Incidental Mutation 'R9524:Kif26a'
ID 719105
Institutional Source Beutler Lab
Gene Symbol Kif26a
Ensembl Gene ENSMUSG00000021294
Gene Name kinesin family member 26A
Synonyms N-11 kinesin
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9524 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 112112642-112148181 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 112140286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 505 (T505M)
Ref Sequence ENSEMBL: ENSMUSP00000119482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000128402]
AlphaFold Q52KG5
Predicted Effect probably damaging
Transcript: ENSMUST00000128402
AA Change: T505M

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000119482
Gene: ENSMUSG00000021294
AA Change: T505M

DomainStartEndE-ValueType
low complexity region 238 248 N/A INTRINSIC
low complexity region 279 297 N/A INTRINSIC
KISc 362 726 9.57e-35 SMART
low complexity region 727 739 N/A INTRINSIC
low complexity region 740 754 N/A INTRINSIC
low complexity region 932 957 N/A INTRINSIC
low complexity region 1005 1012 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1084 1095 N/A INTRINSIC
low complexity region 1328 1360 N/A INTRINSIC
low complexity region 1458 1471 N/A INTRINSIC
low complexity region 1477 1493 N/A INTRINSIC
low complexity region 1519 1538 N/A INTRINSIC
low complexity region 1574 1587 N/A INTRINSIC
low complexity region 1664 1675 N/A INTRINSIC
low complexity region 1699 1713 N/A INTRINSIC
coiled coil region 1780 1812 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature death associated with megacolon and hyperganglionosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik T G 11: 58,180,594 (GRCm39) probably null Het
Adra2c G A 5: 35,438,143 (GRCm39) R305Q probably benign Het
Ahnak A G 19: 9,014,617 (GRCm39) D147G Het
Arhgap30 T A 1: 171,225,114 (GRCm39) S57T probably damaging Het
Aspm T C 1: 139,408,607 (GRCm39) I2498T probably damaging Het
Atr C T 9: 95,792,610 (GRCm39) A1644V possibly damaging Het
Cc2d1a G T 8: 84,870,744 (GRCm39) D101E probably benign Het
Cntfr A G 4: 41,661,995 (GRCm39) L249P probably damaging Het
D130043K22Rik T C 13: 25,071,876 (GRCm39) I940T possibly damaging Het
Dnah12 T G 14: 26,572,494 (GRCm39) C2862G probably null Het
Dnah8 CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT 17: 30,979,841 (GRCm39) probably null Het
Dnah9 A G 11: 65,976,309 (GRCm39) F1247L possibly damaging Het
Dpp10 T C 1: 123,264,611 (GRCm39) Q737R probably damaging Het
Dpp3 A G 19: 4,959,897 (GRCm39) V673A possibly damaging Het
Eif2a A T 3: 58,448,467 (GRCm39) K100I possibly damaging Het
Flnc C A 6: 29,461,109 (GRCm39) N2694K probably damaging Het
Fv1 T A 4: 147,953,768 (GRCm39) D111E possibly damaging Het
Gcnt3 G A 9: 69,941,569 (GRCm39) A333V probably damaging Het
Gpr151 T C 18: 42,712,710 (GRCm39) probably benign Het
Gxylt2 A G 6: 100,727,416 (GRCm39) T177A probably benign Het
Hnmt G A 2: 23,893,880 (GRCm39) L205F possibly damaging Het
Ikbkb A T 8: 23,172,740 (GRCm39) probably null Het
Ikzf2 T C 1: 69,578,337 (GRCm39) S391G probably benign Het
Kif3b A T 2: 153,159,460 (GRCm39) K420N probably benign Het
Kmt2a A G 9: 44,730,294 (GRCm39) V3341A unknown Het
Lce1i T C 3: 92,685,081 (GRCm39) K32E unknown Het
Lmf1 A G 17: 25,881,514 (GRCm39) Y521C probably damaging Het
Mki67 C T 7: 135,305,913 (GRCm39) C655Y probably damaging Het
Morc3 T A 16: 93,667,401 (GRCm39) V593E probably benign Het
Muc16 A G 9: 18,497,314 (GRCm39) F6613L probably benign Het
Naip1 G A 13: 100,563,101 (GRCm39) T688I probably benign Het
Or2n1d T A 17: 38,646,540 (GRCm39) L164* probably null Het
Otop2 T A 11: 115,214,503 (GRCm39) C87S probably benign Het
Picalm T A 7: 89,810,484 (GRCm39) L97* probably null Het
Pik3c2g T A 6: 139,606,768 (GRCm39) W272R probably damaging Het
Plekhg4 G A 8: 106,101,398 (GRCm39) G20R unknown Het
Ppp1r35 G A 5: 137,777,304 (GRCm39) A17T unknown Het
Ppp2r5e A T 12: 75,509,167 (GRCm39) Y371N possibly damaging Het
Rexo1 T C 10: 80,386,872 (GRCm39) E62G probably damaging Het
Rtl1 T C 12: 109,556,973 (GRCm39) E1622G probably damaging Het
Ryr1 T C 7: 28,723,600 (GRCm39) E4181G probably damaging Het
Saxo1 C A 4: 86,397,132 (GRCm39) M135I probably benign Het
Shank2 C A 7: 143,964,183 (GRCm39) P597Q possibly damaging Het
Shld2 G A 14: 33,971,245 (GRCm39) Q547* probably null Het
Slc44a1 G A 4: 53,542,389 (GRCm39) V308I probably benign Het
Slc6a21 A G 7: 44,937,785 (GRCm39) H367R probably benign Het
Snx11 G T 11: 96,660,023 (GRCm39) T222K probably benign Het
Snx4 C T 16: 33,112,228 (GRCm39) Q388* probably null Het
Sulf1 T C 1: 12,918,622 (GRCm39) L831P probably damaging Het
Ugt2a3 A T 5: 87,485,018 (GRCm39) V2D Het
Unc5c T C 3: 141,494,683 (GRCm39) V406A possibly damaging Het
Unc5d A C 8: 29,365,639 (GRCm39) N115K probably damaging Het
Usp28 C A 9: 48,947,026 (GRCm39) T819N probably damaging Het
Usp42 T C 5: 143,702,704 (GRCm39) D639G possibly damaging Het
Vmn2r102 T A 17: 19,897,564 (GRCm39) M193K possibly damaging Het
Vmn2r12 A G 5: 109,239,823 (GRCm39) Y247H probably damaging Het
Vps13d T C 4: 144,822,814 (GRCm39) D2989G Het
Vsig2 A G 9: 37,455,335 (GRCm39) E295G probably benign Het
Wdfy3 T A 5: 102,055,333 (GRCm39) N1579I probably benign Het
Zfp521 T C 18: 13,980,173 (GRCm39) D80G possibly damaging Het
Zfp663 A C 2: 165,195,607 (GRCm39) L204R probably damaging Het
Other mutations in Kif26a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Kif26a APN 12 112,124,066 (GRCm39) missense probably damaging 0.97
IGL01734:Kif26a APN 12 112,143,262 (GRCm39) missense probably benign 0.23
IGL01916:Kif26a APN 12 112,143,328 (GRCm39) missense possibly damaging 0.49
IGL02080:Kif26a APN 12 112,124,000 (GRCm39) missense probably damaging 1.00
IGL02138:Kif26a APN 12 112,141,284 (GRCm39) missense probably damaging 1.00
IGL02145:Kif26a APN 12 112,143,409 (GRCm39) missense probably benign 0.00
IGL02285:Kif26a APN 12 112,123,941 (GRCm39) missense probably damaging 1.00
IGL02393:Kif26a APN 12 112,139,098 (GRCm39) missense probably damaging 1.00
IGL02445:Kif26a APN 12 112,140,177 (GRCm39) missense probably damaging 1.00
IGL02865:Kif26a APN 12 112,144,049 (GRCm39) nonsense probably null
IGL03057:Kif26a APN 12 112,142,208 (GRCm39) nonsense probably null
IGL03204:Kif26a APN 12 112,141,213 (GRCm39) missense probably damaging 1.00
R0013:Kif26a UTSW 12 112,144,314 (GRCm39) missense probably benign 0.03
R0034:Kif26a UTSW 12 112,135,397 (GRCm39) splice site probably benign
R0089:Kif26a UTSW 12 112,143,837 (GRCm39) missense probably damaging 0.98
R0111:Kif26a UTSW 12 112,129,771 (GRCm39) splice site probably benign
R0220:Kif26a UTSW 12 112,123,824 (GRCm39) missense probably damaging 0.98
R0346:Kif26a UTSW 12 112,145,782 (GRCm39) missense probably null 0.09
R0383:Kif26a UTSW 12 112,144,510 (GRCm39) missense possibly damaging 0.94
R0478:Kif26a UTSW 12 112,142,223 (GRCm39) missense probably damaging 1.00
R0494:Kif26a UTSW 12 112,145,905 (GRCm39) splice site probably null
R1163:Kif26a UTSW 12 112,146,379 (GRCm39) missense probably benign 0.08
R1450:Kif26a UTSW 12 112,140,286 (GRCm39) missense probably damaging 1.00
R1512:Kif26a UTSW 12 112,113,389 (GRCm39) missense possibly damaging 0.47
R1616:Kif26a UTSW 12 112,123,680 (GRCm39) critical splice acceptor site probably null
R1723:Kif26a UTSW 12 112,140,292 (GRCm39) missense possibly damaging 0.67
R1728:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R1729:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R1903:Kif26a UTSW 12 112,141,974 (GRCm39) missense probably damaging 1.00
R2283:Kif26a UTSW 12 112,143,787 (GRCm39) missense possibly damaging 0.66
R3862:Kif26a UTSW 12 112,146,323 (GRCm39) missense probably benign 0.30
R3906:Kif26a UTSW 12 112,143,324 (GRCm39) missense probably benign
R4050:Kif26a UTSW 12 112,146,350 (GRCm39) missense probably benign 0.08
R4270:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4271:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4731:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4732:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4733:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4908:Kif26a UTSW 12 112,123,776 (GRCm39) missense probably damaging 1.00
R4946:Kif26a UTSW 12 112,144,228 (GRCm39) missense probably damaging 0.99
R5566:Kif26a UTSW 12 112,123,788 (GRCm39) missense probably damaging 1.00
R6280:Kif26a UTSW 12 112,141,303 (GRCm39) missense probably damaging 0.99
R6422:Kif26a UTSW 12 112,135,309 (GRCm39) missense possibly damaging 0.95
R6513:Kif26a UTSW 12 112,141,926 (GRCm39) missense probably damaging 0.97
R6860:Kif26a UTSW 12 112,113,263 (GRCm39) missense probably damaging 1.00
R6879:Kif26a UTSW 12 112,144,087 (GRCm39) missense probably benign
R7127:Kif26a UTSW 12 112,144,579 (GRCm39) missense probably damaging 1.00
R7366:Kif26a UTSW 12 112,129,976 (GRCm39) critical splice donor site probably null
R7595:Kif26a UTSW 12 112,145,759 (GRCm39) missense probably benign 0.30
R7630:Kif26a UTSW 12 112,142,131 (GRCm39) missense probably damaging 1.00
R7784:Kif26a UTSW 12 112,144,581 (GRCm39) missense possibly damaging 0.66
R7992:Kif26a UTSW 12 112,142,481 (GRCm39) missense probably benign
R8170:Kif26a UTSW 12 112,141,752 (GRCm39) splice site probably null
R9206:Kif26a UTSW 12 112,144,480 (GRCm39) missense possibly damaging 0.92
R9287:Kif26a UTSW 12 112,145,719 (GRCm39) nonsense probably null
R9293:Kif26a UTSW 12 112,112,835 (GRCm39) missense probably damaging 1.00
R9559:Kif26a UTSW 12 112,142,004 (GRCm39) missense probably damaging 1.00
R9687:Kif26a UTSW 12 112,143,625 (GRCm39) missense probably damaging 0.99
R9793:Kif26a UTSW 12 112,142,887 (GRCm39) missense probably damaging 1.00
X0027:Kif26a UTSW 12 112,142,504 (GRCm39) missense probably benign 0.26
Z1176:Kif26a UTSW 12 112,144,052 (GRCm39) missense probably damaging 0.97
Z1177:Kif26a UTSW 12 112,144,045 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGACAGGACTCTTGAGGGTAGG -3'
(R):5'- AGAGCATATGGGAGCTTCGC -3'

Sequencing Primer
(F):5'- AGGCTGTGGAGAGTCTGAG -3'
(R):5'- CACGGACGTGTCTTCAGTG -3'
Posted On 2022-07-18