Incidental Mutation 'R9533:Or2a51'
ID 719561
Institutional Source Beutler Lab
Gene Symbol Or2a51
Ensembl Gene ENSMUSG00000048693
Gene Name olfactory receptor family 2 subfamily A member 51
Synonyms MOR261-5, GA_x6K02T2P3E9-4356476-4355535, Olfr435
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R9533 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 43178580-43179521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43178991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 138 (R138G)
Ref Sequence ENSEMBL: ENSMUSP00000150935 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058118] [ENSMUST00000215565]
AlphaFold Q8VFS3
Predicted Effect probably benign
Transcript: ENSMUST00000058118
AA Change: R138G

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000058912
Gene: ENSMUSG00000048693
AA Change: R138G

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 3e-61 PFAM
Pfam:7tm_1 40 289 4.3e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215565
AA Change: R138G

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 C T 11: 110,102,582 (GRCm39) V881I probably benign Het
Acot1 C T 12: 84,063,988 (GRCm39) S57F Het
Actr3 T C 1: 125,339,048 (GRCm39) I97V probably benign Het
C4b A T 17: 34,956,698 (GRCm39) C633* probably null Het
Cdh19 T A 1: 110,817,589 (GRCm39) T718S probably damaging Het
Coasy T A 11: 100,975,852 (GRCm39) S355T probably benign Het
Coch A G 12: 51,650,132 (GRCm39) I374V possibly damaging Het
Dhrs7l C T 12: 72,675,050 (GRCm39) probably benign Het
Dip2b T A 15: 100,073,178 (GRCm39) M760K probably benign Het
Evi5 A G 5: 107,957,566 (GRCm39) Y428H probably damaging Het
Fst G A 13: 114,592,397 (GRCm39) R107* probably null Het
Gba1 A G 3: 89,114,756 (GRCm39) T387A probably benign Het
Gid8 A T 2: 180,358,713 (GRCm39) Q126L probably damaging Het
Iqgap1 A G 7: 80,383,929 (GRCm39) V1045A possibly damaging Het
Kif23 G A 9: 61,832,924 (GRCm39) S535L probably benign Het
Krt79 G A 15: 101,848,417 (GRCm39) A78V possibly damaging Het
Lama2 A G 10: 26,862,871 (GRCm39) F2964S probably damaging Het
Lamp3 T C 16: 19,519,808 (GRCm39) D125G probably benign Het
Lrrc15 C T 16: 30,092,637 (GRCm39) G234D possibly damaging Het
Myo7b A G 18: 32,108,297 (GRCm39) V1188A probably benign Het
Nbeal2 T C 9: 110,473,729 (GRCm39) T37A probably benign Het
Nlrp1b T C 11: 71,109,095 (GRCm39) I135M probably benign Het
Or6c69 T A 10: 129,747,404 (GRCm39) I248F probably benign Het
P3h2 T C 16: 25,789,725 (GRCm39) Y514C probably damaging Het
Pcdha5 A G 18: 37,093,986 (GRCm39) N165S probably damaging Het
Phf10 G C 17: 15,175,366 (GRCm39) H157D probably damaging Het
Ppip5k2 C T 1: 97,661,792 (GRCm39) R708H probably benign Het
Prr12 A G 7: 44,698,692 (GRCm39) S408P unknown Het
Rab3a A T 8: 71,209,804 (GRCm39) Y123F probably damaging Het
Rbak A T 5: 143,160,172 (GRCm39) S294T probably damaging Het
Sarm1 T C 11: 78,373,996 (GRCm39) D677G probably damaging Het
Scly A T 1: 91,228,413 (GRCm39) probably benign Het
Slc26a6 T C 9: 108,735,481 (GRCm39) V385A probably damaging Het
Slc66a2 T C 18: 80,327,034 (GRCm39) V209A unknown Het
Srp72 T C 5: 77,128,274 (GRCm39) V165A probably benign Het
Tars3 A C 7: 65,333,808 (GRCm39) probably null Het
Tspan1 T A 4: 116,020,211 (GRCm39) M233L probably benign Het
Zfp574 G A 7: 24,780,379 (GRCm39) G467D probably damaging Het
Zfp85 A G 13: 67,897,722 (GRCm39) S117P probably benign Het
Zfp932 C G 5: 110,157,787 (GRCm39) P495R probably damaging Het
Other mutations in Or2a51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02817:Or2a51 APN 6 43,178,993 (GRCm39) missense probably benign 0.01
IGL03385:Or2a51 APN 6 43,178,914 (GRCm39) missense probably benign 0.20
R0455:Or2a51 UTSW 6 43,179,006 (GRCm39) missense probably benign
R1977:Or2a51 UTSW 6 43,178,914 (GRCm39) missense possibly damaging 0.93
R2152:Or2a51 UTSW 6 43,179,003 (GRCm39) missense probably benign
R3821:Or2a51 UTSW 6 43,178,604 (GRCm39) missense probably benign 0.26
R7041:Or2a51 UTSW 6 43,178,837 (GRCm39) missense probably benign 0.05
R9212:Or2a51 UTSW 6 43,178,756 (GRCm39) nonsense probably null
R9743:Or2a51 UTSW 6 43,179,229 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- GTTGACATTGCCTATGCCTGC -3'
(R):5'- TAAGGCAAACACACAGGCTG -3'

Sequencing Primer
(F):5'- TTGCCTATGCCTGCAACACAG -3'
(R):5'- GGCTGCAAAGATAACAACTTGATTG -3'
Posted On 2022-07-18