Incidental Mutation 'R9567:Magi1'
| ID |
721678 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.561)
|
| Stock # |
R9567 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 93655431 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 1405
(A1405V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| PDB Structure |
X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055224
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089317
AA Change: A1405V
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: A1405V
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093769
AA Change: A1189V
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: A1189V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203519
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203688
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204347
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833420G17Rik |
C |
T |
13: 119,602,793 (GRCm39) |
P52S |
probably damaging |
Het |
| 6820408C15Rik |
C |
A |
2: 152,270,867 (GRCm39) |
P30Q |
probably damaging |
Het |
| Adam18 |
C |
T |
8: 25,118,210 (GRCm39) |
V569I |
probably benign |
Het |
| Adnp2 |
A |
T |
18: 80,174,133 (GRCm39) |
L92Q |
probably damaging |
Het |
| Ahi1 |
C |
T |
10: 20,857,300 (GRCm39) |
H632Y |
possibly damaging |
Het |
| Akap9 |
A |
G |
5: 4,127,311 (GRCm39) |
N3720D |
possibly damaging |
Het |
| Alpk3 |
T |
C |
7: 80,742,687 (GRCm39) |
S835P |
possibly damaging |
Het |
| Amer3 |
C |
T |
1: 34,627,836 (GRCm39) |
L692F |
probably benign |
Het |
| Anks6 |
T |
A |
4: 47,044,880 (GRCm39) |
D342V |
unknown |
Het |
| Arap2 |
G |
T |
5: 62,761,841 (GRCm39) |
F1628L |
probably benign |
Het |
| Arhgap21 |
T |
G |
2: 20,896,953 (GRCm39) |
I108L |
possibly damaging |
Het |
| Cacna1h |
T |
C |
17: 25,612,487 (GRCm39) |
I404V |
probably damaging |
Het |
| Cacna2d3 |
G |
T |
14: 28,627,268 (GRCm39) |
A1077E |
probably benign |
Het |
| Cacng6 |
T |
C |
7: 3,483,281 (GRCm39) |
V203A |
probably benign |
Het |
| Clec1b |
A |
T |
6: 129,382,201 (GRCm39) |
D226V |
possibly damaging |
Het |
| Crb1 |
A |
C |
1: 139,171,208 (GRCm39) |
S727R |
probably benign |
Het |
| Dars1 |
T |
C |
1: 128,343,112 (GRCm39) |
I35V |
|
Het |
| Ddo |
T |
A |
10: 40,523,913 (GRCm39) |
V301D |
probably damaging |
Het |
| Diablo |
C |
A |
5: 123,662,196 (GRCm39) |
|
probably benign |
Het |
| Dipk1a |
T |
A |
5: 108,057,368 (GRCm39) |
K397* |
probably null |
Het |
| Dnhd1 |
C |
A |
7: 105,353,473 (GRCm39) |
H2875Q |
probably benign |
Het |
| E230025N22Rik |
A |
G |
18: 36,820,336 (GRCm39) |
L282P |
|
Het |
| Ebna1bp2 |
A |
G |
4: 118,478,190 (GRCm39) |
Q21R |
probably benign |
Het |
| Exoc7 |
C |
T |
11: 116,195,724 (GRCm39) |
V93I |
probably benign |
Het |
| Foxk1 |
T |
A |
5: 142,387,713 (GRCm39) |
Y145* |
probably null |
Het |
| Foxo3 |
C |
T |
10: 42,073,021 (GRCm39) |
V499M |
probably damaging |
Het |
| Fsip2 |
C |
T |
2: 82,798,173 (GRCm39) |
T489M |
probably benign |
Het |
| Gbf1 |
C |
T |
19: 46,260,046 (GRCm39) |
T1067I |
|
Het |
| Ggta1 |
T |
A |
2: 35,313,333 (GRCm39) |
T3S |
possibly damaging |
Het |
| Guf1 |
T |
A |
5: 69,721,951 (GRCm39) |
V370E |
possibly damaging |
Het |
| Hmg20a |
A |
G |
9: 56,384,472 (GRCm39) |
S81G |
probably benign |
Het |
| Igf2r |
G |
A |
17: 12,905,641 (GRCm39) |
T2230I |
probably damaging |
Het |
| Ighmbp2 |
A |
T |
19: 3,332,785 (GRCm39) |
M1K |
probably null |
Het |
| Klhdc9 |
T |
C |
1: 171,187,914 (GRCm39) |
T106A |
probably benign |
Het |
| Kti12 |
T |
C |
4: 108,705,935 (GRCm39) |
M283T |
possibly damaging |
Het |
| Lrig3 |
C |
T |
10: 125,845,964 (GRCm39) |
P798S |
probably benign |
Het |
| Lrp8 |
T |
C |
4: 107,711,469 (GRCm39) |
F333L |
probably damaging |
Het |
| Lyn |
T |
A |
4: 3,746,757 (GRCm39) |
D178E |
probably benign |
Het |
| Mdga1 |
G |
A |
17: 30,076,569 (GRCm39) |
P68S |
probably damaging |
Het |
| Mfsd8 |
T |
C |
3: 40,793,933 (GRCm39) |
S25G |
probably benign |
Het |
| Mgat1 |
C |
A |
11: 49,152,694 (GRCm39) |
S392R |
probably benign |
Het |
| Mtmr2 |
C |
T |
9: 13,713,301 (GRCm39) |
Q493* |
probably null |
Het |
| Myocd |
A |
T |
11: 65,078,410 (GRCm39) |
S462T |
probably damaging |
Het |
| Ndnf |
A |
G |
6: 65,681,164 (GRCm39) |
Y481C |
probably damaging |
Het |
| Neb |
G |
T |
2: 52,065,138 (GRCm39) |
R6258S |
probably damaging |
Het |
| Nlrp4c |
A |
G |
7: 6,063,624 (GRCm39) |
M11V |
probably benign |
Het |
| Nup93 |
T |
C |
8: 95,035,604 (GRCm39) |
S658P |
possibly damaging |
Het |
| Obox2 |
T |
A |
7: 15,130,771 (GRCm39) |
M1K |
probably null |
Het |
| Or10ag55-ps1 |
T |
A |
2: 87,115,037 (GRCm39) |
Y134* |
probably null |
Het |
| Or10g9 |
T |
A |
9: 39,912,367 (GRCm39) |
H52L |
possibly damaging |
Het |
| Or1e20-ps1 |
G |
T |
11: 73,324,789 (GRCm39) |
H88N |
unknown |
Het |
| Or51ag1 |
C |
T |
7: 103,155,727 (GRCm39) |
R142H |
probably benign |
Het |
| Pcdh18 |
T |
A |
3: 49,710,884 (GRCm39) |
I144F |
possibly damaging |
Het |
| Pcdhgb5 |
C |
T |
18: 37,864,982 (GRCm39) |
T259I |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,763,436 (GRCm39) |
T685A |
|
Het |
| Pecam1 |
T |
C |
11: 106,588,121 (GRCm39) |
T139A |
possibly damaging |
Het |
| Pi15 |
T |
A |
1: 17,695,178 (GRCm39) |
L265Q |
probably damaging |
Het |
| Pkd1l3 |
T |
A |
8: 110,394,173 (GRCm39) |
F2053L |
probably damaging |
Het |
| Ppp1r36 |
A |
G |
12: 76,485,900 (GRCm39) |
I353V |
probably benign |
Het |
| Ppp1r9a |
A |
G |
6: 5,157,004 (GRCm39) |
S961G |
probably benign |
Het |
| Rbm42 |
T |
C |
7: 30,345,395 (GRCm39) |
R151G |
possibly damaging |
Het |
| Rnf224 |
T |
C |
2: 25,126,354 (GRCm39) |
|
probably benign |
Het |
| Scn2a |
C |
T |
2: 65,518,974 (GRCm39) |
T400I |
probably damaging |
Het |
| Slc17a5 |
T |
A |
9: 78,445,562 (GRCm39) |
Q457L |
possibly damaging |
Het |
| Slc5a4a |
A |
T |
10: 76,022,396 (GRCm39) |
D577V |
probably benign |
Het |
| Stim2 |
A |
G |
5: 54,232,707 (GRCm39) |
D123G |
probably damaging |
Het |
| Stxbp5l |
A |
G |
16: 37,061,734 (GRCm39) |
F359L |
probably benign |
Het |
| Syne1 |
T |
C |
10: 5,196,386 (GRCm39) |
D3882G |
possibly damaging |
Het |
| Synj1 |
G |
T |
16: 90,790,912 (GRCm39) |
S83Y |
possibly damaging |
Het |
| Tfip11 |
C |
T |
5: 112,479,029 (GRCm39) |
T199I |
probably damaging |
Het |
| Thoc2l |
T |
A |
5: 104,669,644 (GRCm39) |
S1389T |
probably benign |
Het |
| Tiam1 |
T |
A |
16: 89,591,653 (GRCm39) |
D1349V |
probably damaging |
Het |
| Tyw1 |
G |
A |
5: 130,298,065 (GRCm39) |
R202Q |
probably damaging |
Het |
| Ucn3 |
T |
A |
13: 3,991,313 (GRCm39) |
D113V |
probably damaging |
Het |
| Ugt3a1 |
A |
G |
15: 9,306,370 (GRCm39) |
D173G |
possibly damaging |
Het |
| Uimc1 |
C |
A |
13: 55,188,427 (GRCm39) |
R544L |
possibly damaging |
Het |
| Unc13c |
T |
C |
9: 73,536,485 (GRCm39) |
S1623G |
probably damaging |
Het |
| Vmn2r41 |
T |
C |
7: 8,141,391 (GRCm39) |
N691S |
probably benign |
Het |
| Wdr24 |
T |
A |
17: 26,043,190 (GRCm39) |
M4K |
probably damaging |
Het |
| Wdr48 |
T |
C |
9: 119,741,454 (GRCm39) |
F332L |
probably benign |
Het |
| Xpo7 |
A |
G |
14: 70,903,466 (GRCm39) |
V1080A |
probably benign |
Het |
| Zc3h3 |
A |
T |
15: 75,651,261 (GRCm39) |
I653N |
probably damaging |
Het |
| Zfp1005 |
A |
T |
2: 150,109,517 (GRCm39) |
H69L |
possibly damaging |
Het |
| Zfp362 |
T |
A |
4: 128,688,681 (GRCm39) |
M1L |
unknown |
Het |
| Zfp503 |
A |
G |
14: 22,036,041 (GRCm39) |
C292R |
possibly damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGTTGCAATGCTGAGTCTC -3'
(R):5'- CGCTGACAACACTTTGGAAAG -3'
Sequencing Primer
(F):5'- GCTACATTCTTTGTAAGGCCG -3'
(R):5'- CTGACAACACTTTGGAAAGAAGGG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation