Incidental Mutation 'R9567:Ugt3a1'
ID 721716
Institutional Source Beutler Lab
Gene Symbol Ugt3a1
Ensembl Gene ENSMUSG00000072664
Gene Name UDP glycosyltransferases 3 family, polypeptide A1
Synonyms Ugt3a2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R9567 (G1)
Quality Score 163.009
Status Not validated
Chromosome 15
Chromosomal Location 9335670-9370960 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 9306370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 173 (D173G)
Ref Sequence ENSEMBL: ENSMUSP00000022861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022861]
AlphaFold Q3UP75
Predicted Effect possibly damaging
Transcript: ENSMUST00000022861
AA Change: D173G

PolyPhen 2 Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000022861
Gene: ENSMUSG00000072664
AA Change: D173G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:UDPGT 23 521 1.4e-98 PFAM
Pfam:Glyco_tran_28_C 300 451 3.7e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik C T 13: 119,602,793 (GRCm39) P52S probably damaging Het
6820408C15Rik C A 2: 152,270,867 (GRCm39) P30Q probably damaging Het
Adam18 C T 8: 25,118,210 (GRCm39) V569I probably benign Het
Adnp2 A T 18: 80,174,133 (GRCm39) L92Q probably damaging Het
Ahi1 C T 10: 20,857,300 (GRCm39) H632Y possibly damaging Het
Akap9 A G 5: 4,127,311 (GRCm39) N3720D possibly damaging Het
Alpk3 T C 7: 80,742,687 (GRCm39) S835P possibly damaging Het
Amer3 C T 1: 34,627,836 (GRCm39) L692F probably benign Het
Anks6 T A 4: 47,044,880 (GRCm39) D342V unknown Het
Arap2 G T 5: 62,761,841 (GRCm39) F1628L probably benign Het
Arhgap21 T G 2: 20,896,953 (GRCm39) I108L possibly damaging Het
Cacna1h T C 17: 25,612,487 (GRCm39) I404V probably damaging Het
Cacna2d3 G T 14: 28,627,268 (GRCm39) A1077E probably benign Het
Cacng6 T C 7: 3,483,281 (GRCm39) V203A probably benign Het
Clec1b A T 6: 129,382,201 (GRCm39) D226V possibly damaging Het
Crb1 A C 1: 139,171,208 (GRCm39) S727R probably benign Het
Dars1 T C 1: 128,343,112 (GRCm39) I35V Het
Ddo T A 10: 40,523,913 (GRCm39) V301D probably damaging Het
Diablo C A 5: 123,662,196 (GRCm39) probably benign Het
Dipk1a T A 5: 108,057,368 (GRCm39) K397* probably null Het
Dnhd1 C A 7: 105,353,473 (GRCm39) H2875Q probably benign Het
E230025N22Rik A G 18: 36,820,336 (GRCm39) L282P Het
Ebna1bp2 A G 4: 118,478,190 (GRCm39) Q21R probably benign Het
Exoc7 C T 11: 116,195,724 (GRCm39) V93I probably benign Het
Foxk1 T A 5: 142,387,713 (GRCm39) Y145* probably null Het
Foxo3 C T 10: 42,073,021 (GRCm39) V499M probably damaging Het
Fsip2 C T 2: 82,798,173 (GRCm39) T489M probably benign Het
Gbf1 C T 19: 46,260,046 (GRCm39) T1067I Het
Ggta1 T A 2: 35,313,333 (GRCm39) T3S possibly damaging Het
Guf1 T A 5: 69,721,951 (GRCm39) V370E possibly damaging Het
Hmg20a A G 9: 56,384,472 (GRCm39) S81G probably benign Het
Igf2r G A 17: 12,905,641 (GRCm39) T2230I probably damaging Het
Ighmbp2 A T 19: 3,332,785 (GRCm39) M1K probably null Het
Klhdc9 T C 1: 171,187,914 (GRCm39) T106A probably benign Het
Kti12 T C 4: 108,705,935 (GRCm39) M283T possibly damaging Het
