Incidental Mutation 'R9550:Zfp266'
ID |
720442 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp266
|
Ensembl Gene |
ENSMUSG00000060510 |
Gene Name |
zinc finger protein 266 |
Synonyms |
5330440G10Rik, 5730601F06Rik |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.087)
|
Stock # |
R9550 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
20406364-20432713 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 20410482 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 565
(K565R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000066012
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068296]
[ENSMUST00000174462]
[ENSMUST00000215908]
|
AlphaFold |
E9Q2S7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000068296
AA Change: K565R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000066012 Gene: ENSMUSG00000060510 AA Change: K565R
Domain | Start | End | E-Value | Type |
KRAB
|
41 |
101 |
1.4e-27 |
SMART |
internal_repeat_1
|
138 |
318 |
2.7e-16 |
PROSPERO |
ZnF_C2H2
|
343 |
365 |
7.78e-3 |
SMART |
ZnF_C2H2
|
371 |
393 |
1.98e-4 |
SMART |
ZnF_C2H2
|
399 |
421 |
2.27e-4 |
SMART |
ZnF_C2H2
|
427 |
449 |
2.47e-5 |
SMART |
ZnF_C2H2
|
455 |
477 |
2.99e-4 |
SMART |
ZnF_C2H2
|
483 |
505 |
1.47e-3 |
SMART |
ZnF_C2H2
|
511 |
533 |
5.81e-2 |
SMART |
ZnF_C2H2
|
539 |
561 |
2.79e-4 |
SMART |
ZnF_C2H2
|
567 |
589 |
2.09e-3 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000174462
AA Change: K565R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000134217 Gene: ENSMUSG00000060510 AA Change: K565R
Domain | Start | End | E-Value | Type |
KRAB
|
41 |
101 |
1.4e-27 |
SMART |
internal_repeat_1
|
138 |
318 |
2.7e-16 |
PROSPERO |
ZnF_C2H2
|
343 |
365 |
7.78e-3 |
SMART |
ZnF_C2H2
|
371 |
393 |
1.98e-4 |
SMART |
ZnF_C2H2
|
399 |
421 |
2.27e-4 |
SMART |
ZnF_C2H2
|
427 |
449 |
2.47e-5 |
SMART |
ZnF_C2H2
|
455 |
477 |
2.99e-4 |
SMART |
ZnF_C2H2
|
483 |
505 |
1.47e-3 |
SMART |
ZnF_C2H2
|
511 |
533 |
5.81e-2 |
SMART |
ZnF_C2H2
|
539 |
561 |
2.79e-4 |
SMART |
ZnF_C2H2
|
567 |
589 |
2.09e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000215908
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 99.1%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 46 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam26a |
A |
G |
8: 44,022,120 (GRCm39) |
C457R |
probably damaging |
Het |
Adamts9 |
A |
T |
6: 92,878,429 (GRCm39) |
V546E |
probably benign |
Het |
Add3 |
G |
A |
19: 53,233,521 (GRCm39) |
E641K |
possibly damaging |
Het |
Anks1b |
T |
A |
10: 90,412,360 (GRCm39) |
M1K |
probably null |
Het |
C1s2 |
G |
A |
6: 124,605,253 (GRCm39) |
Q361* |
probably null |
Het |
Casp4 |
T |
C |
9: 5,328,465 (GRCm39) |
S316P |
probably damaging |
Het |
Cby2 |
A |
G |
14: 75,820,603 (GRCm39) |
V374A |
probably damaging |
Het |
Cdyl |
A |
G |
13: 36,000,147 (GRCm39) |
T143A |
