Incidental Mutation 'R9525:Ccdc162'
ID 719158
Institutional Source Beutler Lab
Gene Symbol Ccdc162
Ensembl Gene ENSMUSG00000075225
Gene Name coiled-coil domain containing 162
Synonyms Gm29096, Gm6976, 5033413D22Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R9525 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 41414838-41592586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41559222 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 126 (R126W)
Ref Sequence ENSEMBL: ENSMUSP00000140774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019955] [ENSMUST00000099932] [ENSMUST00000189488] [ENSMUST00000190522]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000019955
SMART Domains Protein: ENSMUSP00000019955
Gene: ENSMUSG00000075225

DomainStartEndE-ValueType
coiled coil region 1 37 N/A INTRINSIC
low complexity region 116 138 N/A INTRINSIC
coiled coil region 177 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099932
SMART Domains Protein: ENSMUSP00000097516
Gene: ENSMUSG00000075225

DomainStartEndE-ValueType
coiled coil region 327 366 N/A INTRINSIC
low complexity region 490 512 N/A INTRINSIC
coiled coil region 551 607 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000189488
AA Change: R126W

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000140774
Gene: ENSMUSG00000075225
AA Change: R126W

DomainStartEndE-ValueType
low complexity region 328 347 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000190522
AA Change: R126W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000140852
Gene: ENSMUSG00000100855
AA Change: R126W

DomainStartEndE-ValueType
Pfam:DUF4549 2 145 7.9e-74 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000190522
AA Change: R126W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T A 4: 144,282,000 (GRCm39) D264V possibly damaging Het
Adgrv1 C T 13: 81,593,453 (GRCm39) G4178E possibly damaging Het
Alpk2 A G 18: 65,399,288 (GRCm39) Y2097H probably damaging Het
Anapc2 T C 2: 25,166,339 (GRCm39) S369P probably damaging Het
Atr C T 9: 95,792,610 (GRCm39) A1644V possibly damaging Het
Camsap1 G A 2: 25,843,962 (GRCm39) H230Y probably benign Het
Cbx7 A C 15: 79,814,797 (GRCm39) W35G probably damaging Het
Cc2d2b T C 19: 40,773,430 (GRCm39) Y498H probably damaging Het
Cd274 T A 19: 29,359,879 (GRCm39) L228Q probably benign Het
Cfap57 A T 4: 118,433,778 (GRCm39) I1000N probably damaging Het
Cfhr4 G T 1: 139,702,250 (GRCm39) T78K probably damaging Het
Chadl C A 15: 81,578,220 (GRCm39) G470C probably damaging Het
Clasp2 T C 9: 113,740,677 (GRCm39) L1217P probably damaging Het
Crnkl1 A G 2: 145,770,198 (GRCm39) V215A probably benign Het
Dbx2 G T 15: 95,552,304 (GRCm39) H114N probably benign Het
Ddb2 T G 2: 91,065,180 (GRCm39) T82P probably benign Het
Emc8 T C 8: 121,394,656 (GRCm39) Y21C probably damaging Het
Epha1 A T 6: 42,344,758 (GRCm39) M66K probably damaging Het
Fan1 A C 7: 64,022,007 (GRCm39) probably null Het
Fgd2 T A 17: 29,583,955 (GRCm39) L123Q probably damaging Het
Flnb T A 14: 7,905,481 (GRCm38) V1077E probably damaging Het
Fnbp1l A T 3: 122,352,703 (GRCm39) M251K probably damaging Het
Gal3st2c T A 1: 93,935,928 (GRCm39) F93L probably damaging Het
Gdf2 T C 14: 33,667,564 (GRCm39) *429Q probably null Het
