Incidental Mutation 'R9560:Olfr908'
ID 720962
Institutional Source Beutler Lab
Gene Symbol Olfr908
Ensembl Gene ENSMUSG00000063732
Gene Name olfactory receptor 908
Synonyms GA_x6K02T2PVTD-32216179-32217111, MOR165-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R9560 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38427330-38428261 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38427385 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 19 (S19N)
Ref Sequence ENSEMBL: ENSMUSP00000151016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000215139]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000215139
AA Change: S19N

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,839,082 (GRCm39) R502G probably damaging Het
A930004D18Rik G A 2: 18,032,218 (GRCm39) probably benign Het
Abhd16b T A 2: 181,135,103 (GRCm39) C2S probably damaging Het
Adam2 T C 14: 66,275,102 (GRCm39) M544V probably benign Het
Agbl3 T A 6: 34,823,843 (GRCm39) V841E possibly damaging Het
Aldh1l1 A G 6: 90,536,825 (GRCm39) D127G probably damaging Het
Ap1b1 G A 11: 4,976,363 (GRCm39) E464K probably benign Het
Cdh19 T A 1: 110,821,004 (GRCm39) E578V possibly damaging Het
Chat G A 14: 32,170,942 (GRCm39) Q186* probably null Het
Cited4 A G 4: 120,524,165 (GRCm39) T56A probably benign Het
Cpt1a T C 19: 3,402,531 (GRCm39) L63P possibly damaging Het
Havcr2 C A 11: 46,347,164 (GRCm39) A47E probably benign Het
Hdgfl1 C T 13: 26,953,239 (GRCm39) G278E probably damaging Het
Klf5 A T 14: 99,539,034 (GRCm39) Q149L probably benign Het
Klk10 A G 7: 43,433,746 (GRCm39) Y186C probably damaging Het
Krt79 C T 15: 101,846,277 (GRCm39) E224K probably damaging Het
Llgl2 A G 11: 115,725,682 (GRCm39) D10G probably damaging Het
Lrrc37a C T 11: 103,347,420 (GRCm39) V3092I unknown Het
Minar1 G T 9: 89,484,531 (GRCm39) Q289K probably benign Het
Nbeal1 A G 1: 60,368,544 (GRCm39) T2630A probably damaging Het
Ncor1 T C 11: 62,263,948 (GRCm39) T485A possibly damaging Het
Or10h1b C T 17: 33,395,868 (GRCm39) T164M probably damaging Het
Or10h5 G A 17: 33,434,986 (GRCm39) H111Y probably damaging Het
Or4c104 A C 2: 88,586,290 (GRCm39) I243S possibly damaging Het
Patj G A 4: 98,570,289 (GRCm39) E1705K probably benign Het
Pcdh17 T A 14: 84,770,898 (GRCm39) D1125E probably benign Het
Pfpl G C 19: 12,406,297 (GRCm39) E183Q probably damaging Het
Pnliprp2 T C 19: 58,762,523 (GRCm39) V376A possibly damaging Het
Pramel42 A T 5: 94,685,640 (GRCm39) R433S possibly damaging Het
Scn1a A T 2: 66,158,131 (GRCm39) L414Q probably damaging Het
Sfi1 ACA ACATCTTCCCAAAGCCAGTCA 11: 3,103,382 (GRCm39) probably benign Het
Slc22a23 A G 13: 34,381,851 (GRCm39) V411A possibly damaging Het
Slco1c1 T C 6: 141,515,076 (GRCm39) V657A probably benign Het
Slco3a1 A T 7: 74,153,931 (GRCm39) Y214N probably damaging Het
Sned1 A G 1: 93,202,110 (GRCm39) T633A probably damaging Het
Tmem175 T C 5: 108,789,693 (GRCm39) F96S probably damaging Het
Tmf1 C T 6: 97,147,293 (GRCm39) E558K possibly damaging Het
Tsbp1 A T 17: 34,663,016 (GRCm39) Q103H probably damaging Het
Ubac2 G A 14: 122,145,636 (GRCm39) G98D possibly damaging Het
Unc50 T A 1: 37,476,248 (GRCm39) V136D possibly damaging Het
Vmn1r49 T A 6: 90,049,382 (GRCm39) M207L probably benign Het
Zfp853 T C 5: 143,275,080 (GRCm39) E195G unknown Het
Zfyve9 A T 4: 108,575,334 (GRCm39) N582K possibly damaging Het
Other mutations in Olfr908
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4656:Olfr908 UTSW 9 38,427,852 (GRCm39) missense probably damaging 1.00
R4772:Olfr908 UTSW 9 38,427,897 (GRCm39) unclassified probably benign
R4795:Olfr908 UTSW 9 38,427,799 (GRCm39) missense probably damaging 0.98
R5296:Olfr908 UTSW 9 38,427,412 (GRCm39) missense probably damaging 1.00
R5325:Olfr908 UTSW 9 38,427,454 (GRCm39) missense probably damaging 1.00
R5371:Olfr908 UTSW 9 38,427,434 (GRCm39) small deletion probably benign
R5374:Olfr908 UTSW 9 38,427,434 (GRCm39) small deletion probably benign
R5473:Olfr908 UTSW 9 38,427,508 (GRCm39) missense probably damaging 1.00
R6761:Olfr908 UTSW 9 38,427,561 (GRCm39) missense probably damaging 1.00
R7743:Olfr908 UTSW 9 38,427,624 (GRCm39) missense possibly damaging 0.66
Predicted Primers
Posted On 2022-08-09