Mutagenetix > Incidental Mutation

Incidental Mutation 'R9551:Or11g1'

720506

Institutional Source

Beutler Lab

Gene Symbol

Or11g1

Ensembl Gene

ENSMUSG00000094692

Gene Name

olfactory receptor family 11 subfamily G member 1

Synonyms

GA_x6K02T2PMLR-6110726-6111661, Olfr738, MOR106-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R9551 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50651003-50651938 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 50651625 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Phenylalanine at position 208 (S208F)

Ref Sequence

ENSEMBL: ENSMUSP00000150067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058972] [ENSMUST00000214320] [ENSMUST00000214853] [ENSMUST00000216949]

AlphaFold

L7N1X7

Predicted Effect

probably benign
Transcript: ENSMUST00000058972
AA Change: S208F

PolyPhen 2 Score 0.376 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000059540
Gene: ENSMUSG00000094692
AA Change: S208F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.5e-50	PFAM
Pfam:7TM_GPCR_Srsx	39	309	1.3e-5	PFAM
Pfam:7tm_1	45	294	6.9e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214320
AA Change: S208F

PolyPhen 2 Score 0.376 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000214853
AA Change: S208F

PolyPhen 2 Score 0.376 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000216949

Coding Region Coverage

1x: 99.9%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2200002D01Rik	CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	7: 28,947,048 (GRCm39)		probably benign	Het
Birc6	T	A	17: 74,916,064 (GRCm39)	L1660Q	probably benign	Het
Blvrb	A	G	7: 27,158,786 (GRCm39)	D62G	probably benign	Het
Ccdc68	T	A	18: 70,089,113 (GRCm39)	S219T	probably damaging	Het
Cep120	C	A	18: 53,819,033 (GRCm39)	R886L	possibly damaging	Het
Cep290	T	C	10: 100,372,729 (GRCm39)	S1176P	probably damaging	Het
Cnbp	A	G	6: 87,822,108 (GRCm39)	Y139H	probably damaging	Het
Csmd3	T	A	15: 48,655,356 (GRCm39)		probably benign	Het
Cyp2c66	T	C	19: 39,172,246 (GRCm39)	V387A	probably damaging	Het
Dab2ip	T	A	2: 35,605,330 (GRCm39)	C504S	possibly damaging	Het
Depdc7	C	T	2: 104,553,220 (GRCm39)		probably null	Het
Edrf1	A	G	7: 133,240,742 (GRCm39)	D73G	probably damaging	Het
Elp3	T	C	14: 65,797,634 (GRCm39)	I365V	probably benign	Het
Erbb4	G	A	1: 68,779,642 (GRCm39)	Q45*	probably null	Het
Fam124a	T	G	14: 62,843,988 (GRCm39)	S499A	possibly damaging	Het
Has2	T	C	15: 56,531,090 (GRCm39)	K542E	probably benign	Het
Hnrnpk	A	G	13: 58,544,058 (GRCm39)	S116P	probably benign	Het
Hs3st6	T	C	17: 24,977,228 (GRCm39)	L236P	probably damaging	Het
Il15	T	A	8: 83,061,177 (GRCm39)	H100L	probably benign	Het
Kif14	C	A	1: 136,455,219 (GRCm39)	S1630R	probably damaging	Het
Madd	T	C	2: 91,000,434 (GRCm39)	T544A	probably damaging	Het
Mamdc4	T	C	2: 25,460,035 (GRCm39)	D76G	probably damaging	Het
Mark2	G	T	19: 7,263,263 (GRCm39)	T201N	possibly damaging	Het
Mfsd9	T	C	1: 40,813,152 (GRCm39)	T388A	probably damaging	Het
Mgst3	T	C	1: 167,205,871 (GRCm39)	Y36C	probably damaging	Het
Myh11	T	A	16: 14,064,673 (GRCm39)	E215V		Het
Nmd3	T	C	3: 69,647,329 (GRCm39)	V277A	possibly damaging	Het
Or2y14	C	T	11: 49,404,942 (GRCm39)	T159I	probably damaging	Het
Or6k4	A	T	1: 173,964,885 (GRCm39)	T192S	probably benign	Het
Pbx1	T	C	1: 168,258,910 (GRCm39)	D55G	possibly damaging	Het
Pdzrn3	T	C	6: 101,127,855 (GRCm39)	D937G	probably damaging	Het
Phb1	G	A	11: 95,562,257 (GRCm39)	V45I	probably benign	Het
Pi4ka	T	C	16: 17,125,574 (GRCm39)	E1187G		Het
Piezo2	T	C	18: 63,166,033 (GRCm39)	E2066G	possibly damaging	Het
Pkn2	T	C	3: 142,499,594 (GRCm39)	D977G	probably damaging	Het
Polr1b	C	T	2: 128,957,684 (GRCm39)	R580*	probably null	Het
Pyroxd2	A	G	19: 42,719,756 (GRCm39)		probably null	Het
Rpain	T	C	11: 70,865,816 (GRCm39)	S194P	probably damaging	Het
Scaf1	A	G	7: 44,658,351 (GRCm39)	L176P	probably damaging	Het
Scgb1b12	C	A	7: 32,033,974 (GRCm39)	A78E	probably benign	Het
Scgb2b19	A	G	7: 32,979,198 (GRCm39)	F28S	probably damaging	Het
Setx	T	C	2: 29,020,244 (GRCm39)	M77T	possibly damaging	Het
Skint5	C	T	4: 113,798,052 (GRCm39)	C177Y	possibly damaging	Het
Slco6c1	T	C	1: 97,055,827 (GRCm39)	S25G	probably benign	Het
Sorbs1	G	A	19: 40,361,923 (GRCm39)	R154*	probably null	Het
Ssb	T	A	2: 69,696,982 (GRCm39)	D107E	probably benign	Het
Tcerg1l	T	C	7: 137,995,998 (GRCm39)	D170G	possibly damaging	Het
Tle5	T	C	10: 81,399,988 (GRCm39)	V62A	probably damaging	Het
Tm7sf3	C	T	6: 146,525,179 (GRCm39)	D89N	possibly damaging	Het
Tmco4	G	A	4: 138,779,895 (GRCm39)	V447M	probably damaging	Het
Trf	C	T	9: 103,099,283 (GRCm39)	V339I	probably benign	Het
Ucp1	T	C	8: 84,024,509 (GRCm39)	L278P	probably damaging	Het
Vmn1r82	A	G	7: 12,039,600 (GRCm39)	N291S	possibly damaging	Het
Vmn1r86	A	T	7: 12,836,781 (GRCm39)	Y32N	possibly damaging	Het
Wnt10b	C	A	15: 98,670,713 (GRCm39)	G272W	probably damaging	Het
Xpo4	A	G	14: 57,828,512 (GRCm39)	F783L	possibly damaging	Het
Yipf4	T	C	17: 74,806,024 (GRCm39)	F221S	probably damaging	Het
Zfp1005	C	A	2: 150,109,856 (GRCm39)	T182K	unknown	Het
Zfp512	G	A	5: 31,623,676 (GRCm39)	C14Y	probably benign	Het
Zfp595	A	T	13: 67,465,067 (GRCm39)	S402T	probably damaging	Het
Zfp658	G	T	7: 43,222,567 (GRCm39)	V281F	probably benign	Het
Zfp827	T	G	8: 79,787,403 (GRCm39)	W190G	probably damaging	Het
Zpld2	G	A	4: 133,929,312 (GRCm39)	P331L	probably benign	Het

