Incidental Mutation 'R9522:Scart2'
ID 718954
Institutional Source Beutler Lab
Gene Symbol Scart2
Ensembl Gene ENSMUSG00000054672
Gene Name scavenger receptor family member expressed on T cells 2
Synonyms 5830411N06Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9522 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 140247284-140300736 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 140274074 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 330 (I330N)
Ref Sequence ENSEMBL: ENSMUSP00000131905 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]
AlphaFold B3F5L4
Predicted Effect probably benign
Transcript: ENSMUST00000093984
SMART Domains Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
SR 446 546 8.78e-30 SMART
SR 551 651 1.26e-53 SMART
SR 656 756 2.88e-16 SMART
SR 783 883 7.62e-48 SMART
transmembrane domain 903 925 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000164583
AA Change: I330N

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: I330N

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
Blast:SR 291 349 5e-12 BLAST
SR 354 452 1.65e-34 SMART
SR 456 556 4.53e-32 SMART
SR 562 662 8.78e-30 SMART
SR 667 767 1.26e-53 SMART
SR 772 872 2.88e-16 SMART
SR 899 999 7.62e-48 SMART
transmembrane domain 1019 1041 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001C02Rik A T 5: 30,466,123 (GRCm38) S5C probably damaging Het
Abca14 A T 7: 120,248,145 (GRCm38) Y744F probably null Het
Adam17 C A 12: 21,345,692 (GRCm38) V277F probably damaging Het
Adcy8 C T 15: 64,920,711 (GRCm38) C132Y probably damaging Het
Adgrf3 G A 5: 30,199,484 (GRCm38) P318L possibly damaging Het
Ahcyl1 A T 3: 107,672,082 (GRCm38) I212N probably damaging Het
Allc A T 12: 28,570,654 (GRCm38) F33I probably damaging Het
Arhgap32 A G 9: 32,116,154 (GRCm38) T7A probably benign Het
Bbs4 A G 9: 59,353,408 (GRCm38) probably null Het
Btbd1 G T 7: 81,829,333 (GRCm38) P20H unknown Het
Cass4 A G 2: 172,427,428 (GRCm38) I477V possibly damaging Het
Cep83 A G 10: 94,750,322 (GRCm38) E362G probably damaging Het
Chst13 G A 6: 90,309,524 (GRCm38) P152L probably damaging Het
Cntnap5b A G 1: 100,484,622 (GRCm38) D896G probably benign Het
Crocc2 T C 1: 93,189,707 (GRCm38) V305A probably benign Het
Cse1l G A 2: 166,934,753 (GRCm38) V495I probably benign Het
Ctsj A T 13: 61,004,443 (GRCm38) Y36* probably null Het
Ctss T G 3: 95,546,798 (GRCm38) D220E probably benign Het
Ctu1 T C 7: 43,675,476 (GRCm38) L113P probably benign Het
Cyp2d40 G A 15: 82,764,073 (GRCm38) A13V possibly damaging Het
Dhrs4 A T 14: 55,478,762 (GRCm38) probably benign Het
Dlgap4 G T 2: 156,704,594 (GRCm38) R394L possibly damaging Het
Dpysl5 C A 5: 30,778,055 (GRCm38) Y167* probably null Het
E4f1 C T 17: 24,447,122 (GRCm38) G234D probably damaging Het
Eif3g T A 9: 20,898,156 (GRCm38) T27S probably benign Het
Eif3g G T 9: 20,898,155 (GRCm38) T27N probably benign Het
Fcrl2 A G 3: 87,256,794 (GRCm38) F343L possibly damaging Het
Fdft1 T C 14: 63,159,148 (GRCm38) probably null Het
Hsd3b9 T C 3: 98,446,467 (GRCm38) S239G probably benign Het
Igf2r G T 17: 12,698,328 (GRCm38) Q1562K probably benign Het
Ilf3 G A 9: 21,394,237 (GRCm38) V232I probably benign Het
