Incidental Mutation 'R9561:Zfp609'
| ID |
721016 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp609
|
| Ensembl Gene |
ENSMUSG00000040524 |
| Gene Name |
zinc finger protein 609 |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.620)
|
| Stock # |
R9561 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
65599673-65734846 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 65604512 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 1324
(Q1324*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159109]
|
| AlphaFold |
Q8BZ47 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000159109
AA Change: Q1324*
|
| SMART Domains |
Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: Q1324*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
101 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
139 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
405 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
520 |
2.14e0 |
SMART |
|
low complexity region
|
629 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1210 |
1219 |
N/A |
INTRINSIC |
|
low complexity region
|
1257 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1329 |
1348 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
A |
G |
16: 4,680,980 (GRCm39) |
I106V |
possibly damaging |
Het |
| Aars1 |
C |
A |
8: 111,763,615 (GRCm39) |
F18L |
probably damaging |
Het |
| Abca7 |
C |
T |
10: 79,837,535 (GRCm39) |
T473I |
probably damaging |
Het |
| Ap1m2 |
A |
T |
9: 21,209,524 (GRCm39) |
I384N |
probably damaging |
Het |
| Atg16l2 |
G |
A |
7: 100,948,248 (GRCm39) |
Q99* |
probably null |
Het |
| Bptf |
A |
T |
11: 106,964,954 (GRCm39) |
Y1413* |
probably null |
Het |
| Cat |
T |
C |
2: 103,307,250 (GRCm39) |
T28A |
probably damaging |
Het |
| Ccdc65 |
T |
A |
15: 98,620,759 (GRCm39) |
V418D |
probably benign |
Het |
| Cd226 |
A |
C |
18: 89,265,444 (GRCm39) |
I241L |
probably benign |
Het |
| Crybg1 |
A |
G |
10: 43,873,428 (GRCm39) |
S1227P |
probably benign |
Het |
| Csn2 |
C |
T |
5: 87,842,794 (GRCm39) |
A78T |
probably benign |
Het |
| Cyp21a1 |
T |
A |
17: 35,021,652 (GRCm39) |
H305L |
possibly damaging |
Het |
| Ddx55 |
A |
G |
5: 124,706,707 (GRCm39) |
E572G |
possibly damaging |
Het |
| Dguok |
A |
G |
6: 83,467,548 (GRCm39) |
Y100H |
probably damaging |
Het |
| Dync1h1 |
T |
A |
12: 110,615,533 (GRCm39) |
S2955R |
probably damaging |
Het |
| Etfbkmt |
A |
T |
6: 149,045,640 (GRCm39) |
|
probably benign |
Het |
| Fam222a |
T |
A |
5: 114,749,347 (GRCm39) |
I181N |
probably damaging |
Het |
| Fam24b |
T |
C |
7: 130,927,877 (GRCm39) |
D104G |
probably benign |
Het |
| Fbn2 |
A |
T |
18: 58,181,611 (GRCm39) |
C1883* |
probably null |
Het |
| Fchsd2 |
T |
G |
7: 100,920,778 (GRCm39) |
L461R |
probably benign |
Het |
| Hdgfl1 |
C |
T |
13: 26,953,239 (GRCm39) |
G278E |
probably damaging |
Het |
| Hectd4 |
G |
A |
5: 121,472,532 (GRCm39) |
R2756Q |
possibly damaging |
Het |
| Ints14 |
A |
G |
9: 64,882,932 (GRCm39) |
D261G |
probably damaging |
Het |
| Mapkapk5 |
C |
T |
5: 121,672,490 (GRCm39) |
A163T |
probably benign |
Het |
| Micu3 |
A |
T |
8: 40,835,156 (GRCm39) |
K504* |
probably null |
Het |
| Myh1 |
C |
G |
11: 67,108,618 (GRCm39) |
H1345D |
possibly damaging |
Het |
| Myh7 |
C |
A |
14: 55,216,146 (GRCm39) |
R1289L |
probably damaging |
Het |
| Neb |
G |
T |
2: 52,132,068 (GRCm39) |
H280Q |
|
Het |
| Nrbp1 |
T |
A |
5: 31,404,771 (GRCm39) |
|
probably null |
Het |
| Oacyl |
T |
A |
18: 65,831,414 (GRCm39) |
V17D |
possibly damaging |
Het |
| Obsl1 |
C |
A |
1: 75,480,157 (GRCm39) |
R463L |
possibly damaging |
Het |
| Or1f19 |
T |
A |
16: 3,410,725 (GRCm39) |
L155Q |
probably damaging |
Het |
| Or8b40 |
G |
A |
9: 38,028,010 (GRCm39) |
S311N |
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,217,128 (GRCm39) |
C2184* |
probably null |
Het |
| Pfpl |
G |
C |
19: 12,406,297 (GRCm39) |
E183Q |
probably damaging |
Het |
| Phrf1 |
T |
G |
7: 140,834,815 (GRCm39) |
S198A |
unknown |
Het |
| Plekhg2 |
C |
G |
7: 28,064,249 (GRCm39) |
A431P |
probably damaging |
Het |
| Ppp1r13b |
C |
T |
12: 111,810,077 (GRCm39) |
D244N |
probably damaging |
Het |
| Raph1 |
T |
C |
1: 60,564,887 (GRCm39) |
E200G |
possibly damaging |
Het |
| Rnf6 |
A |
G |
5: 146,147,936 (GRCm39) |
S361P |
probably benign |
Het |
| Scgb2b19 |
G |
A |
7: 32,978,039 (GRCm39) |
A86V |
probably benign |
Het |
| Sec23b |
T |
A |
2: 144,408,728 (GRCm39) |
C138S |
possibly damaging |
Het |
| Slco1c1 |
T |
C |
6: 141,505,606 (GRCm39) |
S511P |
possibly damaging |
Het |
| Tas2r130 |
A |
G |
6: 131,607,175 (GRCm39) |
S207P |
probably damaging |
Het |
| Tdpoz1 |
A |
T |
3: 93,578,540 (GRCm39) |
H81Q |
probably benign |
Het |
| Usp8 |
A |
G |
2: 126,578,414 (GRCm39) |
K289E |
probably damaging |
Het |
| Vmn1r18 |
A |
C |
6: 57,367,202 (GRCm39) |