Gdpd5 A G 7: 99,104,156 (GRCm39) T455A possibly damaging Het
Gm8356 G T 14: 17,691,339 (GRCm39) Q109K Het
Gpr20 A T 15: 73,567,681 (GRCm39) V236E probably benign Het
Gpr39 T C 1: 125,800,323 (GRCm39) V358A probably damaging Het
Grin1 T C 2: 25,187,472 (GRCm39) N613D probably damaging Het
H2bc15 G T 13: 21,938,305 (GRCm39) A5S unknown Het
Hepacam2 A G 6: 3,476,046 (GRCm39) V293A probably benign Het
Igf1r G A 7: 67,864,682 (GRCm39) R1160Q probably damaging Het
Iqcd T C 5: 120,738,217 (GRCm39) Y12H probably benign Het
Itih1 T C 14: 30,658,711 (GRCm39) S393G probably benign Het
Klhl33 T C 14: 51,128,929 (GRCm39) M507V probably null Het
Mast4 G T 13: 102,872,944 (GRCm39) H2141Q probably benign Het
Mkrn2 T A 6: 115,587,486 (GRCm39) D54E probably damaging Het
Mrm3 A G 11: 76,141,104 (GRCm39) T371A possibly damaging Het
Msantd5f3 G A 4: 73,573,061 (GRCm39) S100N probably benign Het
Mylk2 T A 2: 152,759,552 (GRCm39) M414K probably damaging Het
Nlrp4b A G 7: 10,448,748 (GRCm39) E317G probably damaging Het
Or51b6b A T 7: 103,310,142 (GRCm39) I105N probably damaging Het
Or51i2 A G 7: 103,689,820 (GRCm39) I272M possibly damaging Het
Or8k20 A G 2: 86,106,484 (GRCm39) S116P probably benign Het
Pcdhb18 T A 18: 37,624,887 (GRCm39) V739E probably damaging Het
Pkhd1l1 A T 15: 44,448,322 (GRCm39) T3834S possibly damaging Het
Pkp3 A G 7: 140,668,310 (GRCm39) D546G probably damaging Het
Pot1a A T 6: 25,745,916 (GRCm39) M595K probably benign Het
Pus7l A G 15: 94,438,764 (GRCm39) I27T probably damaging Het
Rbp3 A G 14: 33,676,402 (GRCm39) I117V probably benign Het
Rnf19a A T 15: 36,247,375 (GRCm39) L454H probably damaging Het
Rps6kb1 C A 11: 86,410,746 (GRCm39) K167N possibly damaging Het
Saxo1 A T 4: 86,363,186 (GRCm39) Y432* probably null Het
Setdb2 A T 14: 59,646,841 (GRCm39) V558E probably benign Het
Spmap2l A G 5: 77,195,138 (GRCm39) N104S probably benign Het
Tbck T C 3: 132,456,966 (GRCm39) F627L probably damaging Het
Tbpl2 T G 2: 23,986,547 (GRCm39) M1L probably benign Het
Timp2 A C 11: 118,194,678 (GRCm39) D170E probably benign Het
Tomm40 A G 7: 19,436,812 (GRCm39) Y303H probably damaging Het
Trgv5 T C 13: 19,376,885 (GRCm39) C111R probably damaging Het
Trhr T C 15: 44,060,873 (GRCm39) I131T possibly damaging Het
Vmn1r159 A G 7: 22,542,417 (GRCm39) V205A probably damaging Het
Vmn2r25 G T 6: 123,800,164 (GRCm39) T726K probably damaging Het
Wwox T A 8: 115,433,105 (GRCm39) V257E probably benign Het
Xxylt1 A G 16: 30,869,593 (GRCm39) I169T probably benign Het
Zfp1007 A T 5: 109,824,846 (GRCm39) N201K Het
Zfp457 T C 13: 67,441,492 (GRCm39) Y361C probably damaging Het
Other mutations in Ccdc162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Ccdc162 APN 10 41,457,335 (GRCm39) missense probably benign 0.01
IGL01366:Ccdc162 APN 10 41,456,302 (GRCm39) missense possibly damaging 0.49
IGL01924:Ccdc162 APN 10 41,445,883 (GRCm39) missense probably damaging 1.00
IGL02504:Ccdc162 APN 10 41,428,384 (GRCm39) missense probably damaging 1.00
IGL02678:Ccdc162 APN 10 41,437,151 (GRCm39) missense probably damaging 0.99
IGL02955:Ccdc162 APN 10 41,437,123 (GRCm39) missense probably damaging 1.00
beeswax UTSW 10 41,437,222 (GRCm39) missense possibly damaging 0.57
