Mutagenetix > Incidental Mutation

Incidental Mutation 'R9530:Vmn1r234'

719458

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r234

Ensembl Gene

ENSMUSG00000057203

Gene Name

vomeronasal 1 receptor 234

Synonyms

V1rf1

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R9530 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

21449088-21450078 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 21449104 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 6 (H6R)

Ref Sequence

ENSEMBL: ENSMUSP00000078579 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079633]

AlphaFold

Q8R298

Predicted Effect

probably damaging
Transcript: ENSMUST00000079633
AA Change: H6R

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000078579
Gene: ENSMUSG00000057203
AA Change: H6R

Domain	Start	End	E-Value	Type
Pfam:TAS2R	25	315	2.8e-14	PFAM
Pfam:V1R	57	318	2.3e-26	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	A	G	7: 41,274,165 (GRCm39)	N96S	possibly damaging	Het
Acsl6	C	T	11: 54,220,783 (GRCm39)	T301I	probably damaging	Het
Ankrd7	C	A	6: 18,868,258 (GRCm39)	Q127K	probably benign	Het
Ap1s1	T	C	5: 137,064,612 (GRCm39)	M155V	probably benign	Het
Appbp2	A	C	11: 85,107,306 (GRCm39)	C61W	probably damaging	Het
Atosb	C	T	4: 43,034,753 (GRCm39)	R322Q	probably damaging	Het
Ccng1	A	G	11: 40,644,885 (GRCm39)	V4A	probably benign	Het
Cd163	G	T	6: 124,294,491 (GRCm39)	E550*	probably null	Het
Cdh2	A	G	18: 16,783,466 (GRCm39)	Y88H	probably damaging	Het
Cyp2c69	A	G	19: 39,848,311 (GRCm39)	S304P	possibly damaging	Het
Dync2i1	A	G	12: 116,175,411 (GRCm39)	I922T	possibly damaging	Het
Erbb3	T	C	10: 128,410,291 (GRCm39)	I656V	probably benign	Het
Fhod3	T	A	18: 25,248,910 (GRCm39)	I1363K	probably damaging	Het
Garre1	A	G	7: 33,963,069 (GRCm39)	V201A	probably benign	Het
Heatr1	G	A	13: 12,439,607 (GRCm39)	R1395H	probably damaging	Het
Herc4	T	C	10: 63,126,382 (GRCm39)	I578T	probably benign	Het
Herc6	T	A	6: 57,602,899 (GRCm39)	L526*	probably null	Het
Ighv5-9	A	G	12: 113,625,677 (GRCm39)	M22T	probably benign	Het
Klhl36	A	G	8: 120,591,808 (GRCm39)	E17G	possibly damaging	Het
Mast2	A	C	4: 116,169,535 (GRCm39)	L766R	probably damaging	Het
Megf8	G	A	7: 25,030,124 (GRCm39)	V420M	probably benign	Het
Met	T	C	6: 17,558,831 (GRCm39)	V1153A	probably damaging	Het
Mrpl21	T	A	19: 3,340,998 (GRCm39)	I196N	possibly damaging	Het
Or7g21	G	A	9: 19,033,051 (GRCm39)	V264I	probably benign	Het
Polrmt	C	T	10: 79,574,545 (GRCm39)	A883T	probably benign	Het
Prkcg	G	A	7: 3,375,965 (GRCm39)	D537N	possibly damaging	Het
Rpap3	A	T	15: 97,579,655 (GRCm39)	D452E	probably benign	Het
Slc8a2	A	G	7: 15,879,269 (GRCm39)	D585G	probably null	Het
St18	T	A	1: 6,872,997 (GRCm39)	I244N	probably benign	Het
Stat1	T	A	1: 52,187,160 (GRCm39)		probably null	Het
Stk39	A	G	2: 68,198,755 (GRCm39)	Y288H	probably damaging	Het
Tas2r140	G	A	6: 133,032,494 (GRCm39)	S88F	probably benign	Het
Tbc1d32	T	C	10: 56,072,507 (GRCm39)	E308G	probably damaging	Het
Tcf7l1	T	C	6: 72,604,687 (GRCm39)	T486A	probably benign	Het
Tie1	T	C	4: 118,343,817 (GRCm39)	T42A	possibly damaging	Het
Tnnt2	A	G	1: 135,779,793 (GRCm39)	T297A	possibly damaging	Het
Triobp	G	C	15: 78,886,321 (GRCm39)	G1867R	probably damaging	Het
Vmn2r93	T	A	17: 18,518,562 (GRCm39)	I7N	probably damaging	Het
Vwa8	T	A	14: 79,172,639 (GRCm39)	S294T	probably benign	Het
Yjefn3	A	G	8: 70,340,633 (GRCm39)	V197A	probably benign	Het
Zcchc4	CAGAG	CAG	5: 52,953,568 (GRCm39)		probably null	Het
Zfhx3	A	G	8: 109,527,010 (GRCm39)	E969G	probably damaging	Het
Zfp112	G	T	7: 23,824,665 (GRCm39)	C215F	probably benign	Het
Zfp994	A	T	17: 22,420,514 (GRCm39)	L145Q	probably damaging	Het

