Incidental Mutation 'R9526:Pde4d'
| ID |
719269 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4d
|
| Ensembl Gene |
ENSMUSG00000021699 |
| Gene Name |
phosphodiesterase 4D, cAMP specific |
| Synonyms |
9630011N22Rik, dunce, Dpde3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9526 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
108790711-110092503 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 110071915 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 303
(I303N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113488
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074103]
[ENSMUST00000079975]
[ENSMUST00000117420]
[ENSMUST00000117879]
[ENSMUST00000119507]
[ENSMUST00000119672]
[ENSMUST00000120664]
[ENSMUST00000122041]
[ENSMUST00000120671]
[ENSMUST00000135275]
[ENSMUST00000177907]
|
| AlphaFold |
Q01063 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000074103
AA Change: I234N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000073742
Gene: ENSMUSG00000021699
AA Change: I234N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
18 |
N/A |
INTRINSIC |
|
HDc
|
329 |
504 |
1.12e-2 |
SMART |
|
low complexity region
|
652 |
667 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000079975
AA Change: I254N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000078891
Gene: ENSMUSG00000021699
AA Change: I254N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
349 |
524 |
1.12e-2 |
SMART |
|
low complexity region
|
672 |
687 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117420
AA Change: I73N
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000113610
Gene: ENSMUSG00000021699
AA Change: I73N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
168 |
343 |
1.12e-2 |
SMART |
|
low complexity region
|
491 |
506 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117879
AA Change: I60N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112774
Gene: ENSMUSG00000021699
AA Change: I60N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
155 |
330 |
1.12e-2 |
SMART |
|
low complexity region
|
478 |
493 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119507
AA Change: I259N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114089
Gene: ENSMUSG00000021699
AA Change: I259N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
354 |
529 |
1.12e-2 |
SMART |
|
low complexity region
|
677 |
692 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119672
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120664
AA Change: I140N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113024
Gene: ENSMUSG00000021699
AA Change: I140N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
235 |
410 |
1.12e-2 |
SMART |
|
low complexity region
|
558 |
573 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000122041
AA Change: I303N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113488
Gene: ENSMUSG00000021699
AA Change: I303N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
398 |
573 |
1.12e-2 |
SMART |
|
low complexity region
|
721 |
736 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120671
AA Change: I359N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112991
Gene: ENSMUSG00000021699
AA Change: I359N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
84 |
N/A |
INTRINSIC |
|
HDc
|
454 |
629 |
1.12e-2 |
SMART |
|
low complexity region
|
777 |
792 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135275
AA Change: I256N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000119583
Gene: ENSMUSG00000021699
AA Change: I256N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
HDc
|
351 |
526 |
1.12e-2 |
SMART |
|
low complexity region
|
674 |
689 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000121592
Gene: ENSMUSG00000021699
AA Change: I309N
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1E9K|A
|
22 |
59 |
9e-18 |
PDB |
|
low complexity region
|
69 |
85 |
N/A |
INTRINSIC |
|
HDc
|
405 |
580 |
1.12e-2 |
SMART |
|
low complexity region
|
728 |
743 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114945
Gene: ENSMUSG00000021699
AA Change: I23N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PDEase_I
|
121 |
189 |
2.6e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177907
AA Change: I303N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000136485
Gene: ENSMUSG00000021699
AA Change: I303N
| Domain | Start | End | E-Value | Type |
|---|
|
HDc
|
398 |
573 |
1.12e-2 |
SMART |
|
low complexity region
|
721 |
736 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actn1 |
A |
G |
12: 80,230,393 (GRCm39) |
L287S |
probably damaging |
Het |
| Adgrf1 |
A |
T |
17: 43,616,237 (GRCm39) |
Q292L |
possibly damaging |
Het |
| Arhgap32 |
A |
G |
9: 32,172,026 (GRCm39) |
D1602G |
probably benign |
Het |
| Atrnl1 |
C |
T |
19: 57,617,551 (GRCm39) |
P109S |
probably damaging |
Het |
| Camsap1 |
G |
A |
2: 25,843,962 (GRCm39) |
H230Y |
probably benign |
Het |
| Capns1 |
C |
T |
7: 29,891,612 (GRCm39) |
C144Y |
probably damaging |
Het |
| Ccdc17 |
G |
A |
4: 116,455,994 (GRCm39) |
V341I |
possibly damaging |
Het |
| Cd36 |
T |
C |
5: 18,002,033 (GRCm39) |
T323A |
probably damaging |
Het |
| Cdc14a |
CGCTGCTGCTGCTGCTGCTG |
CGCTGCTGCTGCTGCTG |
3: 116,087,509 (GRCm39) |
|
probably benign |
Het |
| Ckap2l |
G |
A |
2: 129,111,161 (GRCm39) |
Q679* |
probably null |
Het |
| Clec4g |
T |
A |
8: 3,768,565 (GRCm39) |
N93I |
probably benign |
Het |
| Cntnap2 |
T |
A |
6: 45,992,165 (GRCm39) |
L364Q |
probably damaging |
Het |
| Cul9 |
A |
G |
17: 46,841,026 (GRCm39) |
M748T |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 118,150,711 (GRCm39) |
I349N |
probably damaging |
Het |
| Dnajc14 |
T |
A |
10: 128,642,260 (GRCm39) |
Y61N |
probably benign |
Het |
| Dock6 |
A |
T |
9: 21,713,802 (GRCm39) |
Y1909* |
probably null |
Het |
| Dock8 |
T |
A |
19: 25,165,739 (GRCm39) |
D1874E |
probably benign |
Het |
| Dpm1 |
A |
G |
2: 168,072,210 (GRCm39) |
S22P |
probably benign |
Het |
| Dysf |
T |
C |
6: 84,128,885 (GRCm39) |
L1385P |
probably damaging |
Het |
| Egf |
T |
C |
3: 129,491,421 (GRCm39) |
T859A |
probably benign |
Het |
| Eif2b1 |
A |
T |
5: 124,711,867 (GRCm39) |
S162T |
probably benign |
Het |
| Emilin1 |
T |
C |
5: 31,075,484 (GRCm39) |
L575P |
probably damaging |
Het |
| Erp27 |
T |
A |
6: 136,886,550 (GRCm39) |
Q161L |
probably benign |
Het |
| Fbxw10 |
C |
A |
11: 62,765,945 (GRCm39) |
D738E |
possibly damaging |
Het |
| Fcgbp |
T |
G |
7: 27,790,937 (GRCm39) |
C733G |
probably damaging |
Het |
| Fgb |
T |
A |
3: 82,957,122 (GRCm39) |
|
probably benign |
Het |
| Gata3os |
A |
T |
2: 9,887,634 (GRCm39) |
T12S |
unknown |
Het |
| Got1l1 |
G |
T |
8: 27,688,503 (GRCm39) |
Q283K |
probably benign |
Het |
| Grk2 |
G |
A |
19: 4,340,871 (GRCm39) |
R226C |
probably damaging |
Het |
| Hoxa10 |
T |
C |
6: 52,211,334 (GRCm39) |
D194G |
probably benign |
Het |
| Ipcef1 |
G |
A |
10: 6,840,620 (GRCm39) |
T363I |
probably damaging |
Het |
| Itga10 |
C |
A |
3: 96,564,273 (GRCm39) |
T922N |
probably damaging |
Het |
| Itgad |
T |
C |
7: 127,777,552 (GRCm39) |
I144T |
probably benign |
Het |
| Kat6b |
C |
A |
14: 21,567,564 (GRCm39) |
Q208K |
possibly damaging |
Het |
| Kidins220 |
T |
G |
12: 25,088,383 (GRCm39) |
L1042R |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,486,355 (GRCm39) |
S4733G |
probably damaging |
Het |
| Lrig3 |
A |
G |
10: 125,850,736 (GRCm39) |
I1101V |
probably benign |
Het |
| Lrp1 |
T |
A |
10: 127,431,229 (GRCm39) |
N311I |
probably damaging |
Het |
| Man2a1 |
A |
T |
17: 64,958,310 (GRCm39) |
K275I |
probably benign |
Het |
| Map3k10 |
T |
A |
7: 27,364,434 (GRCm39) |
N318I |
probably damaging |
Het |
| Map3k8 |
G |
A |
18: 4,333,869 (GRCm39) |
R408W |
probably damaging |
Het |
| Mast1 |
A |
G |