honeycomb UTSW 10 41,520,637 (GRCm39) missense probably benign 0.35
FR4304:Ccdc162 UTSW 10 41,432,117 (GRCm39) missense possibly damaging 0.49
R0432:Ccdc162 UTSW 10 41,417,856 (GRCm39) missense probably benign 0.01
R0585:Ccdc162 UTSW 10 41,462,375 (GRCm39) missense probably benign 0.03
R0645:Ccdc162 UTSW 10 41,462,407 (GRCm39) splice site probably benign
R0731:Ccdc162 UTSW 10 41,455,139 (GRCm39) missense probably damaging 1.00
R1426:Ccdc162 UTSW 10 41,429,178 (GRCm39) missense possibly damaging 0.89
R1447:Ccdc162 UTSW 10 41,456,243 (GRCm39) missense probably damaging 1.00
R1712:Ccdc162 UTSW 10 41,415,427 (GRCm39) missense probably benign 0.35
R2138:Ccdc162 UTSW 10 41,457,293 (GRCm39) missense probably benign 0.15
R2351:Ccdc162 UTSW 10 41,431,968 (GRCm39) critical splice donor site probably null
R2394:Ccdc162 UTSW 10 41,445,894 (GRCm39) missense probably damaging 1.00
R2431:Ccdc162 UTSW 10 41,445,841 (GRCm39) missense probably benign
R2571:Ccdc162 UTSW 10 41,428,393 (GRCm39) missense probably damaging 1.00
R2873:Ccdc162 UTSW 10 41,531,095 (GRCm39) missense possibly damaging 0.68
R2926:Ccdc162 UTSW 10 41,437,203 (GRCm39) start gained probably benign
R2999:Ccdc162 UTSW 10 41,456,286 (GRCm39) missense probably benign 0.00
R3412:Ccdc162 UTSW 10 41,415,545 (GRCm39) splice site probably benign
R3712:Ccdc162 UTSW 10 41,463,375 (GRCm39) missense probably benign
R3736:Ccdc162 UTSW 10 41,465,564 (GRCm39) splice site probably null
R4112:Ccdc162 UTSW 10 41,532,324 (GRCm39) missense possibly damaging 0.77
R4557:Ccdc162 UTSW 10 41,463,384 (GRCm39) missense probably benign 0.01
R4580:Ccdc162 UTSW 10 41,437,136 (GRCm39) missense probably benign 0.02
R4685:Ccdc162 UTSW 10 41,557,682 (GRCm39) missense possibly damaging 0.89
R4837:Ccdc162 UTSW 10 41,549,863 (GRCm39) missense probably benign 0.00
R5155:Ccdc162 UTSW 10 41,455,147 (GRCm39) missense probably damaging 1.00
R5155:Ccdc162 UTSW 10 41,429,576 (GRCm39) splice site probably null
R5645:Ccdc162 UTSW 10 41,428,352 (GRCm39) missense probably benign 0.06
R5656:Ccdc162 UTSW 10 41,445,930 (GRCm39) missense probably benign 0.26
R5682:Ccdc162 UTSW 10 41,432,799 (GRCm39) nonsense probably null
R5808:Ccdc162 UTSW 10 41,531,500 (GRCm39) missense possibly damaging 0.62
R5909:Ccdc162 UTSW 10 41,437,111 (GRCm39) missense probably damaging 1.00
R6000:Ccdc162 UTSW 10 41,437,159 (GRCm39) missense possibly damaging 0.75
R6057:Ccdc162 UTSW 10 41,510,037 (GRCm39) missense possibly damaging 0.72
R6211:Ccdc162 UTSW 10 41,506,141 (GRCm39) nonsense probably null
R6264:Ccdc162 UTSW 10 41,570,464 (GRCm39) missense probably benign 0.31
R6329:Ccdc162 UTSW 10 41,539,147 (GRCm39) missense possibly damaging 0.76
R6349:Ccdc162 UTSW 10 41,570,396 (GRCm39) missense probably damaging 0.97
R6398:Ccdc162 UTSW 10 41,503,145 (GRCm39) missense probably damaging 1.00
R6453:Ccdc162 UTSW 10 41,426,821 (GRCm39) missense probably damaging 1.00
R6602:Ccdc162 UTSW 10 41,491,976 (GRCm39) missense probably benign 0.00
R6627:Ccdc162 UTSW 10 41,539,181 (GRCm39) missense probably damaging 1.00
R6722:Ccdc162 UTSW 10 41,520,637 (GRCm39) missense probably benign 0.35
R6750:Ccdc162 UTSW 10 41,437,222 (GRCm39) missense possibly damaging 0.57
R6968:Ccdc162 UTSW 10 41,549,840 (GRCm39) missense possibly damaging 0.55
R6970:Ccdc162 UTSW 10 41,491,954 (GRCm39) missense probably benign 0.03
R6989:Ccdc162 UTSW 10 41,457,349 (GRCm39) missense probably damaging 0.99
R7008:Ccdc162 UTSW 10 41,428,411 (GRCm39) missense probably damaging 1.00
R7135:Ccdc162 UTSW 10 41,549,855 (GRCm39) missense probably benign 0.00
R7139:Ccdc162 UTSW 10 41,542,717 (GRCm39) missense possibly damaging 0.49
R7224:Ccdc162 UTSW 10 41,437,187 (GRCm39) missense probably damaging 1.00
R7230:Ccdc162 UTSW 10 41,554,809 (GRCm39) missense probably damaging 1.00
R7256:Ccdc162 UTSW 10 41,431,997 (GRCm39) missense probably damaging 0.99
R7261:Ccdc162 UTSW 10 41,437,136 (GRCm39) missense probably benign 0.02
R7390:Ccdc162 UTSW 10 41,510,044 (GRCm39) missense probably benign
R7712:Ccdc162 UTSW 10 41,503,223 (GRCm39) missense possibly damaging 0.56
R7726:Ccdc162 UTSW 10 41,429,071 (GRCm39) missense probably benign 0.00
R7754:Ccdc162 UTSW 10 41,463,371 (GRCm39) missense probably damaging 1.00
R7764:Ccdc162 UTSW 10 41,566,109 (GRCm39) missense possibly damaging 0.95
R8053:Ccdc162 UTSW 10 41,520,577 (GRCm39) missense probably benign
R8088:Ccdc162 UTSW 10 41,499,410 (GRCm39) missense possibly damaging 0.68
R8094:Ccdc162 UTSW 10 41,488,864 (GRCm39) missense probably benign 0.02
R8097:Ccdc162 UTSW 10 41,510,115 (GRCm39) missense probably benign 0.03
R8321:Ccdc162 UTSW 10 41,510,029 (GRCm39) missense probably damaging 0.98
R8377:Ccdc162 UTSW 10 41,457,306 (GRCm39) missense probably benign 0.08
R8399:Ccdc162 UTSW 10 41,415,517 (GRCm39) missense probably damaging 1.00
R8669:Ccdc162 UTSW 10 41,428,352 (GRCm39) missense probably benign 0.06
R8772:Ccdc162 UTSW 10 41,506,033 (GRCm39) missense probably damaging 0.99
R8810:Ccdc162 UTSW 10 41,542,737 (GRCm39) missense probably benign 0.41
R8903:Ccdc162 UTSW 10 41,531,440 (GRCm39) critical splice donor site probably null
R8928:Ccdc162 UTSW 10 41,462,245 (GRCm39) splice site probably benign
R8950:Ccdc162 UTSW 10 41,474,507 (GRCm39) missense probably benign 0.00
R8960:Ccdc162 UTSW 10 41,429,178 (GRCm39) missense probably damaging 0.96
R8985:Ccdc162 UTSW 10 41,432,102 (GRCm39) missense probably damaging 1.00
R9071:Ccdc162 UTSW 10 41,457,174 (GRCm39) nonsense probably null
R9254:Ccdc162 UTSW 10 41,488,944 (GRCm39) critical splice acceptor site probably null
R9297:Ccdc162 UTSW 10 41,506,110 (GRCm39) missense probably benign
R9318:Ccdc162 UTSW 10 41,506,110 (GRCm39) missense probably benign
R9518:Ccdc162 UTSW 10 41,465,572 (GRCm39) missense probably damaging 1.00
R9539:Ccdc162 UTSW 10 41,463,407 (GRCm39) missense possibly damaging 0.54
R9638:Ccdc162 UTSW 10 41,437,159 (GRCm39) missense probably benign 0.01
Z1176:Ccdc162 UTSW 10 41,530,993 (GRCm39) missense possibly damaging 0.84
Z1176:Ccdc162 UTSW 10 41,481,104 (GRCm39) missense possibly damaging 0.84
Z1176:Ccdc162 UTSW 10 41,429,127 (GRCm39) missense probably benign 0.00
Z1176:Ccdc162 UTSW 10 41,566,088 (GRCm39) missense probably benign 0.00
Z1177:Ccdc162 UTSW 10 41,559,191 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAAGCTTACTGGCCGTGTTG -3'
(R):5'- AACCAGACTTCATTTGATGGTGTTC -3'

Sequencing Primer
(F):5'- TGGTTAAACATGCCAGCTGC -3'
(R):5'- CGTAAGGCTCGATCAGC -3'
Posted On 2022-07-18