probably benign |
Het |
Cep85 |
T |
C |
4: 133,858,598 (GRCm39) |
T760A |
probably damaging |
Het |
Chd2 |
A |
G |
7: 73,119,439 (GRCm39) |
L1035P |
probably damaging |
Het |
Cpne8 |
T |
C |
15: 90,453,760 (GRCm39) |
I208V |
probably benign |
Het |
Cux1 |
A |
G |
5: 136,340,387 (GRCm39) |
L641P |
probably damaging |
Het |
Dlgap1 |
T |
A |
17: 71,093,902 (GRCm39) |
M741K |
possibly damaging |
Het |
Dnajc16 |
T |
C |
4: 141,495,058 (GRCm39) |
Y518C |
possibly damaging |
Het |
Dtnb |
A |
G |
12: 3,768,437 (GRCm39) |
N343D |
possibly damaging |
Het |
Dusp3 |
A |
T |
11: 101,872,668 (GRCm39) |
S43T |
probably benign |
Het |
Epha8 |
G |
T |
4: 136,665,897 (GRCm39) |
L420M |
probably damaging |
Het |
Espn |
C |
T |
4: 152,215,534 (GRCm39) |
R575H |
probably damaging |
Het |
Gls |
A |
T |
1: 52,251,373 (GRCm39) |
L328* |
probably null |
Het |
H2-T23 |
T |
C |
17: 36,342,712 (GRCm39) |
D142G |
probably damaging |
Het |
Hck |
A |
G |
2: 152,976,651 (GRCm39) |
M262V |
probably benign |
Het |
Igkv14-126 |
G |
T |
6: 67,873,199 (GRCm39) |
L13F |
possibly damaging |
Het |
Muc2 |
C |
T |
7: 141,308,242 (GRCm39) |
R913C |
probably damaging |
Het |
Mypop |
A |
T |
7: 18,726,245 (GRCm39) |
T71S |
probably damaging |
Het |
Nadsyn1 |
A |
G |
7: 143,353,615 (GRCm39) |
I536T |
probably damaging |
Het |
Obsl1 |
T |
C |
1: 75,474,910 (GRCm39) |
E830G |
possibly damaging |
Het |
Or1q1 |
T |
A |
2: 36,887,137 (GRCm39) |
I105N |
probably damaging |
Het |
Or8d2b |
T |
C |
9: 38,788,937 (GRCm39) |
V155A |
probably benign |
Het |
Pcdha8 |
A |
T |
18: 37,127,399 (GRCm39) |
Y627F |
possibly damaging |
Het |
Polr1b |
T |
A |
2: 128,962,205 (GRCm39) |
S742R |
unknown |
Het |
Ppm1e |
A |
T |
11: 87,121,919 (GRCm39) |
N679K |
probably benign |
Het |
Raly |
AGCAGCAGTGGTGGAGGAGGAGGCAGCAGTGGTGGAGG |
AGCAGCAGTGGTGGAGG |
2: 154,705,754 (GRCm39) |
|
probably benign |
Het |
Rgs12 |
G |
T |
5: 35,196,665 (GRCm39) |
G1430C |
probably damaging |
Het |
Rhcg |
T |
C |
7: 79,248,296 (GRCm39) |
Y436C |
probably damaging |
Het |
Ripor3 |
T |
C |
2: 167,822,807 (GRCm39) |
D918G |
probably benign |
Het |
Rlf |
A |
G |
4: 121,003,620 (GRCm39) |
F1897L |
probably damaging |
Het |
Sin3a |
T |
C |
9: 56,996,768 (GRCm39) |
V99A |
probably benign |
Het |
Slc22a29 |
A |
T |
19: 8,195,224 (GRCm39) |
L137* |
probably null |
Het |
Sufu |
A |
G |
19: 46,385,675 (GRCm39) |
Y45C |
probably damaging |
Het |
Thsd1 |
C |
T |
8: 22,733,026 (GRCm39) |
|
probably benign |
Het |
Tiam2 |
T |
A |
17: 3,559,706 (GRCm39) |
L1249Q |
probably damaging |
Het |
Toe1 |
C |
T |
4: 116,661,916 (GRCm39) |
V418M |
probably benign |
Het |
Trappc12 |
T |
C |
12: 28,761,985 (GRCm39) |
|
probably null |
Het |
Triobp |
A |
G |
15: 78,858,077 (GRCm39) |
D1226G |
probably damaging |
Het |
Zfhx4 |
T |
C |
3: 5,464,572 (GRCm39) |
S1602P |
probably damaging |
