Incidental Mutation 'R9557:Wdr89'
ID 720820
Institutional Source Beutler Lab
Gene Symbol Wdr89
Ensembl Gene ENSMUSG00000045690
Gene Name WD repeat domain 89
Synonyms 2600001A11Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9557 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 75677370-75716311 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 75679666 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 196 (V196A)
Ref Sequence ENSEMBL: ENSMUSP00000050532 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062370] [ENSMUST00000187307]
AlphaFold Q9D0R9
Predicted Effect probably damaging
Transcript: ENSMUST00000062370
AA Change: V196A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050532
Gene: ENSMUSG00000045690
AA Change: V196A

DomainStartEndE-ValueType
WD40 20 56 3.82e1 SMART
WD40 59 98 1.85e-3 SMART
WD40 103 147 2.64e2 SMART
WD40 157 198 6.38e-7 SMART
WD40 205 244 1.1e2 SMART
WD40 308 348 1.82e-2 SMART
low complexity region 366 379 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000187307
AA Change: V196A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000140172
Gene: ENSMUSG00000045690
AA Change: V196A

DomainStartEndE-ValueType
WD40 20 56 3.82e1 SMART
WD40 59 98 1.85e-3 SMART
WD40 103 147 2.64e2 SMART
WD40 157 198 6.38e-7 SMART
WD40 205 244 1.1e2 SMART
WD40 308 348 1.82e-2 SMART
low complexity region 366 379 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 T A 3: 59,659,160 (GRCm39) N204K possibly damaging Het
Aadacl2fm3 T G 3: 59,784,654 (GRCm39) F376V possibly damaging Het
Abca5 A G 11: 110,197,109 (GRCm39) L523P probably damaging Het
Adcy5 T C 16: 35,091,327 (GRCm39) V590A probably damaging Het
Alg1 A T 16: 5,057,820 (GRCm39) D238V probably damaging Het
Ankrd55 C A 13: 112,485,347 (GRCm39) P187H probably damaging Het
Aox4 G T 1: 58,285,095 (GRCm39) V616F probably benign Het
Apc C A 18: 34,451,412 (GRCm39) H2769Q probably damaging Het
Bach1 C G 16: 87,516,603 (GRCm39) S381R probably benign Het
C2cd2l G A 9: 44,231,127 (GRCm39) A20V probably benign Het
Catsperg1 T C 7: 28,904,223 (GRCm39) D266G probably damaging Het
Ces4a A G 8: 105,869,527 (GRCm39) S233G possibly damaging Het
Comp T A 8: 70,829,854 (GRCm39) D359E probably benign Het
Cyp2b13 A C 7: 25,780,123 (GRCm39) N91T probably benign Het
Dhx9 A C 1: 153,333,292 (GRCm39) M1151R probably benign Het
Dync2i2 G A 2: 29,922,534 (GRCm39) A366V possibly damaging Het
E2f5 G T 3: 14,653,311 (GRCm39) L142F probably benign Het
Egflam G T 15: 7,241,656 (GRCm39) N917K probably damaging Het
Ercc6l2 C T 13: 63,989,936 (GRCm39) R254C probably damaging Het
Erh G A 12: 80,689,571 (GRCm39) P18S probably benign Het
Fam110b T C 4: 5,799,064 (GRCm39) S161P probably damaging Het
Fam210a TAAAATGTTCCAAA TAAA 18: 68,408,848 (GRCm39) probably null Het
Fbn1 T C 2: 125,180,458 (GRCm39) I1775V probably damaging Het
Fry C A 5: 150,389,781 (GRCm39) Q137K Het
Gm4787 A T 12: 81,426,074 (GRCm39) L28* probably null Het
Gpr179 A G 11: 97,235,029 (GRCm39) F434L probably damaging Het
Grik2 T C 10: 49,404,105 (GRCm39) Y252C probably damaging Het
H1f0 C T 15: 78,912,947 (GRCm39) P9L probably damaging Het
Hectd4 A G 5: 121,459,617 (GRCm39) T829A possibly damaging Het
Ing4 A G 6: 125,025,354 (GRCm39) E245G probably benign Het
Lgr4 C T 2: 109,827,084 (GRCm39) A196V probably damaging Het
Lrrc51 T A 7: 101,562,329 (GRCm39) K176N probably benign Het
Lrrc9 T A 12: 72,532,981 (GRCm39) M950K probably benign Het
Lrrd1 A T 5: 3,901,432 (GRCm39) D579V probably damaging Het
Magi3 C T 3: 103,922,473 (GRCm39) A1415T probably benign Het
Magi3 A C 3: 103,924,933 (GRCm39) I1072S probably damaging Het
Mast1 G A 8: 85,657,474 (GRCm39) T101I probably damaging Het
Mccc1 A T 3: 36,049,976 (GRCm39) V72E probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Megf8 A T 7: 25,058,511 (GRCm39) Q2169L possibly damaging Het
Mllt6 A G 11: 97,564,310 (GRCm39) D342G probably benign Het
Mycbp2 T A 14: 103,372,697 (GRCm39) T4050S probably benign Het
Nbeal1 A G 1: 60,274,509 (GRCm39) T307A probably benign Het
Or11g27 A G 14: 50,771,552 (GRCm39) T228A probably benign Het
Or52d3 T C 7: 104,229,768 (GRCm39) I305T probably damaging Het
Plat T C 8: 23,262,669 (GRCm39) F125L probably benign Het
Ppm1b T A 17: 85,301,501 (GRCm39) M127K probably benign Het
Ppp4r1 C A 17: 66,110,258 (GRCm39) D52E probably benign Het
Rasgrp3 T G 17: 75,807,139 (GRCm39) I201S probably damaging Het
Rfpl4b T A 10: 38,696,870 (GRCm39) M244L probably benign Het
Rhbdl3 A T 11: 80,244,277 (GRCm39) H328L probably benign Het
Rsad2 T A 12: 26,495,521 (GRCm39) I325F probably damaging Het
Shank2 T C 7: 143,963,847 (GRCm39) V485A probably benign Het
Slc6a5 A G 7: 49,561,474 (GRCm39) N2S probably benign Het
Sox4 G T 13: 29,136,913 (GRCm39) A31E probably damaging Het
Suv39h2 A T 2: 3,475,451 (GRCm39) C2S Het
Tet2 A G 3: 133,191,566 (GRCm39) I956T probably benign Het
Topaz1 A G 9: 122,578,530 (GRCm39) D480G possibly damaging Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Ugt1a6b G T 1: 88,034,820 (GRCm39) G53* probably null Het
Vmn1r173 T C 7: 23,402,209 (GRCm39) V148A probably damaging Het
Vnn1 G A 10: 23,776,723 (GRCm39) C358Y probably damaging Het
Wfdc6a T A 2: 164,425,758 (GRCm39) D71V possibly damaging Het
Zc3h3 T C 15: 75,711,145 (GRCm39) K439E probably damaging Het
Zfp367 T C 13: 64,300,586 (GRCm39) H73R probably damaging Het
Zfp955a G A 17: 33,461,107 (GRCm39) R342* probably null Het
Other mutations in Wdr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00837:Wdr89 APN 12 75,679,825 (GRCm39) nonsense probably null
IGL02176:Wdr89 APN 12 75,679,897 (GRCm39) missense probably damaging 0.96
IGL02472:Wdr89 APN 12 75,679,743 (GRCm39) missense probably damaging 1.00
IGL02973:Wdr89 APN 12 75,679,873 (GRCm39) missense probably damaging 0.98
R0003:Wdr89 UTSW 12 75,679,367 (GRCm39) missense probably benign 0.00
R2060:Wdr89 UTSW 12 75,679,762 (GRCm39) missense probably damaging 1.00
R4494:Wdr89 UTSW 12 75,679,521 (GRCm39) missense probably damaging 1.00
R5120:Wdr89 UTSW 12 75,679,412 (GRCm39) missense probably damaging 1.00
R5195:Wdr89 UTSW 12 75,680,062 (GRCm39) missense probably benign 0.23
R6572:Wdr89 UTSW 12 75,680,159 (GRCm39) missense probably damaging 1.00
R7487:Wdr89 UTSW 12 75,679,388 (GRCm39) missense probably benign
R7835:Wdr89 UTSW 12 75,679,673 (GRCm39) missense probably damaging 1.00
R8445:Wdr89 UTSW 12 75,679,636 (GRCm39) missense probably damaging 0.99
R8765:Wdr89 UTSW 12 75,679,688 (GRCm39) missense probably damaging 1.00
R9202:Wdr89 UTSW 12 75,679,943 (GRCm39) missense probably benign 0.00
R9269:Wdr89 UTSW 12 75,679,564 (GRCm39) missense possibly damaging 0.50
R9340:Wdr89 UTSW 12 75,679,937 (GRCm39) missense probably benign 0.11
R9522:Wdr89 UTSW 12 75,679,924 (GRCm39) missense probably damaging 1.00
R9760:Wdr89 UTSW 12 75,680,026 (GRCm39) missense probably damaging 0.99
X0023:Wdr89 UTSW 12 75,679,951 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACACGTGATCGGTTCATCTG -3'
(R):5'- TCATCAGCTTTGATGTCAACTGC -3'

Sequencing Primer
(F):5'- CTGTATCCAGATGATTGAGATCCCAC -3'
(R):5'- CAGCTTTGATGTCAACTGCAAAGATC -3'
Posted On 2022-08-09