Irx5 C T 8: 92,360,631 (GRCm38) T397M possibly damaging Het
Kif16b A T 2: 142,849,907 (GRCm38) V219D probably damaging Het
Klkb1 T C 8: 45,277,015 (GRCm38) I276M probably benign Het
Large2 A G 2: 92,369,921 (GRCm38) L115P probably damaging Het
Lrrc3b T C 14: 15,358,423 (GRCm38) D61G probably benign Het
Map7 A G 10: 20,229,896 (GRCm38) Y31C possibly damaging Het
Moxd2 T A 6: 40,880,441 (GRCm38) I462F probably benign Het
Or2n1d A T 17: 38,335,429 (GRCm38) T91S possibly damaging Het
Or5b98 T A 19: 12,954,013 (GRCm38) C141* probably null Het
Or9m2 G A 2: 87,990,831 (GRCm38) C240Y probably damaging Het
Phf20l1 T C 15: 66,632,820 (GRCm38) V770A possibly damaging Het
Ppfia4 G A 1: 134,313,148 (GRCm38) A819V probably damaging Het
Qrfpr A G 3: 36,182,527 (GRCm38) W242R probably damaging Het
Rgs3 A G 4: 62,605,492 (GRCm38) I53M probably benign Het
Rif1 T C 2: 52,081,299 (GRCm38) F263S probably damaging Het
Rpl22l1 T C 3: 28,806,594 (GRCm38) probably null Het
Ryr3 T A 2: 112,730,414 (GRCm38) I3001F probably benign Het
Safb2 A G 17: 56,566,900 (GRCm38) I675T probably damaging Het
Sec16b C T 1: 157,564,765 (GRCm38) S901L probably damaging Het
Setd5 T G 6: 113,115,034 (GRCm38) I272S probably damaging Het
Slc40a1 A T 1: 45,909,512 (GRCm38) M536K probably damaging Het
Slfn3 T C 11: 83,212,999 (GRCm38) V232A probably benign Het
Spata31d1b T C 13: 59,716,966 (GRCm38) S643P probably benign Het
Tbc1d23 T C 16: 57,198,744 (GRCm38) D251G probably benign Het
Tbccd1 T C 16: 22,822,499 (GRCm38) E376G possibly damaging Het
Tmem184a G T 5: 139,805,730 (GRCm38) P368T probably benign Het
Top1mt T C 15: 75,667,460 (GRCm38) D362G probably damaging Het
Top6bl T C 19: 4,627,246 (GRCm38) H612R probably benign Het
Ugt3a2 C A 15: 9,370,123 (GRCm38) P451H probably damaging Het
Unc80 G A 1: 66,638,062 (GRCm38) C2050Y possibly damaging Het
Usp48 G A 4: 137,613,685 (GRCm38) G332E probably benign Het
Vmn1r179 T C 7: 23,928,777 (GRCm38) V131A probably damaging Het
Wdr89 A G 12: 75,633,150 (GRCm38) F110S probably damaging Het
Znrf3 T C 11: 5,282,379 (GRCm38) Y282C probably damaging Het
Zscan18 T C 7: 12,769,370 (GRCm38) D754G possibly damaging Het
Other mutations in Scart2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Scart2 APN 7 140,294,842 (GRCm38) missense probably damaging 0.99
IGL01101:Scart2 APN 7 140,296,104 (GRCm38) missense probably benign 0.35
IGL01120:Scart2 APN 7 140,296,559 (GRCm38) missense probably benign 0.02
IGL01958:Scart2 APN 7 140,274,127 (GRCm38) missense probably damaging 1.00
IGL02150:Scart2 APN 7 140,297,859 (GRCm38) missense possibly damaging 0.84
IGL02193:Scart2 APN 7 140,249,000 (GRCm38) missense probably benign 0.17
IGL02239:Scart2 APN 7 140,295,843 (GRCm38) missense probably damaging 1.00
IGL02335:Scart2 APN 7 140,296,540 (GRCm38) missense probably damaging 1.00
IGL02569:Scart2 APN 7 140,298,362 (GRCm38) missense probably benign 0.01
IGL02993:Scart2 APN 7 140,296,573 (GRCm38) missense probably benign 0.07
IGL03261:Scart2 APN 7 140,294,833 (GRCm38) missense probably benign 0.00
IGL03365:Scart2 APN 7 140,296,769 (GRCm38) missense probably damaging 1.00
IGL03399:Scart2 APN 7 140,247,956 (GRCm38) missense probably benign 0.00
