3: 87,164,101 (GRCm39) F343L possibly damaging Het
Fdft1 T C 14: 63,396,597 (GRCm39) probably null Het
Hsd3b9 T C 3: 98,353,783 (GRCm39) S239G probably benign Het
Igf2r G T 17: 12,917,215 (GRCm39) Q1562K probably benign Het
Ilf3 G A 9: 21,305,533 (GRCm39) V232I probably benign Het
Irx5 C T 8: 93,087,259 (GRCm39) T397M possibly damaging Het
Kif16b A T 2: 142,691,827 (GRCm39) V219D probably damaging Het
Klkb1 T C 8: 45,730,052 (GRCm39) I276M probably benign Het
Large2 A G 2: 92,200,266 (GRCm39) L115P probably damaging Het
Lrrc3b T C 14: 15,358,423 (GRCm38) D61G probably benign Het
Map7 A G 10: 20,105,642 (GRCm39) Y31C possibly damaging Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Or5b98 T A 19: 12,931,377 (GRCm39) C141* probably null Het
Or9m2 G A 2: 87,821,175 (GRCm39) C240Y probably damaging Het
Phf20l1 T C 15: 66,504,669 (GRCm39) V770A possibly damaging Het
Ppfia4 G A 1: 134,240,886 (GRCm39) A819V probably damaging Het
Qrfpr A G 3: 36,236,676 (GRCm39) W242R probably damaging Het
Rgs3 A G 4: 62,523,729 (GRCm39) I53M probably benign Het
Rif1 T C 2: 51,971,311 (GRCm39) F263S probably damaging Het
Rpl22l1 T C 3: 28,860,743 (GRCm39) probably null Het
Ryr3 T A 2: 112,560,759 (GRCm39) I3001F probably benign Het
Safb2 A G 17: 56,873,900 (GRCm39) I675T probably damaging Het
Scart2 T A 7: 139,853,987 (GRCm39) I330N possibly damaging Het
Sec16b C T 1: 157,392,335 (GRCm39) S901L probably damaging Het
Setd5 T G 6: 113,091,995 (GRCm39) I272S probably damaging Het
Slc40a1 A T 1: 45,948,672 (GRCm39) M536K probably damaging Het
Slfn3 T C 11: 83,103,825 (GRCm39) V232A probably benign Het
Spata31d1b T C 13: 59,864,780 (GRCm39) S643P probably benign Het
Tbc1d23 T C 16: 57,019,107 (GRCm39) D251G probably benign Het
Tbccd1 T C 16: 22,641,249 (GRCm39) E376G possibly damaging Het
Tmem184a G T 5: 139,791,485 (GRCm39) P368T probably benign Het
Top1mt T C 15: 75,539,309 (GRCm39) D362G probably damaging Het
Top6bl T C 19: 4,677,274 (GRCm39) H612R probably benign Het
Ugt3a1 C A 15: 9,370,209 (GRCm39) P451H probably damaging Het
Unc80 G A 1: 66,677,221 (GRCm39) C2050Y possibly damaging Het
Usp48 G A 4: 137,340,996 (GRCm39) G332E probably benign Het
Vmn1r179 T C 7: 23,628,202 (GRCm39) V131A probably damaging Het
Wdr89 A G 12: 75,679,924 (GRCm39) F110S probably damaging Het
Znrf3 T C 11: 5,232,379 (GRCm39) Y282C probably damaging Het
Zscan18 T C 7: 12,503,297 (GRCm39) D754G possibly damaging Het
Other mutations in Moxd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Moxd2 APN 6 40,861,113 (GRCm39) splice site probably benign
IGL02113:Moxd2 APN 6 40,862,338 (GRCm39) missense probably benign 0.06
IGL02223:Moxd2 APN 6 40,861,967 (GRCm39) missense probably damaging 1.00
IGL03204:Moxd2 APN 6 40,864,239 (GRCm39) missense probably benign 0.04