Other mutations in Or11g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01608:Or11g1	APN	14	50,651,910 (GRCm39)	missense	probably benign
IGL01935:Or11g1	APN	14	50,651,012 (GRCm39)	missense	probably benign
IGL02431:Or11g1	APN	14	50,651,226 (GRCm39)	missense	probably damaging	1.00
BB008:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
BB018:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
PIT4480001:Or11g1	UTSW	14	50,651,372 (GRCm39)	missense	probably benign	0.14
R0620:Or11g1	UTSW	14	50,651,154 (GRCm39)	missense	probably benign	0.20
R1445:Or11g1	UTSW	14	50,651,858 (GRCm39)	missense	probably damaging	1.00
R1831:Or11g1	UTSW	14	50,651,658 (GRCm39)	splice site	probably null
R1915:Or11g1	UTSW	14	50,651,798 (GRCm39)	missense	probably damaging	1.00
R4748:Or11g1	UTSW	14	50,651,333 (GRCm39)	missense	possibly damaging	0.77
R5301:Or11g1	UTSW	14	50,651,030 (GRCm39)	missense	probably benign	0.09
R5767:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55
R5831:Or11g1	UTSW	14	50,651,439 (GRCm39)	splice site	probably null
R6173:Or11g1	UTSW	14	50,651,654 (GRCm39)	missense	possibly damaging	0.70
R6176:Or11g1	UTSW	14	50,651,847 (GRCm39)	missense	probably damaging	1.00
R7356:Or11g1	UTSW	14	50,651,159 (GRCm39)	missense	probably damaging	1.00
R7678:Or11g1	UTSW	14	50,651,471 (GRCm39)	missense	probably damaging	0.98
R7931:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
R8508:Or11g1	UTSW	14	50,651,132 (GRCm39)	missense	probably benign	0.00
R8696:Or11g1	UTSW	14	50,651,420 (GRCm39)	missense	possibly damaging	0.95
R9374:Or11g1	UTSW	14	50,651,625 (GRCm39)	missense	probably benign	0.38
R9470:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- ATCCTTCTCTCATGACTGGGCG -3'
(R):5'- CACTCCAGCTGCATGTTCAG -3'

Sequencing Primer
(F):5'- GCAACATCCTTGTGATCAGTTG -3'
(R):5'- GATGTTGGGCTCACATACATGACC -3'

Posted On

2022-08-09