Incidental Mutation 'R9546:Prl3d1'
ID 720140
Institutional Source Beutler Lab
Gene Symbol Prl3d1
Ensembl Gene ENSMUSG00000057170
Gene Name prolactin family 3, subfamily d, member 1
Synonyms Pl-1, Csh1, PL-Ia, prolactin-like 2, Pl1, placental lactogen 1, mPL-I
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R9546 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 27278173-27284241 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 27278982 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 59 (Y59F)
Ref Sequence ENSEMBL: ENSMUSP00000080731 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082079] [ENSMUST00000225330]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000082079
AA Change: Y59F

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000080731
Gene: ENSMUSG00000057170
AA Change: Y59F

DomainStartEndE-ValueType
Pfam:Hormone_1 17 224 5.1e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225330
AA Change: Y60F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 G A 11: 110,135,042 (GRCm39) Q248* probably null Het
Adgrf4 A T 17: 42,978,283 (GRCm39) C353* probably null Het
Aifm3 T C 16: 17,317,604 (GRCm39) V75A probably benign Het
Apc A G 18: 34,445,311 (GRCm39) K736E possibly damaging Het
Atad2 A G 15: 57,989,973 (GRCm39) S168P probably damaging Het
Ccdc122 T A 14: 77,306,313 (GRCm39) V28E probably damaging Het
Cd5l T C 3: 87,268,201 (GRCm39) V16A probably benign Het
Cdk11b T C 4: 155,733,589 (GRCm39) S682P unknown Het
Chd8 T C 14: 52,453,408 (GRCm39) I1218V probably damaging Het
Clec1b A C 6: 129,382,167 (GRCm39) I215L probably benign Het
Dnah14 A C 1: 181,420,992 (GRCm39) probably null Het
Ednrb T C 14: 104,080,459 (GRCm39) I152V probably benign Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Epn2 T C 11: 61,437,407 (GRCm39) E55G probably damaging Het
Ern1 A G 11: 106,300,853 (GRCm39) S514P probably benign Het
Fbxo4 G A 15: 3,998,493 (GRCm39) P322S probably damaging Het
Gli3 T A 13: 15,788,443 (GRCm39) D149E probably benign Het
Gm12258 A G 11: 58,749,922 (GRCm39) K366E unknown Het
Gm9195 G T 14: 72,718,347 (GRCm39) H110N possibly damaging Het
Grb10 A G 11: 11,893,919 (GRCm39) I389T probably benign Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Hexb T C 13: 97,322,176 (GRCm39) D203G probably damaging Het
Hhatl A G 9: 121,618,649 (GRCm39) Y118H probably damaging Het
Ighv1-69 A G 12: 115,586,885 (GRCm39) F83L possibly damaging Het
Iglon5 A T 7: 43,123,891 (GRCm39) M336K probably benign Het
Iyd A T 10: 3,501,884 (GRCm39) I177F possibly damaging Het
Kdm4c A C 4: 74,323,104 (GRCm39) D1012A possibly damaging Het
Klhl12 T A 1: 134,413,562 (GRCm39) L349Q probably damaging Het
Lrp2 A G 2: 69,287,165 (GRCm39) probably null Het
Mrm2 T A 5: 140,314,334 (GRCm39) H167L probably damaging Het
Mrpl50 T A 4: 49,514,338 (GRCm39) H111L probably damaging Het
Mtcl3 C A 10: 29,022,805 (GRCm39) R51S probably damaging Het
Nags A T 11: 102,039,081 (GRCm39) T471S probably damaging Het
Nod2 A T 8: 89,379,621 (GRCm39) R41W probably benign Het
Notch1 T A 2: 26,371,127 (GRCm39) N320Y probably damaging Het
Nr2c1 A G 10: 94,026,528 (GRCm39) K468E possibly damaging Het
Nsf G A 11: 103,801,275 (GRCm39) Q247* probably null Het
Obsl1 T C 1: 75,482,030 (GRCm39) H280R probably damaging Het
Or4p20 T C 2: 88,254,049 (GRCm39) M107V probably benign Het
Pcdha3 C T 18: 37,079,389 (GRCm39) R44C probably damaging Het
Pcsk4 A G 10: 80,157,741 (GRCm39) S623P possibly damaging Het
Pdcd6ip A T 9: 113,484,174 (GRCm39) Y818N unknown Het
Plk2 T A 13: 110,535,301 (GRCm39) I445K possibly damaging Het
Pramel51 C A 12: 88,148,651 (GRCm39) probably benign Het
Prdm2 A T 4: 142,861,561 (GRCm39) S576R probably damaging Het
Ptprj C T 2: 90,274,805 (GRCm39) V1186I probably benign Het
Raly AGCAGCAGTGGTGGAGGAGGAGGCAGCAGTGGTGGAGG AGCAGCAGTGGTGGAGG 2: 154,705,754 (GRCm39) probably benign Het
Ros1 C T 10: 51,994,215 (GRCm39) probably null Het
Ryr2 C T 13: 11,602,101 (GRCm39) probably null Het
Scn7a A T 2: 66,582,603 (GRCm39) I98N possibly damaging Het
Spi1 T A 2: 90,943,617 (GRCm39) S54T probably benign Het
Ssna1 C T 2: 25,162,316 (GRCm39) V16I probably benign Het
Sult3a2 G A 10: 33,655,670 (GRCm39) P103L possibly damaging Het
Syne1 C T 10: 5,193,123 (GRCm39) G3975D probably damaging Het
Tbc1d1 T C 5: 64,330,950 (GRCm39) V43A possibly damaging Het
Tut4 A G 4: 108,370,429 (GRCm39) D776G probably benign Het
Uba5 A G 9: 103,931,567 (GRCm39) S222P probably damaging Het
Vmn2r24 A C 6: 123,764,266 (GRCm39) E381A probably damaging Het
Vmn2r95 G A 17: 18,661,721 (GRCm39) G489D probably benign Het
Wdr17 A T 8: 55,112,735 (GRCm39) F789I probably damaging Het
Xpnpep1 A T 19: 52,990,959 (GRCm39) L422Q probably damaging Het
Zfand3 T A 17: 30,372,302 (GRCm39) H107Q probably benign Het
Other mutations in Prl3d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1104:Prl3d1 UTSW 13 27,283,992 (GRCm39) missense probably benign 0.25
R1389:Prl3d1 UTSW 13 27,282,693 (GRCm39) nonsense probably null
R2253:Prl3d1 UTSW 13 27,278,981 (GRCm39) missense possibly damaging 0.95
R5589:Prl3d1 UTSW 13 27,278,927 (GRCm39) missense probably damaging 1.00
R5739:Prl3d1 UTSW 13 27,283,995 (GRCm39) missense probably benign 0.29
R7184:Prl3d1 UTSW 13 27,282,619 (GRCm39) missense probably damaging 1.00
R7203:Prl3d1 UTSW 13 27,282,684 (GRCm39) missense possibly damaging 0.49
R7637:Prl3d1 UTSW 13 27,284,052 (GRCm39) missense probably damaging 1.00
R7655:Prl3d1 UTSW 13 27,284,018 (GRCm39) missense possibly damaging 0.80
R7656:Prl3d1 UTSW 13 27,284,018 (GRCm39) missense possibly damaging 0.80
R8050:Prl3d1 UTSW 13 27,284,011 (GRCm39) nonsense probably null
R8964:Prl3d1 UTSW 13 27,283,926 (GRCm39) missense possibly damaging 0.86
R9559:Prl3d1 UTSW 13 27,280,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AATATAACGGCTGAGGACCCTC -3'
(R):5'- TCCGGTGACAAAGTTCAAAAC -3'

Sequencing Primer
(F):5'- GCATCCTAAGATAATCCATCTGTTG -3'
(R):5'- AAACTTTATATTCTACCCATTCCAC -3'
Posted On 2022-07-18