IGL03385:Moxd2 APN 6 40,855,952 (GRCm39) missense probably damaging 1.00
R0084:Moxd2 UTSW 6 40,856,342 (GRCm39) missense probably null 0.01
R1213:Moxd2 UTSW 6 40,868,831 (GRCm39) unclassified probably benign
R1326:Moxd2 UTSW 6 40,857,288 (GRCm39) missense probably benign 0.00
R1652:Moxd2 UTSW 6 40,864,337 (GRCm39) missense probably damaging 1.00
R1940:Moxd2 UTSW 6 40,860,466 (GRCm39) missense probably damaging 1.00
R2040:Moxd2 UTSW 6 40,861,887 (GRCm39) splice site probably null
R2088:Moxd2 UTSW 6 40,861,901 (GRCm39) missense probably damaging 1.00
R3018:Moxd2 UTSW 6 40,855,820 (GRCm39) missense probably benign 0.01
R3962:Moxd2 UTSW 6 40,862,331 (GRCm39) missense probably benign
R4248:Moxd2 UTSW 6 40,855,933 (GRCm39) missense probably damaging 1.00
R4438:Moxd2 UTSW 6 40,860,996 (GRCm39) missense probably damaging 1.00
R4715:Moxd2 UTSW 6 40,864,181 (GRCm39) missense probably damaging 1.00
R4732:Moxd2 UTSW 6 40,855,793 (GRCm39) missense probably benign
R4733:Moxd2 UTSW 6 40,855,793 (GRCm39) missense probably benign
R4760:Moxd2 UTSW 6 40,868,537 (GRCm39) missense probably benign 0.06
R4851:Moxd2 UTSW 6 40,855,756 (GRCm39) missense probably damaging 1.00
R5087:Moxd2 UTSW 6 40,856,270 (GRCm39) missense probably damaging 1.00
R5187:Moxd2 UTSW 6 40,856,271 (GRCm39) missense probably benign 0.18
R5339:Moxd2 UTSW 6 40,862,354 (GRCm39) missense probably damaging 1.00
R5452:Moxd2 UTSW 6 40,859,048 (GRCm39) splice site probably null
R5860:Moxd2 UTSW 6 40,857,341 (GRCm39) missense probably damaging 1.00
R5973:Moxd2 UTSW 6 40,855,744 (GRCm39) missense probably damaging 0.96
R6015:Moxd2 UTSW 6 40,860,688 (GRCm39) missense probably damaging 1.00
R6316:Moxd2 UTSW 6 40,860,481 (GRCm39) missense probably damaging 1.00
R7500:Moxd2 UTSW 6 40,868,746 (GRCm39) missense probably benign
R7561:Moxd2 UTSW 6 40,864,337 (GRCm39) missense probably damaging 1.00
R7840:Moxd2 UTSW 6 40,862,378 (GRCm39) missense possibly damaging 0.95
R8042:Moxd2 UTSW 6 40,862,301 (GRCm39) missense probably benign 0.40
R9147:Moxd2 UTSW 6 40,860,978 (GRCm39) missense probably damaging 1.00
R9148:Moxd2 UTSW 6 40,860,978 (GRCm39) missense probably damaging 1.00
R9169:Moxd2 UTSW 6 40,860,490 (GRCm39) missense possibly damaging 0.94
R9259:Moxd2 UTSW 6 40,860,969 (GRCm39) missense probably damaging 1.00
R9291:Moxd2 UTSW 6 40,857,362 (GRCm39) missense probably damaging 1.00
R9448:Moxd2 UTSW 6 40,864,160 (GRCm39) missense probably benign 0.01
R9635:Moxd2 UTSW 6 40,863,000 (GRCm39) missense possibly damaging 0.93
X0052:Moxd2 UTSW 6 40,859,462 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGAATCAACACTGAATGGAACAGG -3'
(R):5'- CAATACTTGTTCAATGGCAGGAAAC -3'

Sequencing Primer
(F):5'- TGTGATTCGCCCAGCCC -3'
(R):5'- CTGAGGAGAAAGGAAGTGATCTG -3'
Posted On 2022-07-18