Incidental Mutation 'R9545:Lzts1'
ID 720057
Institutional Source Beutler Lab
Gene Symbol Lzts1
Ensembl Gene ENSMUSG00000036306
Gene Name leucine zipper, putative tumor suppressor 1
Synonyms FEZ1, PSD-Zip70, F37
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9545 (G1)
Quality Score 149.008
Status Not validated
Chromosome 8
Chromosomal Location 69585321-69636877 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 69591286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 287 (K287N)
Ref Sequence ENSEMBL: ENSMUSP00000039397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037049] [ENSMUST00000185176]
AlphaFold P60853
Predicted Effect probably damaging
Transcript: ENSMUST00000037049
AA Change: K287N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000039397
Gene: ENSMUSG00000036306
AA Change: K287N

DomainStartEndE-ValueType
low complexity region 50 62 N/A INTRINSIC
low complexity region 305 350 N/A INTRINSIC
Pfam:Fez1 378 568 3.9e-68 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000185176
AA Change: K287N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139117
Gene: ENSMUSG00000036306
AA Change: K287N

DomainStartEndE-ValueType
low complexity region 50 62 N/A INTRINSIC
low complexity region 305 350 N/A INTRINSIC
Pfam:Fez1 378 569 2.3e-79 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
PHENOTYPE: Heterozygous or homozygous inactivation of this gene leads to increased incidence of spontaneous and carcinogen-induced tumors. Homozygtes for a null allele show working memory and cognitive deficits, enhanced anxiety, defects in glutamatergic synaptic transmission, and impaired spine maturation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,416,538 (GRCm39) L4100Q probably damaging Het
Acss2 C A 2: 155,403,716 (GRCm39) P652T probably damaging Het
Agl A T 3: 116,582,338 (GRCm39) I228N possibly damaging Het
Ap5m1 C G 14: 49,311,271 (GRCm39) Q114E possibly damaging Het
Apob C T 12: 8,033,890 (GRCm39) T201I possibly damaging Het
As3mt G A 19: 46,696,233 (GRCm39) V14I probably damaging Het
Atp1a4 T C 1: 172,078,464 (GRCm39) N258S probably benign Het
Atxn1l C T 8: 110,458,688 (GRCm39) V525M probably damaging Het
B4galnt4 T C 7: 140,644,804 (GRCm39) V208A probably benign Het
Bet1 A T 6: 4,077,973 (GRCm39) S89T probably damaging Het
Cdhr1 T G 14: 36,817,016 (GRCm39) N115T possibly damaging Het
Cstf1 C T 2: 172,212,885 (GRCm39) probably benign Het
Dcdc2c G T 12: 28,602,295 (GRCm39) T3K possibly damaging Het
Deup1 C T 9: 15,519,120 (GRCm39) E129K possibly damaging Het
Dgkg T C 16: 22,385,168 (GRCm39) E446G possibly damaging Het
Dolk A G 2: 30,176,016 (GRCm39) S10P probably benign Het
Gm1110 T C 9: 26,800,977 (GRCm39) T406A probably benign Het
Gm8439 C T 4: 120,445,957 (GRCm39) probably benign Het
Gna12 A G 5: 140,746,575 (GRCm39) I290T probably damaging Het
Gtf2h1 T C 7: 46,458,112 (GRCm39) probably null Het
Il4 C T 11: 53,504,837 (GRCm39) R76H probably damaging Het
Itgal T C 7: 126,929,422 (GRCm39) F1113S probably damaging Het
Kcnc3 T C 7: 44,245,357 (GRCm39) L549P probably damaging Het
Klhl26 T C 8: 70,904,164 (GRCm39) D582G probably damaging Het
Lhfpl5 C A 17: 28,799,079 (GRCm39) A196D probably damaging Het
Lipm T C 19: 34,090,392 (GRCm39) M191T probably benign Het
Lrp6 A G 6: 134,483,329 (GRCm39) Y459H probably damaging Het
Mfsd14b C A 13: 65,221,414 (GRCm39) V293L probably benign Het
Mmp23 T A 4: 155,735,980 (GRCm39) Q224L probably benign Het
Ms4a13 C G 19: 11,147,332 (GRCm39) S194T unknown Het
Ms4a2 A G 19: 11,596,237 (GRCm39) F164S probably benign Het
Nudt15 A T 14: 73,760,918 (GRCm39) C58S probably damaging Het
Or2w25 A G 11: 59,504,275 (GRCm39) T162A probably benign Het
Or8h6 T C 2: 86,703,615 (GRCm39) I151V probably benign Het
Or9i1 A G 19: 13,839,217 (GRCm39) H20R possibly damaging Het
Panx3 A G 9: 37,575,437 (GRCm39) F142L probably damaging Het
Pik3r6 T C 11: 68,422,365 (GRCm39) Y255H probably damaging Het
Pnpt1 T C 11: 29,106,840 (GRCm39) V637A probably benign Het
Ppfibp2 T C 7: 107,337,504 (GRCm39) L602P probably damaging Het
Ppp2r3d T C 9: 101,089,214 (GRCm39) N370D probably benign Het
Ppp2r5d A T 17: 46,995,687 (GRCm39) I454N probably damaging Het
Pramel17 C A 4: 101,693,097 (GRCm39) C301F probably damaging Het
Radil A G 5: 142,492,392 (GRCm39) V412A probably benign Het
Reep3 TTGACAGATTTCATG TTG 10: 66,850,703 (GRCm39) probably benign Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Skic3 T A 13: 76,259,832 (GRCm39) V44D probably damaging Het
Spink5 G A 18: 44,136,262 (GRCm39) V558I possibly damaging Het
Stxbp5l T C 16: 37,028,625 (GRCm39) probably null Het
Svs5 T A 2: 164,079,313 (GRCm39) Q198L possibly damaging Het
Thap2 A T 10: 115,208,834 (GRCm39) N95K probably benign Het
Tie1 A G 4: 118,336,112 (GRCm39) V718A probably benign Het
Trpm3 G A 19: 22,878,458 (GRCm39) E632K probably benign Het
Ube4a A T 9: 44,843,638 (GRCm39) probably null Het
Utp20 A G 10: 88,618,511 (GRCm39) I1163T probably benign Het
Vav2 C T 2: 27,173,351 (GRCm39) R491Q probably damaging Het
Wapl T A 14: 34,399,050 (GRCm39) F40I probably damaging Het
Wdfy3 A C 5: 102,100,957 (GRCm39) I220R Het
Xrra1 T A 7: 99,535,334 (GRCm39) V213D possibly damaging Het
Zwilch A T 9: 64,051,415 (GRCm39) V550E probably damaging Het
Other mutations in Lzts1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Lzts1 APN 8 69,588,744 (GRCm39) missense probably benign 0.07
IGL01313:Lzts1 APN 8 69,591,759 (GRCm39) missense probably benign 0.11
IGL02371:Lzts1 APN 8 69,591,450 (GRCm39) missense probably damaging 0.99
IGL02508:Lzts1 APN 8 69,593,500 (GRCm39) nonsense probably null
IGL03238:Lzts1 APN 8 69,591,446 (GRCm39) missense probably damaging 1.00
R0645:Lzts1 UTSW 8 69,588,392 (GRCm39) missense possibly damaging 0.92
R1442:Lzts1 UTSW 8 69,591,638 (GRCm39) missense probably damaging 0.99
R1887:Lzts1 UTSW 8 69,591,485 (GRCm39) missense probably damaging 1.00
R2366:Lzts1 UTSW 8 69,593,257 (GRCm39) splice site probably null
R4238:Lzts1 UTSW 8 69,588,579 (GRCm39) missense possibly damaging 0.61
R4489:Lzts1 UTSW 8 69,588,347 (GRCm39) missense possibly damaging 0.94
R4508:Lzts1 UTSW 8 69,588,270 (GRCm39) missense probably benign 0.00
R4965:Lzts1 UTSW 8 69,591,414 (GRCm39) missense probably benign 0.44
R5159:Lzts1 UTSW 8 69,591,236 (GRCm39) missense probably benign 0.44
R5643:Lzts1 UTSW 8 69,591,729 (GRCm39) missense possibly damaging 0.94
R5644:Lzts1 UTSW 8 69,591,729 (GRCm39) missense possibly damaging 0.94
R5782:Lzts1 UTSW 8 69,593,350 (GRCm39) missense probably benign 0.00
R6146:Lzts1 UTSW 8 69,593,524 (GRCm39) missense probably benign 0.01
R7069:Lzts1 UTSW 8 69,593,397 (GRCm39) missense probably damaging 1.00
R7444:Lzts1 UTSW 8 69,588,331 (GRCm39) missense probably damaging 1.00
R8088:Lzts1 UTSW 8 69,588,474 (GRCm39) missense probably benign 0.01
R8100:Lzts1 UTSW 8 69,593,397 (GRCm39) missense probably damaging 1.00
R9012:Lzts1 UTSW 8 69,593,550 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTCCTGCTCCTTCATTAGG -3'
(R):5'- ACACAAGGCATCATCCTTCAGG -3'

Sequencing Primer
(F):5'- GCTCCTTCATTAGGCTCTCTAG -3'
(R):5'- CCTTCAGGACAGTAATATGATGAGCC -3'
Posted On 2022-07-18