8: 85,647,805 (GRCm39) |
M523T |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,873,593 (GRCm39) |
H1925R |
probably benign |
Het |
| Med12l |
C |
T |
3: 58,984,207 (GRCm39) |
S461L |
probably damaging |
Het |
| Mfap1a |
T |
C |
2: 121,333,237 (GRCm39) |
K65E |
probably damaging |
Het |
| Mical1 |
T |
C |
10: 41,358,602 (GRCm39) |
S507P |
probably benign |
Het |
| Miga2 |
T |
C |
2: 30,268,400 (GRCm39) |
V433A |
unknown |
Het |
| Mpdz |
T |
C |
4: 81,274,653 (GRCm39) |
T848A |
probably benign |
Het |
| Mycn |
A |
G |
12: 12,989,778 (GRCm39) |
V206A |
probably benign |
Het |
| Ndst1 |
G |
A |
18: 60,838,220 (GRCm39) |
Q342* |
probably null |
Het |
| Nectin1 |
A |
G |
9: 43,702,369 (GRCm39) |
M39V |
probably benign |
Het |
| Nectin4 |
A |
T |
1: 171,210,209 (GRCm39) |
R234* |
probably null |
Het |
| Ngb |
C |
G |
12: 87,145,317 (GRCm39) |
V113L |
possibly damaging |
Het |
| Nphp3 |
T |
A |
9: 103,913,337 (GRCm39) |
Y990N |
probably damaging |
Het |
| Nrdc |
T |
C |
4: 108,915,833 (GRCm39) |
|
probably null |
Het |
| Or10a2 |
A |
T |
7: 106,673,739 (GRCm39) |
K235* |
probably null |
Het |
| Or1e23 |
T |
A |
11: 73,407,351 (GRCm39) |
I225F |
probably damaging |
Het |
| Or5p60 |
T |
A |
7: 107,723,801 (GRCm39) |
Y223F |
probably benign |
Het |
| Osbpl6 |
A |
G |
2: 76,415,603 (GRCm39) |
Y655C |
probably damaging |
Het |
| Pcdhgb4 |
A |
G |
18: 37,855,882 (GRCm39) |
Q759R |
probably benign |
Het |
| Pcsk4 |
T |
C |
10: 80,161,800 (GRCm39) |
D164G |
probably damaging |
Het |
| Pdf |
T |
A |
8: 107,774,972 (GRCm39) |
M87L |
probably benign |
Het |
| Pigb |
A |
G |
9: 72,941,840 (GRCm39) |
S140P |
probably damaging |
Het |
| Plch1 |
T |
A |
3: 63,758,549 (GRCm39) |
|
probably benign |
Het |
| Plxna1 |
G |
T |
6: 89,319,633 (GRCm39) |
D557E |
probably benign |
Het |
| Polr2e |
C |
T |
10: 79,872,792 (GRCm39) |
V149M |
probably benign |
Het |
| Polr3a |
A |
T |
14: 24,503,313 (GRCm39) |
C1174S |
probably benign |
Het |
| Prb1c |
T |
A |
6: 132,338,891 (GRCm39) |
N109I |
unknown |
Het |
| Psmd2 |
T |
A |
16: 20,474,369 (GRCm39) |
S308R |
probably benign |
Het |
| Ptger1 |
T |
A |
8: 84,396,002 (GRCm39) |
V353E |
probably damaging |
Het |
| Ptprc |
A |
G |
1: 137,996,111 (GRCm39) |
M940T |
probably benign |
Het |
| Pus7l |
T |
C |
15: 94,425,781 (GRCm39) |
N540S |
probably damaging |
Het |
| Rap1gds1 |
T |
A |
3: 138,756,317 (GRCm39) |
I13L |
probably benign |
Het |
| Rasl10b |
A |
T |
11: 83,303,590 (GRCm39) |
N49I |
probably damaging |
Het |
| Rftn1 |
A |
T |
17: 50,301,237 (GRCm39) |
N537K |
probably benign |
Het |
| Rnase4 |
A |
G |
14: 51,342,645 (GRCm39) |
Y123C |
probably damaging |
Het |
| Rnf181 |
A |
C |
6: 72,338,302 (GRCm39) |
N26K |
probably benign |
Het |
| Rnf31 |
G |
A |
14: 55,836,269 (GRCm39) |
|
probably null |
Het |
| Rpusd3 |
C |
G |
6: 113,393,200 (GRCm39) |
C304S |
unknown |
Het |
| Rsf1 |
CGGC |
CGGCGGCGGGGGC |
7: 97,229,139 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
C |
A |
2: 112,664,270 (GRCm39) |
V1694L |
probably benign |
Het |
| Sanbr |
T |
C |
11: 23,559,098 (GRCm39) |
Y372C |
probably damaging |
Het |
| Sephs2 |
T |
C |
7: 126,872,346 (GRCm39) |
D249G |
probably damaging |
Het |
| Serpina10 |
A |
G |
12: 103,583,217 (GRCm39) |
I409T |
probably damaging |
Het |
| Serpina5 |
C |
T |
12: 104,069,403 (GRCm39) |
A205V |
probably damaging |
Het |
| Sfr1 |
T |
A |
19: 47,723,453 (GRCm39) |
V319E |
probably damaging |
Het |
| Skil |
T |
A |
3: 31,171,639 (GRCm39) |
Y542N |
probably benign |
Het |
| Slc15a5 |
T |
C |
6: 138,049,954 (GRCm39) |
T154A |
probably benign |
Het |
| Slc27a2 |
T |
A |
2: 126,429,846 (GRCm39) |
L618Q |
probably damaging |
Het |
| Slc6a6 |
A |
T |
6: 91,726,808 (GRCm39) |
Y483F |
probably benign |
Het |
| Sprr1b |
T |
C |
3: 92,344,443 (GRCm39) |
I144M |
probably benign |
Het |
| Stat5a |
T |
A |
11: 100,771,161 (GRCm39) |
V580E |
|
Het |
| Tnk1 |
C |
