Incidental Mutation 'R9542:Zmym4'
| ID |
719927 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmym4
|
| Ensembl Gene |
ENSMUSG00000042446 |
| Gene Name |
zinc finger, MYM-type 4 |
| Synonyms |
Zfp262, 6330503C17Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.513)
|
| Stock # |
R9542 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 126799164 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 724
(N724S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
| AlphaFold |
A2A791 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106108
AA Change: N724S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: N724S
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
|
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
|
TRASH
|
441 |
479 |
1.77e0 |
SMART |
|
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
|
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
|
TRASH
|
579 |
615 |
2.82e1 |
SMART |
|
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
|
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
|
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
|
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
|
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
|
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135003
AA Change: N383S
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: N383S
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
|
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
|
TRASH
|
190 |
228 |
1.77e0 |
SMART |
|
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
|
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
|
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
|
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
|
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
|
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
|
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acbd6 |
T |
C |
1: 155,443,356 (GRCm39) |
S105P |
probably benign |
Het |
| Acot12 |
G |
A |
13: 91,931,110 (GRCm39) |
V453M |
probably damaging |
Het |
| Actr2 |
C |
T |
11: 20,044,350 (GRCm39) |
M85I |
probably benign |
Het |
| Anxa9 |
T |
C |
3: 95,210,379 (GRCm39) |
D62G |
probably benign |
Het |
| Arnt |
C |
T |
3: 95,397,954 (GRCm39) |
A599V |
probably benign |
Het |
| Ash1l |
A |
G |
3: 88,950,566 (GRCm39) |
E2153G |
probably damaging |
Het |
| Asic5 |
A |
T |
3: 81,911,850 (GRCm39) |
T149S |
probably benign |
Het |
| Atcay |
G |
A |
10: 81,043,686 (GRCm39) |
T353I |
unknown |
Het |
| Aven |
T |
C |
2: 112,455,517 (GRCm39) |
F143L |
probably damaging |
Het |
| BB014433 |
GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG |
GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG |
8: 15,092,160 (GRCm39) |
|
probably benign |
Het |
| BC024139 |
T |
A |
15: 76,009,715 (GRCm39) |
L149F |
probably damaging |
Het |
| C3 |
T |
C |
17: 57,532,037 (GRCm39) |
Y228C |
probably damaging |
Het |
| Cacna1d |
A |
G |
14: 29,845,316 (GRCm39) |
F640L |
probably benign |
Het |
| Ccdc187 |
T |
C |
2: 26,145,930 (GRCm39) |
R1220G |
possibly damaging |
Het |
| Cdc42bpb |
G |
A |
12: 111,268,508 (GRCm39) |
Q1231* |
probably null |
Het |
| Cdh20 |
T |
A |
1: 104,875,067 (GRCm39) |
V283E |
probably damaging |
Het |
| Cep63 |
T |
C |
9: 102,484,533 (GRCm39) |
I241V |
probably benign |
Het |
| Dis3 |
A |
G |
14: 99,316,975 (GRCm39) |
V787A |
probably damaging |
Het |
| Dock9 |
A |
G |
14: 121,864,775 (GRCm39) |
F727S |
probably damaging |
Het |
| Eif5b |
G |
T |
1: 38,057,131 (GRCm39) |
E63* |
probably null |
Het |
| Fanca |
A |
G |
8: 124,023,078 (GRCm39) |
V553A |
probably damaging |
Het |
| Flacc1 |
C |
T |
1: 58,717,504 (GRCm39) |
A136T |
probably benign |
Het |
| Gm37240 |
A |
C |
3: 84,417,196 (GRCm39) |
H174Q |
probably benign |
Het |
| Kcnc4 |
C |
T |
3: 107,365,571 (GRCm39) |
W212* |
probably null |
Het |
| Myh2 |
G |
A |
11: 67,072,002 (GRCm39) |
E577K |
possibly damaging |
Het |
| Ncoa1 |
C |
T |
12: 4,325,178 (GRCm39) |
V967I |
possibly damaging |
Het |
| Nmur2 |
T |
C |
11: 55,931,649 (GRCm39) |
T21A |
probably damaging |
Het |
| Nrde2 |
A |
G |
12: 100,110,426 (GRCm39) |
C197R |
probably damaging |
Het |
| Or2m12 |
A |
T |
16: 19,104,943 (GRCm39) |
D183E |
probably benign |
Het |
| Or2o1 |
C |
A |
11: 49,051,073 (GRCm39) |
C77* |
probably null |
Het |
| Or52ad1 |
T |
C |
7: 102,995,569 (GRCm39) |
I189V |
probably benign |
Het |
| Or8h7 |
G |
T |
2: 86,720,813 (GRCm39) |
H235Q |
probably benign |
Het |
| Pard3b |
C |
T |
1: 62,250,786 (GRCm39) |
R572* |
probably null |
Het |
| Pdcd6ip |
T |
C |
9: 113,520,589 (GRCm39) |
S132G |
probably damaging |
Het |
| Pdzrn3 |
A |
T |
6: 101,149,235 (GRCm39) |
F364L |
probably benign |
Het |
| Pfpl |
G |
C |
19: 12,406,297 (GRCm39) |
E183Q |
probably damaging |
Het |
| Pgr |
G |
T |
9: 8,901,532 (GRCm39) |
C355F |
possibly damaging |
Het |
| Pkhd1 |
T |
G |
1: 20,188,004 (GRCm39) |
S3435R |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,410,284 (GRCm39) |
D2597G |
probably benign |
Het |
| Pramel30 |
T |
C |
4: 144,057,095 (GRCm39) |
Y93H |
possibly damaging |
Het |
| Prrc2c |
T |
C |
1: 162,508,359 (GRCm39) |
E2410G |
possibly damaging |
Het |
| Rpap2 |
C |
G |
5: 107,768,180 (GRCm39) |
S339R |
probably benign |
Het |
| Rrp36 |
G |
C |
17: 46,983,492 (GRCm39) |
R69G |
possibly damaging |
Het |
| Rrp8 |
T |
C |
7: 105,382,606 (GRCm39) |
T449A |
probably benign |
Het |
| Scn3a |
T |
C |
2: 65,366,860 (GRCm39) |
D54G |
probably damaging |
Het |
| Serinc2 |
C |
T |
4: 130,152,516 (GRCm39) |
W228* |
probably null |
Het |
| Serpinb9g |
A |
G |
13: 33,679,141 (GRCm39) |
K337R |
probably benign |
Het |
| Slc28a2b |
A |
T |
2: 122,324,822 (GRCm39) |
K131N |
probably benign |
Het |
| Spata31 |
A |
T |
13: 65,070,077 (GRCm39) |
I742F |
probably damaging |
Het |
| Speg |
C |
T |
1: 75,399,426 (GRCm39) |
P2291L |
probably benign |
Het |
| Ss18l2 |
T |
A |
9: 121,541,666 (GRCm39) |
L61* |
probably null |
Het |
| Suco |
C |
T |
1: 161,661,668 (GRCm39) |
R921H |
probably damaging |
Het |
| Taok2 |
A |
T |
7: 126,466,008 (GRCm39) |
I910N |
probably damaging |
Het |
| Tmem18 |
G |
A |
12: 30,638,557 (GRCm39) |
M106I |
|
Het |
| Tob1 |
T |
G |
11: 94,105,234 (GRCm39) |
S257A |
unknown |
Het |
| Trim67 |
G |
C |
8: 125,521,497 (GRCm39) |
K286N |
possibly damaging |
Het |
| Trmt112 |
A |
G |
19: 6,887,956 (GRCm39) |
N62S |
probably benign |
Het |
| Tsc2 |
C |
T |
17: 24,819,308 (GRCm39) |
|
probably null |
Het |
| Ttn |
C |
T |
2: 76,715,357 (GRCm39) |
E7912K |
unknown |
Het |
| Ube2j1 |
G |
T |
4: 33,040,793 (GRCm39) |
E100* |
probably null |
Het |
| Urgcp |
A |
T |
11: 5,667,517 (GRCm39) |
F317I |
possibly damaging |
Het |
| Vps9d1 |
A |
T |
8: 123,970,522 (GRCm39) |
D588E |
probably damaging |
Het |
| Wdr38 |
A |
T |
2: 38,890,210 (GRCm39) |
T115S |
probably damaging |
Het |
| Zfp119a |
G |
A |
17: 56,172,593 (GRCm39) |
Q417* |
probably null |
Het |
| Zfp687 |
C |
T |
3: 94,916,442 (GRCm39) |
C860Y |
probably damaging |
Het |
|
| Other mutations in Zmym4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
|
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACTGGCATAGTAATCCCTTTAG -3'
(R):5'- GTCTCAAAATTGCACCATTTGG -3'
Sequencing Primer
(F):5'- CTGGCATAGTAATCCCTTTAGTCAAC -3'
(R):5'- CTGGCCTGGAACTTAGTCTATAGAC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation