Incidental Mutation 'R9529:Vmn2r13'
| ID |
719381 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r13
|
| Ensembl Gene |
ENSMUSG00000091635 |
| Gene Name |
vomeronasal 2, receptor 13 |
| Synonyms |
Gm4867 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.081)
|
| Stock # |
R9529 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109303889-109339973 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 109304064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Asparagine
at position 789
(T789N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052977
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053253]
|
| AlphaFold |
L7N1X2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000053253
AA Change: T789N
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: T789N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
463 |
2.8e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
1.3e-18 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
1.8e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
A |
C |
5: 113,331,682 (GRCm39) |
L844R |
possibly damaging |
Het |
| Aadacl4fm2 |
A |
G |
4: 144,282,082 (GRCm39) |
Y237H |
probably benign |
Het |
| Abca8a |
A |
T |
11: 109,947,167 (GRCm39) |
Y1036* |
probably null |
Het |
| Abcg3 |
T |
C |
5: 105,121,973 (GRCm39) |
T135A |
probably damaging |
Het |
| Arhgef28 |
G |
A |
13: 98,213,773 (GRCm39) |
A30V |
probably damaging |
Het |
| Cald1 |
T |
A |
6: 34,662,947 (GRCm39) |
D3E |
probably damaging |
Het |
| Ccdc89 |
T |
A |
7: 90,076,573 (GRCm39) |
L261Q |
probably damaging |
Het |
| Ceacam1 |
T |
C |
7: 25,171,231 (GRCm39) |
D411G |
possibly damaging |
Het |
| Chil4 |
T |
A |
3: 106,118,656 (GRCm39) |
N87Y |
probably damaging |
Het |
| Ciita |
T |
A |
16: 10,328,640 (GRCm39) |
L308Q |
probably benign |
Het |
| Clptm1 |
T |
C |
7: 19,371,600 (GRCm39) |
I278V |
probably benign |
Het |
| Col5a3 |
A |
T |
9: 20,685,308 (GRCm39) |
|
probably null |
Het |
| Ddost |
T |
A |
4: 138,038,780 (GRCm39) |
D336E |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,561,495 (GRCm39) |
Y2054C |
probably damaging |
Het |
| Erc2 |
T |
A |
14: 28,197,723 (GRCm39) |
L1000H |
unknown |
Het |
| Fhip2b |
T |
C |
14: 70,822,579 (GRCm39) |
E714G |
probably damaging |
Het |
| Gdpd4 |
T |
C |
7: 97,610,793 (GRCm39) |
V71A |
possibly damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,545,175 (GRCm39) |
Y2811H |
probably damaging |
Het |
| Hmox2 |
C |
T |
16: 4,582,818 (GRCm39) |
Q184* |
probably null |
Het |
| Igkv9-124 |
G |
T |
6: 67,919,280 (GRCm39) |
T44N |
probably benign |
Het |
| Kmt2d |
G |
A |
15: 98,737,649 (GRCm39) |
T5149I |
unknown |
Het |
| Lamb2 |
T |
A |
9: 108,363,477 (GRCm39) |
D885E |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,407,680 (GRCm39) |
S220P |
probably damaging |
Het |
| Muc2 |
A |
T |
7: 141,287,453 (GRCm39) |
T211S |
possibly damaging |
Het |
| Mup13 |
A |
T |
4: 61,184,117 (GRCm39) |
C15S |
possibly damaging |
Het |
| Myh3 |
T |
C |
11: 66,979,556 (GRCm39) |
|
probably null |
Het |
| Nek10 |
A |
G |
14: 14,850,833 (GRCm38) |
I293V |
probably benign |
Het |
| Or10d3 |
G |
A |
9: 39,461,723 (GRCm39) |
T148I |
probably benign |
Het |
| Or2a52 |
T |
A |
6: 43,144,432 (GRCm39) |
S147T |
possibly damaging |
Het |
| Or6c68 |
A |
G |
10: 129,158,205 (GRCm39) |
T238A |
probably damaging |
Het |
| Pdss2 |
G |
A |
10: 43,269,990 (GRCm39) |
V278I |
probably benign |
Het |
| Prex1 |
T |
C |
2: 166,431,518 (GRCm39) |
K748R |
probably damaging |
Het |
| Ptprb |
A |
G |
10: 116,174,519 (GRCm39) |
|
probably null |
Het |
| Ranbp17 |
G |
A |
11: 33,424,826 (GRCm39) |
S510L |
unknown |
Het |
| Rp1 |
T |
A |
1: 4,416,447 (GRCm39) |
H1555L |
probably benign |
Het |
| Rsph6a |
A |
G |
7: 18,799,535 (GRCm39) |
K389E |
probably benign |
Het |
| Ryk |
T |
C |
9: 102,746,518 (GRCm39) |
V151A |
probably benign |