T |
11: 69,746,011 (GRCm39) |
D305N |
probably damaging |
Het |
| Tox2 |
A |
G |
2: 163,164,930 (GRCm39) |
*523W |
probably null |
Het |
| Trav12-2 |
A |
G |
14: 53,854,085 (GRCm39) |
N20D |
probably benign |
Het |
| Trav16 |
T |
A |
14: 53,981,046 (GRCm39) |
N78K |
probably damaging |
Het |
| Trf |
C |
T |
9: 103,104,130 (GRCm39) |
A78T |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,711,543 (GRCm39) |
|
probably benign |
Het |
| Vmn2r67 |
T |
A |
7: 84,785,834 (GRCm39) |
M724L |
probably benign |
Het |
| Vmn2r94 |
A |
T |
17: 18,477,261 (GRCm39) |
F383L |
probably benign |
Het |
| Vwa2 |
T |
C |
19: 56,895,208 (GRCm39) |
S461P |
probably benign |
Het |
| Zfp991 |
G |
A |
4: 147,264,327 (GRCm39) |
G568E |
probably damaging |
Het |
| Zfpl1 |
A |
G |
19: 6,134,440 (GRCm39) |
F15S |
probably damaging |
Het |
|
| Other mutations in Pde4d |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00465:Pde4d
|
APN |
13 |
110,073,221 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL00792:Pde4d
|
APN |
13 |
110,071,929 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01014:Pde4d
|
APN |
13 |
110,086,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01660:Pde4d
|
APN |
13 |
110,074,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02233:Pde4d
|
APN |
13 |
109,877,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02405:Pde4d
|
APN |
13 |
108,996,743 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02544:Pde4d
|
APN |
13 |
109,877,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02885:Pde4d
|
APN |
13 |
110,084,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03286:Pde4d
|
APN |
13 |
110,091,040 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03406:Pde4d
|
APN |
13 |
110,091,125 (GRCm39) |
unclassified |
probably benign |
|
|
Heliosphere
|
UTSW |
13 |
109,253,476 (GRCm39) |
missense |
probably benign |
|
|
Stubbs
|
UTSW |
13 |
109,909,256 (GRCm39) |
intron |
probably benign |
|
|
IGL03055:Pde4d
|
UTSW |
13 |
110,071,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0020:Pde4d
|
UTSW |
13 |
110,091,104 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0020:Pde4d
|
UTSW |
13 |
110,091,104 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0054:Pde4d
|
UTSW |
13 |
109,876,955 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0054:Pde4d
|
UTSW |
13 |
109,876,955 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0357:Pde4d
|
UTSW |
13 |
110,087,802 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0482:Pde4d
|
UTSW |
13 |
110,073,244 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0689:Pde4d
|
UTSW |
13 |
109,877,078 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0884:Pde4d
|
UTSW |
13 |
110,087,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1169:Pde4d
|
UTSW |
13 |
110,087,462 (GRCm39) |
splice site |
probably null |
|
|
R1225:Pde4d
|
UTSW |
13 |
110,086,755 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1246:Pde4d
|
UTSW |
13 |
110,087,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1344:Pde4d
|
UTSW |
13 |
110,086,921 (GRCm39) |
nonsense |
probably null |
|
|
R1351:Pde4d
|
UTSW |
13 |
110,087,809 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1371:Pde4d
|
UTSW |
13 |
109,253,595 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1418:Pde4d
|
UTSW |
13 |
110,086,921 (GRCm39) |
nonsense |
probably null |
|
|
R2197:Pde4d
|
UTSW |
13 |
110,084,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2440:Pde4d
|
UTSW |
13 |
110,063,731 (GRCm39) |
intron |
probably benign |
|
|
R3114:Pde4d
|
UTSW |
13 |
110,084,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3115:Pde4d
|
UTSW |
13 |
110,084,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Pde4d
|
UTSW |
13 |
110,087,866 (GRCm39) |
nonsense |
probably null |
|
|
R3742:Pde4d
|
UTSW |
13 |
109,877,013 (GRCm39) |
missense |
probably benign |
0.42 |
|
R3797:Pde4d
|
UTSW |
13 |
109,769,431 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3983:Pde4d
|
UTSW |
13 |
109,876,940 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4618:Pde4d
|
UTSW |
13 |
110,070,411 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4768:Pde4d
|
UTSW |
13 |
110,070,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4795:Pde4d
|
UTSW |
13 |
110,074,705 (GRCm39) |
intron |
probably benign |
|
|
R4824:Pde4d
|
UTSW |
13 |
109,253,400 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4942:Pde4d
|
UTSW |
13 |
108,996,733 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4984:Pde4d
|
UTSW |
13 |
109,876,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5180:Pde4d
|
UTSW |
13 |
109,877,007 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5267:Pde4d
|
UTSW |
13 |
109,397,343 (GRCm39) |
intron |
probably benign |
|
|
R5311:Pde4d
|
UTSW |
13 |
109,769,399 (GRCm39) |
missense |
probably benign |
|
|
R5311:Pde4d
|
UTSW |
13 |
109,769,398 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5376:Pde4d
|
UTSW |
13 |
109,909,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5551:Pde4d
|
UTSW |
13 |
110,084,930 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5753:Pde4d
|
UTSW |
13 |
109,909,256 (GRCm39) |
intron |
probably benign |
|
|
R5754:Pde4d
|
UTSW |
13 |
110,074,547 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5838:Pde4d
|
UTSW |
13 |
109,876,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5864:Pde4d
|
UTSW |
13 |
110,074,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6039:Pde4d
|
UTSW |
13 |
110,084,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6039:Pde4d
|
UTSW |
13 |
110,084,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6049:Pde4d
|
UTSW |
13 |
109,169,119 (GRCm39) |
nonsense |
probably null |
|
|
R6214:Pde4d
|
UTSW |
13 |
110,085,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Pde4d
|
UTSW |
13 |
110,085,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Pde4d
|
UTSW |
13 |
110,086,755 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6431:Pde4d
|
UTSW |
13 |
109,738,320 (GRCm39) |
splice site |
probably null |
|
|
R6501:Pde4d
|
UTSW |
13 |
109,253,476 (GRCm39) |
missense |
probably benign |
|
|
R6534:Pde4d
|
UTSW |
13 |
109,769,435 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6709:Pde4d
|
UTSW |
13 |
110,084,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4d
|
UTSW |
13 |
109,769,432 (GRCm39) |
nonsense |
probably null |
|
|
R7164:Pde4d
|
UTSW |
13 |
109,169,222 (GRCm39) |
missense |
probably benign |
|
|
R7222:Pde4d
|
UTSW |
13 |
109,894,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7417:Pde4d
|
UTSW |
13 |
109,769,322 (GRCm39) |
splice site |
probably null |
|
|
R7489:Pde4d
|
UTSW |
13 |
109,253,301 (GRCm39) |
missense |
unknown |
|
|
R7563:Pde4d
|
UTSW |
13 |
110,087,541 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7861:Pde4d
|
UTSW |
13 |
110,071,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8167:Pde4d
|
UTSW |
13 |
109,578,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8197:Pde4d
|
UTSW |
13 |
110,084,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8469:Pde4d
|
UTSW |
13 |
108,996,722 (GRCm39) |
missense |
probably benign |
|
|
R8715:Pde4d
|
UTSW |
13 |
110,071,876 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8926:Pde4d
|
UTSW |
13 |
110,074,625 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9054:Pde4d
|
UTSW |
13 |
110,071,924 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9406:Pde4d
|
UTSW |
13 |
109,877,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9516:Pde4d
|
UTSW |
13 |
109,397,196 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGCAGTTACGGTTGGTCC -3'
(R):5'- GTCTCACTATGTAGTTCCTGGAAC -3'
Sequencing Primer
(F):5'- CAGTTACGGTTGGTCCATTTATATG -3'
(R):5'- GGAACTACACTGGAGTCTCACTATG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation