Incidental Mutation 'R9568:Or6z5'
ID 721756
Institutional Source Beutler Lab
Gene Symbol Or6z5
Ensembl Gene ENSMUSG00000054938
Gene Name olfactory receptor family 6 subfamily Z member 5
Synonyms Olfr1346, GA_x6K02T2QGBW-3203957-3204898, MOR103-6
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R9568 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 6477111-6478052 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6477334 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 75 (E75G)
Ref Sequence ENSEMBL: ENSMUSP00000146519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056144] [ENSMUST00000207658] [ENSMUST00000209866] [ENSMUST00000215302]
AlphaFold Q8VGH6
Predicted Effect probably damaging
Transcript: ENSMUST00000056144
AA Change: E75G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050553
Gene: ENSMUSG00000054938
AA Change: E75G

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 7.2e-44 PFAM
Pfam:7tm_1 45 295 5.4e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207658
AA Change: E75G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000209866
Predicted Effect probably damaging
Transcript: ENSMUST00000215302
AA Change: E75G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6a T G 12: 113,508,020 (GRCm39) V131G possibly damaging Het
Agr3 G T 12: 35,998,349 (GRCm39) M149I probably benign Het
Alox12b T A 11: 69,054,836 (GRCm39) C280S possibly damaging Het
Amhr2 C A 15: 102,353,954 (GRCm39) Q16K probably benign Het
Ank1 A G 8: 23,609,381 (GRCm39) T1387A probably benign Het
B3gnt9 A C 8: 105,980,203 (GRCm39) F395C probably damaging Het
BC048562 A G 9: 108,322,905 (GRCm39) D80G probably damaging Het
Ccdc65 T A 15: 98,620,819 (GRCm39) M438K possibly damaging Het
Ccz1 T C 5: 143,938,251 (GRCm39) R240G probably damaging Het
Cish A T 9: 107,177,593 (GRCm39) S90C probably benign Het
Col5a2 A T 1: 45,430,998 (GRCm39) S881T possibly damaging Het
Col6a6 G A 9: 105,657,926 (GRCm39) T762I possibly damaging Het
Cpa1 A G 6: 30,640,060 (GRCm39) K49E probably benign Het
Cpb1 T C 3: 20,320,697 (GRCm39) probably null Het
Csmd3 A G 15: 48,150,942 (GRCm39) S483P probably damaging Het
Cul9 G A 17: 46,831,044 (GRCm39) T1643I possibly damaging Het
Dock2 T C 11: 34,599,638 (GRCm39) K314E possibly damaging Het
Elp1 G T 4: 56,786,711 (GRCm39) P411T probably damaging Het
Fam186b T G 15: 99,176,571 (GRCm39) K773T probably damaging Het
Fancl T A 11: 26,418,672 (GRCm39) V259E probably benign Het
Fat4 T G 3: 38,946,156 (GRCm39) I1683S probably damaging Het
Fcamr T A 1: 130,732,356 (GRCm39) H114Q probably damaging Het
Fndc11 T C 2: 180,864,046 (GRCm39) F284L probably damaging Het
Galns A G 8: 123,311,649 (GRCm39) probably null Het
Gch1 A G 14: 47,426,637 (GRCm39) S30P probably benign Het
Gcnt3 A G 9: 69,942,346 (GRCm39) I74T probably benign Het
Gfral A T 9: 76,104,383 (GRCm39) C210S probably damaging Het
Gm26566 G A 4: 88,640,247 (GRCm39) A13T unknown Het
Gm9936 A T 5: 114,995,166 (GRCm39) D150E unknown Het
Gsn C A 2: 35,174,003 (GRCm39) D75E probably benign Het
Ighd2-7 T C 12: 113,420,344 (GRCm39) T5A possibly damaging Het
Itsn1 G T 16: 91,649,782 (GRCm39) R152L probably benign Het
Klhl3 A T 13: 58,157,126 (GRCm39) L620Q probably damaging Het
Larp7-ps G T 4: 92,079,915 (GRCm39) Y24* probably null Het
Lpl G A 8: 69,340,235 (GRCm39) V77M probably benign Het
Lrfn3 A T 7: 30,058,916 (GRCm39) H436Q probably benign Het
Lrp1b A G 2: 40,569,227 (GRCm39) C3965R Het
Lrrc2 G A 9: 110,799,228 (GRCm39) probably null Het
Manea C A 4: 26,340,468 (GRCm39) D165Y probably damaging Het
Myom1 A T 17: 71,394,476 (GRCm39) Q992L probably damaging Het
Naip5 T C 13: 100,359,821 (GRCm39) T472A probably benign Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nyap1 C T 5: 137,733,394 (GRCm39) W546* probably null Het
Olfml3 T G 3: 103,644,282 (GRCm39) Y129S possibly damaging Het
Or4d5 A T 9: 40,011,864 (GRCm39) D307E probably benign Het
Or5h19 C A 16: 58,856,213 (GRCm39) V296F probably damaging Het
Or9k2b T A 10: 130,015,814 (GRCm39) I312F probably benign Het
P2rx6 A C 16: 17,385,300 (GRCm39) probably null Het
Plxnb2 A T 15: 89,045,160 (GRCm39) Y1095* probably null Het
Pmepa1 G A 2: 173,069,794 (GRCm39) R216C probably damaging Het
Prodh A G 16: 17,902,619 (GRCm39) probably benign Het
Ptch1 A G 13: 63,689,987 (GRCm39) Y389H probably damaging Het
Ptgs2 G T 1: 149,976,842 (GRCm39) probably null Het
Rbm14 A G 19: 4,861,464 (GRCm39) Y25H probably damaging Het
Rfc2 T C 5: 134,622,112 (GRCm39) L197P probably damaging Het
Rnf19b G T 4: 128,967,397 (GRCm39) W313L probably damaging Het
Sh3rf1 G T 8: 61,825,585 (GRCm39) A527S probably benign Het
Slc12a1 A G 2: 125,032,218 (GRCm39) Y623C probably damaging Het
Slc25a54 T A 3: 109,005,932 (GRCm39) W147R probably damaging Het
Slc4a1 A G 11: 102,247,680 (GRCm39) L401P probably damaging Het
Slc4a7 A G 14: 14,796,073 (GRCm38) probably null Het
Stab2 A G 10: 86,699,420 (GRCm39) Y1933H probably damaging Het
Supt5 A T 7: 28,014,688 (GRCm39) V1037E probably damaging Het
Sv2b A T 7: 74,775,428 (GRCm39) H466Q probably benign Het
Tmco5 G A 2: 116,710,730 (GRCm39) E17K probably damaging Het
Tmem69 G A 4: 116,411,972 (GRCm39) S12F probably damaging Het
Trp53 C A 11: 69,478,392 (GRCm39) Y100* probably null Het
Trpm7 A T 2: 126,664,510 (GRCm39) H956Q probably benign Het
Tsnaxip1 G A 8: 106,569,135 (GRCm39) R495H probably benign Het
Vmn1r237 A T 17: 21,534,777 (GRCm39) I167F probably benign Het
Vmn1r70 A G 7: 10,368,292 (GRCm39) D260G probably benign Het
Zbtb38 G A 9: 96,570,944 (GRCm39) H47Y probably damaging Het
Zfp184 G T 13: 22,142,897 (GRCm39) C201F probably benign Het
Zfp384 T A 6: 125,001,796 (GRCm39) I147N possibly damaging Het
Other mutations in Or6z5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0057:Or6z5 UTSW 7 6,477,679 (GRCm39) missense probably damaging 1.00
R0446:Or6z5 UTSW 7 6,478,024 (GRCm39) missense probably benign 0.00
R0531:Or6z5 UTSW 7 6,477,234 (GRCm39) missense possibly damaging 0.81
R0622:Or6z5 UTSW 7 6,477,598 (GRCm39) missense possibly damaging 0.46
R1596:Or6z5 UTSW 7 6,477,514 (GRCm39) missense probably damaging 1.00
R2233:Or6z5 UTSW 7 6,477,441 (GRCm39) missense possibly damaging 0.94
R2234:Or6z5 UTSW 7 6,477,441 (GRCm39) missense possibly damaging 0.94
R2235:Or6z5 UTSW 7 6,477,441 (GRCm39) missense possibly damaging 0.94
R4441:Or6z5 UTSW 7 6,477,924 (GRCm39) missense probably benign 0.01
R4888:Or6z5 UTSW 7 6,477,612 (GRCm39) missense probably damaging 0.97
R4890:Or6z5 UTSW 7 6,477,848 (GRCm39) nonsense probably null
R5696:Or6z5 UTSW 7 6,477,742 (GRCm39) splice site probably null
R6173:Or6z5 UTSW 7 6,477,835 (GRCm39) missense probably damaging 1.00
R6643:Or6z5 UTSW 7 6,477,720 (GRCm39) missense probably benign 0.11
R7404:Or6z5 UTSW 7 6,477,163 (GRCm39) missense probably damaging 1.00
R8120:Or6z5 UTSW 7 6,477,119 (GRCm39) missense probably benign 0.02
R8961:Or6z5 UTSW 7 6,477,763 (GRCm39) missense probably benign
R9009:Or6z5 UTSW 7 6,477,399 (GRCm39) missense probably benign 0.02
R9744:Or6z5 UTSW 7 6,477,210 (GRCm39) missense probably benign
Z1177:Or6z5 UTSW 7 6,477,389 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- ACAACTGGCCAATAGGTCTGATG -3'
(R):5'- CTGAGTAGTGCAGTGGACAG -3'

Sequencing Primer
(F):5'- ATGACCAGGATTTTATTCTACTGGG -3'
(R):5'- CAGCAGATGGCCACATAGCG -3'
Posted On 2022-08-09