Incidental Mutation 'R9541:Or5ak25'
ID 719859
Institutional Source Beutler Lab
Gene Symbol Or5ak25
Ensembl Gene ENSMUSG00000075218
Gene Name olfactory receptor family 5 subfamily AK member 25
Synonyms MOR203-3, GA_x6K02T2Q125-46915844-46914897, Olfr995
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R9541 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85268553-85269500 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85269025 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 159 (H159L)
Ref Sequence ENSEMBL: ENSMUSP00000149952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099924] [ENSMUST00000214679] [ENSMUST00000216933] [ENSMUST00000217218]
AlphaFold Q8VF74
Predicted Effect possibly damaging
Transcript: ENSMUST00000099924
AA Change: H159L

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000097508
Gene: ENSMUSG00000075218
AA Change: H159L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-50 PFAM
Pfam:7tm_1 41 290 2.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214679
Predicted Effect possibly damaging
Transcript: ENSMUST00000216933
AA Change: H159L

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000217218
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 45,801,079 (GRCm39) I450V probably benign Het
Adam21 T C 12: 81,607,724 (GRCm39) T13A probably benign Het
Adamts4 C A 1: 171,084,695 (GRCm39) P644H probably damaging Het
Ak9 C T 10: 41,243,173 (GRCm39) A689V Het
Ankhd1 G A 18: 36,757,697 (GRCm39) S209N Het
Anks1b A T 10: 90,412,947 (GRCm39) T32S probably benign Het
Atp13a4 G T 16: 29,241,544 (GRCm39) T708K Het
B4gat1 C T 19: 5,089,896 (GRCm39) P298S probably damaging Het
Btbd9 A G 17: 30,439,438 (GRCm39) L583P possibly damaging Het
Ciart C A 3: 95,788,527 (GRCm39) C104F possibly damaging Het
Coq5 T C 5: 115,417,901 (GRCm39) S44P probably benign Het
Dennd5b A G 6: 148,899,872 (GRCm39) V1175A probably benign Het
Filip1 T A 9: 79,727,135 (GRCm39) K495* probably null Het
Fscn2 G A 11: 120,258,771 (GRCm39) V439M probably damaging Het
Gcn1 A G 5: 115,754,416 (GRCm39) I2339V probably benign Het
Gmppa T A 1: 75,417,094 (GRCm39) S176R probably damaging Het
Gpatch3 G A 4: 133,305,595 (GRCm39) E277K probably benign Het
Hcn4 A G 9: 58,767,685 (GRCm39) D1082G probably damaging Het
Hdgfl2 T A 17: 56,405,976 (GRCm39) D487E unknown Het
Ifna14 A T 4: 88,490,010 (GRCm39) M9K probably null Het
Igkv4-81 A G 6: 68,967,925 (GRCm39) Y59H Het
Il2rb T A 15: 78,372,393 (GRCm39) N108I probably benign Het
Jarid2 C T 13: 45,068,253 (GRCm39) R1092W possibly damaging Het
Kdm5d T G Y: 910,801 (GRCm39) C304W probably damaging Het
Khnyn T C 14: 56,124,109 (GRCm39) I121T possibly damaging Het
Lmcd1 A T 6: 112,306,824 (GRCm39) H332L probably damaging Het
Lrp1b T C 2: 41,234,600 (GRCm39) D1117G Het
Med25 A G 7: 44,541,267 (GRCm39) V82A possibly damaging Het
Mindy2 G A 9: 70,512,508 (GRCm39) R581C possibly damaging Het
Mindy3 T C 2: 12,391,449 (GRCm39) T257A probably damaging Het
Myo1e A T 9: 70,204,628 (GRCm39) Y76F probably damaging Het
Npas2 A T 1: 39,377,194 (GRCm39) I519F possibly damaging Het
Or2h2c C T 17: 37,422,824 (GRCm39) D17N probably benign Het
Or4f52 T A 2: 111,061,275 (GRCm39) T288S probably damaging Het
Otx1 A G 11: 21,947,052 (GRCm39) F86L probably damaging Het
Pcm1 A G 8: 41,780,616 (GRCm39) D1856G probably benign Het
Pcsk7 G A 9: 45,820,768 (GRCm39) E67K probably benign Het
Pkd2 A G 5: 104,607,927 (GRCm39) Y142C probably damaging Het
Ptpre A G 7: 135,266,740 (GRCm39) D236G probably benign Het
Rasd2 T C 8: 75,945,200 (GRCm39) C10R probably benign Het
Rd3 C A 1: 191,717,294 (GRCm39) R140S possibly damaging Het
Rusc1 T G 3: 88,998,922 (GRCm39) T287P possibly damaging Het
Slc22a7 T C 17: 46,749,084 (GRCm39) S78G probably damaging Het
Sltm A T 9: 70,481,057 (GRCm39) H303L unknown Het
Syne4 G A 7: 30,016,343 (GRCm39) V228I probably benign Het
Timm22 T A 11: 76,300,641 (GRCm39) C138S possibly damaging Het
Trib2 T A 12: 15,866,827 (GRCm39) I15L unknown Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Tyro3 T C 2: 119,642,589 (GRCm39) V591A possibly damaging Het
Vmn2r69 A G 7: 85,056,209 (GRCm39) V643A probably benign Het
Zfp281 G T 1: 136,555,303 (GRCm39) Q760H probably damaging Het
Other mutations in Or5ak25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02102:Or5ak25 APN 2 85,268,611 (GRCm39) missense probably damaging 1.00
IGL02540:Or5ak25 APN 2 85,269,259 (GRCm39) missense probably benign 0.05
IGL02687:Or5ak25 APN 2 85,268,930 (GRCm39) missense possibly damaging 0.93
IGL02713:Or5ak25 APN 2 85,268,981 (GRCm39) missense probably damaging 0.99
R0318:Or5ak25 UTSW 2 85,268,581 (GRCm39) missense possibly damaging 0.91
R0463:Or5ak25 UTSW 2 85,268,630 (GRCm39) missense probably damaging 1.00
R0638:Or5ak25 UTSW 2 85,268,845 (GRCm39) missense probably benign 0.03
R1668:Or5ak25 UTSW 2 85,269,220 (GRCm39) missense probably benign 0.00
R1718:Or5ak25 UTSW 2 85,269,149 (GRCm39) missense probably benign 0.39
R4981:Or5ak25 UTSW 2 85,268,813 (GRCm39) missense probably damaging 1.00
R5261:Or5ak25 UTSW 2 85,269,241 (GRCm39) missense probably benign
R7036:Or5ak25 UTSW 2 85,268,774 (GRCm39) missense probably damaging 1.00
R7899:Or5ak25 UTSW 2 85,268,741 (GRCm39) missense probably benign 0.39
R8209:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8226:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8803:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R9037:Or5ak25 UTSW 2 85,269,139 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TTCTTCCTCCCTGCAGTAGAGG -3'
(R):5'- TTGGTCTATGCCACATTTGCG -3'

Sequencing Primer
(F):5'- CCCTGCAGTAGAGGACATCTTTAG -3'
(R):5'- ACATTTGCGACCAGTGACTG -3'
Posted On 2022-07-18