Incidental Mutation 'R9565:Tasor'
ID 721523
Institutional Source Beutler Lab
Gene Symbol Tasor
Ensembl Gene ENSMUSG00000040651
Gene Name transcription activation suppressor
Synonyms D14Abb1e, Fam208a, 4933409E02Rik, MommeD6
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9565 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 27150791-27205512 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 27201766 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022450] [ENSMUST00000022450] [ENSMUST00000050480] [ENSMUST00000223689]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000022450
SMART Domains Protein: ENSMUSP00000022450
Gene: ENSMUSG00000040651

DomainStartEndE-ValueType
low complexity region 20 27 N/A INTRINSIC
low complexity region 42 61 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
Pfam:DUF3715 153 314 1.5e-55 PFAM
low complexity region 442 457 N/A INTRINSIC
low complexity region 1087 1102 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000022450
SMART Domains Protein: ENSMUSP00000022450
Gene: ENSMUSG00000040651

DomainStartEndE-ValueType
low complexity region 20 27 N/A INTRINSIC
low complexity region 42 61 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
Pfam:DUF3715 153 314 1.5e-55 PFAM
low complexity region 442 457 N/A INTRINSIC
low complexity region 1087 1102 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000050480
SMART Domains Protein: ENSMUSP00000052546
Gene: ENSMUSG00000046753

DomainStartEndE-ValueType
coiled coil region 252 284 N/A INTRINSIC
Pfam:CCDC66 409 561 1e-49 PFAM
low complexity region 715 721 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000223689
Predicted Effect probably benign
Transcript: ENSMUST00000225139
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for ENU mutations are not viable past gastrulation. [provided by MGI curators]
Allele List at MGI

All alleles(26) : Gene trapped(26)

Other mutations in this stock
Total: 123 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco2 G A 15: 81,773,635 (GRCm39) R58Q probably null Het
Actl11 A T 9: 107,808,121 (GRCm39) T815S possibly damaging Het
Actr5 A G 2: 158,470,135 (GRCm39) D255G probably damaging Het
Acvr1 T C 2: 58,338,385 (GRCm39) K446E probably damaging Het
Adam39 T C 8: 41,277,755 (GRCm39) Y49H probably benign Het
Adcy7 TGG TG 8: 89,053,053 (GRCm39) probably null Het
Amn1 C T 6: 149,090,103 (GRCm39) probably benign Het
Ankdd1a C T 9: 65,411,452 (GRCm39) A352T possibly damaging Het
Aoc1l2 T C 6: 48,907,909 (GRCm39) M303T probably benign Het
Arl4c A G 1: 88,629,134 (GRCm39) C85R probably damaging Het
Asgr2 T A 11: 69,996,310 (GRCm39) probably null Het
Bdkrb1 G A 12: 105,571,078 (GRCm39) V215I probably benign Het
Btn2a2 C A 13: 23,662,848 (GRCm39) K367N possibly damaging Het
Btnl10 T A 11: 58,813,189 (GRCm39) F273I probably benign Het
C7 T A 15: 5,086,579 (GRCm39) probably null Het
Cap1 A G 4: 122,758,505 (GRCm39) V225A probably benign Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Ccdc18 A G 5: 108,339,800 (GRCm39) T782A probably damaging Het
Ccdc187 T C 2: 26,183,698 (GRCm39) S101G possibly damaging Het
Ccdc30 T C 4: 119,250,821 (GRCm39) N141S possibly damaging Het
