Incidental Mutation 'R9562:Dop1a'
| ID |
721104 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dop1a
|
| Ensembl Gene |
ENSMUSG00000034973 |
| Gene Name |
DOP1 leucine zipper like protein A |
| Synonyms |
D9Ertd809e, B130005I07Rik, Dopey1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.338)
|
| Stock # |
R9562 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
86349194-86436683 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 86424811 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glutamine
at position 2085
(R2085Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000034987
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034987]
[ENSMUST00000185919]
[ENSMUST00000189817]
[ENSMUST00000190957]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000034987
AA Change: R2085Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000034987
Gene: ENSMUSG00000034973
AA Change: R2085Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
11 |
300 |
1e-117 |
PFAM |
|
low complexity region
|
631 |
649 |
N/A |
INTRINSIC |
|
low complexity region
|
961 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1105 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1268 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1318 |
N/A |
INTRINSIC |
|
low complexity region
|
1335 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1575 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
2217 |
2227 |
N/A |
INTRINSIC |
|
low complexity region
|
2351 |
2362 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185919
|
| SMART Domains |
Protein: ENSMUSP00000140040
Gene: ENSMUSG00000034973
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
10 |
306 |
1.9e-106 |
PFAM |
|
low complexity region
|
629 |
647 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
1071 |
1082 |
N/A |
INTRINSIC |
|
low complexity region
|
1103 |
1116 |
N/A |
INTRINSIC |
|
low complexity region
|
1266 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1342 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1587 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189817
AA Change: R153Q
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190957
AA Change: R2085Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140740
Gene: ENSMUSG00000034973
AA Change: R2085Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
10 |
305 |
1.3e-108 |
PFAM |
|
low complexity region
|
631 |
649 |
N/A |
INTRINSIC |
|
low complexity region
|
961 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1105 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1268 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1318 |
N/A |
INTRINSIC |
|
low complexity region
|
1335 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1575 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
2217 |
2227 |
N/A |
INTRINSIC |
|
low complexity region
|
2351 |
2362 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 129 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acacb |
C |
A |
5: 114,371,397 (GRCm39) |
P1842Q |
probably damaging |
Het |
| Aco2 |
G |
A |
15: 81,773,635 (GRCm39) |
R58Q |
probably null |
Het |
| Acvr1 |
T |
C |
2: 58,338,385 (GRCm39) |
K446E |
probably damaging |
Het |
| Adam39 |
T |
C |
8: 41,277,755 (GRCm39) |
Y49H |
probably benign |
Het |
| Afg3l2 |
C |
T |
18: 67,554,365 (GRCm39) |
V446M |
probably damaging |
Het |
| Aire |
A |
G |
10: 77,871,579 (GRCm39) |
V397A |
probably benign |
Het |
| Ankdd1a |
C |
T |
9: 65,411,452 (GRCm39) |
A352T |
possibly damaging |
Het |
| Aoc1l2 |
T |
C |
6: 48,907,909 (GRCm39) |
M303T |
probably benign |
Het |
| Arfip2 |
T |
C |
7: 105,286,079 (GRCm39) |
D270G |
possibly damaging |
Het |
| Arl4c |
A |
G |
1: 88,629,134 (GRCm39) |
C85R |
probably damaging |
Het |
| Arpp21 |
A |
C |
9: 111,956,354 (GRCm39) |
V541G |
possibly damaging |
Het |
| Atp2a3 |
T |
A |
11: 72,873,578 (GRCm39) |
M817K |
probably damaging |
Het |
| Bahcc1 |
C |
T |
11: 120,150,035 (GRCm39) |
H106Y |
possibly damaging |
Het |
| Bcl9l |
A |
G |
9: 44,412,076 (GRCm39) |
S21G |
possibly damaging |
Het |
| C7 |
T |
A |
15: 5,086,579 (GRCm39) |
|
probably null |
Het |
| Cabcoco1 |
T |
C |
10: 68,272,725 (GRCm39) |
D220G |
possibly damaging |
Het |
| Cacna1e |
T |
A |
1: 154,283,486 (GRCm39) |
D1960V |
probably benign |
Het |
| Casp4 |
A |
T |
9: 5,324,832 (GRCm39) |
T215S |
probably damaging |
Het |
| Ccdc187 |
T |
C |
2: 26,183,698 (GRCm39) |
S101G |
possibly damaging |
Het |
| Cdk12 |
A |
G |
11: 98,140,628 (GRCm39) |
N1290D |
unknown |
Het |
| Cdo1 |
C |
A |
18: 46,861,104 (GRCm39) |
V36L |
probably benign |
Het |
| Col5a3 |
G |
A |
9: 20,714,429 (GRCm39) |
A381V |
unknown |
Het |
| Cspg4b |
T |
C |
13: 113,504,574 (GRCm39) |
I1901T |
|
Het |
| Dcpp2 |
A |
G |
17: 24,119,453 (GRCm39) |
E89G |
probably damaging |
Het |
| Dhx57 |
G |
T |
17: 80,561,817 (GRCm39) |
A899E |
probably damaging |
Het |
| Dnaaf1 |
T |
C |
8: 120,309,392 (GRCm39) |
I160T |
probably damaging |
Het |
| Dnah1 |
C |
A |
14: 30,986,394 (GRCm39) |
A3698S |
probably damaging |
Het |
| Dnah12 |
C |
A |
14: 26,597,281 (GRCm39) |
R3547S |
possibly damaging |
Het |
| Dnah3 |
A |
G |
7: 119,610,114 (GRCm39) |
V1774A |
probably benign |
Het |
| Duox1 |
T |
C |
2: 122,151,203 (GRCm39) |
Y293H |
probably damaging |
Het |
| Efcab5 |
G |
A |
11: 77,022,934 (GRCm39) |
T593I |
probably damaging |
Het |
| Elp1 |
G |
T |
4: 56,772,521 (GRCm39) |
P867T |
probably benign |
Het |
| Epas1 |
T |
A |
17: 87,112,667 (GRCm39) |
D88E |
probably damaging |
Het |
| Epdr1 |
A |
G |
13: 19,778,821 (GRCm39) |
F92L |
possibly damaging |
Het |
| Ercc6 |
T |
C |
14: 32,296,924 (GRCm39) |
W1305R |
probably damaging |
Het |
| Etv6 |
A |
G |
6: 134,225,672 (GRCm39) |
N212S |
probably benign |
Het |
| Fam20b |
A |
T |
1: 156,530,010 (GRCm39) |
Y141* |
probably null |
Het |
| Fancm |
A |
G |
12: 65,168,494 (GRCm39) |
N1619S |
probably damaging |
Het |
| Fbln5 |
A |
T |
12: 101,734,722 (GRCm39) |
N183K |
probably damaging |
Het |
| Fer1l6 |
A |
G |
15: 58,490,370 (GRCm39) |
D976G |
possibly damaging |
Het |
| Fgb |
T |
C |
3: 82,952,409 (GRCm39) |
|
probably null |
Het |
| Fhod1 |
A |
T |
8: 106,074,422 (GRCm39) |
Y22N |
unknown |
Het |
| Foxl3 |
C |
A |
5: 138,807,213 (GRCm39) |
Q164K |
probably benign |
Het |
| Galm |
C |
T |
17: 80,490,859 (GRCm39) |
Q166* |
probably null |
Het |
| Gbe1 |
A |
T |
16: 70,198,664 (GRCm39) |
Y119F |
probably benign |
Het |
| Gcnt7 |
T |
A |
2: 172,293,180 (GRCm39) |
Y369F |
probably damaging |
Het |
| Gdap2 |
T |
C |
3: 100,099,006 (GRCm39) |
I366T |
possibly damaging |
Het |
| Gm14295 |
T |
C |
2: 176,499,162 (GRCm39) |
V4A |
probably benign |
Het |
| Gm32742 |
T |
A |
9: 51,068,327 (GRCm39) |
Y249F |
probably benign |
Het |
| Gm40460 |
A |
T |
7: 141,794,701 (GRCm39) |
C39S |
unknown |
Het |
| Gm6370 |
T |
A |
5: 146,429,281 (GRCm39) |
C120* |
probably null |
Het |
| Harbi1 |
T |
A |
2: 91,542,698 (GRCm39) |
L53* |
probably null |
Het |
| Herc3 |
A |
G |
6: 58,835,999 (GRCm39) |
N280S |
probably null |
Het |
| Hipk2 |
T |
A |
6: 38,724,390 (GRCm39) |
R447W |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,312,786 (GRCm39) |
I4176V |
probably benign |
Het |
| Ifi211 |
A |
T |
1: 173,733,052 (GRCm39) |
I203N |
probably benign |
Het |
| Kcnc1 |
G |
A |
7: 46,077,010 (GRCm39) |
V271M |
probably benign |
Het |
| Kcng1 |
T |
A |
2: 168,104,797 (GRCm39) |
I350F |
probably damaging |
Het |
| Kif21b |
A |
T |
1: 136,077,090 (GRCm39) |
I371F |
probably damaging |
Het |
| Klrc1 |
A |
G |
6: 129,655,746 (GRCm39) |
F43S |
probably damaging |
Het |
| Krtap6-2 |
A |
G |
16: 89,216,722 (GRCm39) |
S82P |
unknown |
Het |
| Lamb1 |
T |
A |
12: 31,322,492 (GRCm39) |
M186K |
probably damaging |
Het |
| Lrig2 |
T |
C |
3: 104,375,924 (GRCm39) |
K451E |
possibly damaging |
Het |
| Lrrc15 |
G |
A |
16: 30,093,016 (GRCm39) |
L108F |
probably damaging |
Het |
| Mark3 |
A |
G |
12: 111,570,960 (GRCm39) |
I87V |
probably damaging |
Het |
| Mlh1 |
T |
C |
9: 111,060,013 (GRCm39) |
K622E |
|
Het |
| Mrgprb2 |
G |
A |
7: 48,202,674 (GRCm39) |
T17M |
possibly damaging |
Het |
| Msantd5f4 |
G |
T |
4: 73,557,190 (GRCm39) |
V8F |
probably damaging |
Het |
| Mtmr4 |
C |
T |
11: 87,493,241 (GRCm39) |
R225C |
probably damaging |
Het |
| Nfatc1 |
A |
G |
18: 80,678,916 (GRCm39) |
L824P |
probably damaging |
Het |
| Nlrp4f |
A |
T |
13: 65,347,053 (GRCm39) |
D46E |
probably damaging |
Het |
| Oga |
CTCGGGTC |
CTC |
19: 45,743,096 (GRCm39) |
|
probably null |
Het |
| Or10h5 |
G |
T |
17: 33,434,415 (GRCm39) |
T301N |
probably benign |
Het |
| Or13n4 |
A |
C |
7: 106,423,020 (GRCm39) |
F238V |
probably damaging |
Het |
| Or1l4 |
G |
T |
2: 37,091,575 (GRCm39) |
M107I |
probably benign |
Het |
| Or2w25 |
T |
A |
11: 59,504,580 (GRCm39) |
N263K |
probably damaging |
Het |
| Or6z7 |
G |
C |
7: 6,483,243 (GRCm39) |
A304G |
probably null |
Het |
| Or7e173 |
T |
A |
9: 19,939,045 (GRCm39) |
Y63F |
probably damaging |
Het |
| Or8b1 |
G |
T |
9: 38,400,092 (GRCm39) |
A256S |
possibly damaging |
Het |
| Otulin |
A |
G |
15: 27,608,812 (GRCm39) |
Y244H |
probably damaging |
Het |
| Pabpc4 |
T |
C |
4: 123,180,653 (GRCm39) |
I125T |
probably damaging |
Het |
| Parp14 |
A |
G |
16: 35,677,775 (GRCm39) |
I731T |
probably benign |
Het |
| Parp8 |
T |
C |
13: 117,029,631 (GRCm39) |
T531A |
probably benign |
Het |
| Parvg |
G |
T |
15: 84,213,065 (GRCm39) |
V49L |
probably benign |
Het |
| Pcdha12 |
T |
C |
18: 37,155,284 (GRCm39) |
S668P |
probably damaging |
Het |
| Pcdhb9 |
A |
C |
18: 37,534,665 (GRCm39) |
N220H |
probably benign |
Het |
| Pcdhga4 |
T |
G |
18: 37,819,527 (GRCm39) |
S359A |
probably benign |
Het |
| Pi4k2b |
T |
A |
5: 52,908,799 (GRCm39) |
S208R |
probably damaging |
Het |
| Plxnb2 |
T |
C |
15: 89,050,136 (GRCm39) |
Y487C |
probably damaging |
Het |
| Pm20d1 |
G |
A |
1: 131,730,501 (GRCm39) |
V252I |
probably damaging |
Het |
| Pxdc1 |
T |
A |
13: 34,836,258 (GRCm39) |
H54L |
probably damaging |
Het |
| Rag1 |
A |
T |
2: 101,473,327 (GRCm39) |
V605E |
probably damaging |
Het |
| Rasgrf2 |
A |
T |
13: 92,034,469 (GRCm39) |
|
probably null |
Het |
| Relch |
T |
C |
1: 105,591,876 (GRCm39) |
V15A |
probably damaging |
Het |
| Rflnb |
T |
A |
11: 75,912,951 (GRCm39) |
T146S |
probably damaging |
Het |
| Rfx5 |
T |
A |
3: 94,866,639 (GRCm39) |
L646Q |
unknown |
Het |
| Rnf43 |
A |
G |
11: 87,618,891 (GRCm39) |
T81A |
probably benign |
Het |
| Ros1 |
T |
C |
10: 51,943,170 (GRCm39) |
D2048G |
probably damaging |
Het |
| Rpl13a-ps1 |
T |
A |
19: 50,018,612 (GRCm39) |
K188I |
possibly damaging |
Het |
| Rpl24 |
T |
A |
16: 55,790,509 (GRCm39) |
S122T |
probably benign |
Het |
| Ryr2 |
G |
A |
13: 11,760,104 (GRCm39) |
T1549M |
probably damaging |
Het |
| Sbf2 |
T |
C |
7: 110,040,702 (GRCm39) |
Q375R |
possibly damaging |
Het |
| Sec23a |
A |
T |
12: 59,048,817 (GRCm39) |
F131I |
possibly damaging |
Het |
| Secisbp2 |
T |
C |
13: 51,837,320 (GRCm39) |
I827T |
probably damaging |
Het |
| Serpinb6d |
A |
G |
13: 33,854,756 (GRCm39) |
R244G |
probably benign |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Snx17 |
C |
A |
5: 31,355,088 (GRCm39) |
Q368K |
probably damaging |
Het |
| Stac |
T |
A |
9: 111,401,411 (GRCm39) |
E345V |
probably benign |
Het |
| Stx4a |
A |
G |
7: 127,445,375 (GRCm39) |
N164S |
possibly damaging |
Het |
| Tasor |
T |
C |
14: 27,201,766 (GRCm39) |
|
probably null |
Het |
| Tbcb |
A |
T |
7: 29,930,549 (GRCm39) |
|
probably null |
Het |
| Tecpr2 |
T |
C |
12: 110,914,141 (GRCm39) |
S1151P |
possibly damaging |
Het |
| Timm50 |
A |
G |
7: 28,007,069 (GRCm39) |
F202S |
possibly damaging |
Het |
| Tle2 |
A |
G |
10: 81,417,567 (GRCm39) |
D244G |
probably benign |
Het |
| Tlr4 |
G |
A |
4: 66,759,522 (GRCm39) |
V772I |
possibly damaging |
Het |
| Tmem214 |
G |
A |
5: 31,027,043 (GRCm39) |
W11* |
probably null |
Het |
| Tmem241 |
A |
T |
18: 12,176,356 (GRCm39) |
L227* |
probably null |
Het |
| Top2b |
A |
C |
14: 16,365,718 (GRCm38) |
T14P |
probably benign |
Het |
| Trim44 |
T |
C |
2: 102,187,827 (GRCm39) |
T309A |
probably benign |
Het |
| Trps1 |
A |
C |
15: 50,524,657 (GRCm39) |
I1091S |
probably damaging |
Het |
| Tspan2 |
C |
A |
3: 102,672,583 (GRCm39) |
T200K |
probably damaging |
Het |
| Tuba8 |
A |
G |
6: 121,200,063 (GRCm39) |
N249S |
probably benign |
Het |
| Vmn1r189 |
A |
G |
13: 22,286,426 (GRCm39) |
L137P |
probably damaging |
Het |
| Vmn2r29 |
A |
T |
7: 7,244,855 (GRCm39) |
W340R |
probably benign |
Het |
| Vmn2r52 |
A |
C |
7: 9,893,476 (GRCm39) |
D554E |
probably benign |
Het |
| Zc3h4 |
C |
G |
7: 16,168,891 (GRCm39) |
P1075R |
unknown |
Het |
| Zfp599 |
A |
G |
9: 22,160,999 (GRCm39) |
S389P |
probably damaging |
Het |
| Zfp777 |
A |
T |
6: 48,021,580 (GRCm39) |
V14D |
possibly damaging |
Het |
| Zswim8 |
C |
T |
14: 20,762,150 (GRCm39) |
Q262* |
probably null |
Het |
|
| Other mutations in Dop1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Dop1a
|
APN |
9 |
86,433,732 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,552 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,551 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,553 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00577:Dop1a
|
APN |
9 |
86,402,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00741:Dop1a
|
APN |
9 |
86,404,859 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL00959:Dop1a
|
APN |
9 |
86,369,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01339:Dop1a
|
APN |
9 |
86,433,730 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01608:Dop1a
|
APN |
9 |
86,389,614 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL01760:Dop1a
|
APN |
9 |
86,401,976 (GRCm39) |
missense |
probably benign |
|
|
IGL01788:Dop1a
|
APN |
9 |
86,413,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01844:Dop1a
|
APN |
9 |
86,396,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01923:Dop1a
|
APN |
9 |
86,404,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02036:Dop1a
|
APN |
9 |
86,413,818 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02308:Dop1a
|
APN |
9 |
86,402,141 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02494:Dop1a
|
APN |
9 |
86,408,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02698:Dop1a
|
APN |
9 |
86,406,412 (GRCm39) |
splice site |
probably benign |
|
|
IGL02731:Dop1a
|
APN |
9 |
86,369,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02821:Dop1a
|
APN |
9 |
86,402,209 (GRCm39) |
missense |
probably benign |
|
|
IGL02952:Dop1a
|
APN |
9 |
86,414,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL03071:Dop1a
|
APN |
9 |
86,371,668 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03271:Dop1a
|
APN |
9 |
86,386,275 (GRCm39) |
nonsense |
probably null |
|
|
IGL03344:Dop1a
|
APN |
9 |
86,418,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Beg
|
UTSW |
9 |
86,430,225 (GRCm39) |
nonsense |
probably null |
|
|
covet
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
crave
|
UTSW |
9 |
86,399,092 (GRCm39) |
missense |
probably benign |
|
|
desire
|
UTSW |
9 |
86,402,109 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
groak
|
UTSW |
9 |
86,403,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Querer
|
UTSW |
9 |
86,386,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
yearn
|
UTSW |
9 |
86,386,220 (GRCm39) |
splice site |
probably null |
|
|
R0055:Dop1a
|
UTSW |
9 |
86,394,705 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0285:Dop1a
|
UTSW |
9 |
86,394,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0415:Dop1a
|
UTSW |
9 |
86,388,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Dop1a
|
UTSW |
9 |
86,389,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Dop1a
|
UTSW |
9 |
86,402,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Dop1a
|
UTSW |
9 |
86,367,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1118:Dop1a
|
UTSW |
9 |
86,397,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Dop1a
|
UTSW |
9 |
86,367,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1272:Dop1a
|
UTSW |
9 |
86,403,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Dop1a
|
UTSW |
9 |
86,424,785 (GRCm39) |
splice site |
probably null |
|
|
R1584:Dop1a
|
UTSW |
9 |
86,430,225 (GRCm39) |
nonsense |
probably null |
|
|
R1601:Dop1a
|
UTSW |
9 |
86,418,303 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1674:Dop1a
|
UTSW |
9 |
86,418,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1706:Dop1a
|
UTSW |
9 |
86,436,133 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1856:Dop1a
|
UTSW |
9 |
86,374,057 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1926:Dop1a
|
UTSW |
9 |
86,405,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1929:Dop1a
|
UTSW |
9 |
86,376,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2029:Dop1a
|
UTSW |
9 |
86,403,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Dop1a
|
UTSW |
9 |
86,403,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Dop1a
|
UTSW |
9 |
86,403,652 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2271:Dop1a
|
UTSW |
9 |
86,376,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dop1a
|
UTSW |
9 |
86,403,495 (GRCm39) |
nonsense |
probably null |
|
|
R2379:Dop1a
|
UTSW |
9 |
86,403,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Dop1a
|
UTSW |
9 |
86,395,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3737:Dop1a
|
UTSW |
9 |
86,376,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3804:Dop1a
|
UTSW |
9 |
86,403,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3916:Dop1a
|
UTSW |
9 |
86,403,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3921:Dop1a
|
UTSW |
9 |
86,402,324 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4035:Dop1a
|
UTSW |
9 |
86,376,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4392:Dop1a
|
UTSW |
9 |
86,385,196 (GRCm39) |
intron |
probably benign |
|
|
R4404:Dop1a
|
UTSW |
9 |
86,404,866 (GRCm39) |
nonsense |
probably null |
|
|
R4513:Dop1a
|
UTSW |
9 |
86,402,612 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4624:Dop1a
|
UTSW |
9 |
86,403,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4659:Dop1a
|
UTSW |
9 |
86,384,085 (GRCm39) |
intron |
probably benign |
|
|
R4910:Dop1a
|
UTSW |
9 |
86,374,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4919:Dop1a
|
UTSW |
9 |
86,402,109 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5061:Dop1a
|
UTSW |
9 |
86,385,161 (GRCm39) |
splice site |
probably benign |
|
|
R5079:Dop1a
|
UTSW |
9 |
86,369,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5118:Dop1a
|
UTSW |
9 |
86,388,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5169:Dop1a
|
UTSW |
9 |
86,415,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5176:Dop1a
|
UTSW |
9 |
86,403,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5190:Dop1a
|
UTSW |
9 |
86,369,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Dop1a
|
UTSW |
9 |
86,397,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Dop1a
|
UTSW |
9 |
86,402,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Dop1a
|
UTSW |
9 |
86,427,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5501:Dop1a
|
UTSW |
9 |
86,389,783 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5554:Dop1a
|
UTSW |
9 |
86,403,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5707:Dop1a
|
UTSW |
9 |
86,385,050 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5826:Dop1a
|
UTSW |
9 |
86,389,623 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5921:Dop1a
|
UTSW |
9 |
86,383,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5934:Dop1a
|
UTSW |
9 |
86,424,495 (GRCm39) |
nonsense |
probably null |
|
|
R5936:Dop1a
|
UTSW |
9 |
86,418,565 (GRCm39) |
nonsense |
probably null |
|
|
R6046:Dop1a
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Dop1a
|
UTSW |
9 |
86,397,347 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6072:Dop1a
|
UTSW |
9 |
86,389,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6104:Dop1a
|
UTSW |
9 |
86,402,860 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6125:Dop1a
|
UTSW |
9 |
86,403,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Dop1a
|
UTSW |
9 |
86,386,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6930:Dop1a
|
UTSW |
9 |
86,413,825 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6949:Dop1a
|
UTSW |
9 |
86,382,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Dop1a
|
UTSW |
9 |
86,403,695 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7035:Dop1a
|
UTSW |
9 |
86,406,355 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7069:Dop1a
|
UTSW |
9 |
86,432,222 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7101:Dop1a
|
UTSW |
9 |
86,389,722 (GRCm39) |
missense |
probably benign |
|
|
R7202:Dop1a
|
UTSW |
9 |
86,386,220 (GRCm39) |
splice site |
probably null |
|
|
R7222:Dop1a
|
UTSW |
9 |
86,404,929 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7233:Dop1a
|
UTSW |
9 |
86,403,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7236:Dop1a
|
UTSW |
9 |
86,397,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7252:Dop1a
|
UTSW |
9 |
86,382,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7268:Dop1a
|
UTSW |
9 |
86,394,830 (GRCm39) |
nonsense |
probably null |
|
|
R7353:Dop1a
|
UTSW |
9 |
86,394,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7481:Dop1a
|
UTSW |
9 |
86,417,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7498:Dop1a
|
UTSW |
9 |
86,376,464 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7507:Dop1a
|
UTSW |
9 |
86,418,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7525:Dop1a
|
UTSW |
9 |
86,388,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Dop1a
|
UTSW |
9 |
86,403,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7751:Dop1a
|
UTSW |
9 |
86,389,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7753:Dop1a
|
UTSW |
9 |
86,371,755 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7839:Dop1a
|
UTSW |
9 |
86,424,818 (GRCm39) |
nonsense |
probably null |
|
|
R7868:Dop1a
|
UTSW |
9 |
86,384,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8061:Dop1a
|
UTSW |
9 |
86,403,246 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8067:Dop1a
|
UTSW |
9 |
86,400,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8156:Dop1a
|
UTSW |
9 |
86,376,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8196:Dop1a
|
UTSW |
9 |
86,405,151 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8223:Dop1a
|
UTSW |
9 |
86,400,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Dop1a
|
UTSW |
9 |
86,396,054 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8276:Dop1a
|
UTSW |
9 |
86,399,092 (GRCm39) |
missense |
probably benign |
|
|
R8306:Dop1a
|
UTSW |
9 |
86,402,259 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8353:Dop1a
|
UTSW |
9 |
86,403,639 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8362:Dop1a
|
UTSW |
9 |
86,395,941 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8403:Dop1a
|
UTSW |
9 |
86,382,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8817:Dop1a
|
UTSW |
9 |
86,396,003 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8862:Dop1a
|
UTSW |
9 |
86,406,404 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8888:Dop1a
|
UTSW |
9 |
86,403,587 (GRCm39) |
missense |
probably benign |
|
|
R8972:Dop1a
|
UTSW |
9 |
86,403,300 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9001:Dop1a
|
UTSW |
9 |
86,436,374 (GRCm39) |
makesense |
probably null |
|
|
R9011:Dop1a
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9021:Dop1a
|
UTSW |
9 |
86,402,490 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9039:Dop1a
|
UTSW |
9 |
86,382,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Dop1a
|
UTSW |
9 |
86,395,208 (GRCm39) |
missense |
probably benign |
|
|
R9178:Dop1a
|
UTSW |
9 |
86,371,796 (GRCm39) |
nonsense |
probably null |
|
|
R9238:Dop1a
|
UTSW |
9 |
86,415,027 (GRCm39) |
missense |
probably benign |
|
|
R9313:Dop1a
|
UTSW |
9 |
86,406,641 (GRCm39) |
makesense |
probably null |
|
|
R9334:Dop1a
|
UTSW |
9 |
86,403,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Dop1a
|
UTSW |
9 |
86,425,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Dop1a
|
UTSW |
9 |
86,385,151 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9677:Dop1a
|
UTSW |
9 |
86,425,098 (GRCm39) |
missense |
|
|
|
RF004:Dop1a
|
UTSW |
9 |
86,436,244 (GRCm39) |
missense |
probably benign |
|
|
X0019:Dop1a
|
UTSW |
9 |
86,413,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0019:Dop1a
|
UTSW |
9 |
86,388,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ZE80:Dop1a
|
UTSW |
9 |
86,382,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATGGTTACACCTTTTCGTGTC -3'
(R):5'- CTCCAGCTGAAAGACACAGG -3'
Sequencing Primer
(F):5'- GTGTCTCACTTTTCTTATGGTGAC -3'
(R):5'- AAGGCCTTCTACTTTTGCTAGACAG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation