Incidental Mutation 'R9533:Zfp574'
ID 719562
Institutional Source Beutler Lab
Gene Symbol Zfp574
Ensembl Gene ENSMUSG00000045252
Gene Name zinc finger protein 574
Synonyms A630056B21Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9533 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 24775099-24782917 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24780379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 467 (G467D)
Ref Sequence ENSEMBL: ENSMUSP00000057817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]
AlphaFold Q8BY46
Predicted Effect probably damaging
Transcript: ENSMUST00000053410
AA Change: G467D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: G467D

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000179556
AA Change: G467D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: G467D

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Meta Mutation Damage Score 0.1000 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 C T 11: 110,102,582 (GRCm39) V881I probably benign Het
Acot1 C T 12: 84,063,988 (GRCm39) S57F Het
Actr3 T C 1: 125,339,048 (GRCm39) I97V probably benign Het
C4b A T 17: 34,956,698 (GRCm39) C633* probably null Het
Cdh19 T A 1: 110,817,589 (GRCm39) T718S probably damaging Het
Coasy T A 11: 100,975,852 (GRCm39) S355T probably benign Het
Coch A G 12: 51,650,132 (GRCm39) I374V possibly damaging Het
Dhrs7l C T 12: 72,675,050 (GRCm39) probably benign Het
Dip2b T A 15: 100,073,178 (GRCm39) M760K probably benign Het
Evi5 A G 5: 107,957,566 (GRCm39) Y428H probably damaging Het
Fst G A 13: 114,592,397 (GRCm39) R107* probably null Het
Gba1 A G 3: 89,114,756 (GRCm39) T387A probably benign Het
Gid8 A T 2: 180,358,713 (GRCm39) Q126L probably damaging Het
Iqgap1 A G 7: 80,383,929 (GRCm39) V1045A possibly damaging Het
Kif23 G A 9: 61,832,924 (GRCm39) S535L probably benign Het
Krt79 G A 15: 101,848,417 (GRCm39) A78V possibly damaging Het
Lama2 A G 10: 26,862,871 (GRCm39) F2964S probably damaging Het
Lamp3 T C 16: 19,519,808 (GRCm39) D125G probably benign Het
Lrrc15 C T 16: 30,092,637 (GRCm39) G234D possibly damaging Het
Myo7b A G 18: 32,108,297 (GRCm39) V1188A probably benign Het
Nbeal2 T C 9: 110,473,729 (GRCm39) T37A probably benign Het
Nlrp1b T C 11: 71,109,095 (GRCm39) I135M probably benign Het
Or2a51 A G 6: 43,178,991 (GRCm39) R138G probably benign Het
Or6c69 T A 10: 129,747,404 (GRCm39) I248F probably benign Het
P3h2 T C 16: 25,789,725 (GRCm39) Y514C probably damaging Het
Pcdha5 A G 18: 37,093,986 (GRCm39) N165S probably damaging Het
Phf10 G C 17: 15,175,366 (GRCm39) H157D probably damaging Het
Ppip5k2 C T 1: 97,661,792 (GRCm39) R708H probably benign Het
Prr12 A G 7: 44,698,692 (GRCm39) S408P unknown Het
Rab3a A T 8: 71,209,804 (GRCm39) Y123F probably damaging Het
Rbak A T 5: 143,160,172 (GRCm39) S294T probably damaging Het
Sarm1 T C 11: 78,373,996 (GRCm39) D677G probably damaging Het
Scly A T 1: 91,228,413 (GRCm39) probably benign Het
Slc26a6 T C 9: 108,735,481 (GRCm39) V385A probably damaging Het
Slc66a2 T C 18: 80,327,034 (GRCm39) V209A unknown Het
Srp72 T C 5: 77,128,274 (GRCm39) V165A probably benign Het
Tars3 A C 7: 65,333,808 (GRCm39) probably null Het
Tspan1 T A 4: 116,020,211 (GRCm39) M233L probably benign Het
Zfp85 A G 13: 67,897,722 (GRCm39) S117P probably benign Het
Zfp932 C G 5: 110,157,787 (GRCm39) P495R probably damaging Het
Other mutations in Zfp574
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Zfp574 APN 7 24,781,015 (GRCm39) missense probably benign 0.00
IGL02370:Zfp574 APN 7 24,779,014 (GRCm39) missense possibly damaging 0.95
IGL02706:Zfp574 APN 7 24,780,790 (GRCm39) missense probably damaging 0.98
IGL03119:Zfp574 APN 7 24,779,898 (GRCm39) missense probably benign
glue UTSW 7 24,780,515 (GRCm39) missense
BB004:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
BB014:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R0866:Zfp574 UTSW 7 24,779,323 (GRCm39) missense probably damaging 1.00
R2429:Zfp574 UTSW 7 24,779,482 (GRCm39) nonsense probably null
R3123:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3124:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3125:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R4581:Zfp574 UTSW 7 24,780,738 (GRCm39) missense probably damaging 0.98
R4591:Zfp574 UTSW 7 24,778,969 (GRCm39) start gained probably benign
R4915:Zfp574 UTSW 7 24,780,151 (GRCm39) missense probably damaging 0.98
R4953:Zfp574 UTSW 7 24,780,388 (GRCm39) missense probably damaging 0.97
R5305:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
R5541:Zfp574 UTSW 7 24,781,375 (GRCm39) missense probably damaging 0.99
R5934:Zfp574 UTSW 7 24,779,757 (GRCm39) missense probably benign
R6088:Zfp574 UTSW 7 24,779,764 (GRCm39) missense probably benign 0.01
R7061:Zfp574 UTSW 7 24,779,622 (GRCm39) missense possibly damaging 0.95
R7563:Zfp574 UTSW 7 24,780,777 (GRCm39) missense possibly damaging 0.94
R7615:Zfp574 UTSW 7 24,780,001 (GRCm39) missense possibly damaging 0.95
R7927:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R8017:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8019:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8788:Zfp574 UTSW 7 24,779,816 (GRCm39) missense unknown
R8871:Zfp574 UTSW 7 24,780,562 (GRCm39) missense probably damaging 0.99
R8915:Zfp574 UTSW 7 24,780,769 (GRCm39) missense probably damaging 1.00
R9484:Zfp574 UTSW 7 24,781,404 (GRCm39) missense possibly damaging 0.77
R9606:Zfp574 UTSW 7 24,780,640 (GRCm39) missense probably damaging 1.00
R9623:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
X0026:Zfp574 UTSW 7 24,780,477 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGGGAAGACCTTTGTTAACCTC -3'
(R):5'- CTGGTGAGTTGAAAGGCTTAGAGC -3'

Sequencing Primer
(F):5'- GGAAGACCTTTGTTAACCTCACCAAG -3'
(R):5'- GCTTAGAGCAGTCAGGGC -3'
Posted On 2022-07-18