Incidental Mutation 'R9566:Oasl1'
ID 721581
Institutional Source Beutler Lab
Gene Symbol Oasl1
Ensembl Gene ENSMUSG00000041827
Gene Name 2'-5' oligoadenylate synthetase-like 1
Synonyms 7530414C13Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9566 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 115061299-115075974 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115066331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 150 (T150A)
Ref Sequence ENSEMBL: ENSMUSP00000031540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031540] [ENSMUST00000112143]
AlphaFold Q8VI94
Predicted Effect probably benign
Transcript: ENSMUST00000031540
AA Change: T150A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000031540
Gene: ENSMUSG00000041827
AA Change: T150A

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 162 348 8e-76 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112143
AA Change: T150A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000107771
Gene: ENSMUSG00000041827
AA Change: T150A

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 163 346 1.9e-79 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik G A 2: 151,314,226 (GRCm39) T484I probably benign Het
4930568D16Rik C A 2: 35,244,645 (GRCm39) E236* probably null Het
Abca13 C A 11: 9,414,927 (GRCm39) T3998K probably damaging Het
Adam8 A G 7: 139,565,285 (GRCm39) V643A probably benign Het
Adamtsl2 T C 2: 26,979,773 (GRCm39) probably null Het
Akr1c18 A T 13: 4,195,203 (GRCm39) probably null Het
Atf7ip2 C T 16: 10,044,893 (GRCm39) S222L probably benign Het
Atp2c1 A T 9: 105,343,828 (GRCm39) I127N probably damaging Het
Bcl11b A G 12: 107,881,784 (GRCm39) Y844H possibly damaging Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Btnl4 A G 17: 34,688,263 (GRCm39) I505T probably benign Het
Cacna1b G A 2: 24,498,092 (GRCm39) Q2024* probably null Het
Cars1 A G 7: 143,113,384 (GRCm39) probably null Het
Ccne2 A G 4: 11,193,026 (GRCm39) K49E probably benign Het
Ccnk A G 12: 108,152,695 (GRCm39) N4S probably benign Het
Cfap91 A G 16: 38,155,996 (GRCm39) F76L probably damaging Het
Clasp1 A G 1: 118,479,801 (GRCm39) D1027G probably benign Het
Copb1 A T 7: 113,825,997 (GRCm39) N662K probably benign Het
Cox8b C T 7: 140,478,926 (GRCm39) S63N probably benign Het
Cpa4 C A 6: 30,579,608 (GRCm39) D138E probably benign Het
Dcc A G 18: 71,943,866 (GRCm39) C262R possibly damaging Het
Dennd5a C T 7: 109,533,254 (GRCm39) G172E probably benign Het
Dgke C T 11: 88,932,273 (GRCm39) probably null Het
Dnah11 A G 12: 117,938,728 (GRCm39) Y3247H possibly damaging Het
Dnajc21 T G 15: 10,464,019 (GRCm39) I49L possibly damaging Het
Dnm1 A G 2: 32,228,011 (GRCm39) probably null Het
Ecd A T 14: 20,393,368 (GRCm39) Y93* probably null Het
Epm2aip1 T C 9: 111,101,807 (GRCm39) L260P probably damaging Het
Eqtn G A 4: 94,813,185 (GRCm39) P134S probably damaging Het
Ercc1 T A 7: 19,088,377 (GRCm39) C243* probably null Het
Fbln2 C A 6: 91,231,513 (GRCm39) H537N probably benign Het
Ffar2 A G 7: 30,518,847 (GRCm39) F231S probably damaging Het
Fhod1 G A 8: 106,064,516 (GRCm39) A172V unknown Het
Gbp8 C T 5: 105,198,799 (GRCm39) V39M probably damaging Het
Gm5773 T C 3: 93,680,742 (GRCm39) L138P probably damaging Het
Gtf2ird2 A G 5: 134,246,256 (GRCm39) E838G probably damaging Het
Gucy2e C A 11: 69,118,947 (GRCm39) V682L probably damaging Het
Hmcn1 T G 1: 150,498,660 (GRCm39) N4073T probably benign Het
Il22b A T 10: 118,130,860 (GRCm39) L12H probably damaging Het
Ist1 A T 8: 110,408,816 (GRCm39) S94T probably benign Het
Klhl24 A T 16: 19,934,669 (GRCm39) N381Y probably damaging Het
Krtap24-1 C T 16: 88,408,886 (GRCm39) C80Y Het
Lcp2 T A 11: 34,000,944 (GRCm39) D42E Het
Map1s G A 8: 71,365,580 (GRCm39) A162T probably benign Het
Mbd5 T G 2: 49,169,521 (GRCm39) V1564G probably damaging Het
Mettl15 A T 2: 108,923,592 (GRCm39) S277T possibly damaging Het
Mfsd12 C G 10: 81,196,962 (GRCm39) T177S probably benign Het
Mlxipl A G 5: 135,152,616 (GRCm39) D244G possibly damaging Het
Mutyh G A 4: 116,673,780 (GRCm39) V164M probably damaging Het
Mypop A G 7: 18,726,534 (GRCm39) D167G probably benign Het
Nbeal2 C T 9: 110,457,989 (GRCm39) V2169M probably benign Het
Nifk G T 1: 118,260,492 (GRCm39) V259F probably damaging Het
Obox6 G A 7: 15,568,352 (GRCm39) R175C Het
Or2y11 T C 11: 49,443,162 (GRCm39) V196A probably benign Het
Or5p52 T A 7: 107,502,409 (GRCm39) C162S possibly damaging Het
Or5p69 A T 7: 107,966,783 (GRCm39) I29F probably benign Het
Per3 A G 4: 151,113,335 (GRCm39) F331S Het
Pitrm1 A G 13: 6,613,452 (GRCm39) D508G probably benign Het
Plec T A 15: 76,062,790 (GRCm39) I2427F possibly damaging Het
Prkd3 A T 17: 79,292,652 (GRCm39) V140D probably damaging Het
Prpf3 G A 3: 95,760,800 (GRCm39) A34V probably damaging Het
Ptar1 A G 19: 23,686,206 (GRCm39) T173A probably benign Het
Resf1 A G 6: 149,227,352 (GRCm39) N133D possibly damaging Het
Rest G T 5: 77,416,277 (GRCm39) E164* probably null Het
Rnpepl1 A C 1: 92,847,468 (GRCm39) D685A Het
Sc5d T C 9: 42,170,008 (GRCm39) N71S probably damaging Het
Serpinb3c A T 1: 107,200,425 (GRCm39) S239R probably damaging Het
Slc28a3 C T 13: 58,758,653 (GRCm39) probably benign Het
Smagp T C 15: 100,519,844 (GRCm39) Y60C probably damaging Het
Spink10 T A 18: 62,790,939 (GRCm39) M75K probably benign Het
Spryd7 T C 14: 61,777,639 (GRCm39) N147S probably benign Het
Steap4 A G 5: 8,025,646 (GRCm39) E69G possibly damaging Het
Svil C A 18: 5,099,661 (GRCm39) H1732Q probably damaging Het
Tgoln1 T C 6: 72,592,911 (GRCm39) T190A probably benign Het
Tmem63c C T 12: 87,108,305 (GRCm39) S106F possibly damaging Het
Trpv5 T C 6: 41,637,456 (GRCm39) D375G probably null Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Ugt2b38 A G 5: 87,558,209 (GRCm39) L484P probably damaging Het
Uox A T 3: 146,330,308 (GRCm39) T179S possibly damaging Het
Usp34 A G 11: 23,317,529 (GRCm39) I882V Het
Vmn2r124 A G 17: 18,293,581 (GRCm39) K556R probably benign Het
Vmn2r57 A G 7: 41,077,089 (GRCm39) F359S probably benign Het
Wasf2 T C 4: 132,921,766 (GRCm39) V295A unknown Het
Znhit1 G A 5: 137,015,785 (GRCm39) probably benign Het
Zscan22 C T 7: 12,640,866 (GRCm39) T370M probably damaging Het
Other mutations in Oasl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Oasl1 APN 5 115,075,466 (GRCm39) missense probably benign 0.01
IGL02061:Oasl1 APN 5 115,061,651 (GRCm39) missense probably damaging 0.97
IGL02888:Oasl1 APN 5 115,075,241 (GRCm39) missense probably damaging 1.00
IGL03230:Oasl1 APN 5 115,075,115 (GRCm39) missense probably damaging 1.00
ammonite UTSW 5 115,074,996 (GRCm39) missense probably damaging 1.00
dreadnaught UTSW 5 115,074,129 (GRCm39) critical splice donor site probably null
nautilus UTSW 5 115,075,242 (GRCm39) missense probably damaging 1.00
spirogyra UTSW 5 115,075,465 (GRCm39) missense probably benign 0.00
IGL03048:Oasl1 UTSW 5 115,075,400 (GRCm39) missense possibly damaging 0.56
R1510:Oasl1 UTSW 5 115,066,167 (GRCm39) missense probably benign 0.00
R1680:Oasl1 UTSW 5 115,074,003 (GRCm39) missense probably damaging 1.00
R1918:Oasl1 UTSW 5 115,061,528 (GRCm39) missense possibly damaging 0.84
R2090:Oasl1 UTSW 5 115,073,993 (GRCm39) missense probably damaging 1.00
R3977:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R3978:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R3980:Oasl1 UTSW 5 115,070,957 (GRCm39) missense probably damaging 1.00
R4158:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4159:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4160:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4161:Oasl1 UTSW 5 115,075,073 (GRCm39) missense possibly damaging 0.77
R4797:Oasl1 UTSW 5 115,066,217 (GRCm39) missense probably benign 0.00
R5354:Oasl1 UTSW 5 115,075,055 (GRCm39) missense probably damaging 1.00
R5443:Oasl1 UTSW 5 115,074,129 (GRCm39) critical splice donor site probably null
R5820:Oasl1 UTSW 5 115,075,037 (GRCm39) missense possibly damaging 0.94
R5919:Oasl1 UTSW 5 115,066,329 (GRCm39) missense probably damaging 1.00
R6746:Oasl1 UTSW 5 115,075,242 (GRCm39) missense probably damaging 1.00
R7471:Oasl1 UTSW 5 115,073,985 (GRCm39) missense probably damaging 1.00
R7720:Oasl1 UTSW 5 115,067,980 (GRCm39) missense probably damaging 1.00
R7766:Oasl1 UTSW 5 115,075,169 (GRCm39) missense probably damaging 1.00
R8115:Oasl1 UTSW 5 115,074,996 (GRCm39) missense probably damaging 1.00
R8243:Oasl1 UTSW 5 115,066,220 (GRCm39) missense probably benign 0.04
R8358:Oasl1 UTSW 5 115,075,465 (GRCm39) missense probably benign 0.00
R9695:Oasl1 UTSW 5 115,074,054 (GRCm39) missense probably damaging 1.00
Z1177:Oasl1 UTSW 5 115,070,804 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TCAGGAGCACTACAGACGTG -3'
(R):5'- GATGAGTTTCTGTTTCCCCAAGTC -3'

Sequencing Primer
(F):5'- CTGTTTCCACAGCTTCCAGGAAG -3'
(R):5'- TTTCCCCAAGTCGGCATGG -3'
Posted On 2022-08-09