Incidental Mutation 'R9151:Pou2f1'
| ID |
720404 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pou2f1
|
| Ensembl Gene |
ENSMUSG00000026565 |
| Gene Name |
POU domain, class 2, transcription factor 1 |
| Synonyms |
Oct-1z, Oct-1A, Oct-1B, Oct-1C, oct-1, Oct1, 2810482H01Rik, Otf-1, Otf1 |
| MMRRC Submission |
068973-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9151 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
165692723-165830247 bp(-) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to T
at 165703640 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027850]
[ENSMUST00000069609]
[ENSMUST00000111426]
[ENSMUST00000111427]
[ENSMUST00000111429]
[ENSMUST00000159212]
[ENSMUST00000160260]
[ENSMUST00000160908]
[ENSMUST00000161971]
[ENSMUST00000178336]
[ENSMUST00000184643]
[ENSMUST00000187313]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027850
|
| SMART Domains |
Protein: ENSMUSP00000027850
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
137 |
152 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
199 |
217 |
N/A |
INTRINSIC |
|
POU
|
241 |
315 |
1.55e-52 |
SMART |
|
low complexity region
|
316 |
332 |
N/A |
INTRINSIC |
|
HOX
|
342 |
404 |
2.54e-19 |
SMART |
|
low complexity region
|
422 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
520 |
N/A |
INTRINSIC |
|
low complexity region
|
529 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
675 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
705 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069609
|
| SMART Domains |
Protein: ENSMUSP00000064000
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
572 |
N/A |
INTRINSIC |
|
low complexity region
|
581 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
737 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
757 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111426
|
| SMART Domains |
Protein: ENSMUSP00000107055
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
6.7e-55 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
1.3e-21 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111427
|
| SMART Domains |
Protein: ENSMUSP00000107056
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
781 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111429
|
| SMART Domains |
Protein: ENSMUSP00000107057
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159212
|
| SMART Domains |
Protein: ENSMUSP00000125371
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
1.55e-52 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
2.54e-19 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
715 |
725 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
745 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160260
|
| SMART Domains |
Protein: ENSMUSP00000124738
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
616 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
762 |
772 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
792 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160908
|
| SMART Domains |
Protein: ENSMUSP00000125444
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161971
|
| SMART Domains |
Protein: ENSMUSP00000124297
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
1.5e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178336
|
| SMART Domains |
Protein: ENSMUSP00000136456
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
1.7e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184643
|
| SMART Domains |
Protein: ENSMUSP00000138962
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184799
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187313
|
| SMART Domains |
Protein: ENSMUSP00000140926
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
2.5e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
low complexity region
|
195 |
204 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194366
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (71/71) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
PHENOTYPE: Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
A |
G |
11: 110,188,908 (GRCm39) |
F850L |
probably benign |
Het |
| Adam1a |
A |
T |
5: 121,657,411 (GRCm39) |
D627E |
probably damaging |
Het |
| Add2 |
C |
A |
6: 86,081,459 (GRCm39) |
|
probably benign |
Het |
| Anpep |
T |
C |
7: 79,491,785 (GRCm39) |
N72S |
probably benign |
Het |
| Aqp6 |
A |
G |
15: 99,501,655 (GRCm39) |
T238A |
possibly damaging |
Het |
| Arhgef38 |
G |
T |
3: 132,912,706 (GRCm39) |
T111K |
|
Het |
| Atg10 |
A |
G |
13: 91,189,032 (GRCm39) |
Y93H |
probably damaging |
Het |
| Bean1 |
CT |
C |
8: 104,908,664 (GRCm39) |
|
probably null |
Het |
| Cald1 |
A |
G |
6: 34,732,682 (GRCm39) |
N286S |
unknown |
Het |
| Caps2 |
A |
T |
10: 112,031,829 (GRCm39) |
I322F |
possibly damaging |
Het |
| Cbx3 |
T |
A |
6: 51,455,533 (GRCm39) |
S95T |
probably benign |
Het |
| Ccdc24 |
T |
C |
4: 117,727,102 (GRCm39) |
T83A |
unknown |
Het |
| Cntn1 |
T |
C |
15: 92,140,864 (GRCm39) |
Y197H |
probably damaging |
Het |
| Cpd |
A |
G |
11: 76,675,275 (GRCm39) |
I1282T |
possibly damaging |
Het |
| Crat |
A |
T |
2: 30,295,052 (GRCm39) |
S454R |
probably damaging |
Het |
| D2hgdh |
G |
A |
1: 93,754,338 (GRCm39) |
V126I |
probably benign |
Het |
| Dcst1 |
A |
G |
3: 89,271,558 (GRCm39) |
V75A |
probably benign |
Het |
| Dnm1l |
T |
C |
16: 16,176,668 (GRCm39) |
D21G |
probably benign |
Het |
| Evc2 |
A |
G |
5: 37,504,823 (GRCm39) |
N74D |
probably benign |
Het |
| Gm19965 |
A |
T |
1: 116,748,942 (GRCm39) |
M208L |
|
Het |
| Gprc6a |
T |
G |
10: 51,497,182 (GRCm39) |
T454P |
possibly damaging |
Het |
| Gprin1 |
C |
T |
13: 54,886,778 (GRCm39) |
V499M |
probably benign |
Het |
| Gtf3c5 |
A |
G |
2: 28,463,577 (GRCm39) |
Y194H |
probably damaging |
Het |
| Hcn4 |
T |
C |
9: 58,767,880 (GRCm39) |
V1147A |
possibly damaging |
Het |
| Ighv1-82 |
A |
C |
12: 115,916,342 (GRCm39) |
V56G |
probably damaging |
Het |
| Ins2 |
T |
C |
7: 142,232,505 (GRCm39) |
D93G |
possibly damaging |
Het |
| Itgb8 |
A |
G |
12: 119,130,535 (GRCm39) |
S658P |
probably benign |
Het |
| Kcnmb1 |
T |
C |
11: 33,920,263 (GRCm39) |
F159L |
probably benign |
Het |
| Klf1 |
C |
T |
8: 85,629,954 (GRCm39) |
L260F |
probably benign |
Het |
| Larp4 |
T |
A |
15: 99,888,205 (GRCm39) |
S140T |
possibly damaging |
Het |
| Maneal |
C |
A |
4: 124,755,542 (GRCm39) |
R140L |
probably benign |
Het |
| Mfsd11 |
T |
A |
11: 116,750,323 (GRCm39) |
V114D |
|
Het |
| Muc4 |
A |
G |
16: 32,752,617 (GRCm38) |
T832A |
probably benign |
Het |
| Myh11 |
T |
G |
16: 14,050,439 (GRCm39) |
I509L |
|
Het |
| Myh13 |
A |
T |
11: 67,252,149 (GRCm39) |
E1419V |
probably damaging |
Het |
| Myh7b |
A |
G |
2: 155,474,439 (GRCm39) |
E1718G |
probably damaging |
Het |
| Myo9b |
T |
A |
8: 71,807,871 (GRCm39) |
|
probably benign |
Het |
| Notch1 |
A |
T |
2: 26,367,939 (GRCm39) |
L656Q |
probably benign |
Het |
| Nova1 |
A |
G |
12: 46,746,813 (GRCm39) |
I488T |
probably damaging |
Het |
| Or51r1 |
A |
T |
7: 102,228,500 (GRCm39) |
E266V |
probably damaging |
Het |
| Or5b113 |
A |
T |
19: 13,342,222 (GRCm39) |
T77S |
possibly damaging |
Het |
| Or5b21 |
A |
G |
19: 12,839,976 (GRCm39) |
Y279C |
probably damaging |
Het |
| Or5d18 |
A |
G |
2: 87,864,697 (GRCm39) |
V262A |
probably damaging |
Het |
| Or6c35 |
A |
G |
10: 129,169,623 (GRCm39) |
N291S |
probably damaging |
Het |
| Or6d13 |
A |
T |
6: 116,517,990 (GRCm39) |
N192I |
possibly damaging |
Het |
| Pax6 |
C |
T |
2: 105,523,097 (GRCm39) |
S325L |
probably benign |
Het |
| Phldb1 |
T |
C |
9: 44,619,740 (GRCm39) |
D142G |
probably null |
Het |
| Phldb3 |
T |
G |
7: 24,324,048 (GRCm39) |
|
probably benign |
Het |
| Pikfyve |
G |
T |
1: 65,235,898 (GRCm39) |
R190L |
probably damaging |
Het |
| Plagl2 |
A |
T |
2: 153,074,540 (GRCm39) |
H120Q |
probably damaging |
Het |
| Pramel58 |
A |
G |
5: 94,831,836 (GRCm39) |
Y281C |
possibly damaging |
Het |
| Prpf6 |
A |
G |
2: 181,250,001 (GRCm39) |
R54G |
possibly damaging |
Het |
| Prss33 |
T |
C |
17: 24,052,966 (GRCm39) |
E236G |
probably benign |
Het |
| Ptpru |
T |
C |
4: 131,522,278 (GRCm39) |
Y709C |
probably benign |
Het |
| Rcc1l |
A |
G |
5: 134,197,057 (GRCm39) |
V212A |
probably benign |
Het |
| Rtl1 |
G |
A |
12: 109,560,007 (GRCm39) |
L611F |
|
Het |
| Scp2 |
A |
G |
4: 107,931,603 (GRCm39) |
I344T |
possibly damaging |
Het |
| Serpinb2 |
A |
T |
1: 107,449,890 (GRCm39) |
D101V |
possibly damaging |
Het |
| Slc13a1 |
T |
C |
6: 24,097,662 (GRCm39) |
T422A |
probably damaging |
Het |
| Slc38a10 |
G |
T |
11: 120,007,762 (GRCm39) |
T406K |
probably benign |
Het |
| Smad4 |
T |
C |
18: 73,782,806 (GRCm39) |
E376G |
probably damaging |
Het |
| Smarcb1 |
T |
C |
10: 75,750,916 (GRCm39) |
E115G |
probably benign |
Het |