Other mutations in Vmn1r234

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn1r234	APN	17	21,449,860 (GRCm39)	missense	possibly damaging	0.95
IGL01485:Vmn1r234	APN	17	21,449,171 (GRCm39)	missense	possibly damaging	0.53
IGL02149:Vmn1r234	APN	17	21,449,269 (GRCm39)	missense	probably benign	0.00
IGL02291:Vmn1r234	APN	17	21,449,193 (GRCm39)	missense	probably benign	0.28
IGL02993:Vmn1r234	APN	17	21,449,965 (GRCm39)	missense	probably damaging	0.99
IGL03223:Vmn1r234	APN	17	21,449,653 (GRCm39)	missense	probably damaging	0.98
R0626:Vmn1r234	UTSW	17	21,450,007 (GRCm39)	missense	probably benign	0.17
R1274:Vmn1r234	UTSW	17	21,449,513 (GRCm39)	frame shift	probably null
R1275:Vmn1r234	UTSW	17	21,449,513 (GRCm39)	frame shift	probably null
R1288:Vmn1r234	UTSW	17	21,449,513 (GRCm39)	frame shift	probably null
R1289:Vmn1r234	UTSW	17	21,449,513 (GRCm39)	frame shift	probably null
R1319:Vmn1r234	UTSW	17	21,449,172 (GRCm39)	missense	probably benign	0.01
R1412:Vmn1r234	UTSW	17	21,449,512 (GRCm39)	missense	probably benign	0.01
R2323:Vmn1r234	UTSW	17	21,449,965 (GRCm39)	missense	probably benign	0.10
R3755:Vmn1r234	UTSW	17	21,449,271 (GRCm39)	missense	probably damaging	0.98
R4299:Vmn1r234	UTSW	17	21,449,283 (GRCm39)	missense	probably benign	0.03
R5301:Vmn1r234	UTSW	17	21,449,589 (GRCm39)	missense	probably benign	0.11
R5741:Vmn1r234	UTSW	17	21,449,731 (GRCm39)	missense	probably benign	0.21
R6197:Vmn1r234	UTSW	17	21,449,589 (GRCm39)	missense	probably benign	0.04
R6218:Vmn1r234	UTSW	17	21,449,983 (GRCm39)	missense	possibly damaging	0.71
R6486:Vmn1r234	UTSW	17	21,449,604 (GRCm39)	missense	probably benign	0.11
R7482:Vmn1r234	UTSW	17	21,449,637 (GRCm39)	missense	probably benign	0.07
R7635:Vmn1r234	UTSW	17	21,449,479 (GRCm39)	missense	probably damaging	1.00
R8295:Vmn1r234	UTSW	17	21,449,101 (GRCm39)	missense	probably benign	0.01
R9506:Vmn1r234	UTSW	17	21,449,503 (GRCm39)	missense	probably benign	0.03
X0028:Vmn1r234	UTSW	17	21,449,152 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- ATGCCTCTCAGTATCCTGAAAC -3'
(R):5'- GTGCATCAAAATCCAGTCCATG -3'

Sequencing Primer
(F):5'- AGATTCCTTCATCTTCACTGATAACC -3'
(R):5'- CCAGTCCATGTGCTTTAATTTGTATG -3'

Posted On

2022-07-18