Incidental Mutation 'R9552:Zfp827'
ID 720554
Institutional Source Beutler Lab
Gene Symbol Zfp827
Ensembl Gene ENSMUSG00000071064
Gene Name zinc finger protein 827
Synonyms D630040G17Rik, 2810449M09Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.920) question?
Stock # R9552 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 79755066-79920395 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 79787403 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Glycine at position 190 (W190G)
Ref Sequence ENSEMBL: ENSMUSP00000096214 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087927] [ENSMUST00000098614] [ENSMUST00000119254]
AlphaFold Q505G8
Predicted Effect probably damaging
Transcript: ENSMUST00000087927
AA Change: W190G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000085238
Gene: ENSMUSG00000071064
AA Change: W190G

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 422 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000098614
AA Change: W190G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064
AA Change: W190G

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.31e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.31e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119254
AA Change: W190G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064
AA Change: W190G

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.25e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.25e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
Abhd6 T C 14: 8,028,329 (GRCm38) I20T possibly damaging Het
Adamts1 A G 16: 85,599,505 (GRCm39) S32P probably benign Het
Ak7 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 12: 105,676,448 (GRCm39) probably benign Het
Arhgap21 A T 2: 20,886,397 (GRCm39) V270E probably damaging Het
Birc6 T A 17: 74,916,064 (GRCm39) L1660Q probably benign Het
Blvrb A G 7: 27,158,786 (GRCm39) D62G probably benign Het
Ccdc68 T A 18: 70,089,113 (GRCm39) S219T probably damaging Het
Cnbp A G 6: 87,822,108 (GRCm39) Y139H probably damaging Het
Csmd3 T A 15: 48,655,356 (GRCm39) probably benign Het
Cyp2c66 T C 19: 39,172,246 (GRCm39) V387A probably damaging Het
Cyp2j7 C T 4: 96,115,840 (GRCm39) R202H probably damaging Het
Edrf1 A G 7: 133,240,742 (GRCm39) D73G probably damaging Het
Ercc6 C T 14: 32,284,525 (GRCm39) R763C probably damaging Het
Gm8159 T A 14: 15,850,264 (GRCm39) I161K probably damaging Het
Gramd1c A T 16: 43,807,294 (GRCm39) M356K probably damaging Het
Has2 T C 15: 56,531,090 (GRCm39) K542E probably benign Het
Hipk3 T C 2: 104,301,850 (GRCm39) N114S probably benign Het
Hs3st6 T C 17: 24,977,228 (GRCm39) L236P probably damaging Het
Il15 T A 8: 83,061,177 (GRCm39) H100L probably benign Het
Kcnh5 T C 12: 75,023,334 (GRCm39) Y578C probably benign Het
Lctl A G 9: 64,025,049 (GRCm39) I12V probably benign Het
Mark2 G T 19: 7,263,263 (GRCm39) T201N possibly damaging Het
Mef2c A G 13: 83,810,461 (GRCm39) N371S probably benign Het
Mgst3 T C 1: 167,205,871 (GRCm39) Y36C probably damaging Het
Ndst1 G T 18: 60,845,931 (GRCm39) T126K probably damaging Het
Nid1 T A 13: 13,677,045 (GRCm39) I995N probably damaging Het
Nr2e1 A T 10: 42,447,487 (GRCm39) M175K probably benign Het
Nrxn1 T C 17: 90,937,450 (GRCm39) K669R probably damaging Het
Or5d14 C T 2: 87,880,509 (GRCm39) W153* probably null Het
Or6k4 A T 1: 173,964,885 (GRCm39) T192S probably benign Het
Pbx1 T C 1: 168,258,910 (GRCm39) D55G possibly damaging Het
Pck2 T A 14: 55,780,081 (GRCm39) I110N probably damaging Het
Pkn2 T C 3: 142,499,594 (GRCm39) D977G probably damaging Het
Pyroxd2 A G 19: 42,719,756 (GRCm39) probably null Het
Rapgef4 A G 2: 72,008,561 (GRCm39) I246M probably benign Het
Rnasel T A 1: 153,630,673 (GRCm39) N396K possibly damaging Het
Scaf1 A G 7: 44,658,351 (GRCm39) L176P probably damaging Het
Scgb1b12 C A 7: 32,033,974 (GRCm39) A78E probably benign Het
Scgb2b19 A G 7: 32,979,198 (GRCm39) F28S probably damaging Het
Skint5 C T 4: 113,798,052 (GRCm39) C177Y possibly damaging Het
Slitrk5 C T 14: 111,916,496 (GRCm39) T40I probably benign Het
Slu7 G A 11: 43,329,095 (GRCm39) V106I probably benign Het
Sorbs1 G A 19: 40,361,923 (GRCm39) R154* probably null Het
Stc2 A G 11: 31,310,332 (GRCm39) S235P probably benign Het
Stt3a T C 9: 36,645,675 (GRCm39) D672G probably benign Het
Tcerg1l T C 7: 137,995,998 (GRCm39) D170G possibly damaging Het
Tcf15 T C 2: 151,986,039 (GRCm39) L165P probably damaging Het
Tgm1 T C 14: 55,950,933 (GRCm39) probably benign Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Tmco4 G A 4: 138,779,895 (GRCm39) V447M probably damaging Het
Trf C T 9: 103,099,283 (GRCm39) V339I probably benign Het
Ucp1 T C 8: 84,024,509 (GRCm39) L278P probably damaging Het
Unc80 A G 1: 66,717,282 (GRCm39) D2946G possibly damaging Het
Vmn1r82 A G 7: 12,039,600 (GRCm39) N291S possibly damaging Het
Vmn1r86 A T 7: 12,836,781 (GRCm39) Y32N possibly damaging Het
Wdr49 T C 3: 75,230,931 (GRCm39) D577G probably benign Het
Wnt10b C A 15: 98,670,713 (GRCm39) G272W probably damaging Het
Yipf4 T C 17: 74,806,024 (GRCm39) F221S probably damaging Het
Zfp512 G A 5: 31,623,676 (GRCm39) C14Y probably benign Het
Zfp658 G T 7: 43,222,567 (GRCm39) V281F probably benign Het
Zpld2 G A 4: 133,929,312 (GRCm39) P331L probably benign Het
Other mutations in Zfp827
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Zfp827 APN 8 79,787,362 (GRCm39) missense possibly damaging 0.82
IGL01545:Zfp827 APN 8 79,797,063 (GRCm39) missense probably damaging 1.00
IGL01552:Zfp827 APN 8 79,802,820 (GRCm39) missense probably damaging 1.00
IGL02261:Zfp827 APN 8 79,906,708 (GRCm39) missense probably damaging 0.97
IGL02451:Zfp827 APN 8 79,787,601 (GRCm39) missense probably damaging 1.00
IGL03130:Zfp827 APN 8 79,787,586 (GRCm39) missense probably damaging 1.00
IGL03411:Zfp827 APN 8 79,803,116 (GRCm39) missense probably damaging 0.99
E0354:Zfp827 UTSW 8 79,863,206 (GRCm39) missense probably damaging 1.00
R0502:Zfp827 UTSW 8 79,905,706 (GRCm39) splice site probably null
R0547:Zfp827 UTSW 8 79,786,939 (GRCm39) missense probably damaging 1.00
R0926:Zfp827 UTSW 8 79,844,821 (GRCm39) missense probably benign 0.00
R0975:Zfp827 UTSW 8 79,787,814 (GRCm39) missense probably benign 0.00
R1305:Zfp827 UTSW 8 79,787,523 (GRCm39) missense possibly damaging 0.95
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1638:Zfp827 UTSW 8 79,802,975 (GRCm39) missense possibly damaging 0.94
R1714:Zfp827 UTSW 8 79,787,202 (GRCm39) missense probably damaging 1.00
R2044:Zfp827 UTSW 8 79,802,865 (GRCm39) missense probably benign
R2132:Zfp827 UTSW 8 79,912,350 (GRCm39) missense possibly damaging 0.53
R3844:Zfp827 UTSW 8 79,863,248 (GRCm39) missense probably damaging 0.99
R4329:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R4629:Zfp827 UTSW 8 79,787,011 (GRCm39) missense probably damaging 0.99
R4873:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4875:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4936:Zfp827 UTSW 8 79,787,812 (GRCm39) missense probably benign
R4965:Zfp827 UTSW 8 79,787,910 (GRCm39) missense probably benign
R5103:Zfp827 UTSW 8 79,797,032 (GRCm39) missense probably damaging 1.00
R5366:Zfp827 UTSW 8 79,912,333 (GRCm39) missense possibly damaging 0.94
R5794:Zfp827 UTSW 8 79,797,071 (GRCm39) missense probably damaging 1.00
R5825:Zfp827 UTSW 8 79,905,645 (GRCm39) missense probably damaging 1.00
R6118:Zfp827 UTSW 8 79,803,067 (GRCm39) missense possibly damaging 0.75
R6236:Zfp827 UTSW 8 79,797,105 (GRCm39) missense probably damaging 1.00
R6263:Zfp827 UTSW 8 79,905,702 (GRCm39) missense probably damaging 1.00
R6306:Zfp827 UTSW 8 79,787,324 (GRCm39) missense probably damaging 1.00
R6490:Zfp827 UTSW 8 79,916,606 (GRCm39) utr 3 prime probably benign
R6497:Zfp827 UTSW 8 79,906,757 (GRCm39) missense probably damaging 1.00
R7250:Zfp827 UTSW 8 79,916,721 (GRCm39) missense
R7290:Zfp827 UTSW 8 79,916,442 (GRCm39) missense possibly damaging 0.86
R7443:Zfp827 UTSW 8 79,917,047 (GRCm39) missense
R7708:Zfp827 UTSW 8 79,902,591 (GRCm39) missense probably damaging 1.00
R7754:Zfp827 UTSW 8 79,916,958 (GRCm39) missense
R7836:Zfp827 UTSW 8 79,912,979 (GRCm39) missense probably damaging 1.00
R7995:Zfp827 UTSW 8 79,844,887 (GRCm39) missense possibly damaging 0.86
R8162:Zfp827 UTSW 8 79,787,206 (GRCm39) nonsense probably null
R8747:Zfp827 UTSW 8 79,755,316 (GRCm39) start codon destroyed probably null
R8798:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R8980:Zfp827 UTSW 8 79,803,092 (GRCm39) missense probably benign 0.00
R9099:Zfp827 UTSW 8 79,917,107 (GRCm39) missense
R9178:Zfp827 UTSW 8 79,818,564 (GRCm39) missense probably damaging 1.00
R9246:Zfp827 UTSW 8 79,803,132 (GRCm39) missense possibly damaging 0.75
R9277:Zfp827 UTSW 8 79,787,029 (GRCm39) missense probably damaging 0.97
R9318:Zfp827 UTSW 8 79,844,982 (GRCm39) missense possibly damaging 0.75
R9339:Zfp827 UTSW 8 79,844,887 (GRCm39) missense probably benign 0.00
R9425:Zfp827 UTSW 8 79,905,588 (GRCm39) missense probably damaging 1.00
R9499:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9544:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9551:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9588:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9665:Zfp827 UTSW 8 79,906,756 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TGAGCAGCAATTTGAGGCG -3'
(R):5'- CACTTTCTTAGACAAGGCCGCC -3'

Sequencing Primer
(F):5'- AGCAATTTGAGGCGGCTGC -3'
(R):5'- TTAGACAAGGCCGCCAAGGTG -3'
Posted On 2022-08-09