Incidental Mutation 'R9524:Vmn2r102'
| ID |
719112 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9524 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19897564 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 193
(M193K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000171741
AA Change: M193K
PolyPhen 2
Score 0.737 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: M193K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930438A08Rik |
T |
G |
11: 58,180,594 (GRCm39) |
|
probably null |
Het |
| Adra2c |
G |
A |
5: 35,438,143 (GRCm39) |
R305Q |
probably benign |
Het |
| Ahnak |
A |
G |
19: 9,014,617 (GRCm39) |
D147G |
|
Het |
| Arhgap30 |
T |
A |
1: 171,225,114 (GRCm39) |
S57T |
probably damaging |
Het |
| Aspm |
T |
C |
1: 139,408,607 (GRCm39) |
I2498T |
probably damaging |
Het |
| Atr |
C |
T |
9: 95,792,610 (GRCm39) |
A1644V |
possibly damaging |
Het |
| Cc2d1a |
G |
T |
8: 84,870,744 (GRCm39) |
D101E |
probably benign |
Het |
| Cntfr |
A |
G |
4: 41,661,995 (GRCm39) |
L249P |
probably damaging |
Het |
| D130043K22Rik |
T |
C |
13: 25,071,876 (GRCm39) |
I940T |
possibly damaging |
Het |
| Dnah12 |
T |
G |
14: 26,572,494 (GRCm39) |
C2862G |
probably null |
Het |
| Dnah8 |
CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT |
CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT |
17: 30,979,841 (GRCm39) |
|
probably null |
Het |
| Dnah9 |
A |
G |
11: 65,976,309 (GRCm39) |
F1247L |
possibly damaging |
Het |
| Dpp10 |
T |
C |
1: 123,264,611 (GRCm39) |
Q737R |
probably damaging |
Het |
| Dpp3 |
A |
G |
19: 4,959,897 (GRCm39) |
V673A |
possibly damaging |
Het |
| Eif2a |
A |
T |
3: 58,448,467 (GRCm39) |
K100I |
possibly damaging |
Het |
| Flnc |
C |
A |
6: 29,461,109 (GRCm39) |
N2694K |
probably damaging |
Het |
| Fv1 |
T |
A |
4: 147,953,768 (GRCm39) |
D111E |
possibly damaging |
Het |
| Gcnt3 |
G |
A |
9: 69,941,569 (GRCm39) |
A333V |
probably damaging |
Het |
| Gpr151 |
T |
C |
18: 42,712,710 (GRCm39) |
|
probably benign |
Het |
| Gxylt2 |
A |
G |
6: 100,727,416 (GRCm39) |
T177A |
probably benign |
Het |
| Hnmt |
G |
A |
2: 23,893,880 (GRCm39) |
L205F |
possibly damaging |
Het |
| Ikbkb |
A |
T |
8: 23,172,740 (GRCm39) |
|
probably null |
Het |
| Ikzf2 |
T |
C |
1: 69,578,337 (GRCm39) |
S391G |
probably benign |
Het |
| Kif26a |
C |
T |
12: 112,140,286 (GRCm39) |
T505M |
probably damaging |
Het |
| Kif3b |
A |
T |
2: 153,159,460 (GRCm39) |
K420N |
probably benign |
Het |
| Kmt2a |
A |
G |
9: 44,730,294 (GRCm39) |
V3341A |
unknown |
Het |
| Lce1i |
T |
C |
3: 92,685,081 (GRCm39) |
K32E |
unknown |
Het |
| Lmf1 |
A |
G |
17: 25,881,514 (GRCm39) |
Y521C |
probably damaging |
Het |
| Mki67 |
C |
T |
7: 135,305,913 (GRCm39) |
C655Y |
probably damaging |
Het |
| Morc3 |
T |
A |
16: 93,667,401 (GRCm39) |
V593E |
probably benign |
Het |
| Muc16 |
A |
G |
9: 18,497,314 (GRCm39) |
F6613L |
probably benign |
Het |
| Naip1 |
G |
A |
13: 100,563,101 (GRCm39) |
T688I |
probably benign |
Het |
| Or2n1d |
T |
A |
17: 38,646,540 (GRCm39) |
L164* |
probably null |
Het |
| Otop2 |
T |
A |
11: 115,214,503 (GRCm39) |
C87S |
probably benign |
Het |
| Picalm |
T |
A |
7: 89,810,484 (GRCm39) |
L97* |
probably null |
Het |
| Pik3c2g |
T |
A |
6: 139,606,768 (GRCm39) |
W272R |
probably damaging |
Het |
| Plekhg4 |
G |
A |
8: 106,101,398 (GRCm39) |
G20R |
unknown |
Het |
| Ppp1r35 |
G |
A |
5: 137,777,304 (GRCm39) |
A17T |
unknown |
Het |
| Ppp2r5e |
A |
T |
12: 75,509,167 (GRCm39) |
Y371N |
possibly damaging |
Het |
| Rexo1 |
T |
C |
10: 80,386,872 (GRCm39) |
E62G |
probably damaging |
Het |
| Rtl1 |
T |
C |
12: 109,556,973 (GRCm39) |
E1622G |
probably damaging |
Het |
| Ryr1 |
T |
C |
7: 28,723,600 (GRCm39) |
E4181G |
probably damaging |
Het |
| Saxo1 |
C |
A |
4: 86,397,132 (GRCm39) |
M135I |
probably benign |
Het |
| Shank2 |
C |
A |
7: 143,964,183 (GRCm39) |
P597Q |
possibly damaging |
Het |
| Shld2 |
G |
A |
14: 33,971,245 (GRCm39) |
Q547* |
probably null |
Het |
| Slc44a1 |
G |
A |
4: 53,542,389 (GRCm39) |
V308I |
probably benign |
Het |
| Slc6a21 |
A |
G |
7: 44,937,785 (GRCm39) |
H367R |
probably benign |
Het |
| Snx11 |
G |
T |
11: 96,660,023 (GRCm39) |
T222K |
probably benign |
Het |
| Snx4 |
C |
T |
16: 33,112,228 (GRCm39) |
Q388* |
probably null |
Het |
| Sulf1 |
T |
C |
1: 12,918,622 (GRCm39) |
L831P |
probably damaging |
Het |
| Ugt2a3 |
A |
T |
5: 87,485,018 (GRCm39) |
V2D |
|
Het |
| Unc5c |
T |
C |
3: 141,494,683 (GRCm39) |
V406A |
possibly damaging |
Het |
| Unc5d |
A |
C |
8: 29,365,639 (GRCm39) |
N115K |
probably damaging |
Het |
| Usp28 |
C |
A |
9: 48,947,026 (GRCm39) |
T819N |
probably damaging |
Het |
| Usp42 |
T |
C |
5: 143,702,704 (GRCm39) |
D639G |
possibly damaging |
Het |
| Vmn2r12 |
A |
G |
5: 109,239,823 (GRCm39) |
Y247H |
probably damaging |
Het |
| Vps13d |
T |
C |
4: 144,822,814 (GRCm39) |
D2989G |
|
Het |
| Vsig2 |
A |
G |
9: 37,455,335 (GRCm39) |
E295G |
probably benign |
Het |
| Wdfy3 |
T |
A |
5: 102,055,333 (GRCm39) |
N1579I |
probably benign |
Het |
| Zfp521 |
T |
C |
18: 13,980,173 (GRCm39) |
D80G |
possibly damaging |
Het |
| Zfp663 |
A |
C |
2: 165,195,607 (GRCm39) |
L204R |
probably damaging |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTAAATGTAGTGACTGGAATGTCCC -3'
(R):5'- ATCCATATGTTCCCAGAATTTGGC -3'
Sequencing Primer
(F):5'- GTGACTGGAATGTCCCTTTAAAAC -3'
(R):5'- CCCAGAATTTGGCAAAATGTGAAGTC -3'
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| Posted On |
2022-07-18 |
Incidental Mutation