Het |
| Ryr3 |
T |
A |
2: 112,465,660 (GRCm39) |
N4838I |
possibly damaging |
Het |
| Sbno1 |
G |
A |
5: 124,517,413 (GRCm39) |
R1233* |
probably null |
Het |
| Scn2a |
A |
T |
2: 65,594,932 (GRCm39) |
K1927M |
probably damaging |
Het |
| Sec22c |
A |
T |
9: 121,513,860 (GRCm39) |
I259N |
probably damaging |
Het |
| Slc6a15 |
A |
T |
10: 103,240,583 (GRCm39) |
D402V |
probably benign |
Het |
| Stk38 |
G |
A |
17: 29,207,210 (GRCm39) |
T111I |
probably damaging |
Het |
| Tmem237 |
G |
A |
1: 59,147,215 (GRCm39) |
T306I |
probably damaging |
Het |
| Tmprss11a |
T |
C |
5: 86,576,501 (GRCm39) |
K117E |
probably benign |
Het |
| Tmprss9 |
A |
T |
10: 80,730,640 (GRCm39) |
D722V |
probably damaging |
Het |
| Trpc1 |
T |
C |
9: 95,592,250 (GRCm39) |
Y575C |
probably damaging |
Het |
| Ube2d2b |
A |
G |
5: 107,978,438 (GRCm39) |
M30V |
probably benign |
Het |
| Usp36 |
A |
T |
11: 118,159,461 (GRCm39) |
L661* |
probably null |
Het |
| Vmn2r5 |
T |
C |
3: 64,400,018 (GRCm39) |
T550A |
probably benign |
Het |
| Xirp2 |
T |
C |
2: 67,355,540 (GRCm39) |
S3434P |
possibly damaging |
Het |
| Zfp106 |
A |
G |
2: 120,351,007 (GRCm39) |
V1571A |
probably damaging |
Het |
| Zfp438 |
A |
G |
18: 5,213,501 (GRCm39) |
S486P |
possibly damaging |
Het |
| Zfp616 |
A |
G |
11: 73,975,660 (GRCm39) |
H643R |
probably damaging |
Het |
| Zfp616 |
A |
G |
11: 73,976,596 (GRCm39) |
K955R |
possibly damaging |
Het |
|
| Other mutations in Vmn2r13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Vmn2r13
|
APN |
5 |
109,303,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r13
|
APN |
5 |
109,304,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01946:Vmn2r13
|
APN |
5 |
109,322,085 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01971:Vmn2r13
|
APN |
5 |
109,321,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02636:Vmn2r13
|
APN |
5 |
109,339,883 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03062:Vmn2r13
|
APN |
5 |
109,304,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03173:Vmn2r13
|
APN |
5 |
109,319,645 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03301:Vmn2r13
|
APN |
5 |
109,305,955 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03383:Vmn2r13
|
APN |
5 |
109,304,398 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03048:Vmn2r13
|
UTSW |
5 |
109,304,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0123:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0134:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0220:Vmn2r13
|
UTSW |
5 |
109,304,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0225:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r13
|
UTSW |
5 |
109,304,395 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0410:Vmn2r13
|
UTSW |
5 |
109,321,679 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0787:Vmn2r13
|
UTSW |
5 |
109,304,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1200:Vmn2r13
|
UTSW |
5 |
109,322,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Vmn2r13
|
UTSW |
5 |
109,322,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1782:Vmn2r13
|
UTSW |
5 |
109,306,040 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1939:Vmn2r13
|
UTSW |
5 |
109,339,852 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2029:Vmn2r13
|
UTSW |
5 |
109,339,943 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2125:Vmn2r13
|
UTSW |
5 |
109,306,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2126:Vmn2r13
|
UTSW |
5 |
109,306,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2379:Vmn2r13
|
UTSW |
5 |
109,319,644 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2680:Vmn2r13
|
UTSW |
5 |
109,322,178 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2888:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2889:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2890:Vmn2r13
|
UTSW |
5 |