Lrig3 C T 10: 125,845,964 (GRCm39) P798S probably benign Het
Lrp8 T C 4: 107,711,469 (GRCm39) F333L probably damaging Het
Lyn T A 4: 3,746,757 (GRCm39) D178E probably benign Het
Magi1 G A 6: 93,655,431 (GRCm39) A1405V probably damaging Het
Magi1 A C 6: 93,659,931 (GRCm39) probably null Het
Mdga1 G A 17: 30,076,569 (GRCm39) P68S probably damaging Het
Mfsd8 T C 3: 40,793,933 (GRCm39) S25G probably benign Het
Mgat1 C A 11: 49,152,694 (GRCm39) S392R probably benign Het
Mtmr2 C T 9: 13,713,301 (GRCm39) Q493* probably null Het
Myocd A T 11: 65,078,410 (GRCm39) S462T probably damaging Het
Ndnf A G 6: 65,681,164 (GRCm39) Y481C probably damaging Het
Neb G T 2: 52,065,138 (GRCm39) R6258S probably damaging Het
Nlrp4c A G 7: 6,063,624 (GRCm39) M11V probably benign Het
Nup93 T C 8: 95,035,604 (GRCm39) S658P possibly damaging Het
Obox2 T A 7: 15,130,771 (GRCm39) M1K probably null Het
Or10ag55-ps1 T A 2: 87,115,037 (GRCm39) Y134* probably null Het
Or10g9 T A 9: 39,912,367 (GRCm39) H52L possibly damaging Het
Or1e20-ps1 G T 11: 73,324,789 (GRCm39) H88N unknown Het
Or51ag1 C T 7: 103,155,727 (GRCm39) R142H probably benign Het
Pcdh18 T A 3: 49,710,884 (GRCm39) I144F possibly damaging Het
Pcdhgb5 C T 18: 37,864,982 (GRCm39) T259I probably damaging Het
Pclo A G 5: 14,763,436 (GRCm39) T685A Het
Pecam1 T C 11: 106,588,121 (GRCm39) T139A possibly damaging Het
Pi15 T A 1: 17,695,178 (GRCm39) L265Q probably damaging Het
Pkd1l3 T A 8: 110,394,173 (GRCm39) F2053L probably damaging Het
Ppp1r36 A G 12: 76,485,900 (GRCm39) I353V probably benign Het
Ppp1r9a A G 6: 5,157,004 (GRCm39) S961G probably benign Het
Rbm42 T C 7: 30,345,395 (GRCm39) R151G possibly damaging Het
Rnf224 T C 2: 25,126,354 (GRCm39) probably benign Het
Scn2a C T 2: 65,518,974 (GRCm39) T400I probably damaging Het
Slc17a5 T A 9: 78,445,562 (GRCm39) Q457L possibly damaging Het
Slc5a4a A T 10: 76,022,396 (GRCm39) D577V probably benign Het
Stim2 A G 5: 54,232,707 (GRCm39) D123G probably damaging Het
Stxbp5l A G 16: 37,061,734 (GRCm39) F359L probably benign Het
Syne1 T C 10: 5,196,386 (GRCm39) D3882G possibly damaging Het
Synj1 G T 16: 90,790,912 (GRCm39) S83Y possibly damaging Het
Tfip11 C T 5: 112,479,029 (GRCm39) T199I probably damaging Het
Thoc2l T A 5: 104,669,644 (GRCm39) S1389T probably benign Het
Tiam1 T A 16: 89,591,653 (GRCm39) D1349V probably damaging Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Ucn3 T A 13: 3,991,313 (GRCm39) D113V probably damaging Het
Uimc1 C A 13: 55,188,427 (GRCm39) R544L possibly damaging Het
Unc13c T C 9: 73,536,485 (GRCm39) S1623G probably damaging Het
Vmn2r41 T C 7: 8,141,391 (GRCm39) N691S probably benign Het
Wdr24 T A 17: 26,043,190 (GRCm39) M4K probably damaging Het
Wdr48 T C 9: 119,741,454 (GRCm39) F332L probably benign Het
Xpo7 A G 14: 70,903,466 (GRCm39) V1080A probably benign Het
Zc3h3 A T 15: 75,651,261 (GRCm39) I653N probably damaging Het
Zfp1005 A T 2: 150,109,517 (GRCm39) H69L possibly damaging Het
Zfp362 T A 4: 128,688,681 (GRCm39) M1L unknown Het
Zfp503 A G 14: 22,036,041 (GRCm39) C292R possibly damaging Het
Other mutations in Ugt3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00912:Ugt3a1 APN 15 9,310,698 (GRCm39) missense probably damaging 1.00
IGL01109:Ugt3a1 APN 15 9,367,354 (GRCm39) missense probably damaging 0.99
IGL01131:Ugt3a1 APN 15 9,365,248 (GRCm39) missense probably damaging 1.00
IGL01627:Ugt3a1 APN 15 9,335,806 (GRCm39) missense probably damaging 1.00
IGL01746:Ugt3a1 APN 15 9,361,754 (GRCm39) missense probably damaging 1.00
IGL01752:Ugt3a1 APN 15 9,306,232 (GRCm39) missense probably damaging 1.00
IGL01949:Ugt3a1 APN 15 9,335,815 (GRCm39) missense probably damaging 1.00
IGL02213:Ugt3a1 APN 15 9,370,310 (GRCm39) missense probably benign 0.00
IGL02407:Ugt3a1 APN 15 9,365,316 (GRCm39) nonsense probably null
IGL02438:Ugt3a1 APN 15 9,292,062 (GRCm39) missense possibly damaging 0.90
IGL02588:Ugt3a1 APN 15 9,361,542 (GRCm39) missense probably benign
IGL02894:Ugt3a1 APN 15 9,367,487 (GRCm39) missense probably damaging 1.00
IGL02966:Ugt3a1 APN 15 9,370,154 (GRCm39) missense probably damaging 1.00
IGL03385:Ugt3a1 APN 15 9,338,824 (GRCm39) missense probably damaging 0.99
IGL03493:Ugt3a1 APN 15 9,361,569 (GRCm39) missense probably damaging 0.96
PIT4354001:Ugt3a1 UTSW 15 9,306,446 (GRCm39) nonsense probably null
R0127:Ugt3a1 UTSW 15 9,306,342 (GRCm39) missense probably benign 0.01
R0554:Ugt3a1 UTSW 15 9,351,206 (GRCm39) missense probably benign 0.14
R0647:Ugt3a1 UTSW 15 9,310,635 (GRCm39) missense probably benign 0.00
R0833:Ugt3a1 UTSW 15 9,370,236 (GRCm39) missense probably damaging 0.96
R0841:Ugt3a1 UTSW 15 9,306,214 (GRCm39) missense probably benign 0.07
R1071:Ugt3a1 UTSW 15 9,367,454 (GRCm39) missense possibly damaging 0.82
R1395:Ugt3a1 UTSW 15 9,306,378 (GRCm39) missense possibly damaging 0.92
R1513:Ugt3a1 UTSW 15 9,361,610 (GRCm39) missense probably benign 0.07
R1616:Ugt3a1 UTSW 15 9,306,330 (GRCm39) nonsense probably null
R1844:Ugt3a1 UTSW 15 9,351,254 (GRCm39) missense probably benign 0.07
R1874:Ugt3a1 UTSW 15 9,365,437 (GRCm39) missense probably damaging 1.00
R2305:Ugt3a1 UTSW 15 9,351,203 (GRCm39) missense probably benign
R2338:Ugt3a1 UTSW 15 9,292,059 (GRCm39) splice site probably benign
R3052:Ugt3a1 UTSW 15 9,365,374 (GRCm39) missense probably damaging 1.00
R3755:Ugt3a1 UTSW 15 9,367,498 (GRCm39) missense probably benign 0.21
R3797:Ugt3a1 UTSW 15 9,310,727 (GRCm39) nonsense probably null
R3945:Ugt3a1 UTSW 15 9,370,184 (GRCm39) missense possibly damaging 0.91
R4135:Ugt3a1 UTSW 15 9,338,810 (GRCm39) missense probably damaging 0.98
R4261:Ugt3a1 UTSW 15 9,335,879 (GRCm39) splice site probably null
R4305:Ugt3a1 UTSW 15 9,306,360 (GRCm39) missense possibly damaging 0.92
R4385:Ugt3a1 UTSW 15 9,306,565 (GRCm39) missense probably benign 0.15
R4438:Ugt3a1 UTSW 15 9,351,283 (GRCm39) missense probably benign 0.01
R4570:Ugt3a1 UTSW 15 9,338,807 (GRCm39) missense probably benign 0.12
R4572:Ugt3a1 UTSW 15 9,306,479 (GRCm39) missense probably benign 0.00
R4611:Ugt3a1 UTSW 15 9,306,486 (GRCm39) nonsense probably null
R4744:Ugt3a1 UTSW 15 9,310,639 (GRCm39) missense probably benign 0.36
R4791:Ugt3a1 UTSW 15 9,361,665 (GRCm39) missense probably damaging 1.00
R4957:Ugt3a1 UTSW 15 9,365,274 (GRCm39) missense probably benign 0.27
R5011:Ugt3a1 UTSW 15 9,365,373 (GRCm39) missense probably damaging 1.00
R5035:Ugt3a1 UTSW 15 9,361,704 (GRCm39) missense probably benign 0.01
R5554:Ugt3a1 UTSW 15 9,370,287 (GRCm39) missense probably damaging 1.00
R5573:Ugt3a1 UTSW 15 9,361,769 (GRCm39) missense probably damaging 1.00
R5631:Ugt3a1 UTSW 15 9,361,971 (GRCm39) missense probably damaging 0.98
R5696:Ugt3a1 UTSW 15 9,361,534 (GRCm39) splice site silent
R5715:Ugt3a1 UTSW 15 9,306,430 (GRCm39) missense probably damaging 0.96
R6036:Ugt3a1 UTSW 15 9,306,172 (GRCm39) missense probably benign 0.01
R6036:Ugt3a1 UTSW 15 9,306,172 (GRCm39) missense probably benign 0.01
R6156:Ugt3a1 UTSW 15 9,310,762 (GRCm39) missense possibly damaging 0.83
R6228:Ugt3a1 UTSW 15 9,310,726 (GRCm39) missense possibly damaging 0.81
R6265:Ugt3a1 UTSW 15 9,361,665 (GRCm39) missense probably damaging 1.00
R6302:Ugt3a1 UTSW 15 9,365,397 (GRCm39) missense probably damaging 1.00
R6311:Ugt3a1 UTSW 15 9,361,604 (GRCm39) nonsense probably null
R6344:Ugt3a1 UTSW 15 9,306,317 (GRCm39) missense probably damaging 0.98
R6380:Ugt3a1 UTSW 15 9,306,541 (GRCm39) missense probably benign 0.00
R6383:Ugt3a1 UTSW 15 9,306,541 (GRCm39) missense probably benign 0.00
R6680:Ugt3a1 UTSW 15 9,370,154 (GRCm39) missense probably damaging 1.00
R6737:Ugt3a1 UTSW 15 9,311,895 (GRCm39) missense probably benign 0.30
R6848:Ugt3a1 UTSW 15 9,280,138 (GRCm39) splice site probably null
R6937:Ugt3a1 UTSW 15 9,292,158 (GRCm39) missense probably benign 0.00
R7061:Ugt3a1 UTSW 15 9,306,240 (GRCm39) missense probably benign 0.12
R7672:Ugt3a1 UTSW 15 9,310,779 (GRCm39) nonsense probably null
R7840:Ugt3a1 UTSW 15 9,311,903 (GRCm39) missense probably damaging 1.00
R7945:Ugt3a1 UTSW 15 9,284,261 (GRCm39) critical splice donor site probably null
R8105:Ugt3a1 UTSW 15 9,306,476 (GRCm39) missense probably benign 0.00
R8229:Ugt3a1 UTSW 15 9,367,463 (GRCm39) missense probably damaging 0.99
R8296:Ugt3a1 UTSW 15 9,362,024 (GRCm39) missense probably benign 0.18
R8414:Ugt3a1 UTSW 15 9,310,669 (GRCm39) missense possibly damaging 0.82
R8809:Ugt3a1 UTSW 15 9,367,345 (GRCm39) missense possibly damaging 0.69
R8981:Ugt3a1 UTSW 15 9,312,014 (GRCm39) missense probably benign 0.20
R9066:Ugt3a1 UTSW 15 9,367,384 (GRCm39) missense possibly damaging 0.94
R9071:Ugt3a1 UTSW 15 9,370,224 (GRCm39) nonsense probably null
R9111:Ugt3a1 UTSW 15 9,306,333 (GRCm39) missense possibly damaging 0.69
R9151:Ugt3a1 UTSW 15 9,362,051 (GRCm39) missense probably benign 0.03
R9451:Ugt3a1 UTSW 15 9,292,158 (GRCm39) missense probably benign 0.00
R9522:Ugt3a1 UTSW 15 9,370,209 (GRCm39) missense probably damaging 1.00
R9609:Ugt3a1 UTSW 15 9,361,905 (GRCm39) missense probably damaging 1.00
R9657:Ugt3a1 UTSW 15 9,280,133 (GRCm39) missense probably damaging 0.98
Z1177:Ugt3a1 UTSW 15 9,367,343 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCAATACTTTGCGGACTTATGC -3'
(R):5'- ACAGCTCAGCTTTCAGTAGAAG -3'

Sequencing Primer
(F):5'- TGCAGTCACTTATTAAGCAGAAAGG -3'
(R):5'- CTCAGCTTTCAGTAGAAGGTCAGAC -3'
Posted On 2022-08-09