N117K |
probably benign |
Het |
| Vps13c |
G |
T |
9: 67,872,794 (GRCm39) |
G3270V |
probably damaging |
Het |
| Wdr20 |
A |
G |
12: 110,760,187 (GRCm39) |
T358A |
probably benign |
Het |
| Wwc1 |
A |
C |
11: 35,870,796 (GRCm39) |
|
probably null |
Het |
| Yars2 |
G |
T |
16: 16,127,242 (GRCm39) |
V436L |
possibly damaging |
Het |
| Zfp81 |
T |
C |
17: 33,553,774 (GRCm39) |
T347A |
probably benign |
Het |
| Zgpat |
T |
C |
2: 181,021,366 (GRCm39) |
V292A |
probably benign |
Het |
|
| Other mutations in Zfp609 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00956:Zfp609
|
APN |
9 |
65,610,045 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01688:Zfp609
|
APN |
9 |
65,611,307 (GRCm39) |
missense |
probably benign |
|
|
IGL01718:Zfp609
|
APN |
9 |
65,609,682 (GRCm39) |
nonsense |
probably null |
|
|
IGL01860:Zfp609
|
APN |
9 |
65,610,116 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02441:Zfp609
|
APN |
9 |
65,610,611 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02490:Zfp609
|
APN |
9 |
65,611,250 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02614:Zfp609
|
APN |
9 |
65,610,072 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02794:Zfp609
|
APN |
9 |
65,611,602 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02959:Zfp609
|
APN |
9 |
65,610,675 (GRCm39) |
missense |
probably benign |
|
|
IGL02967:Zfp609
|
APN |
9 |
65,604,901 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03036:Zfp609
|
APN |
9 |
65,609,927 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03182:Zfp609
|
APN |
9 |
65,608,287 (GRCm39) |
missense |
probably benign |
0.02 |
|
H8441:Zfp609
|
UTSW |
9 |
65,702,169 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0304:Zfp609
|
UTSW |
9 |
65,608,470 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0487:Zfp609
|
UTSW |
9 |
65,609,916 (GRCm39) |
missense |
unknown |
|
|
R0505:Zfp609
|
UTSW |
9 |
65,610,744 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0684:Zfp609
|
UTSW |
9 |
65,638,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1480:Zfp609
|
UTSW |
9 |
65,610,593 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1507:Zfp609
|
UTSW |
9 |
65,702,059 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1579:Zfp609
|
UTSW |
9 |
65,611,754 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1655:Zfp609
|
UTSW |
9 |
65,610,836 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1692:Zfp609
|
UTSW |
9 |
65,702,593 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Zfp609
|
UTSW |
9 |
65,638,282 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1735:Zfp609
|
UTSW |
9 |
65,610,374 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Zfp609
|
UTSW |
9 |
65,702,040 (GRCm39) |
missense |
probably benign |
|
|
R1970:Zfp609
|
UTSW |
9 |
65,702,559 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2059:Zfp609
|
UTSW |
9 |
65,611,716 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2302:Zfp609
|
UTSW |
9 |
65,702,179 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3404:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3405:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4514:Zfp609
|
UTSW |
9 |
65,610,977 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4533:Zfp609
|
UTSW |
9 |
65,610,890 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5043:Zfp609
|
UTSW |
9 |
65,608,109 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5499:Zfp609
|
UTSW |
9 |
65,610,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7081:Zfp609
|
UTSW |
9 |
65,609,723 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7514:Zfp609
|
UTSW |
9 |
65,613,418 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7677:Zfp609
|
UTSW |
9 |
65,604,456 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7684:Zfp609
|
UTSW |
9 |
65,638,362 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8229:Zfp609
|
UTSW |
9 |
65,610,782 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8266:Zfp609
|
UTSW |
9 |
65,610,996 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8278:Zfp609
|
UTSW |
9 |
65,604,804 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8934:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8938:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8940:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8986:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9267:Zfp609
|
UTSW |
9 |
65,608,328 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9456:Zfp609
|
UTSW |
9 |
65,611,125 (GRCm39) |
missense |
|
|
|
X0028:Zfp609
|
UTSW |
9 |
65,604,362 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTTGTTACAGGCAGTACTAC -3'
(R):5'- ACTTGGGTGACTTGATACCAGC -3'
Sequencing Primer
(F):5'- CTTACCTGCGGCATAGGGTAG -3'
(R):5'- GGTGACTTGATACCAGCCTCATAAG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation