Incidental Mutation 'R9529:Tmprss11a'
ID 719378
Institutional Source Beutler Lab
Gene Symbol Tmprss11a
Ensembl Gene ENSMUSG00000072845
Gene Name transmembrane protease, serine 11a
Synonyms LOC194597
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9529 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 86558269-86616849 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86576501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 117 (K117E)
Ref Sequence ENSEMBL: ENSMUSP00000098634 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101073]
AlphaFold Q3UQ41
Predicted Effect probably benign
Transcript: ENSMUST00000101073
AA Change: K117E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000098634
Gene: ENSMUSG00000072845
AA Change: K117E

DomainStartEndE-ValueType
low complexity region 17 32 N/A INTRINSIC
Pfam:SEA 36 135 3.2e-23 PFAM
Tryp_SPc 157 383 1.98e-87 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice for a targeted mutation appear normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik A C 5: 113,331,682 (GRCm39) L844R possibly damaging Het
Aadacl4fm2 A G 4: 144,282,082 (GRCm39) Y237H probably benign Het
Abca8a A T 11: 109,947,167 (GRCm39) Y1036* probably null Het
Abcg3 T C 5: 105,121,973 (GRCm39) T135A probably damaging Het
Arhgef28 G A 13: 98,213,773 (GRCm39) A30V probably damaging Het
Cald1 T A 6: 34,662,947 (GRCm39) D3E probably damaging Het
Ccdc89 T A 7: 90,076,573 (GRCm39) L261Q probably damaging Het
Ceacam1 T C 7: 25,171,231 (GRCm39) D411G possibly damaging Het
Chil4 T A 3: 106,118,656 (GRCm39) N87Y probably damaging Het
Ciita T A 16: 10,328,640 (GRCm39) L308Q probably benign Het
Clptm1 T C 7: 19,371,600 (GRCm39) I278V probably benign Het
Col5a3 A T 9: 20,685,308 (GRCm39) probably null Het
Ddost T A 4: 138,038,780 (GRCm39) D336E probably benign Het
Dnah7a T C 1: 53,561,495 (GRCm39) Y2054C probably damaging Het
Erc2 T A 14: 28,197,723 (GRCm39) L1000H unknown Het
Fhip2b T C 14: 70,822,579 (GRCm39) E714G probably damaging Het
Gdpd4 T C 7: 97,610,793 (GRCm39) V71A possibly damaging Het
Hmcn1 A G 1: 150,545,175 (GRCm39) Y2811H probably damaging Het
Hmox2 C T 16: 4,582,818 (GRCm39) Q184* probably null Het
Igkv9-124 G T 6: 67,919,280 (GRCm39) T44N probably benign Het
Kmt2d G A 15: 98,737,649 (GRCm39) T5149I unknown Het
Lamb2 T A 9: 108,363,477 (GRCm39) D885E probably benign Het
Macf1 A G 4: 123,407,680 (GRCm39) S220P probably damaging Het
Muc2 A T 7: 141,287,453 (GRCm39) T211S possibly damaging Het
Mup13 A T 4: 61,184,117 (GRCm39) C15S possibly damaging Het
Myh3 T C 11: 66,979,556 (GRCm39) probably null Het
Nek10 A G 14: 14,850,833 (GRCm38) I293V probably benign Het
Or10d3 G A 9: 39,461,723 (GRCm39) T148I probably benign Het
Or2a52 T A 6: 43,144,432 (GRCm39) S147T possibly damaging Het
Or6c68 A G 10: 129,158,205 (GRCm39) T238A probably damaging Het
Pdss2 G A 10: 43,269,990 (GRCm39) V278I probably benign Het
Prex1 T C 2: 166,431,518 (GRCm39) K748R probably damaging Het
Ptprb A G 10: 116,174,519 (GRCm39) probably null Het
Ranbp17 G A 11: 33,424,826 (GRCm39) S510L unknown Het
Rp1 T A 1: 4,416,447 (GRCm39) H1555L probably benign Het
Rsph6a A G 7: 18,799,535 (GRCm39) K389E probably benign Het
Ryk T C 9: 102,746,518 (GRCm39) V151A probably benign Het
Ryr3 T A 2: 112,465,660 (GRCm39) N4838I possibly damaging Het
Sbno1 G A 5: 124,517,413 (GRCm39) R1233* probably null Het
Scn2a A T 2: 65,594,932 (GRCm39) K1927M probably damaging Het
Sec22c A T 9: 121,513,860 (GRCm39) I259N probably damaging Het
Slc6a15 A T 10: 103,240,583 (GRCm39) D402V probably benign Het
Stk38 G A 17: 29,207,210 (GRCm39) T111I probably damaging Het
Tmem237 G A 1: 59,147,215 (GRCm39) T306I probably damaging Het
Tmprss9 A T 10: 80,730,640 (GRCm39) D722V probably damaging Het
Trpc1 T C 9: 95,592,250 (GRCm39) Y575C probably damaging Het
Ube2d2b A G 5: 107,978,438 (GRCm39) M30V probably benign Het
Usp36 A T 11: 118,159,461 (GRCm39) L661* probably null Het
Vmn2r13 G T 5: 109,304,064 (GRCm39) T789N probably damaging Het
Vmn2r5 T C 3: 64,400,018 (GRCm39) T550A probably benign Het
Xirp2 T C 2: 67,355,540 (GRCm39) S3434P possibly damaging Het
Zfp106 A G 2: 120,351,007 (GRCm39) V1571A probably damaging Het
Zfp438 A G 18: 5,213,501 (GRCm39) S486P possibly damaging Het
Zfp616 A G 11: 73,975,660 (GRCm39) H643R probably damaging Het
Zfp616 A G 11: 73,976,596 (GRCm39) K955R possibly damaging Het
Other mutations in Tmprss11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01596:Tmprss11a APN 5 86,570,378 (GRCm39) missense probably damaging 1.00
IGL02413:Tmprss11a APN 5 86,570,507 (GRCm39) missense possibly damaging 0.50
IGL02533:Tmprss11a APN 5 86,562,386 (GRCm39) missense probably damaging 0.96
R1202:Tmprss11a UTSW 5 86,559,784 (GRCm39) critical splice acceptor site probably null
R1273:Tmprss11a UTSW 5 86,562,447 (GRCm39) missense probably benign 0.10
R1704:Tmprss11a UTSW 5 86,576,561 (GRCm39) missense probably benign 0.25
R1756:Tmprss11a UTSW 5 86,568,038 (GRCm39) missense probably damaging 1.00
R1783:Tmprss11a UTSW 5 86,567,891 (GRCm39) missense probably damaging 0.98
R1967:Tmprss11a UTSW 5 86,579,702 (GRCm39) missense probably benign 0.23
R2944:Tmprss11a UTSW 5 86,576,511 (GRCm39) missense probably benign 0.19
R3881:Tmprss11a UTSW 5 86,593,664 (GRCm39) missense possibly damaging 0.85
R4512:Tmprss11a UTSW 5 86,576,437 (GRCm39) missense probably benign 0.00
R4515:Tmprss11a UTSW 5 86,568,055 (GRCm39) missense probably damaging 1.00
R4530:Tmprss11a UTSW 5 86,576,540 (GRCm39) missense possibly damaging 0.79
R4543:Tmprss11a UTSW 5 86,559,668 (GRCm39) nonsense probably null
R4881:Tmprss11a UTSW 5 86,570,432 (GRCm39) missense probably damaging 1.00
R5066:Tmprss11a UTSW 5 86,567,859 (GRCm39) critical splice donor site probably null
R5186:Tmprss11a UTSW 5 86,567,938 (GRCm39) missense probably damaging 1.00
R5254:Tmprss11a UTSW 5 86,559,665 (GRCm39) missense probably damaging 0.99
R5313:Tmprss11a UTSW 5 86,559,674 (GRCm39) missense probably damaging 1.00
R6516:Tmprss11a UTSW 5 86,567,987 (GRCm39) missense probably damaging 1.00
R6920:Tmprss11a UTSW 5 86,576,494 (GRCm39) missense probably benign 0.23
R7018:Tmprss11a UTSW 5 86,576,429 (GRCm39) missense probably damaging 0.96
R7566:Tmprss11a UTSW 5 86,591,993 (GRCm39) missense possibly damaging 0.50
R7962:Tmprss11a UTSW 5 86,567,879 (GRCm39) missense probably damaging 1.00
R9299:Tmprss11a UTSW 5 86,570,361 (GRCm39) nonsense probably null
R9479:Tmprss11a UTSW 5 86,562,402 (GRCm39) nonsense probably null
R9591:Tmprss11a UTSW 5 86,567,897 (GRCm39) missense possibly damaging 0.79
X0057:Tmprss11a UTSW 5 86,593,667 (GRCm39) missense probably benign 0.03
X0063:Tmprss11a UTSW 5 86,562,437 (GRCm39) missense probably damaging 1.00
Z1176:Tmprss11a UTSW 5 86,576,490 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTCAGACATGCTTTCGTCAG -3'
(R):5'- TTGACTTGCTCAGCACCTG -3'

Sequencing Primer
(F):5'- TCAAATGCCTCATCTTTAGGTTG -3'
(R):5'- CACCTGAGGCAGATCTGGAAATC -3'
Posted On 2022-07-18