109,339,840 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3014:Vmn2r13
|
UTSW |
5 |
109,319,627 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3683:Vmn2r13
|
UTSW |
5 |
109,304,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4074:Vmn2r13
|
UTSW |
5 |
109,304,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4599:Vmn2r13
|
UTSW |
5 |
109,304,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Vmn2r13
|
UTSW |
5 |
109,323,065 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4805:Vmn2r13
|
UTSW |
5 |
109,304,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4822:Vmn2r13
|
UTSW |
5 |
109,321,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4943:Vmn2r13
|
UTSW |
5 |
109,322,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5263:Vmn2r13
|
UTSW |
5 |
109,321,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r13
|
UTSW |
5 |
109,339,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5502:Vmn2r13
|
UTSW |
5 |
109,321,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5554:Vmn2r13
|
UTSW |
5 |
109,339,860 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5563:Vmn2r13
|
UTSW |
5 |
109,321,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5819:Vmn2r13
|
UTSW |
5 |
109,321,966 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6074:Vmn2r13
|
UTSW |
5 |
109,322,167 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6416:Vmn2r13
|
UTSW |
5 |
109,321,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6419:Vmn2r13
|
UTSW |
5 |
109,323,085 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6484:Vmn2r13
|
UTSW |
5 |
109,304,540 (GRCm39) |
nonsense |
probably null |
|
|
R6486:Vmn2r13
|
UTSW |
5 |
109,304,425 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6545:Vmn2r13
|
UTSW |
5 |
109,304,806 (GRCm39) |
splice site |
probably null |
|
|
R6700:Vmn2r13
|
UTSW |
5 |
109,322,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6897:Vmn2r13
|
UTSW |
5 |
109,306,015 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6957:Vmn2r13
|
UTSW |
5 |
109,304,753 (GRCm39) |
nonsense |
probably null |
|
|
R7276:Vmn2r13
|
UTSW |
5 |
109,321,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Vmn2r13
|
UTSW |
5 |
109,339,909 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7443:Vmn2r13
|
UTSW |
5 |
109,339,909 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7555:Vmn2r13
|
UTSW |
5 |
109,319,557 (GRCm39) |
splice site |
probably null |
|
|
R7607:Vmn2r13
|
UTSW |
5 |
109,321,506 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7719:Vmn2r13
|
UTSW |
5 |
109,319,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8116:Vmn2r13
|
UTSW |
5 |
109,322,926 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8242:Vmn2r13
|
UTSW |
5 |
109,322,872 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8294:Vmn2r13
|
UTSW |
5 |
109,322,978 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8340:Vmn2r13
|
UTSW |
5 |
109,322,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8692:Vmn2r13
|
UTSW |
5 |
109,319,514 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8742:Vmn2r13
|
UTSW |
5 |
109,304,263 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9022:Vmn2r13
|
UTSW |
5 |
109,304,242 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9281:Vmn2r13
|
UTSW |
5 |
109,303,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9708:Vmn2r13
|
UTSW |
5 |
109,322,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9746:Vmn2r13
|
UTSW |
5 |
109,339,773 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0066:Vmn2r13
|
UTSW |
5 |
109,304,085 (GRCm39) |
missense |
probably benign |
0.44 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGTGCTACCATACATTGTAAG -3'
(R):5'- ATTTGCAACAAAGGCTCAGTC -3'
Sequencing Primer
(F):5'- CAAAGCAAAAACATATGATGAGTACC -3'
(R):5'- ACAAAGGCTCAGTCATTGCCTTC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation