Incidental Mutation 'R9546:Prl3d1'
ID 720140
Institutional Source Beutler Lab
Gene Symbol Prl3d1
Ensembl Gene ENSMUSG00000057170
Gene Name prolactin family 3, subfamily d, member 1
Synonyms Pl-1, PL-Ia, Csh1, prolactin-like 2, mPL-I, Pl1, placental lactogen 1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R9546 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 27094190-27100258 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 27094999 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 59 (Y59F)
Ref Sequence ENSEMBL: ENSMUSP00000080731 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082079] [ENSMUST00000225330]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000082079
AA Change: Y59F

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000080731
Gene: ENSMUSG00000057170
AA Change: Y59F

DomainStartEndE-ValueType
Pfam:Hormone_1 17 224 5.1e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225330
AA Change: Y60F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 G A 11: 110,244,216 Q248* probably null Het
Adgrf4 A T 17: 42,667,392 C353* probably null Het
Aifm3 T C 16: 17,499,740 V75A probably benign Het
Apc A G 18: 34,312,258 K736E possibly damaging Het
Atad2 A G 15: 58,126,577 S168P probably damaging Het
Ccdc122 T A 14: 77,068,873 V28E probably damaging Het
Cd5l T C 3: 87,360,894 V16A probably benign Het
Cdk11b T C 4: 155,649,132 S682P unknown Het
Chd8 T C 14: 52,215,951 I1218V probably damaging Het
Clec1b A C 6: 129,405,204 I215L probably benign Het
Dnah14 A C 1: 181,593,427 probably null Het
Ednrb T C 14: 103,843,023 I152V probably benign Het
Epha8 G T 4: 136,938,586 L420M probably damaging Het
Epn2 T C 11: 61,546,581 E55G probably damaging Het
Ern1 A G 11: 106,410,027 S514P probably benign Het
Fbxo4 G A 15: 3,969,011 P322S probably damaging Het
Gli3 T A 13: 15,613,858 D149E probably benign Het
Gm10436 C A 12: 88,181,881 probably benign Het
Gm12258 A G 11: 58,859,096 K366E unknown Het
Gm9195 G T 14: 72,480,907 H110N possibly damaging Het
Grb10 A G 11: 11,943,919 I389T probably benign Het
Grip1 G A 10: 120,038,664 E778K possibly damaging Het
Hexb T C 13: 97,185,668 D203G probably damaging Het
Hhatl A G 9: 121,789,583 Y118H probably damaging Het
Ighv1-69 A G 12: 115,623,265 F83L possibly damaging Het
Iglon5 A T 7: 43,474,467 M336K probably benign Het
Iyd A T 10: 3,551,884 I177F possibly damaging Het
Kdm4c A C 4: 74,404,867 D1012A possibly damaging Het
Klhl12 T A 1: 134,485,824 L349Q probably damaging Het
Lrp2 A G 2: 69,456,821 probably null Het
Mrm2 T A 5: 140,328,579 H167L probably damaging Het
Mrpl50 T A 4: 49,514,338 H111L probably damaging Het
Nags A T 11: 102,148,255 T471S probably damaging Het
Nod2 A T 8: 88,652,993 R41W probably benign Het
Notch1 T A 2: 26,481,115 N320Y probably damaging Het
Nr2c1 A G 10: 94,190,666 K468E possibly damaging Het
Nsf G A 11: 103,910,449 Q247* probably null Het
Obsl1 T C 1: 75,505,386 H280R probably damaging Het
Olfr1181 T C 2: 88,423,705 M107V probably benign Het
Pcdha3 C T 18: 36,946,336 R44C probably damaging Het
Pcsk4 A G 10: 80,321,907 S623P possibly damaging Het
Pdcd6ip A T 9: 113,655,106 Y818N unknown Het
Plk2 T A 13: 110,398,767 I445K possibly damaging Het
Prdm2 A T 4: 143,134,991 S576R probably damaging Het
Ptprj C T 2: 90,444,461 V1186I probably benign Het
Raly AGCAGCAGTGGTGGAGGAGGAGGCAGCAGTGGTGGAGG AGCAGCAGTGGTGGAGG 2: 154,863,834 probably benign Het
Ros1 C T 10: 52,118,119 probably null Het
Ryr2 C T 13: 11,587,215 probably null Het
Scn7a A T 2: 66,752,259 I98N possibly damaging Het
Soga3 C A 10: 29,146,809 R51S probably damaging Het
Spi1 T A 2: 91,113,272 S54T probably benign Het
Ssna1 C T 2: 25,272,304 V16I probably benign Het
Sult3a2 G A 10: 33,779,674 P103L possibly damaging Het
Syne1 C T 10: 5,243,123 G3975D probably damaging Het
Tbc1d1 T C 5: 64,173,607 V43A possibly damaging Het
Uba5 A G 9: 104,054,368 S222P probably damaging Het
Vmn2r24 A C 6: 123,787,307 E381A probably damaging Het
Vmn2r95 G A 17: 18,441,459 G489D probably benign Het
Wdr17 A T 8: 54,659,700 F789I probably damaging Het
Xpnpep1 A T 19: 53,002,528 L422Q probably damaging Het
Zcchc11 A G 4: 108,513,232 D776G probably benign Het
Zfand3 T A 17: 30,153,328 H107Q probably benign Het
Other mutations in Prl3d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1104:Prl3d1 UTSW 13 27100009 missense probably benign 0.25
R1389:Prl3d1 UTSW 13 27098710 nonsense probably null
R2253:Prl3d1 UTSW 13 27094998 missense possibly damaging 0.95
R5589:Prl3d1 UTSW 13 27094944 missense probably damaging 1.00
R5739:Prl3d1 UTSW 13 27100012 missense probably benign 0.29
R7184:Prl3d1 UTSW 13 27098636 missense probably damaging 1.00
R7203:Prl3d1 UTSW 13 27098701 missense possibly damaging 0.49
R7637:Prl3d1 UTSW 13 27100069 missense probably damaging 1.00
R7655:Prl3d1 UTSW 13 27100035 missense possibly damaging 0.80
R7656:Prl3d1 UTSW 13 27100035 missense possibly damaging 0.80
R8050:Prl3d1 UTSW 13 27100028 nonsense probably null
R8964:Prl3d1 UTSW 13 27099943 missense possibly damaging 0.86
R9559:Prl3d1 UTSW 13 27096487 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AATATAACGGCTGAGGACCCTC -3'
(R):5'- TCCGGTGACAAAGTTCAAAAC -3'

Sequencing Primer
(F):5'- GCATCCTAAGATAATCCATCTGTTG -3'
(R):5'- AAACTTTATATTCTACCCATTCCAC -3'
Posted On 2022-07-18