Incidental Mutation 'R9564:Celsr2'
| ID |
721318 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9564 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108321834 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 326
(Y326C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000090558
AA Change: Y326C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: Y326C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 135 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700097O09Rik |
A |
T |
12: 55,104,090 (GRCm39) |
N176K |
possibly damaging |
Het |
| 3110009E18Rik |
T |
A |
1: 120,097,006 (GRCm39) |
V134E |
|
Het |
| Abca8a |
T |
A |
11: 109,965,010 (GRCm39) |
H429L |
probably benign |
Het |
| Acsf2 |
T |
A |
11: 94,463,891 (GRCm39) |
I98F |
possibly damaging |
Het |
| Actr5 |
A |
G |
2: 158,470,135 (GRCm39) |
D255G |
probably damaging |
Het |
| Adam21 |
C |
T |
12: 81,605,833 (GRCm39) |
C643Y |
probably damaging |
Het |
| Adcy7 |
TGG |
TG |
8: 89,053,053 (GRCm39) |
|
probably null |
Het |
| AI429214 |
A |
G |
8: 37,461,067 (GRCm39) |
S72G |
possibly damaging |
Het |
| Akap13 |
T |
C |
7: 75,259,161 (GRCm39) |
V595A |
probably benign |
Het |
| Akt3 |
T |
C |
1: 176,907,769 (GRCm39) |
T209A |
possibly damaging |
Het |
| Alpk2 |
C |
T |
18: 65,439,014 (GRCm39) |
G793D |
probably damaging |
Het |
| Amotl1 |
T |
C |
9: 14,473,513 (GRCm39) |
K562R |
possibly damaging |
Het |
| Ankib1 |
T |
A |
5: 3,805,733 (GRCm39) |
N178I |
possibly damaging |
Het |
| Arfgef1 |
A |
T |
1: 10,217,758 (GRCm39) |
D1560E |
probably benign |
Het |
| Arhgap20 |
AAGAGAG |
AAGAG |
9: 51,761,413 (GRCm39) |
|
probably null |
Het |
| Arpc5l |
A |
G |
2: 38,905,124 (GRCm39) |
T152A |
probably benign |
Het |
| Asic3 |
C |
G |
5: 24,620,875 (GRCm39) |
D252E |
possibly damaging |
Het |
| Atf7 |
T |
A |
15: 102,442,712 (GRCm39) |
M466L |
probably benign |
Het |
| Bcl9l |
A |
G |
9: 44,420,554 (GRCm39) |
D1320G |
probably damaging |
Het |
| Bdkrb1 |
G |
A |
12: 105,571,078 (GRCm39) |
V215I |
probably benign |
Het |
| Brpf3 |
T |
G |
17: 29,026,152 (GRCm39) |
D408E |
probably benign |
Het |
| Btn2a2 |
C |
A |
13: 23,662,848 (GRCm39) |
K367N |
possibly damaging |
Het |
| Btnl10 |
T |
A |
11: 58,813,189 (GRCm39) |
F273I |
probably benign |
Het |
| C1qtnf12 |
C |
T |
4: 156,049,473 (GRCm39) |
T145I |
probably benign |
Het |
| Cacna1s |
T |
C |
1: 136,046,516 (GRCm39) |
C1763R |
probably benign |
Het |
| Ccdc154 |
C |
A |
17: 25,387,381 (GRCm39) |
Q372K |
possibly damaging |
Het |
| Cd300ld2 |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
11: 114,903,257 (GRCm39) |
|
probably benign |
Het |
| Cfap46 |
A |
T |
7: 139,231,471 (GRCm39) |
V914E |
|
Het |
| Coil |
T |
A |
11: 88,872,626 (GRCm39) |
V329E |
possibly damaging |
Het |
| Copb1 |
A |
G |
7: 113,836,034 (GRCm39) |
I449T |
possibly damaging |
Het |
| Copg1 |
T |
G |
6: 87,869,683 (GRCm39) |
S187R |
probably damaging |
Het |
| Cps1 |
T |
A |
1: 67,198,048 (GRCm39) |
F371Y |
probably benign |
Het |
| Cpt1b |
A |
T |
15: 89,303,472 (GRCm39) |
F554L |
probably damaging |
Het |
| Ctdsp2 |
A |
G |
10: 126,832,040 (GRCm39) |
D216G |
probably damaging |
Het |
| Ctla2b |
A |
T |
13: 61,043,856 (GRCm39) |
Y104* |
probably null |
Het |
| Cyp2j6 |
A |
G |
4: 96,414,245 (GRCm39) |
I340T |
probably damaging |
Het |
| Ddi1 |
T |
A |
9: 6,265,730 (GRCm39) |
D213V |
probably damaging |
Het |
| Degs1l |
G |
T |
1: 180,882,810 (GRCm39) |
V191F |
possibly damaging |
Het |
| Dennd2b |
G |
T |
7: 109,125,536 (GRCm39) |
D980E |
probably damaging |
Het |
| Dlgap1 |
T |
G |
17: 70,964,458 (GRCm39) |
N400K |
probably benign |
Het |
| Dnah5 |
G |
A |
15: 28,290,422 (GRCm39) |
V1271M |
probably benign |
Het |
| Dnah8 |
T |
A |
17: 30,932,021 (GRCm39) |
V1463E |
probably benign |
Het |
| Dstyk |
G |
A |
1: 132,362,023 (GRCm39) |
R151H |
probably damaging |
Het |
| Ehd3 |
T |
G |
17: 74,137,361 (GRCm39) |
V510G |
probably benign |
Het |
| Enthd1 |
G |
T |
15: 80,444,235 (GRCm39) |
Q107K |
probably damaging |
Het |
| Entpd7 |
A |
G |
19: 43,705,889 (GRCm39) |
E237G |
probably benign |
Het |
| Fadd |
A |
T |
7: 144,136,048 (GRCm39) |
C27S |
probably damaging |
Het |
| Fan1 |
A |
G |
7: 63,999,240 (GRCm39) |
L874P |
possibly damaging |
Het |
| Fbxw17 |
T |
C |
13: 50,579,605 (GRCm39) |
W141R |
probably damaging |
Het |
| Fig4 |
A |
G |
10: 41,161,387 (GRCm39) |
V63A |
probably benign |
Het |
| Fmo3 |
T |
C |
1: 162,786,021 (GRCm39) |
D323G |
probably damaging |
Het |
| Gas8 |
T |
A |
8: 124,263,179 (GRCm39) |
V452E |
possibly damaging |
Het |
| Gdf9 |
T |
A |
11: 53,327,511 (GRCm39) |
S156T |
probably damaging |
Het |
| Hlcs |
T |
C |
16: 93,935,580 (GRCm39) |
S571G |
probably benign |
Het |
| Hmox2 |
A |
G |
16: 4,582,870 (GRCm39) |
Y201C |
probably damaging |
Het |
| Ikzf3 |
T |
A |
11: 98,358,032 (GRCm39) |
D435V |
probably damaging |
Het |
| Kank2 |
T |
C |
9: 21,705,852 (GRCm39) |
T389A |
possibly damaging |
Het |
| Kank2 |
A |
G |
9: 21,706,631 (GRCm39) |
L129P |
probably damaging |
Het |
| Kdr |
T |
A |
5: 76,125,565 (GRCm39) |
K339N |
probably benign |
Het |
| Lmntd2 |
A |
G |
7: 140,790,701 (GRCm39) |
S516P |
|
Het |
| Lrrc37 |
T |
C |
11: 103,503,822 (GRCm39) |
I2715M |
unknown |
Het |
| Lrrc40 |
T |
A |
3: 157,746,078 (GRCm39) |
V51D |
probably benign |
Het |
| Lrrtm1 |
A |
G |
6: 77,221,536 (GRCm39) |
N331S |
probably benign |
Het |
| Lvrn |
T |
G |
18: 47,017,506 (GRCm39) |
I612S |
probably damaging |
Het |
| Map3k3 |
T |
A |
11: 106,041,860 (GRCm39) |
I413N |
probably damaging |
Het |
| Mcm9 |
C |
T |
10: 53,506,104 (GRCm39) |
A57T |
possibly damaging |
Het |
| Met |
T |
A |
6: 17,531,425 (GRCm39) |
F568I |
probably benign |
Het |
| Mkx |
A |
G |
18: 7,002,457 (GRCm39) |
F30L |
probably benign |
Het |
| Mrc1 |
A |
G |
2: 14,266,117 (GRCm39) |
