Incidental Mutation 'R9544:Or1j11'
ID 719978
Institutional Source Beutler Lab
Gene Symbol Or1j11
Ensembl Gene ENSMUSG00000094464
Gene Name olfactory receptor family 1 subfamily E member 1
Synonyms GA_x6K02T2NLDC-33116096-33117025, MOR136-3, Olfr339
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R9544 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 36311412-36312341 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 36311784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 125 (A125S)
Ref Sequence ENSEMBL: ENSMUSP00000149068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071437] [ENSMUST00000216645]
AlphaFold Q8VGK8
Predicted Effect probably damaging
Transcript: ENSMUST00000071437
AA Change: A125S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071383
Gene: ENSMUSG00000094464
AA Change: A125S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-55 PFAM
Pfam:7tm_1 41 290 5e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216645
AA Change: A125S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5530400C23Rik A G 6: 133,271,202 (GRCm39) E82G possibly damaging Het
Adra2a C G 19: 54,035,454 (GRCm39) P270R probably benign Het
Alox12b A T 11: 69,054,812 (GRCm39) I272F possibly damaging Het
Als2 C A 1: 59,250,468 (GRCm39) E425D probably benign Het
Arhgap21 C A 2: 20,858,938 (GRCm39) C1252F possibly damaging Het
Arhgap31 T G 16: 38,423,976 (GRCm39) T697P probably damaging Het
Aspm C A 1: 139,385,523 (GRCm39) T389K probably benign Het
B4galnt3 T A 6: 120,209,905 (GRCm39) I73F probably damaging Het
Btn2a2 A G 13: 23,672,008 (GRCm39) V27A probably benign Het
Cep97 A T 16: 55,735,303 (GRCm39) N570K possibly damaging Het
Cfh T C 1: 140,036,266 (GRCm39) I751V probably benign Het
Chd3 A G 11: 69,241,046 (GRCm39) C1516R probably damaging Het
Cul3 A G 1: 80,258,576 (GRCm39) F487L probably damaging Het
Dock1 T C 7: 134,348,186 (GRCm39) S266P possibly damaging Het
Dock6 A T 9: 21,732,830 (GRCm39) Y1118* probably null Het
Dolpp1 T A 2: 30,282,515 (GRCm39) Y23N probably damaging Het
Egf T C 3: 129,511,617 (GRCm39) M517V probably benign Het
Endou C A 15: 97,609,969 (GRCm39) K442N probably damaging Het
Fam210b C T 2: 172,194,633 (GRCm39) R162W probably damaging Het
Fbxw27 ATGT AT 9: 109,602,322 (GRCm39) probably null Het
Flt3 T A 5: 147,291,442 (GRCm39) Q641L possibly damaging Het
Ighv3-3 T A 12: 114,160,270 (GRCm39) I47F probably damaging Het
Il4 C T 11: 53,504,837 (GRCm39) R76H probably damaging Het
Inpp5f A C 7: 128,278,515 (GRCm39) D435A possibly damaging Het
Kcnq2 T G 2: 180,729,407 (GRCm39) D532A probably damaging Het
Krtap11-1 A C 16: 89,368,062 (GRCm39) probably benign Het
Lamp3 T A 16: 19,494,832 (GRCm39) probably null Het
Lcn3 A T 2: 25,656,151 (GRCm39) I69L probably benign Het
Lrrc43 A T 5: 123,641,307 (GRCm39) H497L probably damaging Het
Luc7l2 T G 6: 38,580,315 (GRCm39) S305A unknown Het
Malrd1 C T 2: 15,640,809 (GRCm39) T513I unknown Het
Mllt3 T A 4: 87,759,418 (GRCm39) D210V probably damaging Het
Mmp14 A G 14: 54,673,251 (GRCm39) H53R possibly damaging Het
Ndst4 A C 3: 125,476,808 (GRCm39) H11P probably damaging Het
Nln G A 13: 104,198,356 (GRCm39) T152M probably benign Het
Oas1c A G 5: 120,946,202 (GRCm39) F99L probably benign Het
Or10s1 T C 9: 39,986,353 (GRCm39) L254P probably damaging Het
Or1e35 T C 11: 73,797,637 (GRCm39) K227R probably benign Het
Or5w15 G A 2: 87,568,644 (GRCm39) T8I probably benign Het
Or7g25 T A 9: 19,160,561 (GRCm39) I45F probably damaging Het
Pappa2 C A 1: 158,784,817 (GRCm39) Q64H probably damaging Het
Pcdhb15 T C 18: 37,608,948 (GRCm39) F727L probably benign Het
Pcsk1 A T 13: 75,259,039 (GRCm39) N271I probably damaging Het
Pkhd1l1 G A 15: 44,410,239 (GRCm39) G2582D probably damaging Het
Psma4 A T 9: 54,862,245 (GRCm39) Q123L probably damaging Het
Selenbp2 A T 3: 94,605,368 (GRCm39) I127F possibly damaging Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Slc29a3 G T 10: 60,551,960 (GRCm39) C361* probably null Het
Slx4 C A 16: 3,797,917 (GRCm39) R1489L probably damaging Het
Sorl1 A C 9: 41,993,105 (GRCm39) Y306* probably null Het
Tbc1d16 G T 11: 119,101,335 (GRCm39) H58Q probably damaging Het
Tfdp2 A G 9: 96,169,663 (GRCm39) T5A probably damaging Het
Thbs1 G T 2: 117,953,932 (GRCm39) G1061V probably damaging Het
Timm29 G A 9: 21,504,662 (GRCm39) R110H probably damaging Het
Tmf1 C T 6: 97,147,293 (GRCm39) E558K possibly damaging Het
Trappc11 T C 8: 47,972,713 (GRCm39) T287A possibly damaging Het
Unc119b G A 5: 115,272,827 (GRCm39) T48M probably benign Het
Vmn1r123 T C 7: 20,896,987 (GRCm39) I293T probably benign Het
Vmn2r67 G A 7: 84,786,317 (GRCm39) H563Y possibly damaging Het
Vps8 G T 16: 21,336,893 (GRCm39) V763L probably benign Het
Wdr3 A T 3: 100,050,752 (GRCm39) Y722* probably null Het
Xrn1 A G 9: 95,920,756 (GRCm39) T1339A probably benign Het
Zfp827 T A 8: 79,905,604 (GRCm39) H860Q probably damaging Het
Other mutations in Or1j11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Or1j11 APN 2 36,311,716 (GRCm39) missense probably benign 0.44
IGL01447:Or1j11 APN 2 36,311,466 (GRCm39) missense probably damaging 0.97
IGL01845:Or1j11 APN 2 36,312,105 (GRCm39) missense probably benign 0.27
IGL02728:Or1j11 APN 2 36,312,156 (GRCm39) missense possibly damaging 0.95
IGL02941:Or1j11 APN 2 36,312,132 (GRCm39) missense probably damaging 1.00
R0128:Or1j11 UTSW 2 36,312,299 (GRCm39) missense probably benign 0.16
R0130:Or1j11 UTSW 2 36,312,299 (GRCm39) missense probably benign 0.16
R1432:Or1j11 UTSW 2 36,311,655 (GRCm39) missense probably damaging 1.00
R1451:Or1j11 UTSW 2 36,311,877 (GRCm39) missense probably benign 0.01
R1656:Or1j11 UTSW 2 36,311,658 (GRCm39) missense probably benign 0.00
R1854:Or1j11 UTSW 2 36,311,886 (GRCm39) missense probably damaging 0.97
R2012:Or1j11 UTSW 2 36,311,931 (GRCm39) missense probably benign 0.00
R2093:Or1j11 UTSW 2 36,311,941 (GRCm39) missense probably benign 0.00
R2136:Or1j11 UTSW 2 36,311,950 (GRCm39) missense probably damaging 1.00
R2282:Or1j11 UTSW 2 36,312,012 (GRCm39) missense probably benign 0.00
R4363:Or1j11 UTSW 2 36,311,544 (GRCm39) missense probably damaging 1.00
R4466:Or1j11 UTSW 2 36,312,308 (GRCm39) missense probably benign 0.00
R4628:Or1j11 UTSW 2 36,311,869 (GRCm39) nonsense probably null
R4839:Or1j11 UTSW 2 36,312,012 (GRCm39) missense probably benign 0.00
R6023:Or1j11 UTSW 2 36,311,523 (GRCm39) missense probably damaging 0.98
R6305:Or1j11 UTSW 2 36,311,634 (GRCm39) missense probably damaging 1.00
R6486:Or1j11 UTSW 2 36,311,556 (GRCm39) missense probably damaging 1.00
R6851:Or1j11 UTSW 2 36,311,832 (GRCm39) missense probably damaging 0.97
R6864:Or1j11 UTSW 2 36,311,832 (GRCm39) missense probably damaging 0.97
R7771:Or1j11 UTSW 2 36,312,156 (GRCm39) missense possibly damaging 0.95
R8165:Or1j11 UTSW 2 36,311,715 (GRCm39) missense probably damaging 1.00
R8307:Or1j11 UTSW 2 36,312,333 (GRCm39) missense probably benign 0.03
R8961:Or1j11 UTSW 2 36,312,177 (GRCm39) missense probably damaging 1.00
R9152:Or1j11 UTSW 2 36,311,439 (GRCm39) missense possibly damaging 0.90
R9179:Or1j11 UTSW 2 36,312,126 (GRCm39) missense probably damaging 1.00
R9588:Or1j11 UTSW 2 36,311,784 (GRCm39) missense probably damaging 1.00
R9690:Or1j11 UTSW 2 36,311,530 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCATCAGGCTGGACTCTC -3'
(R):5'- TTCAGCAAGGTAGAGAGGTCAC -3'

Sequencing Primer
(F):5'- AGGCTGGACTCTCACCTC -3'
(R):5'- CACAGAAATAGTGGGGGATGGTATTG -3'
Posted On 2022-07-18