| Spata31h1 |
A |
T |
10: 82,120,928 (GRCm39) |
H4027Q |
probably damaging |
Het |
| Taf5 |
G |
A |
19: 47,063,370 (GRCm39) |
V307I |
probably damaging |
Het |
| Tnc |
T |
C |
4: 63,938,686 (GRCm39) |
N51S |
possibly damaging |
Het |
| Trp53inp2 |
G |
T |
2: 155,228,558 (GRCm39) |
R171L |
possibly damaging |
Het |
| Ttc13 |
A |
T |
8: 125,402,021 (GRCm39) |
D579E |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,775,896 (GRCm39) |
N1761K |
unknown |
Het |
| Ttpa |
C |
T |
4: 20,008,401 (GRCm39) |
|
probably benign |
Het |
| Ugt3a1 |
G |
A |
15: 9,362,051 (GRCm39) |
V276I |
probably benign |
Het |
| Usp4 |
T |
A |
9: 108,244,011 (GRCm39) |
H296Q |
probably benign |
Het |
| Vmn1r119 |
T |
A |
7: 20,745,593 (GRCm39) |
H263L |
possibly damaging |
Het |
| Vmn2r81 |
A |
G |
10: 79,103,905 (GRCm39) |
D176G |
|
Het |
| Wdr1 |
A |
T |
5: 38,687,468 (GRCm39) |
|
probably benign |
Het |
| Zfp488 |
T |
G |
14: 33,692,695 (GRCm39) |
Q156P |
possibly damaging |
Het |
|
| Other mutations in Pou2f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Pou2f1
|
APN |
1 |
165,729,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Pou2f1
|
APN |
1 |
165,724,159 (GRCm39) |
splice site |
probably benign |
|
|
IGL01627:Pou2f1
|
APN |
1 |
165,708,002 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01707:Pou2f1
|
APN |
1 |
165,742,685 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02735:Pou2f1
|
APN |
1 |
165,703,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02740:Pou2f1
|
APN |
1 |
165,710,685 (GRCm39) |
nonsense |
probably null |
|
|
IGL03117:Pou2f1
|
APN |
1 |
165,762,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03272:Pou2f1
|
APN |
1 |
165,724,049 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0021:Pou2f1
|
UTSW |
1 |
165,703,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Pou2f1
|
UTSW |
1 |
165,719,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2171:Pou2f1
|
UTSW |
1 |
165,707,925 (GRCm39) |
unclassified |
probably benign |
|
|
R3722:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3789:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3901:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4225:Pou2f1
|
UTSW |
1 |
165,738,889 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4459:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4460:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4820:Pou2f1
|
UTSW |
1 |
165,719,517 (GRCm39) |
intron |
probably benign |
|
|
R4838:Pou2f1
|
UTSW |
1 |
165,744,492 (GRCm39) |
missense |
probably null |
1.00 |
|
R5579:Pou2f1
|
UTSW |
1 |
165,742,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Pou2f1
|
UTSW |
1 |
165,742,699 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5951:Pou2f1
|
UTSW |
1 |
165,710,625 (GRCm39) |
unclassified |
probably benign |
|
|
R6128:Pou2f1
|
UTSW |
1 |
165,703,056 (GRCm39) |
unclassified |
probably benign |
|
|
R6145:Pou2f1
|
UTSW |
1 |
165,703,002 (GRCm39) |
unclassified |
probably benign |
|
|
R6216:Pou2f1
|
UTSW |
1 |
165,707,889 (GRCm39) |
unclassified |
probably benign |
|
|
R6971:Pou2f1
|
UTSW |
1 |
165,759,258 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7052:Pou2f1
|
UTSW |
1 |
165,742,684 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7403:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7404:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7741:Pou2f1
|
UTSW |
1 |
165,703,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8011:Pou2f1
|
UTSW |
1 |
165,722,472 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8478:Pou2f1
|
UTSW |
1 |
165,759,287 (GRCm39) |
start codon destroyed |
probably null |
|
|
R8804:Pou2f1
|
UTSW |
1 |
165,708,039 (GRCm39) |
missense |
unknown |
|
|
R8892:Pou2f1
|
UTSW |
1 |
165,708,027 (GRCm39) |
missense |
unknown |
|
|
R9126:Pou2f1
|
UTSW |
1 |
165,722,603 (GRCm39) |
missense |
unknown |
|
|
R9469:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9665:Pou2f1
|
UTSW |
1 |
165,703,600 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF012:Pou2f1
|
UTSW |
1 |
165,740,800 (GRCm39) |
missense |
unknown |
|
|
X0022:Pou2f1
|
UTSW |
1 |
165,724,025 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGCTTACTGGGTTGCTGG -3'
(R):5'- ACTGGTCTGCAACTCTCATGATTC -3'
Sequencing Primer
(F):5'- CTGGTGAGCAGAGAGAGGTTCTG -3'
(R):5'- GCAACTCTCATGATTCCTCCCTG -3'
|
| Posted On |
2022-08-08 |
Incidental Mutation