Incidental Mutation 'R9554:Ccnyl1'
ID 720639
Institutional Source Beutler Lab
Gene Symbol Ccnyl1
Ensembl Gene ENSMUSG00000070871
Gene Name cyclin Y-like 1
Synonyms 9630037P07Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R9554 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 64729963-64764805 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64753750 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 187 (Y187C)
Ref Sequence ENSEMBL: ENSMUSP00000109711 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094898] [ENSMUST00000114077] [ENSMUST00000187170] [ENSMUST00000187638]
AlphaFold D3YUJ3
Predicted Effect probably benign
Transcript: ENSMUST00000094898
AA Change: Y111C

PolyPhen 2 Score 0.378 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000092499
Gene: ENSMUSG00000070871
AA Change: Y111C

DomainStartEndE-ValueType
CYCLIN 123 208 1.3e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000114077
AA Change: Y187C

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000109711
Gene: ENSMUSG00000070871
AA Change: Y187C

DomainStartEndE-ValueType
low complexity region 37 58 N/A INTRINSIC
CYCLIN 199 284 1.3e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187170
AA Change: Y111C

PolyPhen 2 Score 0.378 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000139498
Gene: ENSMUSG00000070871
AA Change: Y111C

DomainStartEndE-ValueType
CYCLIN 123 208 1.3e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187638
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and teratozoospermia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,029,107 (GRCm39) E817G probably benign Het
Abhd12b A G 12: 70,215,988 (GRCm39) T182A probably benign Het
Allc A T 12: 28,607,414 (GRCm39) C279* probably null Het
Ang A G 14: 51,338,976 (GRCm39) D39G probably damaging Het
Atp8b3 G A 10: 80,360,197 (GRCm39) T958M probably damaging Het
Ccn4 G A 15: 66,784,900 (GRCm39) R191K probably benign Het
Cfhr4 A T 1: 139,668,169 (GRCm39) S321R probably benign Het
Chd3 A T 11: 69,251,015 (GRCm39) W616R probably damaging Het
Cyp17a1 C T 19: 46,657,165 (GRCm39) R361H probably damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Dcp1a A G 14: 30,201,691 (GRCm39) Q38R probably benign Het
Ddias T C 7: 92,507,560 (GRCm39) N785S probably benign Het
Depdc5 A G 5: 33,122,076 (GRCm39) N1133S probably benign Het
Dhx8 T A 11: 101,645,614 (GRCm39) Y877* probably null Het
Dlk1 G A 12: 109,420,889 (GRCm39) V15I unknown Het
Fam120b G A 17: 15,626,020 (GRCm39) A458T possibly damaging Het
Fgd4 G A 16: 16,308,353 (GRCm39) T9I probably benign Het
Fhip1b C A 7: 105,038,915 (GRCm39) R108L probably damaging Het
Gfpt1 C T 6: 87,062,323 (GRCm39) R561W probably damaging Het
Gm5773 A G 3: 93,680,340 (GRCm39) D4G probably benign Het
Helz2 T A 2: 180,882,470 (GRCm39) T108S probably damaging Het
Hivep1 G A 13: 42,308,251 (GRCm39) D164N possibly damaging Het
Kif15 G T 9: 122,828,585 (GRCm39) L902F probably damaging Het
Lrp2 T A 2: 69,261,497 (GRCm39) R4481S probably damaging Het
Mcm3ap T C 10: 76,332,310 (GRCm39) V1209A probably damaging Het
Mkrn1 C T 6: 39,376,838 (GRCm39) R377H probably benign Het
Ms4a4a G A 19: 11,367,708 (GRCm39) M191I probably benign Het
Myh11 T A 16: 14,018,580 (GRCm39) N1922I Het
Nbeal1 C T 1: 60,290,287 (GRCm39) Q998* probably null Het
Neil3 C A 8: 54,061,770 (GRCm39) G204C probably damaging Het
Nsmce1 T C 7: 125,066,994 (GRCm39) E262G possibly damaging Het
Oc90 G A 15: 65,761,437 (GRCm39) P194S probably benign Het
Oplah A G 15: 76,193,787 (GRCm39) S57P probably benign Het
Or10u4 A T 10: 129,802,181 (GRCm39) F123L probably benign Het
Or1x6 T A 11: 50,939,223 (GRCm39) Y96* probably null Het
Or2aj4 T A 16: 19,384,722 (GRCm39) I304F possibly damaging Het
Or4a73 C A 2: 89,420,710 (GRCm39) V250F probably damaging Het
Or4d5 T A 9: 40,012,160 (GRCm39) M209L probably benign Het
Or51g1 A T 7: 102,633,774 (GRCm39) I199N probably damaging Het
Or5p70 A G 7: 107,994,365 (GRCm39) T13A probably benign Het
Or8g28 A C 9: 39,169,756 (GRCm39) F71V possibly damaging Het
Pdzd8 A T 19: 59,333,574 (GRCm39) L149Q probably damaging Het
Pid1 A G 1: 84,137,032 (GRCm39) V33A probably benign Het
Polr3gl A G 3: 96,489,037 (GRCm39) V60A possibly damaging Het
Prdm1 A G 10: 44,317,242 (GRCm39) V527A probably benign Het
Sbf2 T C 7: 110,040,671 (GRCm39) I385M probably damaging Het
Setbp1 C T 18: 78,826,599 (GRCm39) S1338N probably benign Het
Sh2b2 T C 5: 136,253,006 (GRCm39) T389A probably benign Het
Skint9 A T 4: 112,248,915 (GRCm39) M171K probably benign Het
Slx4 C A 16: 3,805,820 (GRCm39) M577I probably benign Het
Srcap T C 7: 127,151,577 (GRCm39) S2092P probably damaging Het
Traf6 T A 2: 101,518,953 (GRCm39) H147Q probably benign Het
Ttn T A 2: 76,547,693 (GRCm39) E32159V possibly damaging Het
Ubn1 T C 16: 4,888,492 (GRCm39) S154P unknown Het
Uchl1 T A 5: 66,833,649 (GRCm39) M6K probably damaging Het
Vmn1r193 A T 13: 22,403,989 (GRCm39) M1K probably null Het
Zfp429 T A 13: 67,538,531 (GRCm39) K304N probably benign Het
Zfp607b T A 7: 27,402,464 (GRCm39) S307T probably damaging Het
Other mutations in Ccnyl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03011:Ccnyl1 APN 1 64,747,631 (GRCm39) missense possibly damaging 0.93
R0217:Ccnyl1 UTSW 1 64,752,257 (GRCm39) unclassified probably benign
R3712:Ccnyl1 UTSW 1 64,753,827 (GRCm39) missense probably damaging 1.00
R4544:Ccnyl1 UTSW 1 64,762,735 (GRCm39) missense probably benign 0.00
R4546:Ccnyl1 UTSW 1 64,762,735 (GRCm39) missense probably benign 0.00
R4622:Ccnyl1 UTSW 1 64,757,417 (GRCm39) missense probably damaging 0.99
R4720:Ccnyl1 UTSW 1 64,752,290 (GRCm39) missense probably benign 0.12
R8506:Ccnyl1 UTSW 1 64,753,821 (GRCm39) missense possibly damaging 0.95
R9364:Ccnyl1 UTSW 1 64,753,750 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCACTCAGGAGGAAGTCTCAAG -3'
(R):5'- ATGGGAGAACTCTCTTACTGCC -3'

Sequencing Primer
(F):5'- CTTGACCCCCAGTATTGTAAAGGG -3'
(R):5'- CTATTGCACATTCCGCTG -3'
Posted On 2022-08-09