Incidental Mutation 'R9558:Ogn'
ID 720873
Institutional Source Beutler Lab
Gene Symbol Ogn
Ensembl Gene ENSMUSG00000021390
Gene Name osteoglycin
Synonyms 3110079A16Rik, SLRR3A, mimican, mimecan, OG
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.403) question?
Stock # R9558 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 49761522-49777977 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49764783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 61 (E61G)
Ref Sequence ENSEMBL: ENSMUSP00000021822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021818] [ENSMUST00000021822]
AlphaFold Q62000
Predicted Effect probably benign
Transcript: ENSMUST00000021818
SMART Domains Protein: ENSMUSP00000021818
Gene: ENSMUSG00000021391

DomainStartEndE-ValueType
coiled coil region 1 34 N/A INTRINSIC
Pfam:CENP-P 102 278 3.9e-89 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000021822
AA Change: E61G

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000021822
Gene: ENSMUSG00000021390
AA Change: E61G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 93 123 3.52e0 SMART
LRR_TYP 142 165 4.4e-2 SMART
LRR 166 187 1.33e2 SMART
LRR 212 235 3.78e-1 SMART
LRR 236 256 5.27e1 SMART
low complexity region 263 271 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik C T 10: 76,290,576 (GRCm39) P126L probably damaging Het
Adh7 T A 3: 137,932,043 (GRCm39) I219N probably damaging Het
Ash1l A G 3: 88,889,521 (GRCm39) S467G probably benign Het
Atm T C 9: 53,412,081 (GRCm39) I992V probably benign Het
Bdnf T C 2: 109,539,999 (GRCm39) V31A Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Ccnk A T 12: 108,155,397 (GRCm39) K118I possibly damaging Het
Ccr2 T A 9: 123,906,104 (GRCm39) V128E possibly damaging Het
Cd163 C A 6: 124,297,471 (GRCm39) N872K probably benign Het
Cd38 A G 5: 44,057,792 (GRCm39) I121M probably damaging Het
Cntnap5c A T 17: 58,671,157 (GRCm39) probably null Het
Cyp11b1 T C 15: 74,710,789 (GRCm39) E257G probably benign Het
Cyp2d40 T C 15: 82,645,667 (GRCm39) T113A unknown Het
Ddx23 A G 15: 98,545,433 (GRCm39) V625A possibly damaging Het
Dnaaf9 T C 2: 130,617,660 (GRCm39) N433D probably damaging Het
Fbxw17 T C 13: 50,577,311 (GRCm39) Y68H probably damaging Het
Fignl1 C T 11: 11,751,778 (GRCm39) V426I possibly damaging Het
Ggn C G 7: 28,871,973 (GRCm39) P487R probably damaging Het
Gjb6 G A 14: 57,362,261 (GRCm39) probably benign Het
Gm5930 A G 14: 44,576,014 (GRCm39) F2L possibly damaging Het
Il1r2 A G 1: 40,162,422 (GRCm39) E355G probably damaging Het
Itprid1 T A 6: 55,944,969 (GRCm39) H563Q possibly damaging Het
Jarid2 C T 13: 45,068,253 (GRCm39) R1092W possibly damaging Het
Lama1 A G 17: 68,124,004 (GRCm39) T2810A Het
Ltn1 A T 16: 87,220,295 (GRCm39) S267R probably benign Het
Mapre2 T A 18: 23,991,195 (GRCm39) H196Q possibly damaging Het
Mfap4 A C 11: 61,376,965 (GRCm39) S65R probably benign Het
Mterf1a C T 5: 3,941,807 (GRCm39) W20* probably null Het
Myh1 C G 11: 67,108,618 (GRCm39) H1345D possibly damaging Het
Myh3 T A 11: 66,983,316 (GRCm39) C948S possibly damaging Het
Ndufa8 A G 2: 35,926,605 (GRCm39) S144P probably benign Het
Nudc G A 4: 133,260,776 (GRCm39) R257C probably benign Het
Nufip1 A G 14: 76,348,481 (GRCm39) M37V probably benign Het
Or52n5 T C 7: 104,588,615 (GRCm39) V294A possibly damaging Het
Pcdh8 A G 14: 80,006,380 (GRCm39) S728P probably damaging Het
Pdzrn4 A G 15: 92,299,877 (GRCm39) D249G possibly damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Setd2 C T 9: 110,376,628 (GRCm39) H148Y probably damaging Het
Smok2b G A 17: 13,453,884 (GRCm39) G15R probably damaging Het
Sun1 A G 5: 139,211,019 (GRCm39) T91A probably benign Het
Tbc1d31 G A 15: 57,795,988 (GRCm39) A194T probably damaging Het
Tiparp C T 3: 65,438,852 (GRCm39) S56F possibly damaging Het
Tmf1 C T 6: 97,147,293 (GRCm39) E558K possibly damaging Het
Trip6 A G 5: 137,309,075 (GRCm39) S344P probably benign Het
Ube2q1 A G 3: 89,686,766 (GRCm39) K207E probably benign Het
Ubr2 A G 17: 47,262,843 (GRCm39) V1256A probably benign Het
Vmn1r69 T A 7: 10,314,185 (GRCm39) Y182F probably benign Het
Wipf1 C A 2: 73,268,020 (GRCm39) R126L probably damaging Het
Zc3hav1 T C 6: 38,331,042 (GRCm39) E39G possibly damaging Het
Other mutations in Ogn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Ogn APN 13 49,774,514 (GRCm39) missense probably damaging 1.00
IGL00475:Ogn APN 13 49,776,391 (GRCm39) missense probably benign 0.01
IGL01830:Ogn APN 13 49,762,723 (GRCm39) nonsense probably null
R0116:Ogn UTSW 13 49,774,514 (GRCm39) missense possibly damaging 0.89
R1546:Ogn UTSW 13 49,762,809 (GRCm39) missense probably benign 0.00
R1554:Ogn UTSW 13 49,774,520 (GRCm39) missense probably benign 0.00
R3752:Ogn UTSW 13 49,776,307 (GRCm39) missense probably benign 0.44
R4005:Ogn UTSW 13 49,762,775 (GRCm39) missense possibly damaging 0.82
R5323:Ogn UTSW 13 49,762,817 (GRCm39) missense probably benign 0.00
R5946:Ogn UTSW 13 49,771,761 (GRCm39) missense probably benign 0.01
R7854:Ogn UTSW 13 49,774,514 (GRCm39) missense possibly damaging 0.89
R7970:Ogn UTSW 13 49,762,742 (GRCm39) missense probably benign
R8426:Ogn UTSW 13 49,774,567 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GAGAGAACAAGTGTCCTTTGTCC -3'
(R):5'- ACAGTTTTCATTCACGGTGTG -3'

Sequencing Primer
(F):5'- CAAGTGTCCTTTGTCCAATATGTG -3'
(R):5'- CATGGCATCTAACTATAGACTTTACC -3'
Posted On 2022-08-09