Incidental Mutation 'R9549:Meioc'
ID |
720315 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Meioc
|
Ensembl Gene |
ENSMUSG00000051455 |
Gene Name |
meiosis specific with coiled-coil domain |
Synonyms |
LOC380729, LOC268491, Gm1564 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.117)
|
Stock # |
R9549 (G1)
|
Quality Score |
153.008 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
102556177-102573066 bp(+) (GRCm39) |
Type of Mutation |
intron |
DNA Base Change (assembly) |
C to T
at 102556550 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000116246
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100378]
[ENSMUST00000156590]
|
AlphaFold |
A2AG06 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000100378
|
SMART Domains |
Protein: ENSMUSP00000097947 Gene: ENSMUSG00000051455
Domain | Start | End | E-Value | Type |
low complexity region
|
526 |
537 |
N/A |
INTRINSIC |
low complexity region
|
712 |
728 |
N/A |
INTRINSIC |
Pfam:DUF4582
|
757 |
922 |
5.1e-89 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000156590
|
SMART Domains |
Protein: ENSMUSP00000116246 Gene: ENSMUSG00000051455
Domain | Start | End | E-Value | Type |
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.1%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acan |
A |
G |
7: 78,742,076 (GRCm39) |
Y491C |
probably damaging |
Het |
B3gnt6 |
G |
T |
7: 97,843,656 (GRCm39) |
D101E |
possibly damaging |
Het |
Bnip5 |
A |
T |
17: 29,124,647 (GRCm39) |
H9Q |
|
Het |
Ccnt1 |
A |
G |
15: 98,441,574 (GRCm39) |
S565P |
probably damaging |
Het |
Crebbp |
T |
C |
16: 3,903,111 (GRCm39) |
M2043V |
probably benign |
Het |
Ehbp1 |
T |
G |
11: 22,012,788 (GRCm39) |
D941A |
probably benign |
Het |
Fam171b |
G |
T |
2: 83,643,199 (GRCm39) |
R36L |
probably damaging |
Het |
Fam83c |
T |
A |
2: 155,676,672 (GRCm39) |
I33L |
|
Het |
Fbxo15 |
T |
C |
18: 84,980,805 (GRCm39) |
V260A |
possibly damaging |
Het |
Fez1 |
G |
A |
9: 36,780,211 (GRCm39) |
G336E |
possibly damaging |
Het |
Gm7579 |
CTGTGTG |
CTGTG |
7: 141,765,736 (GRCm39) |
|
probably null |
Het |
Grip1 |
G |
A |
10: 119,874,569 (GRCm39) |
E778K |
possibly damaging |
Het |
Isoc2a |
A |
G |
7: 4,895,058 (GRCm39) |
E162G |
probably damaging |
Het |
Lrig2 |
A |
G |
3: 104,398,191 (GRCm39) |
S313P |
probably damaging |
Het |
Lrrd1 |
T |
A |
5: 3,901,473 (GRCm39) |
S593T |
probably benign |
Het |
Lrrn1 |
A |
G |
6: 107,545,978 (GRCm39) |
Y592C |
probably damaging |
Het |
Map3k9 |
T |
C |
12: 81,771,255 (GRCm39) |
T778A |
probably benign |
Het |
Mapk14 |
T |
A |
17: 28,934,415 (GRCm39) |
V102E |
probably damaging |
Het |
Maz |
A |
G |
7: 126,625,578 (GRCm39) |
F5S |
unknown |
Het |
Mlec |
A |
G |
5: 115,288,271 (GRCm39) |
V195A |
probably benign |
Het |
Mlh3 |
T |
C |
12: 85,313,249 (GRCm39) |
D979G |
probably benign |
Het |
Mto1 |
G |
A |
9: 78,368,961 (GRCm39) |
S541N |
probably benign |
Het |
Mug1 |
G |
A |
6: 121,858,762 (GRCm39) |
G1160E |
probably damaging |
Het |
Nfkb2 |
T |
A |
19: 46,298,111 (GRCm39) |
I496N |
probably damaging |
Het |
Nr1h5 |
T |
C |
3: 102,848,337 (GRCm39) |
D456G |
probably benign |
Het |
Or5an11 |
T |
A |
19: 12,246,408 (GRCm39) |
F271L |
probably benign |
Het |
Paqr5 |
A |
T |
9: 61,863,543 (GRCm39) |
C260S |
possibly damaging |
Het |
Pip5k1b |
C |
A |
19: 24,356,413 (GRCm39) |
C175F |
probably damaging |
Het |
Pkn1 |
T |
C |
8: 84,419,474 (GRCm39) |
E43G |
probably damaging |
Het |
Pld1 |
G |
A |
3: 28,125,381 (GRCm39) |
E432K |
possibly damaging |
Het |
Plekhb2 |
A |
G |
1: 34,902,552 (GRCm39) |
D64G |
probably benign |
Het |
Plekhh3 |
T |
A |
11: 101,056,015 (GRCm39) |
|
probably null |
Het |
Prex2 |
A |
T |
1: 11,256,915 (GRCm39) |
H1209L |
probably damaging |
Het |
Rlf |
T |
C |
4: 121,005,320 (GRCm39) |
Y1330C |
probably damaging |
Het |
Rmdn2 |
T |
G |
17: 79,935,339 (GRCm39) |
S151A |
|
Het |
Sdk1 |
A |
C |
5: 141,940,657 (GRCm39) |
D475A |
possibly damaging |
Het |
Serpina1e |
A |
T |
12: 103,917,243 (GRCm39) |
L142Q |
possibly damaging |
Het |
Setbp1 |
T |
A |
18: 78,902,629 (GRCm39) |
D346V |
probably benign |
Het |
Smg1 |
A |
G |
7: 117,795,254 (GRCm39) |
L431P |
unknown |
Het |
St13 |
G |
A |
15: 81,259,063 (GRCm39) |
A207V |
possibly damaging |
Het |
Thra |
T |
C |
11: 98,653,772 (GRCm39) |
I201T |
probably benign |
Het |
Trim41 |
TTCCTCCTCCTCCTCCTCCTCCTCCTCC |
TTCCTCCTCCTCCTCCTCCTCCTCC |
11: 48,707,084 (GRCm39) |
|
probably benign |
Het |
Trpm6 |
C |
T |
19: 18,853,394 (GRCm39) |
Q1805* |
probably null |
Het |
Uxs1 |
A |
T |
1: 43,810,892 (GRCm39) |
Y231* |
probably null |
Het |
Vash1 |
A |
T |
12: 86,735,870 (GRCm39) |
D252V |
probably damaging |
Het |
Vmn1r61 |
A |
C |
7: 5,614,185 (GRCm39) |
V43G |
probably damaging |
Het |
Vmn2r1 |
A |
G |
3: 63,997,493 (GRCm39) |
H383R |
probably benign |
Het |
Vmn2r105 |
T |
C |
17: 20,448,023 (GRCm39) |
N267S |
probably benign |
Het |
Zfp445 |
T |
C |
9: 122,685,844 (GRCm39) |
E232G |
probably damaging |
Het |
|
Other mutations in Meioc |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01391:Meioc
|
APN |
11 |
102,565,113 (GRCm39) |
missense |
probably benign |
0.33 |
IGL01952:Meioc
|
APN |
11 |
102,563,011 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL02006:Meioc
|
APN |
11 |
102,565,092 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02195:Meioc
|
APN |
11 |
102,565,683 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02339:Meioc
|
APN |
11 |
102,559,274 (GRCm39) |
missense |
probably benign |
0.18 |
IGL02935:Meioc
|
APN |
11 |
102,563,017 (GRCm39) |
missense |
probably benign |
0.06 |
IGL03294:Meioc
|
APN |
11 |
102,571,495 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4519001:Meioc
|
UTSW |
11 |
102,570,783 (GRCm39) |
missense |
probably damaging |
1.00 |
R0285:Meioc
|
UTSW |
11 |
102,563,017 (GRCm39) |
missense |
probably benign |
0.06 |
R0964:Meioc
|
UTSW |
11 |
102,570,857 (GRCm39) |
missense |
probably damaging |
1.00 |
R1074:Meioc
|
UTSW |
11 |
102,566,219 (GRCm39) |
missense |
probably damaging |
1.00 |
R2024:Meioc
|
UTSW |
11 |
102,566,184 (GRCm39) |
missense |
probably benign |
0.00 |
R4012:Meioc
|
UTSW |
11 |
102,566,654 (GRCm39) |
missense |
probably damaging |
0.99 |
R4429:Meioc
|
UTSW |
11 |
102,566,546 (GRCm39) |
missense |
probably damaging |
1.00 |
R4491:Meioc
|
UTSW |
11 |
102,565,746 (GRCm39) |
missense |
possibly damaging |
0.84 |
R4594:Meioc
|
UTSW |
11 |
102,564,992 (GRCm39) |
missense |
probably damaging |
1.00 |
R4752:Meioc
|
UTSW |
11 |
102,565,259 (GRCm39) |
missense |
probably benign |
0.00 |
R5301:Meioc
|
UTSW |
11 |
102,570,871 (GRCm39) |
missense |
probably damaging |
1.00 |
R5352:Meioc
|
UTSW |
11 |
102,566,139 (GRCm39) |
missense |
probably benign |
0.03 |
R5646:Meioc
|
UTSW |
11 |
102,566,083 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5958:Meioc
|
UTSW |
11 |
102,565,979 (GRCm39) |
missense |
probably benign |
0.41 |
R5968:Meioc
|
UTSW |
11 |
102,566,657 (GRCm39) |
missense |
probably damaging |
0.99 |
R6157:Meioc
|
UTSW |
11 |
102,559,227 (GRCm39) |
missense |
probably damaging |
1.00 |
R6410:Meioc
|
UTSW |
11 |
102,565,860 (GRCm39) |
missense |
probably benign |
0.00 |
R6644:Meioc
|
UTSW |
11 |
102,559,286 (GRCm39) |
critical splice donor site |
probably null |
|
R7285:Meioc
|
UTSW |
11 |
102,557,168 (GRCm39) |
missense |
probably benign |
0.00 |
R7440:Meioc
|
UTSW |
11 |
102,565,063 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7815:Meioc
|
UTSW |
11 |
102,566,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R7984:Meioc
|
UTSW |
11 |
102,565,432 (GRCm39) |
missense |
possibly damaging |
0.94 |
R8009:Meioc
|
UTSW |
11 |
102,567,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R8078:Meioc
|
UTSW |
11 |
102,559,226 (GRCm39) |
nonsense |
probably null |
|
R8195:Meioc
|
UTSW |
11 |
102,565,893 (GRCm39) |
nonsense |
probably null |
|
R8429:Meioc
|
UTSW |
11 |
102,565,032 (GRCm39) |
missense |
probably benign |
0.06 |
R8797:Meioc
|
UTSW |
11 |
102,567,686 (GRCm39) |
nonsense |
probably null |
|
R8854:Meioc
|
UTSW |
11 |
102,566,589 (GRCm39) |
missense |
probably damaging |
0.98 |
R8891:Meioc
|
UTSW |
11 |
102,559,246 (GRCm39) |
missense |
probably benign |
0.43 |
R9081:Meioc
|
UTSW |
11 |
102,565,001 (GRCm39) |
missense |
probably benign |
0.00 |
R9360:Meioc
|
UTSW |
11 |
102,565,779 (GRCm39) |
missense |
probably benign |
0.13 |
R9539:Meioc
|
UTSW |
11 |
102,565,506 (GRCm39) |
missense |
probably damaging |
0.99 |
R9751:Meioc
|
UTSW |
11 |
102,566,419 (GRCm39) |
nonsense |
probably null |
|
Z1177:Meioc
|
UTSW |
11 |
102,557,190 (GRCm39) |
frame shift |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AAGTCGGCTAACTGCTCCTTC -3'
(R):5'- TCCTTAAAGAAGAAGCACGCTG -3'
Sequencing Primer
(F):5'- AACAGACCCTGGAGGCG -3'
(R):5'- TGAGGGACGCGCCTTCTC -3'
|
Posted On |
2022-07-18 |