IGL03052:Scart2 UTSW 7 140,248,914 (GRCm38) missense probably damaging 1.00
PIT4791001:Scart2 UTSW 7 140,274,062 (GRCm38) missense possibly damaging 0.53
R0021:Scart2 UTSW 7 140,296,397 (GRCm38) missense probably benign 0.15
R0021:Scart2 UTSW 7 140,296,397 (GRCm38) missense probably benign 0.15
R0347:Scart2 UTSW 7 140,297,854 (GRCm38) missense probably damaging 1.00
R0374:Scart2 UTSW 7 140,248,961 (GRCm38) missense probably damaging 1.00
R0639:Scart2 UTSW 7 140,247,959 (GRCm38) missense probably benign 0.01
R0667:Scart2 UTSW 7 140,261,537 (GRCm38) missense possibly damaging 0.73
R0789:Scart2 UTSW 7 140,248,220 (GRCm38) missense probably damaging 1.00
R0959:Scart2 UTSW 7 140,294,791 (GRCm38) missense probably damaging 1.00
R1316:Scart2 UTSW 7 140,299,670 (GRCm38) missense probably benign 0.09
R1764:Scart2 UTSW 7 140,297,265 (GRCm38) missense probably benign 0.00
R2247:Scart2 UTSW 7 140,249,129 (GRCm38) missense probably null 0.96
R2379:Scart2 UTSW 7 140,299,769 (GRCm38) missense probably benign 0.15
R4112:Scart2 UTSW 7 140,298,368 (GRCm38) nonsense probably null
R4114:Scart2 UTSW 7 140,297,910 (GRCm38) missense probably damaging 1.00
R4346:Scart2 UTSW 7 140,247,965 (GRCm38) missense probably damaging 0.97
R4836:Scart2 UTSW 7 140,299,108 (GRCm38) missense probably benign
R4956:Scart2 UTSW 7 140,298,362 (GRCm38) missense probably benign 0.00
R5208:Scart2 UTSW 7 140,298,036 (GRCm38) missense probably benign 0.00
R5571:Scart2 UTSW 7 140,249,123 (GRCm38) missense probably damaging 1.00
R5583:Scart2 UTSW 7 140,296,826 (GRCm38) missense probably damaging 1.00
R5645:Scart2 UTSW 7 140,248,940 (GRCm38) missense possibly damaging 0.95
R6183:Scart2 UTSW 7 140,296,034 (GRCm38) missense possibly damaging 0.82
R6995:Scart2 UTSW 7 140,261,601 (GRCm38) missense probably benign
R7436:Scart2 UTSW 7 140,261,607 (GRCm38) missense probably benign
R7621:Scart2 UTSW 7 140,296,829 (GRCm38) missense probably damaging 1.00
R7662:Scart2 UTSW 7 140,294,812 (GRCm38) missense possibly damaging 0.58
R7669:Scart2 UTSW 7 140,296,321 (GRCm38) missense possibly damaging 0.47
R7686:Scart2 UTSW 7 140,249,052 (GRCm38) missense probably benign 0.00
R7985:Scart2 UTSW 7 140,296,893 (GRCm38) missense probably damaging 1.00
R8330:Scart2 UTSW 7 140,296,318 (GRCm38) nonsense probably null
R8843:Scart2 UTSW 7 140,249,000 (GRCm38) missense possibly damaging 0.93
R8888:Scart2 UTSW 7 140,261,619 (GRCm38) missense possibly damaging 0.93
R8895:Scart2 UTSW 7 140,261,619 (GRCm38) missense possibly damaging 0.93
R9044:Scart2 UTSW 7 140,248,097 (GRCm38) missense probably damaging 1.00
R9142:Scart2 UTSW 7 140,297,893 (GRCm38) missense probably damaging 1.00
R9152:Scart2 UTSW 7 140,297,343 (GRCm38) missense possibly damaging 0.55
R9470:Scart2 UTSW 7 140,247,432 (GRCm38) missense probably benign 0.07
R9509:Scart2 UTSW 7 140,299,731 (GRCm38) nonsense probably null
R9755:Scart2 UTSW 7 140,261,631 (GRCm38) critical splice donor site probably null
R9794:Scart2 UTSW 7 140,294,803 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCAACAAGTCAGGCTGGC -3'
(R):5'- TGGCGACAACCGTGATGAAC -3'

Sequencing Primer
(F):5'- AGAGGTGCCAGTCCATGTG -3'
(R):5'- CGTGATGAACAGAGAAGATTCTATTG -3'
Posted On 2022-07-18