Mutagenetix > Incidental Mutation

Incidental Mutation 'R9563:Lrrk2'

721278

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R9563 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 91749840 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 1380 (I1380K)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060642
AA Change: I1380K

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: I1380K

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 127 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	G	15: 8,187,079 (GRCm38)	L594V	probably benign	Het
9130409I23Rik	G	T	1: 181,055,245 (GRCm38)	V191F	possibly damaging	Het
A2m	T	A	6: 121,668,050 (GRCm38)	D953E	probably damaging	Het
Acod1	A	C	14: 103,049,673 (GRCm38)	Y80S	probably damaging	Het
Actr5	A	G	2: 158,628,215 (GRCm38)	D255G	probably damaging	Het
Akna	A	G	4: 63,394,707 (GRCm38)	V393A	probably damaging	Het
Amotl1	T	C	9: 14,562,217 (GRCm38)	K562R	possibly damaging	Het
Amz1	T	A	5: 140,752,378 (GRCm38)	D464E	probably damaging	Het
Anapc1	G	A	2: 128,664,060 (GRCm38)	Q619*	probably null	Het
Arfgef3	C	T	10: 18,646,527 (GRCm38)	G584R	probably damaging	Het
Armt1	AC	A	10: 4,450,848 (GRCm38)		probably null	Het
Atr	G	C	9: 95,920,780 (GRCm38)	V1832L	probably damaging	Het
Bsn	T	C	9: 108,107,417 (GRCm38)	D374G		Het
Cap1	A	G	4: 122,864,712 (GRCm38)	V225A	probably benign	Het
Cc2d1a	A	G	8: 84,137,129 (GRCm38)	S562P	probably benign	Het
Ccdc30	T	C	4: 119,393,624 (GRCm38)	N141S	possibly damaging	Het
Cdc42bpb	A	G	12: 111,299,328 (GRCm38)	V1390A	possibly damaging	Het
Cdc42ep1	A	T	15: 78,849,582 (GRCm38)	H294L	probably benign	Het
Col6a6	C	A	9: 105,695,753 (GRCm38)	G2185C	probably benign	Het
Col7a1	T	C	9: 108,962,741 (GRCm38)	V1232A	unknown	Het
Copb1	A	G	7: 114,236,799 (GRCm38)	I449T	possibly damaging	Het
Ctdsp2	A	G	10: 126,996,171 (GRCm38)	D216G	probably damaging	Het
Cttnbp2	A	T	6: 18,427,468 (GRCm38)	L738*	probably null	Het
Cttnbp2	T	A	6: 18,367,383 (GRCm38)	K1645N	probably benign	Het
Cul9	T	A	17: 46,509,971 (GRCm38)	T1927S	probably benign	Het
Cyfip2	A	G	11: 46,260,880 (GRCm38)	C531R	probably benign	Het
Cyp2j6	A	G	4: 96,526,008 (GRCm38)	I340T	probably damaging	Het
Daam1	A	G	12: 71,945,477 (GRCm38)	E322G	unknown	Het
Dab2ip	T	A	2: 35,719,903 (GRCm38)	L710*	probably null	Het
Dph1	T	C	11: 75,185,999 (GRCm38)	T60A	possibly damaging	Het
Eme1	T	C	11: 94,650,513 (GRCm38)	D161G	probably benign	Het
Epha3	C	T	16: 63,546,147 (GRCm38)	G980D	possibly damaging	Het
Eri3	T	A	4: 117,564,816 (GRCm38)	V136E	probably benign	Het
Espl1	T	A	15: 102,319,798 (GRCm38)	I1669N	possibly damaging	Het
Exoc6	T	C	19: 37,599,623 (GRCm38)	I568T	probably damaging	Het
F3	T	A	3: 121,734,173 (GRCm38)	L85H		Het
Fam186b	G	A	15: 99,279,735 (GRCm38)	A570V	probably damaging	Het