N345S |
probably benign |
Het |
| Mstn |
T |
A |
1: 53,103,367 (GRCm39) |
N234K |
probably benign |
Het |
| Mtmr3 |
A |
T |
11: 4,440,992 (GRCm39) |
S554T |
possibly damaging |
Het |
| Mug1 |
G |
A |
6: 121,861,587 (GRCm39) |
V1350I |
probably benign |
Het |
| Myh8 |
T |
C |
11: 67,177,215 (GRCm39) |
V427A |
probably benign |
Het |
| Nr4a2 |
A |
T |
2: 57,000,190 (GRCm39) |
I365N |
probably damaging |
Het |
| Nrxn2 |
A |
G |
19: 6,559,887 (GRCm39) |
D1215G |
probably damaging |
Het |
| Or2d3c |
A |
G |
7: 106,525,847 (GRCm39) |
M273T |
probably benign |
Het |
| Or6c33 |
T |
C |
10: 129,853,287 (GRCm39) |
I19T |
probably benign |
Het |
| Or7g18 |
G |
A |
9: 18,786,640 (GRCm39) |
V3I |
probably benign |
Het |
| Osbpl6 |
T |
A |
2: 76,426,321 (GRCm39) |
W967R |
probably damaging |
Het |
| Pcdhb21 |
T |
C |
18: 37,646,972 (GRCm39) |
S34P |
possibly damaging |
Het |
| Pibf1 |
G |
T |
14: 99,374,610 (GRCm39) |
D350Y |
possibly damaging |
Het |
| Pira1 |
C |
T |
7: 3,742,646 (GRCm39) |
V21M |
possibly damaging |
Het |
| Plekhs1 |
A |
T |
19: 56,461,628 (GRCm39) |
I123F |
probably damaging |
Het |
| Pold2 |
C |
T |
11: 5,824,163 (GRCm39) |
G214D |
probably benign |
Het |
| Pomc |
A |
G |
12: 4,009,971 (GRCm39) |
T71A |
probably benign |
Het |
| Pot1b |
A |
G |
17: 55,969,465 (GRCm39) |
S568P |
possibly damaging |
Het |
| Prkd2 |
C |
A |
7: 16,591,744 (GRCm39) |
Q592K |
possibly damaging |
Het |
| Prss28 |
C |
T |
17: 25,528,911 (GRCm39) |
A84V |
probably damaging |
Het |
| Prtg |
T |
A |
9: 72,766,153 (GRCm39) |
Y649N |
probably damaging |
Het |
| Psip1 |
T |
C |
4: 83,386,888 (GRCm39) |
E161G |
possibly damaging |
Het |
| Rab3gap2 |
A |
G |
1: 185,014,691 (GRCm39) |
D1280G |
probably damaging |
Het |
| Rab3ip |
A |
T |
10: 116,751,780 (GRCm39) |
I329N |
probably damaging |
Het |
| Rarres2 |
C |
T |
6: 48,549,164 (GRCm39) |
G13D |
possibly damaging |
Het |
| Rbp3 |
A |
G |
14: 33,677,477 (GRCm39) |
D475G |
probably damaging |
Het |
| Ric3 |
A |
G |
7: 108,638,018 (GRCm39) |
V246A |
probably damaging |
Het |
| Robo3 |
A |
G |
9: 37,340,900 (GRCm39) |
F124S |
probably damaging |
Het |
| Rpl27a |
C |
A |
7: 109,118,837 (GRCm39) |
H17N |
probably benign |
Het |
| Rptn |
A |
G |
3: 93,304,536 (GRCm39) |
D623G |
probably benign |
Het |
| Rtl1 |
G |
T |
12: 109,556,713 (GRCm39) |
Q1709K |
probably benign |
Het |
| Sacs |
T |
A |
14: 61,449,046 (GRCm39) |
D3697E |
probably damaging |
Het |
| Sec61b |
A |
G |
4: 47,483,049 (GRCm39) |
Y93C |
probably damaging |
Het |
| Serpina3a |
A |
T |
12: 104,084,886 (GRCm39) |
I94L |
probably benign |
Het |
| Skic2 |
C |
T |
17: 35,063,758 (GRCm39) |
A562T |
probably benign |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Slc12a3 |
G |
A |
8: 95,082,983 (GRCm39) |
V874I |
probably benign |
Het |
| Slit1 |
T |
A |
19: 41,591,861 (GRCm39) |
M1254L |
probably benign |
Het |
| Smg1 |
A |
G |
7: 117,812,208 (GRCm39) |
S52P |
unknown |
Het |
| Sorl1 |
A |
G |
9: 41,957,893 (GRCm39) |
Y584H |
probably damaging |
Het |
| Spata32 |
T |
A |
11: 103,099,779 (GRCm39) |
Q242L |
possibly damaging |
Het |
| Sptbn4 |
T |
G |
7: 27,117,504 (GRCm39) |
E415A |
probably damaging |
Het |
| St6galnac5 |
T |
C |
3: 152,545,782 (GRCm39) |
R259G |
probably damaging |
Het |
| Stat3 |
T |
C |
11: 100,784,614 (GRCm39) |
I589V |
probably benign |
Het |
| Tecta |
T |
A |
9: 42,249,123 (GRCm39) |
K1913M |
probably damaging |
Het |
| Tek |
C |
A |
4: 94,762,172 (GRCm39) |
N1103K |
probably damaging |
Het |
| Telo2 |
A |
G |
17: 25,334,199 (GRCm39) |
I16T |
probably benign |
Het |
| Tmem207 |
G |
T |
16: 26,335,499 (GRCm39) |
C79* |
probably null |
Het |
| Topaz1 |
C |
T |
9: 122,579,219 (GRCm39) |
H710Y |
probably benign |
Het |
| Trim33 |
T |
A |
3: 103,238,965 (GRCm39) |
S648T |
probably benign |
Het |
| Trpm6 |
A |
G |
19: 18,851,240 (GRCm39) |
T1734A |
possibly damaging |
Het |
| Trpm8 |
A |
G |
1: 88,254,158 (GRCm39) |
E127G |
possibly damaging |
Het |
| Ttc3 |
T |
A |
16: 94,248,918 (GRCm39) |
C1139S |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,580,330 (GRCm39) |
E23521G |
probably damaging |
Het |
| Ush2a |
T |
C |
1: 188,268,551 (GRCm39) |
I1669T |
possibly damaging |
Het |
| Vcpip1 |
C |
A |
1: 9,817,456 (GRCm39) |
S309I |
possibly damaging |
Het |
| Vmn1r208 |
A |
G |
13: 22,956,789 (GRCm39) |
V236A |
probably damaging |
Het |
| Vmn1r74 |
T |
C |
7: 11,581,534 (GRCm39) |
F278S |
probably damaging |
Het |
| Vmn2r33 |
T |
C |
7: 7,557,081 (GRCm39) |
S540G |
probably benign |
Het |
| Vmn2r52 |
T |
C |
7: 9,905,182 (GRCm39) |
D219G |
probably benign |
Het |
| Wiz |
G |
T |
17: 32,575,939 (GRCm39) |
D812E |
probably benign |
Het |
| Ylpm1 |
C |
T |
12: 85,091,176 (GRCm39) |
P1787S |
probably benign |
Het |
| Zan |
T |
C |
5: 137,404,688 (GRCm39) |
E3858G |
unknown |
Het |
| Zfp760 |
T |
G |
17: 21,942,272 (GRCm39) |
H482Q |
possibly damaging |
Het |
| Zfp78 |
A |
G |
7: 6,381,390 (GRCm39) |
T147A |
probably benign |
Het |
| Zfp808 |
T |
A |
13: 62,320,661 (GRCm39) |
I630K |
possibly damaging |
Het |
| Zpld1 |
T |
A |
16: 55,061,701 (GRCm39) |
R227* |
probably null |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Celsr2
|
UTSW |
3 |
108,301,055 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1848:Celsr2
|
UTSW |
3 |
108,308,626 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Celsr2
|
UTSW |
3 |
108,305,966 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Celsr2
|
UTSW |
3 |
108,320,907 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Celsr2
|
UTSW |
3 |
108,304,547 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTATCATCCTCCACCGACAGG -3'
(R):5'- TGCACAGGATCACGGTATG -3'
Sequencing Primer
(F):5'- GAAAACAATGGCTGTGGAACTCC -3'
(R):5'- GGTATGCCCCGACGGAG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation