Mutagenetix > Incidental Mutation

Incidental Mutation 'R9549:Vmn1r61'

720299

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r61

Ensembl Gene

ENSMUSG00000094313

Gene Name

vomeronasal 1 receptor 61

Synonyms

Gm7186

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R9549 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

5613410-5614312 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 5614185 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 43 (V43G)

Ref Sequence

ENSEMBL: ENSMUSP00000128012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164880]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000164880
AA Change: V43G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000128012
Gene: ENSMUSG00000094313
AA Change: V43G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	294	5.3e-12	PFAM
Pfam:7tm_1	20	279	5e-9	PFAM
Pfam:V1R	31	299	9.5e-21	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	G	7: 78,742,076 (GRCm39)	Y491C	probably damaging	Het
B3gnt6	G	T	7: 97,843,656 (GRCm39)	D101E	possibly damaging	Het
Bnip5	A	T	17: 29,124,647 (GRCm39)	H9Q		Het
Ccnt1	A	G	15: 98,441,574 (GRCm39)	S565P	probably damaging	Het
Crebbp	T	C	16: 3,903,111 (GRCm39)	M2043V	probably benign	Het
Ehbp1	T	G	11: 22,012,788 (GRCm39)	D941A	probably benign	Het
Fam171b	G	T	2: 83,643,199 (GRCm39)	R36L	probably damaging	Het
Fam83c	T	A	2: 155,676,672 (GRCm39)	I33L		Het
Fbxo15	T	C	18: 84,980,805 (GRCm39)	V260A	possibly damaging	Het
Fez1	G	A	9: 36,780,211 (GRCm39)	G336E	possibly damaging	Het
Gm7579	CTGTGTG	CTGTG	7: 141,765,736 (GRCm39)		probably null	Het
Grip1	G	A	10: 119,874,569 (GRCm39)	E778K	possibly damaging	Het
Isoc2a	A	G	7: 4,895,058 (GRCm39)	E162G	probably damaging	Het
Lrig2	A	G	3: 104,398,191 (GRCm39)	S313P	probably damaging	Het
Lrrd1	T	A	5: 3,901,473 (GRCm39)	S593T	probably benign	Het
Lrrn1	A	G	6: 107,545,978 (GRCm39)	Y592C	probably damaging	Het
Map3k9	T	C	12: 81,771,255 (GRCm39)	T778A	probably benign	Het
Mapk14	T	A	17: 28,934,415 (GRCm39)	V102E	probably damaging	Het
Maz	A	G	7: 126,625,578 (GRCm39)	F5S	unknown	Het
Meioc	C	T	11: 102,556,550 (GRCm39)		probably benign	Het
Mlec	A	G	5: 115,288,271 (GRCm39)	V195A	probably benign	Het
Mlh3	T	C	12: 85,313,249 (GRCm39)	D979G	probably benign	Het
Mto1	G	A	9: 78,368,961 (GRCm39)	S541N	probably benign	Het
Mug1	G	A	6: 121,858,762 (GRCm39)	G1160E	probably damaging	Het
Nfkb2	T	A	19: 46,298,111 (GRCm39)	I496N	probably damaging	Het
Nr1h5	T	C	3: 102,848,337 (GRCm39)	D456G	probably benign	Het
Or5an11	T	A	19: 12,246,408 (GRCm39)	F271L	probably benign	Het
Paqr5	A	T	9: 61,863,543 (GRCm39)	C260S	possibly damaging	Het
Pip5k1b	C	A	19: 24,356,413 (GRCm39)	C175F	probably damaging	Het
Pkn1	T	C	8: 84,419,474 (GRCm39)	E43G	probably damaging	Het
Pld1	G	A	3: 28,125,381 (GRCm39)	E432K	possibly damaging	Het
Plekhb2	A	G	1: 34,902,552 (GRCm39)	D64G	probably benign	Het
Plekhh3	T	A	11: 101,056,015 (GRCm39)		probably null	Het
Prex2	A	T	1: 11,256,915 (GRCm39)	H1209L	probably damaging	Het
Rlf	T	C	4: 121,005,320 (GRCm39)	Y1330C	probably damaging	Het
Rmdn2	T	G	17: 79,935,339 (GRCm39)	S151A		Het
Sdk1	A	C	5: 141,940,657 (GRCm39)	D475A	possibly damaging	Het
Serpina1e	A	T	12: 103,917,243 (GRCm39)	L142Q	possibly damaging	Het
Setbp1	T	A	18: 78,902,629 (GRCm39)	D346V	probably benign	Het
Smg1	A	G	7: 117,795,254 (GRCm39)	L431P	unknown	Het
St13	G	A	15: 81,259,063 (GRCm39)	A207V	possibly damaging	Het
Thra	T	C	11: 98,653,772 (GRCm39)	I201T	probably benign	Het
Trim41	TTCCTCCTCCTCCTCCTCCTCCTCCTCC	TTCCTCCTCCTCCTCCTCCTCCTCC	11: 48,707,084 (GRCm39)		probably benign	Het
Trpm6	C	T	19: 18,853,394 (GRCm39)	Q1805*	probably null	Het
Uxs1	A	T	1: 43,810,892 (GRCm39)	Y231*	probably null	Het
Vash1	A	T	12: 86,735,870 (GRCm39)	D252V	probably damaging	Het
Vmn2r1	A	G	3: 63,997,493 (GRCm39)	H383R	probably benign	Het
Vmn2r105	T	C	17: 20,448,023 (GRCm39)	N267S	probably benign	Het
Zfp445	T	C	9: 122,685,844 (GRCm39)	E232G	probably damaging	Het