Fam212a	T	A	9: 107,984,289 (GRCm38)	Y276F	probably benign	Het
Fbxw14	T	C	9: 109,277,267 (GRCm38)	Y234C	probably benign	Het
Fbxw25	T	A	9: 109,654,608 (GRCm38)	N179Y		Het
Foxr1	T	A	9: 44,440,902 (GRCm38)		probably benign	Het
Gas8	T	A	8: 123,536,440 (GRCm38)	V452E	possibly damaging	Het
Gdpd4	T	C	7: 98,000,162 (GRCm38)	V450A	probably damaging	Het
Gm17359	A	T	3: 79,449,309 (GRCm38)	M140L	probably benign	Het
Greb1	T	C	12: 16,724,823 (GRCm38)	Y191C	probably benign	Het
Haus3	G	A	5: 34,167,956 (GRCm38)	R120W	probably benign	Het
Herc1	G	T	9: 66,386,911 (GRCm38)		probably null	Het
Hist1h3i	T	C	13: 21,783,051 (GRCm38)	D107G	probably damaging	Het
Hyal2	T	C	9: 107,570,645 (GRCm38)	W166R	probably damaging	Het
Itga7	C	T	10: 128,953,800 (GRCm38)	A1003V	probably damaging	Het
Itga8	T	A	2: 12,160,408 (GRCm38)	I797F	possibly damaging	Het
Kank2	T	C	9: 21,794,556 (GRCm38)	T389A	possibly damaging	Het
Kcnb2	T	A	1: 15,709,513 (GRCm38)	I203N	probably damaging	Het
Kif21b	T	A	1: 136,149,428 (GRCm38)	L396Q	probably damaging	Het
Kng1	T	G	16: 23,060,420 (GRCm38)	I78S	probably damaging	Het
Ldlrad4	T	C	18: 68,254,480 (GRCm38)	S288P	probably benign	Het
Lmntd2	A	G	7: 141,210,788 (GRCm38)	S516P		Het
Lrp1b	T	A	2: 41,295,699 (GRCm38)	I1449F		Het
Lvrn	T	G	18: 46,884,439 (GRCm38)	I612S	probably damaging	Het
Lyst	T	C	13: 13,637,823 (GRCm38)	L940P	probably benign	Het
Man2a2	T	A	7: 80,356,353 (GRCm38)	M996L	probably benign	Het
Map3k3	T	A	11: 106,151,034 (GRCm38)	I413N	probably damaging	Het
Map4k5	A	G	12: 69,816,393 (GRCm38)	V629A	probably benign	Het
Mapre2	A	G	18: 23,890,924 (GRCm38)	E325G	unknown	Het
Mbnl1	A	G	3: 60,613,294 (GRCm38)	N101S	probably benign	Het
Meltf	T	A	16: 31,885,051 (GRCm38)	C199S	probably damaging	Het
Mmab	T	C	5: 114,436,789 (GRCm38)	E141G	probably benign	Het
Mtus2	T	C	5: 148,313,407 (GRCm38)	L1317P		Het
Muc6	T	A	7: 141,637,870 (GRCm38)	T2297S	possibly damaging	Het
Myom2	A	T	8: 15,108,399 (GRCm38)	K784*	probably null	Het
Nek1	A	G	8: 61,124,123 (GRCm38)	E1118G	probably benign	Het
Nrtn	A	G	17: 56,751,416 (GRCm38)	V195A	probably damaging	Het
Nsd3	G	A	8: 25,714,203 (GRCm38)	V420I		Het
Olfr1094	A	G	2: 86,828,754 (GRCm38)	M1V	probably null	Het
Olfr1451	T	A	19: 12,999,619 (GRCm38)	I211N	probably damaging	Het
Olfr205	T	C	16: 59,329,402 (GRCm38)	I36V	probably benign	Het
Olfr522	G	A	7: 140,162,320 (GRCm38)	T210I	probably damaging	Het
Olfr618	A	T	7: 103,598,018 (GRCm38)	Q234L	probably benign	Het
Olfr677	T	C	7: 105,057,074 (GRCm38)	L276P	possibly damaging	Het
Olfr820	T	C	10: 130,017,418 (GRCm38)	I19T	probably benign	Het
Olfr923	A	T	9: 38,827,718 (GRCm38)	H3L	probably benign	Het
Pde10a	G	T	17: 8,801,878 (GRCm38)	A216S	unknown	Het
Phldb2	T	C	16: 45,824,884 (GRCm38)	T400A	possibly damaging	Het
Pkd1l1	T	A	11: 8,865,502 (GRCm38)	T1920S		Het
Ptgs2	T	A	1: 150,105,668 (GRCm38)	N567K	probably benign	Het
Pwp1	T	A	10: 85,876,506 (GRCm38)	D141E	probably damaging	Het
Rab3ip	T	C	10: 116,918,763 (GRCm38)	E296G	probably null	Het
Rb1cc1	A	G	1: 6,244,115 (GRCm38)	K337R	probably benign	Het
Rbp3	A	G	14: 33,955,520 (GRCm38)	D475G	probably damaging	Het
Ric3	T	C	7: 109,038,790 (GRCm38)	E253G	possibly damaging	Het
Rictor	A	T	15: 6,768,081 (GRCm38)	N306I	possibly damaging	Het
Rnf214	A	T	9: 45,899,843 (GRCm38)	V174E	possibly damaging	Het
Robo3	A	G	9: 37,429,604 (GRCm38)	F124S	probably damaging	Het
Rrad	A	G	8: 104,628,692 (GRCm38)	F228S	probably damaging	Het
Scn3a	A	T	2: 65,461,251 (GRCm38)	M1717K	probably damaging	Het
Scn3b	A	G	9: 40,282,433 (GRCm38)	D152G	probably benign	Het
Scn5a	C	A	9: 119,486,737 (GRCm38)	R1635L	probably damaging	Het
Sec61b	A	G	4: 47,483,049 (GRCm38)	Y93C	probably damaging	Het
Shprh	T	A	10: 11,166,491 (GRCm38)	Y739*	probably null	Het
Skor2	C	T	18: 76,858,681 (GRCm38)	H33Y	unknown	Het
Slc26a7	T	C	4: 14,519,496 (GRCm38)	N508S	probably benign	Het
Slc7a12	A	G	3: 14,499,300 (GRCm38)	I349V	possibly damaging	Het
Slit1	T	C	19: 41,608,435 (GRCm38)	Y1075C	probably damaging	Het
Sltm	C	T	9: 70,573,559 (GRCm38)	A231V	unknown	Het
Smg1	A	G	7: 118,212,985 (GRCm38)	S52P	unknown	Het
Soga1	G	A	2: 157,060,262 (GRCm38)	R278C	probably damaging	Het
Sorl1	A	G	9: 42,046,597 (GRCm38)	Y584H	probably damaging	Het
Ssbp1	T	A	6: 40,478,034 (GRCm38)	S142R	probably benign	Het
Stard3	A	G	11: 98,379,971 (GRCm38)		probably null	Het
Strn3	G	T	12: 51,627,517 (GRCm38)	H531N	possibly damaging	Het
Stx17	A	G	4: 48,180,739 (GRCm38)	T195A	probably damaging	Het
Tekt2	C	T	4: 126,323,651 (GRCm38)	R207H	probably damaging	Het
Tmed5	A	C	5: 108,132,234 (GRCm38)		probably null	Het
Tmem132a	C	T	19: 10,861,596 (GRCm38)	R494H	probably benign	Het
Tom1	A	G	8: 75,060,549 (GRCm38)	K406E	probably benign	Het
Trav5d-4	A	T	14: 53,002,016 (GRCm38)	N43Y	probably damaging	Het
Trbv19	G	T	6: 41,179,011 (GRCm38)	K105N	possibly damaging	Het
Trim34a	C	T	7: 104,261,121 (GRCm38)	Q377*	probably null	Het
Trp53bp2	T	A	1: 182,448,813 (GRCm38)	N786K	probably benign	Het
Trpc3	A	G	3: 36,651,534 (GRCm38)	M504T	probably benign	Het
Ttc28	A	T	5: 111,223,226 (GRCm38)	M545L	probably benign	Het
Uggt1	A	C	1: 36,165,546 (GRCm38)	V996G	possibly damaging	Het
Vmn2r65	G	A	7: 84,940,672 (GRCm38)	Q679*	probably null	Het
Wdfy4	T	C	14: 32,970,876 (GRCm38)	I2958V		Het
Zbtb37	C	T	1: 161,020,270 (GRCm38)	S389N	possibly damaging	Het
Zfp235	T	C	7: 24,142,244 (GRCm38)	V696A	possibly damaging	Het
Zzef1	T	A	11: 72,874,906 (GRCm38)	C1420S	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- AACAACTTAGGCCTGGCAC -3'
(R):5'- TCCATTCTGGTGACAAGGGC -3'

Sequencing Primer
(F):5'- CAGGTTTCTACAACAACGTCTG -3'
(R):5'- CATTCTGGTGACAAGGGCAAAATG -3'

Posted On

2022-08-09