Mutagenetix > Incidental Mutation

Incidental Mutation 'R9568:Dock2'

721778

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, Hch, MBC

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9568 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

34176815-34674719 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 34599638 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 314 (K314E)

Ref Sequence

ENSEMBL: ENSMUSP00000090884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]

AlphaFold

Q8C3J5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000093193
AA Change: K314E

PolyPhen 2 Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: K314E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000101365
AA Change: K314E

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: K314E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000143540
AA Change: K314E

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143
AA Change: K314E

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK-C2	418	617	1.8e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6a	T	G	12: 113,508,020 (GRCm39)	V131G	possibly damaging	Het
Agr3	G	T	12: 35,998,349 (GRCm39)	M149I	probably benign	Het
Alox12b	T	A	11: 69,054,836 (GRCm39)	C280S	possibly damaging	Het
Amhr2	C	A	15: 102,353,954 (GRCm39)	Q16K	probably benign	Het
Ank1	A	G	8: 23,609,381 (GRCm39)	T1387A	probably benign	Het
B3gnt9	A	C	8: 105,980,203 (GRCm39)	F395C	probably damaging	Het
BC048562	A	G	9: 108,322,905 (GRCm39)	D80G	probably damaging	Het
Ccdc65	T	A	15: 98,620,819 (GRCm39)	M438K	possibly damaging	Het
Ccz1	T	C	5: 143,938,251 (GRCm39)	R240G	probably damaging	Het
Cish	A	T	9: 107,177,593 (GRCm39)	S90C	probably benign	Het
Col5a2	A	T	1: 45,430,998 (GRCm39)	S881T	possibly damaging	Het
Col6a6	G	A	9: 105,657,926 (GRCm39)	T762I	possibly damaging	Het
Cpa1	A	G	6: 30,640,060 (GRCm39)	K49E	probably benign	Het
Cpb1	T	C	3: 20,320,697 (GRCm39)		probably null	Het
Csmd3	A	G	15: 48,150,942 (GRCm39)	S483P	probably damaging	Het
Cul9	G	A	17: 46,831,044 (GRCm39)	T1643I	possibly damaging	Het
Elp1	G	T	4: 56,786,711 (GRCm39)	P411T	probably damaging	Het
Fam186b	T	G	15: 99,176,571 (GRCm39)	K773T	probably damaging	Het
Fancl	T	A	11: 26,418,672 (GRCm39)	V259E	probably benign	Het
Fat4	T	G	3: 38,946,156 (GRCm39)	I1683S	probably damaging	Het
Fcamr	T	A	1: 130,732,356 (GRCm39)	H114Q	probably damaging	Het
Fndc11	T	C	2: 180,864,046 (GRCm39)	F284L	probably damaging	Het
Galns	A	G	8: 123,311,649 (GRCm39)		probably null	Het
Gch1	A	G	14: 47,426,637 (GRCm39)	S30P	probably benign	Het
Gcnt3	A	G	9: 69,942,346 (GRCm39)	I74T	probably benign	Het
Gfral	A	T	9: 76,104,383 (GRCm39)	C210S	probably damaging	Het
Gm26566	G	A	4: 88,640,247 (GRCm39)	A13T	unknown	Het
Gm9936	A	T	5: 114,995,166 (GRCm39)	D150E	unknown	Het
Gsn	C	A	2: 35,174,003 (GRCm39)	D75E	probably benign	Het
Ighd2-7	T	C	12: 113,420,344 (GRCm39)	T5A	possibly damaging	Het
Itsn1	G	T	16: 91,649,782 (GRCm39)	R152L	probably benign	Het
Klhl3	A	T	13: 58,157,126 (GRCm39)	L620Q	probably damaging	Het
Larp7-ps	G	T	4: 92,079,915 (GRCm39)	Y24*	probably null	Het
Lpl	G	A	8: 69,340,235 (GRCm39)	V77M	probably benign	Het
Lrfn3	A	T	7: 30,058,916 (GRCm39)	H436Q	probably benign	Het
Lrp1b	A	G	2: 40,569,227 (GRCm39)	C3965R		Het
Lrrc2	G	A	9: 110,799,228 (GRCm39)		probably null	Het
Manea	C	A	4: 26,340,468 (GRCm39)	D165Y	probably damaging	Het
Myom1	A	T	17: 71,394,476 (GRCm39)	Q992L	probably damaging	Het
Naip5	T	C	13: 100,359,821 (GRCm39)	T472A	probably benign	Het
Naip5	T	A	13: 100,356,338 (GRCm39)	E1092D	probably benign	Het
Nyap1	C	T	5: 137,733,394 (GRCm39)	W546*	probably null	Het
Olfml3	T	G	3: 103,644,282 (GRCm39)	Y129S	possibly damaging	Het
Or4d5	A	T	9: 40,011,864 (GRCm39)	D307E	probably benign	Het
Or5h19	C	A	16: 58,856,213 (GRCm39)	V296F	probably damaging	Het
Or6z5	A	G	7: 6,477,334 (GRCm39)	E75G	probably damaging	Het
Or9k2b	T	A	10: 130,015,814 (GRCm39)	I312F	probably benign	Het
P2rx6	A	C	16: 17,385,300 (GRCm39)		probably null	Het
Plxnb2	A	T	15: 89,045,160 (GRCm39)	Y1095*	probably null	Het
Pmepa1	G	A	2: 173,069,794 (GRCm39)	R216C	probably damaging	Het
Prodh	A	G	16: 17,902,619 (GRCm39)		probably benign	Het
Ptch1	A	G	13: 63,689,987 (GRCm39)	Y389H	probably damaging	Het
Ptgs2	G	T	1: 149,976,842 (GRCm39)		probably null	Het
Rbm14	A	G	19: 4,861,464 (GRCm39)	Y25H	probably damaging	Het
Rfc2	T	C	5: 134,622,112 (GRCm39)	L197P	probably damaging	Het
Rnf19b	G	T	4: 128,967,397 (GRCm39)	W313L	probably damaging	Het
Sh3rf1	G	T	8: 61,825,585 (GRCm39)	A527S	probably benign	Het
Slc12a1	A	G	2: 125,032,218 (GRCm39)	Y623C	probably damaging	Het
Slc25a54	T	A	3: 109,005,932 (GRCm39)	W147R	probably damaging	Het
Slc4a1	A	G	11: 102,247,680 (GRCm39)	L401P	probably damaging	Het
Slc4a7	A	G	14: 14,796,073 (GRCm38)		probably null	Het
Stab2	A	G	10: 86,699,420 (GRCm39)	Y1933H	probably damaging	Het
Supt5	A	T	7: 28,014,688 (GRCm39)	V1037E	probably damaging	Het
Sv2b	A	T	7: 74,775,428 (GRCm39)	H466Q	probably benign	Het
Tmco5	G	A	2: 116,710,730 (GRCm39)	E17K	probably damaging	Het
Tmem69	G	A	4: 116,411,972 (GRCm39)	S12F	probably damaging	Het
Trp53	C	A	11: 69,478,392 (GRCm39)	Y100*	probably null	Het
Trpm7	A	T	2: 126,664,510 (GRCm39)	H956Q	probably benign	Het
Tsnaxip1	G	A	8: 106,569,135 (GRCm39)	R495H	probably benign	Het
Vmn1r237	A	T	17: 21,534,777 (GRCm39)	I167F	probably benign	Het
Vmn1r70	A	G	7: 10,368,292 (GRCm39)	D260G	probably benign	Het
Zbtb38	G	A	9: 96,570,944 (GRCm39)	H47Y	probably damaging	Het
Zfp184	G	T	13: 22,142,897 (GRCm39)	C201F	probably benign	Het
Zfp384	T	A	6: 125,001,796 (GRCm39)	I147N	possibly damaging	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,595,488 (GRCm39)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,179,603 (GRCm39)	splice site	probably benign
IGL01061:Dock2	APN	11	34,596,653 (GRCm39)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,589,617 (GRCm39)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,260,390 (GRCm39)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,596,608 (GRCm39)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,189,528 (GRCm39)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,647,100 (GRCm39)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,212,433 (GRCm39)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,212,391 (GRCm39)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,596,668 (GRCm39)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,582,744 (GRCm39)	nonsense	probably null
IGL01835:Dock2	APN	11	34,260,435 (GRCm39)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,599,692 (GRCm39)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,623,183 (GRCm39)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,218,053 (GRCm39)	missense	probably benign
IGL02081:Dock2	APN	11	34,204,355 (GRCm39)	missense	probably benign
IGL02105:Dock2	APN	11	34,605,352 (GRCm39)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,180,670 (GRCm39)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,217,949 (GRCm39)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,622,337 (GRCm39)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,589,567 (GRCm39)	splice site	probably benign
IGL02409:Dock2	APN	11	34,451,204 (GRCm39)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,199,801 (GRCm39)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,451,168 (GRCm39)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,218,048 (GRCm39)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,260,448 (GRCm39)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,583,086 (GRCm39)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,578,360 (GRCm39)	missense	probably damaging	0.99
Arches	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
denali	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
dew	UTSW	11	34,198,636 (GRCm39)	nonsense	probably null
Dinghy	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
Dry	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
frazz	UTSW	11	34,198,572 (GRCm39)	critical splice donor site	probably benign
frizz	UTSW	11	34,208,184 (GRCm39)	splice site	probably benign
gildenstern	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
godsgrace	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
Harborside	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
Landing	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
latest	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
Launch	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
liaoning	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
lucre	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
midas	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
muelle	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
narrowest	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
pier	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
Plank	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
riches	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
skiff	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
Slip	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
toothskin	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
Touch	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
wassup	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
Wharf	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,182,853 (GRCm39)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,611,835 (GRCm39)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,262,453 (GRCm39)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,579,392 (GRCm39)	intron	probably benign
R0149:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,218,052 (GRCm39)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,579,380 (GRCm39)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,595,545 (GRCm39)	splice site	probably benign
R0543:Dock2	UTSW	11	34,244,325 (GRCm39)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,198,621 (GRCm39)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,586,063 (GRCm39)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,414,970 (GRCm39)	splice site	probably benign
R0801:Dock2	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,206,535 (GRCm39)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,586,068 (GRCm39)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,223,309 (GRCm39)	splice site	probably benign
R1445:Dock2	UTSW	11	34,189,705 (GRCm39)	missense	probably benign
R1494:Dock2	UTSW	11	34,232,761 (GRCm39)	nonsense	probably null
R1589:Dock2	UTSW	11	34,597,288 (GRCm39)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,595,474 (GRCm39)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,212,480 (GRCm39)	splice site	probably null
R1749:Dock2	UTSW	11	34,182,767 (GRCm39)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,414,934 (GRCm39)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,618,297 (GRCm39)	splice site	probably benign
R2045:Dock2	UTSW	11	34,244,106 (GRCm39)	splice site	probably null
R2098:Dock2	UTSW	11	34,609,832 (GRCm39)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,216,279 (GRCm39)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,618,242 (GRCm39)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,262,485 (GRCm39)	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34,609,712 (GRCm39)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,182,910 (GRCm39)	splice site	probably benign
R3081:Dock2	UTSW	11	34,181,610 (GRCm39)	missense	probably benign
R3418:Dock2	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,611,787 (GRCm39)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,599,722 (GRCm39)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,244,118 (GRCm39)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,586,298 (GRCm39)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,223,767 (GRCm39)	splice site	probably null
R4884:Dock2	UTSW	11	34,216,248 (GRCm39)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,586,078 (GRCm39)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,178,643 (GRCm39)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,618,233 (GRCm39)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,204,391 (GRCm39)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,199,836 (GRCm39)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
R5860:Dock2	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,599,614 (GRCm39)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,244,123 (GRCm39)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,197,789 (GRCm39)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,179,476 (GRCm39)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,453,396 (GRCm39)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,598,152 (GRCm39)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,182,874 (GRCm39)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,312,822 (GRCm39)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,670 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,669 (GRCm39)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,177,684 (GRCm39)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,260,363 (GRCm39)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,189,675 (GRCm39)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,181,677 (GRCm39)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,605,340 (GRCm39)	nonsense	probably null
R7250:Dock2	UTSW	11	34,586,120 (GRCm39)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,586,032 (GRCm39)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,180,672 (GRCm39)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,609,816 (GRCm39)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,586,105 (GRCm39)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,262,542 (GRCm39)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,611,778 (GRCm39)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,605,282 (GRCm39)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,223,698 (GRCm39)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,598,154 (GRCm39)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,596,677 (GRCm39)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,260,362 (GRCm39)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,609,795 (GRCm39)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,180,825 (GRCm39)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,181,622 (GRCm39)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,212,457 (GRCm39)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
R8743:Dock2	UTSW	11	34,223,252 (GRCm39)	nonsense	probably null
R8757:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,451,215 (GRCm39)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
R8885:Dock2	UTSW	11	34,260,396 (GRCm39)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,599,646 (GRCm39)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,589,670 (GRCm39)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,260,398 (GRCm39)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,622,366 (GRCm39)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,244,139 (GRCm39)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,589,582 (GRCm39)	missense	possibly damaging	0.90
R9593:Dock2	UTSW	11	34,178,607 (GRCm39)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,218,054 (GRCm39)	missense	probably benign
R9697:Dock2	UTSW	11	34,204,417 (GRCm39)	missense	probably benign
R9753:Dock2	UTSW	11	34,223,673 (GRCm39)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,208,128 (GRCm39)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,216,271 (GRCm39)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,182,833 (GRCm39)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,206,564 (GRCm39)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,260,357 (GRCm39)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,583,209 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,388,300 (GRCm39)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,586,039 (GRCm39)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,609,751 (GRCm39)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,262,553 (GRCm39)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- CATAAATCTGAACTTAGTCACCGGTG -3'
(R):5'- TCACAGTCCTTTAAATGACAGTTGC -3'

Sequencing Primer
(F):5'- GACTTCGGTTAGTCGTCACAAATG -3'
(R):5'- AAATGACAGTTGCTTTGTTCCTG -3'

Posted On

2022-08-09