Other mutations in Vmn1r61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01700:Vmn1r61	APN	7	5,614,202 (GRCm39)	missense	possibly damaging	0.82
IGL02859:Vmn1r61	APN	7	5,614,288 (GRCm39)	missense	probably benign	0.37
IGL03344:Vmn1r61	APN	7	5,613,493 (GRCm39)	missense	possibly damaging	0.95
R0189:Vmn1r61	UTSW	7	5,613,699 (GRCm39)	missense	probably benign	0.03
R0336:Vmn1r61	UTSW	7	5,614,066 (GRCm39)	missense	probably benign
R0616:Vmn1r61	UTSW	7	5,613,998 (GRCm39)	missense	possibly damaging	0.65
R1490:Vmn1r61	UTSW	7	5,614,242 (GRCm39)	missense	probably benign	0.00
R1737:Vmn1r61	UTSW	7	5,614,060 (GRCm39)	missense	probably benign	0.01
R1755:Vmn1r61	UTSW	7	5,614,302 (GRCm39)	nonsense	probably null
R1795:Vmn1r61	UTSW	7	5,614,324 (GRCm39)	utr 5 prime	probably benign
R3929:Vmn1r61	UTSW	7	5,614,176 (GRCm39)	missense	probably benign	0.01
R4487:Vmn1r61	UTSW	7	5,613,924 (GRCm39)	missense	possibly damaging	0.76
R4629:Vmn1r61	UTSW	7	5,614,249 (GRCm39)	missense	probably benign	0.08
R4785:Vmn1r61	UTSW	7	5,614,126 (GRCm39)	missense	probably benign
R4785:Vmn1r61	UTSW	7	5,614,124 (GRCm39)	nonsense	probably null
R5108:Vmn1r61	UTSW	7	5,613,519 (GRCm39)	missense	probably benign
R5305:Vmn1r61	UTSW	7	5,613,814 (GRCm39)	missense	probably damaging	1.00
R5914:Vmn1r61	UTSW	7	5,613,529 (GRCm39)	missense	probably damaging	1.00
R6150:Vmn1r61	UTSW	7	5,613,678 (GRCm39)	missense	probably benign	0.00
R6232:Vmn1r61	UTSW	7	5,613,850 (GRCm39)	missense	probably damaging	1.00
R6722:Vmn1r61	UTSW	7	5,613,687 (GRCm39)	missense	possibly damaging	0.55
R7488:Vmn1r61	UTSW	7	5,613,767 (GRCm39)	missense	possibly damaging	0.56
R7496:Vmn1r61	UTSW	7	5,613,430 (GRCm39)	missense	probably benign	0.19
R8353:Vmn1r61	UTSW	7	5,613,886 (GRCm39)	missense	probably benign	0.11
R8453:Vmn1r61	UTSW	7	5,613,886 (GRCm39)	missense	probably benign	0.11
R8847:Vmn1r61	UTSW	7	5,613,817 (GRCm39)	missense	probably damaging	1.00
R9559:Vmn1r61	UTSW	7	5,613,498 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTAGCCCAGTTACCAGGAAC -3'
(R):5'- ACACCACTGTGCTATGAAGC -3'

Sequencing Primer
(F):5'- TGACAAACTGGTAGGTGCTG -3'
(R):5'- CTATGAAGCCATCTCCGGGTTG -3'

Posted On

2022-07-18