Het |
Zfp319 |
T |
C |
8: 96,055,025 (GRCm39) |
T393A |
probably benign |
Het |
|
Other mutations in Zfp266 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
PIT4453001:Zfp266
|
UTSW |
9 |
20,417,299 (GRCm39) |
missense |
probably benign |
|
R0744:Zfp266
|
UTSW |
9 |
20,411,095 (GRCm39) |
missense |
probably damaging |
1.00 |
R0836:Zfp266
|
UTSW |
9 |
20,411,095 (GRCm39) |
missense |
probably damaging |
1.00 |
R2180:Zfp266
|
UTSW |
9 |
20,410,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R2422:Zfp266
|
UTSW |
9 |
20,410,558 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3085:Zfp266
|
UTSW |
9 |
20,412,240 (GRCm39) |
missense |
probably damaging |
0.99 |
R3791:Zfp266
|
UTSW |
9 |
20,410,777 (GRCm39) |
missense |
probably damaging |
0.99 |
R3972:Zfp266
|
UTSW |
9 |
20,411,446 (GRCm39) |
missense |
probably damaging |
1.00 |
R5378:Zfp266
|
UTSW |
9 |
20,410,659 (GRCm39) |
missense |
probably damaging |
1.00 |
R5529:Zfp266
|
UTSW |
9 |
20,418,030 (GRCm39) |
missense |
probably damaging |
0.99 |
R5788:Zfp266
|
UTSW |
9 |
20,417,332 (GRCm39) |
missense |
probably damaging |
0.98 |
R6476:Zfp266
|
UTSW |
9 |
20,410,577 (GRCm39) |
missense |
probably damaging |
1.00 |
R6901:Zfp266
|
UTSW |
9 |
20,410,895 (GRCm39) |
nonsense |
probably null |
|
R7326:Zfp266
|
UTSW |
9 |
20,413,391 (GRCm39) |
missense |
probably benign |
0.03 |
R7417:Zfp266
|
UTSW |
9 |
20,412,232 (GRCm39) |
missense |
probably benign |
|
R7783:Zfp266
|
UTSW |
9 |
20,411,626 (GRCm39) |
missense |
probably benign |
0.04 |
R7917:Zfp266
|
UTSW |
9 |
20,416,423 (GRCm39) |
missense |
probably benign |
0.00 |
R7947:Zfp266
|
UTSW |
9 |
20,410,548 (GRCm39) |
missense |
probably benign |
0.00 |
R8174:Zfp266
|
UTSW |
9 |
20,418,110 (GRCm39) |
start gained |
probably benign |
|
R8194:Zfp266
|
UTSW |
9 |
20,411,610 (GRCm39) |
missense |
probably benign |
0.05 |
R8776:Zfp266
|
UTSW |
9 |
20,411,509 (GRCm39) |
missense |
probably benign |
0.03 |
R8776-TAIL:Zfp266
|
UTSW |
9 |
20,411,509 (GRCm39) |
missense |
probably benign |
0.03 |
R8872:Zfp266
|
UTSW |
9 |
20,411,275 (GRCm39) |
missense |
probably benign |
0.22 |
R9096:Zfp266
|
UTSW |
9 |
20,416,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R9220:Zfp266
|
UTSW |
9 |
20,413,337 (GRCm39) |
nonsense |
probably null |
|
R9284:Zfp266
|
UTSW |
9 |
20,411,300 (GRCm39) |
nonsense |
probably null |
|
R9502:Zfp266
|
UTSW |
9 |
20,413,413 (GRCm39) |
nonsense |
probably null |
|
R9547:Zfp266
|
UTSW |
9 |
20,411,746 (GRCm39) |
missense |
probably benign |
0.40 |
R9752:Zfp266
|
UTSW |
9 |
20,411,496 (GRCm39) |
missense |
probably benign |
0.15 |
|
Predicted Primers |
PCR Primer
(F):5'- GATATTCATGAAAAGGTTCCAGGG -3'
(R):5'- TACTCAGTACTCGGGCCTTG -3'
Sequencing Primer
(F):5'- TAAGGCCAGTGTGAGCCTCTATAAC -3'
(R):5'- GGCCTGATTCATCATGTGAGAACTC -3'
|
Posted On |
2022-08-09 |