Cdc42bpg T G 19: 6,370,696 (GRCm39) L1263R probably damaging Het
Cdc42ep1 A T 15: 78,733,782 (GRCm39) H294L probably benign Het
Cdk12 A G 11: 98,140,628 (GRCm39) N1290D unknown Het
Ces1g A G 8: 94,061,792 (GRCm39) V38A probably benign Het
Cntnap4 A C 8: 113,582,982 (GRCm39) Y1020S probably benign Het
Col7a1 T C 9: 108,791,809 (GRCm39) V1232A unknown Het
Ctdsp2 A G 10: 126,832,040 (GRCm39) D216G probably damaging Het
Cyp2j6 A G 4: 96,414,245 (GRCm39) I340T probably damaging Het
Cyp4f37 A G 17: 32,844,205 (GRCm39) D103G possibly damaging Het
Dlgap1 T G 17: 70,964,458 (GRCm39) N400K probably benign Het
Dnaaf9 G A 2: 130,648,711 (GRCm39) T257M unknown Het
Dnah1 C A 14: 30,986,394 (GRCm39) A3698S probably damaging Het
Dnah12 C A 14: 26,597,281 (GRCm39) R3547S possibly damaging Het
Dnah3 A G 7: 119,610,114 (GRCm39) V1774A probably benign Het
Drc7 A G 8: 95,801,866 (GRCm39) E709G probably damaging Het
Dsc1 T A 18: 20,240,791 (GRCm39) D178V probably damaging Het
Duox1 T C 2: 122,151,203 (GRCm39) Y293H probably damaging Het
Elp1 G T 4: 56,772,521 (GRCm39) P867T probably benign Het
Epas1 T A 17: 87,112,667 (GRCm39) D88E probably damaging Het
Epdr1 A G 13: 19,778,821 (GRCm39) F92L possibly damaging Het
Eri3 T A 4: 117,422,013 (GRCm39) V136E probably benign Het
Espl1 T A 15: 102,228,233 (GRCm39) I1669N possibly damaging Het
Etv6 A G 6: 134,225,672 (GRCm39) N212S probably benign Het
Fam186b A T 15: 99,176,685 (GRCm39) L735Q probably damaging Het
Fam186b G A 15: 99,177,616 (GRCm39) A570V probably damaging Het
Fan1 A G 7: 63,999,240 (GRCm39) L874P possibly damaging Het
Fancm A G 12: 65,168,494 (GRCm39) N1619S probably damaging Het
Fbln5 A T 12: 101,734,722 (GRCm39) N183K probably damaging Het
Fbn2 T C 18: 58,228,298 (GRCm39) H746R probably benign Het
Fbxw17 T C 13: 50,579,605 (GRCm39) W141R probably damaging Het
Fbxw25 T A 9: 109,483,676 (GRCm39) N179Y Het
Gbe1 A T 16: 70,198,664 (GRCm39) Y119F probably benign Het
Gcnt7 T A 2: 172,293,180 (GRCm39) Y369F probably damaging Het
Gdf9 T A 11: 53,327,511 (GRCm39) S156T probably damaging Het
Gm14295 T C 2: 176,499,162 (GRCm39) V4A probably benign Het
Gm8369 A C 19: 11,489,015 (GRCm39) T101P probably benign Het
Herc3 A G 6: 58,835,999 (GRCm39) N280S probably null Het
Hipk2 T A 6: 38,724,390 (GRCm39) R447W probably damaging Het
Hjurp TCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCTGCT TCT 1: 88,194,000 (GRCm39) probably benign Het
Hltf G A 3: 20,136,996 (GRCm39) probably null Het
Ik C A 18: 36,886,959 (GRCm39) D397E probably benign Het
Inka1 T A 9: 107,861,488 (GRCm39) Y276F probably benign Het
Kcnc1 G A 7: 46,077,010 (GRCm39) V271M probably benign Het
Kif21b A T 1: 136,077,090 (GRCm39) I371F probably damaging Het
Klrc1 A G 6: 129,655,746 (GRCm39) F43S probably damaging Het
Krt8 A G 15: 101,912,460 (GRCm39) V72A probably benign Het
Krtap6-2 A G 16: 89,216,722 (GRCm39) S82P unknown Het
Lrrc15 G A 16: 30,093,016 (GRCm39) L108F probably damaging Het
Lvrn T G 18: 47,017,506 (GRCm39) I612S probably damaging Het
Map3k3 T A 11: 106,041,860 (GRCm39) I413N probably damaging Het
Mark3 A G 12: 111,570,960 (GRCm39) I87V probably damaging Het
Mki67 GTT GTTT 7: 135,309,233 (GRCm39) probably null Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mrgprb2 G A 7: 48,202,674 (GRCm39) T17M possibly damaging Het
Msantd5f4 G T 4: 73,557,190 (GRCm39) V8F probably damaging Het
Myh3 C T 11: 66,983,187 (GRCm39) R905* probably null Het
Myh8 T C 11: 67,177,215 (GRCm39) V427A probably benign Het
Myocd T C 11: 65,078,209 (GRCm39) K529E probably damaging Het
Myom2 A T 8: 15,158,399 (GRCm39) K784* probably null Het
Or1l4 G T 2: 37,091,575 (GRCm39) M107I probably benign Het
Or2w25 T G 11: 59,504,339 (GRCm39) I183S probably damaging Het
Or6c33 T C 10: 129,853,287 (GRCm39) I19T probably benign Het
Pabpc4 T C 4: 123,180,653 (GRCm39) I125T probably damaging Het
Parp14 A G 16: 35,677,775 (GRCm39) I731T probably benign Het
Pde6c T A 19: 38,147,008 (GRCm39) probably null Het
Pias3 T A 3: 96,610,867 (GRCm39) C391S possibly damaging Het
Pknox2 A T 9: 36,835,067 (GRCm39) M134K probably damaging Het
Pot1b A G 17: 55,969,465 (GRCm39) S568P possibly damaging Het
Ppp1r3a T A 6: 14,719,466 (GRCm39) T483S probably benign Het
Rag1 A T 2: 101,473,327 (GRCm39) V605E probably damaging Het
Relch T C 1: 105,591,876 (GRCm39) V15A probably damaging Het
Ros1 T C 10: 51,943,170 (GRCm39) D2048G probably damaging Het
Rp2 A G X: 20,243,781 (GRCm39) D252G probably benign Het
Rpgrip1l A C 8: 92,031,516 (GRCm39) H120Q probably benign Het
Rpl24 T A 16: 55,790,509 (GRCm39) S122T probably benign Het
Sec61b A G 4: 47,483,049 (GRCm39) Y93C probably damaging Het
Sema6a A T 18: 47,382,594 (GRCm39) L651Q probably null Het
Serpinb6a T A 13: 34,102,400 (GRCm39) K275I probably damaging Het
Skic2 C T 17: 35,063,758 (GRCm39) A562T probably benign Het
Skor2 C T 18: 76,946,376 (GRCm39) H33Y unknown Het
Slc26a7 T C 4: 14,519,496 (GRCm39) N508S probably benign Het
Slc2a4 A G 11: 69,837,173 (GRCm39) F88L probably damaging Het
Slc8b1 A G 5: 120,665,865 (GRCm39) T399A probably benign Het
Slfn5 A T 11: 82,847,699 (GRCm39) M195L possibly damaging Het
Snx17 C A 5: 31,355,088 (GRCm39) Q368K probably damaging Het
Tbcb A T 7: 29,930,549 (GRCm39) probably null Het
Telo2 A G 17: 25,334,199 (GRCm39) I16T probably benign Het
Timm50 A G 7: 28,007,069 (GRCm39) F202S possibly damaging Het
Tle2 A G 10: 81,417,567 (GRCm39) D244G probably benign Het
Tlr4 G A 4: 66,759,522 (GRCm39) V772I possibly damaging Het
Tmem214 G A 5: 31,027,043 (GRCm39) W11* probably null Het
Top2b A C 14: 16,365,718 (GRCm38) T14P probably benign Het
Trim44 T C 2: 102,187,827 (GRCm39) T309A probably benign Het
Tuba8 A G 6: 121,200,063 (GRCm39) N249S probably benign Het
Tubb4a A G 17: 57,388,027 (GRCm39) V333A probably benign Het
Ugdh C A 5: 65,575,876 (GRCm39) D328Y possibly damaging Het
Vmn1r189 A G 13: 22,286,426 (GRCm39) L137P probably damaging Het
Vmn1r208 A G 13: 22,956,789 (GRCm39) V236A probably damaging Het
Vmn2r29 A T 7: 7,244,855 (GRCm39) W340R probably benign Het
Vmn2r52 A C 7: 9,893,476 (GRCm39) D554E probably benign Het
Wdr36 C T 18: 32,994,168 (GRCm39) Q669* probably null Het
Wiz G T 17: 32,575,939 (GRCm39) D812E probably benign Het
Zfp777 A T 6: 48,021,580 (GRCm39) V14D possibly damaging Het
Other mutations in Tasor
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Tasor APN 14 27,170,163 (GRCm39) missense probably damaging 1.00
IGL00467:Tasor APN 14 27,170,121 (GRCm39) missense probably benign 0.02
IGL01071:Tasor APN 14 27,164,579 (GRCm39) critical splice donor site probably null
IGL01351:Tasor APN 14 27,186,258 (GRCm39) missense probably benign 0.02
IGL01375:Tasor APN 14 27,162,120 (GRCm39) missense probably damaging 1.00
IGL01509:Tasor APN 14 27,181,731 (GRCm39) splice site probably benign
IGL02342:Tasor APN 14 27,198,624 (GRCm39) missense possibly damaging 0.83
IGL03105:Tasor APN 14 27,164,509 (GRCm39) missense probably damaging 0.98
IGL03131:Tasor APN 14 27,183,136 (GRCm39) nonsense probably null
IGL03248:Tasor APN 14 27,198,649 (GRCm39) missense probably damaging 1.00
IGL03383:Tasor APN 14 27,163,918 (GRCm39) missense possibly damaging 0.93
balsam UTSW 14 27,183,107 (GRCm39) missense probably benign 0.01
santa_rosa UTSW 14 27,198,658 (GRCm39) splice site probably null
D4043:Tasor UTSW 14 27,193,949 (GRCm39) missense probably benign 0.07
R0147:Tasor UTSW 14 27,193,725 (GRCm39) missense probably benign 0.23
R0512:Tasor UTSW 14 27,168,363 (GRCm39) missense probably damaging 1.00
R0589:Tasor UTSW 14 27,183,107 (GRCm39) missense probably benign 0.01
R0609:Tasor UTSW 14 27,183,707 (GRCm39) missense probably benign 0.09
R0798:Tasor UTSW 14 27,198,593 (GRCm39) missense probably damaging 1.00
R1107:Tasor UTSW 14 27,201,680 (GRCm39) nonsense probably null
R1205:Tasor UTSW 14 27,183,275 (GRCm39) missense probably damaging 1.00
R1376:Tasor UTSW 14 27,151,338 (GRCm39) missense probably benign 0.00
R1376:Tasor UTSW 14 27,151,338 (GRCm39) missense probably benign 0.00
R1441:Tasor UTSW 14 27,186,217 (GRCm39) nonsense probably null
R1493:Tasor UTSW 14 27,171,926 (GRCm39) missense probably damaging 1.00
R1527:Tasor UTSW 14 27,202,050 (GRCm39) critical splice donor site probably null
R1729:Tasor UTSW 14 27,201,590 (GRCm39) missense probably damaging 1.00
R1752:Tasor UTSW 14 27,193,885 (GRCm39) nonsense probably null
R1960:Tasor UTSW 14 27,201,746 (GRCm39) missense possibly damaging 0.95
R1960:Tasor UTSW 14 27,160,621 (GRCm39) missense probably damaging 1.00
R1965:Tasor UTSW 14 27,164,511 (GRCm39) missense probably damaging 1.00
R2074:Tasor UTSW 14 27,183,170 (GRCm39) missense probably benign 0.03
R2107:Tasor UTSW 14 27,183,744 (GRCm39) critical splice donor site probably null
R2130:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2130:Tasor UTSW 14 27,168,345 (GRCm39) missense probably damaging 1.00
R2131:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2133:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2140:Tasor UTSW 14 27,201,992 (GRCm39) missense probably damaging 1.00
R2184:Tasor UTSW 14 27,188,141 (GRCm39) missense possibly damaging 0.83
R2279:Tasor UTSW 14 27,164,452 (GRCm39) missense probably damaging 1.00
R3979:Tasor UTSW 14 27,199,087 (GRCm39) missense possibly damaging 0.95
R4113:Tasor UTSW 14 27,181,918 (GRCm39) nonsense probably null
R4434:Tasor UTSW 14 27,171,818 (GRCm39) critical splice donor site probably null
R4562:Tasor UTSW 14 27,188,265 (GRCm39) missense possibly damaging 0.67
R4568:Tasor UTSW 14 27,198,658 (GRCm39) splice site probably null
R4754:Tasor UTSW 14 27,183,052 (GRCm39) missense probably benign
R4980:Tasor UTSW 14 27,183,382 (GRCm39) missense probably benign 0.39
R4993:Tasor UTSW 14 27,151,071 (GRCm39) missense possibly damaging 0.88
R5200:Tasor UTSW 14 27,151,183 (GRCm39) missense probably benign 0.41
R5316:Tasor UTSW 14 27,193,992 (GRCm39) missense possibly damaging 0.52
R5599:Tasor UTSW 14 27,201,886 (GRCm39) missense probably benign 0.01
R5678:Tasor UTSW 14 27,151,080 (GRCm39) small insertion probably benign
R5680:Tasor UTSW 14 27,151,080 (GRCm39) small insertion probably benign
R5887:Tasor UTSW 14 27,188,254 (GRCm39) nonsense probably null
R6181:Tasor UTSW 14 27,194,235 (GRCm39) missense probably benign 0.01
R6556:Tasor UTSW 14 27,151,215 (GRCm39) missense probably benign
R6603:Tasor UTSW 14 27,168,343 (GRCm39) missense probably damaging 1.00
R6829:Tasor UTSW 14 27,164,438 (GRCm39) missense possibly damaging 0.90
R6864:Tasor UTSW 14 27,183,115 (GRCm39) missense probably damaging 0.96
R6919:Tasor UTSW 14 27,171,758 (GRCm39) nonsense probably null
R7046:Tasor UTSW 14 27,194,392 (GRCm39) missense probably damaging 1.00
R7057:Tasor UTSW 14 27,183,608 (GRCm39) missense probably damaging 0.97
R7064:Tasor UTSW 14 27,194,288 (GRCm39) missense probably benign 0.09
R7290:Tasor UTSW 14 27,160,610 (GRCm39) missense probably damaging 1.00
R7303:Tasor UTSW 14 27,193,809 (GRCm39) missense probably damaging 1.00
R7439:Tasor UTSW 14 27,193,602 (GRCm39) missense probably damaging 1.00
R7524:Tasor UTSW 14 27,188,160 (GRCm39) missense probably damaging 0.99
R7580:Tasor UTSW 14 27,188,243 (GRCm39) missense probably benign 0.29
R7726:Tasor UTSW 14 27,169,454 (GRCm39) missense probably damaging 0.99
R7771:Tasor UTSW 14 27,189,516 (GRCm39) missense probably damaging 1.00
R7782:Tasor UTSW 14 27,193,901 (GRCm39) missense probably benign 0.07
R7795:Tasor UTSW 14 27,203,340 (GRCm39) missense
R7835:Tasor UTSW 14 27,198,600 (GRCm39) missense probably damaging 1.00
R7954:Tasor UTSW 14 27,169,481 (GRCm39) critical splice donor site probably null
R7981:Tasor UTSW 14 27,168,373 (GRCm39) missense possibly damaging 0.49
R8101:Tasor UTSW 14 27,164,438 (GRCm39) missense possibly damaging 0.90
R8160:Tasor UTSW 14 27,171,913 (GRCm39) missense probably damaging 1.00
R8307:Tasor UTSW 14 27,193,622 (GRCm39) missense probably damaging 1.00
R8913:Tasor UTSW 14 27,188,145 (GRCm39) missense probably damaging 1.00
R9070:Tasor UTSW 14 27,194,484 (GRCm39) missense probably benign 0.14
R9219:Tasor UTSW 14 27,186,344 (GRCm39) missense possibly damaging 0.50
R9420:Tasor UTSW 14 27,163,927 (GRCm39) missense probably damaging 0.99
R9513:Tasor UTSW 14 27,186,271 (GRCm39) nonsense probably null
R9562:Tasor UTSW 14 27,201,766 (GRCm39) critical splice donor site probably null
R9627:Tasor UTSW 14 27,194,123 (GRCm39) missense probably benign
X0002:Tasor UTSW 14 27,194,063 (GRCm39) missense possibly damaging 0.90
Z1176:Tasor UTSW 14 27,199,105 (GRCm39) missense probably damaging 1.00
Z1176:Tasor UTSW 14 27,151,165 (GRCm39) missense probably damaging 0.97
Z1177:Tasor UTSW 14 27,170,207 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGAAAGCTCTGAGTCTGCTGAC -3'
(R):5'- TGTAACTGAGTTGTGATAGCCCAC -3'

Sequencing Primer
(F):5'- GCTGACTCTTCTGAATGTGTATCAG -3'
(R):5'- TGTGATAGCCCACAAGACTTG -3'
Posted On 2022-08-09