Mutagenetix > Incidental Mutation

Incidental Mutation 'R9568:Csmd3'

721792

Institutional Source

Beutler Lab

Gene Symbol

Csmd3

Ensembl Gene

ENSMUSG00000022311

Gene Name

CUB and Sushi multiple domains 3

Synonyms

4930500N14Rik

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9568 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

47444033-48655459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 48150942 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 483 (S483P)

Ref Sequence

ENSEMBL: ENSMUSP00000098235 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100670] [ENSMUST00000160658] [ENSMUST00000162830]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000100670
AA Change: S483P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000098235
Gene: ENSMUSG00000022311
AA Change: S483P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000160658
AA Change: S379P

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000124753
Gene: ENSMUSG00000022311
AA Change: S379P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
CCP	382	439	6.9e-14	SMART
CUB	444	555	9.22e-24	SMART
CCP	560	613	1.29e-13	SMART
CUB	617	725	6.87e-32	SMART
CCP	730	787	5.19e-9	SMART
CUB	791	899	3.23e-37	SMART
CCP	906	959	1.82e-13	SMART
CUB	963	1073	4.87e-23	SMART
CCP	1078	1133	1.82e-13	SMART
CUB	1137	1245	5.02e-25	SMART
CCP	1250	1306	2.5e-11	SMART
CUB	1310	1419	6.27e-26	SMART
CCP	1424	1480	4.41e-12	SMART
CUB	1484	1592	5.37e-34	SMART
CCP	1597	1654	1.18e-12	SMART
CUB	1658	1766	2.27e-23	SMART
CCP	1774	1831	1.84e-9	SMART
CUB	1835	1943	1.8e-35	SMART
CCP	1948	2003	4.48e-13	SMART
CUB	2007	2115	3.95e-32	SMART
CCP	2120	2175	4.02e-15	SMART
CUB	2179	2286	1.74e-33	SMART
CCP	2291	2348	5.82e-12	SMART
CUB	2353	2463	5.3e-24	SMART
CCP	2465	2523	2.11e-9	SMART
CCP	2528	2585	8.23e-12	SMART
CCP	2590	2643	1.14e-14	SMART
CCP	2648	2701	4.76e-17	SMART
CCP	2706	2759	1.85e-14	SMART
CCP	2764	2821	9.9e-15	SMART
CCP	2826	2879	1.79e-12	SMART
CCP	2887	2940	1.72e-14	SMART
CCP	2945	2999	3.17e-13	SMART
CCP	3004	3059	1.25e-11	SMART
CCP	3064	3117	1.25e-11	SMART
CCP	3122	3175	8.23e-12	SMART
CCP	3183	3237	5.6e-14	SMART
CCP	3242	3297	1.89e-11	SMART
transmembrane domain	3461	3483	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162830
AA Change: S483P

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000124775
Gene: ENSMUSG00000022311
AA Change: S483P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6a	T	G	12: 113,508,020 (GRCm39)	V131G	possibly damaging	Het
Agr3	G	T	12: 35,998,349 (GRCm39)	M149I	probably benign	Het
Alox12b	T	A	11: 69,054,836 (GRCm39)	C280S	possibly damaging	Het
Amhr2	C	A	15: 102,353,954 (GRCm39)	Q16K	probably benign	Het
Ank1	A	G	8: 23,609,381 (GRCm39)	T1387A	probably benign	Het
B3gnt9	A	C	8: 105,980,203 (GRCm39)	F395C	probably damaging	Het
BC048562	A	G	9: 108,322,905 (GRCm39)	D80G	probably damaging	Het
Ccdc65	T	A	15: 98,620,819 (GRCm39)	M438K	possibly damaging	Het
Ccz1	T	C	5: 143,938,251 (GRCm39)	R240G	probably damaging	Het
Cish	A	T	9: 107,177,593 (GRCm39)	S90C	probably benign	Het
Col5a2	A	T	1: 45,430,998 (GRCm39)	S881T	possibly damaging	Het
Col6a6	G	A	9: 105,657,926 (GRCm39)	T762I	possibly damaging	Het
Cpa1	A	G	6: 30,640,060 (GRCm39)	K49E	probably benign	Het
Cpb1	T	C	3: 20,320,697 (GRCm39)		probably null	Het
Cul9	G	A	17: 46,831,044 (GRCm39)	T1643I	possibly damaging	Het
Dock2	T	C	11: 34,599,638 (GRCm39)	K314E	possibly damaging	Het
Elp1	G	T	4: 56,786,711 (GRCm39)	P411T	probably damaging	Het
Fam186b	T	G	15: 99,176,571 (GRCm39)	K773T	probably damaging	Het
Fancl	T	A	11: 26,418,672 (GRCm39)	V259E	probably benign	Het
Fat4	T	G	3: 38,946,156 (GRCm39)	I1683S	probably damaging	Het
Fcamr	T	A	1: 130,732,356 (GRCm39)	H114Q	probably damaging	Het
Fndc11	T	C	2: 180,864,046 (GRCm39)	F284L	probably damaging	Het
Galns	A	G	8: 123,311,649 (GRCm39)		probably null	Het
Gch1	A	G	14: 47,426,637 (GRCm39)	S30P	probably benign	Het
Gcnt3	A	G	9: 69,942,346 (GRCm39)	I74T	probably benign	Het
Gfral	A	T	9: 76,104,383 (GRCm39)	C210S	probably damaging	Het
Gm26566	G	A	4: 88,640,247 (GRCm39)	A13T	unknown	Het
Gm9936	A	T	5: 114,995,166 (GRCm39)	D150E	unknown	Het
Gsn	C	A	2: 35,174,003 (GRCm39)	D75E	probably benign	Het
Ighd2-7	T	C	12: 113,420,344 (GRCm39)	T5A	possibly damaging	Het
Itsn1	G	T	16: 91,649,782 (GRCm39)	R152L	probably benign	Het
Klhl3	A	T	13: 58,157,126 (GRCm39)	L620Q	probably damaging	Het
Larp7-ps	G	T	4: 92,079,915 (GRCm39)	Y24*	probably null	Het
Lpl	G	A	8: 69,340,235 (GRCm39)	V77M	probably benign	Het
Lrfn3	A	T	7: 30,058,916 (GRCm39)	H436Q	probably benign	Het
Lrp1b	A	G	2: 40,569,227 (GRCm39)	C3965R		Het
Lrrc2	G	A	9: 110,799,228 (GRCm39)		probably null	Het
Manea	C	A	4: 26,340,468 (GRCm39)	D165Y	probably damaging	Het
Myom1	A	T	17: 71,394,476 (GRCm39)	Q992L	probably damaging	Het
Naip5	T	C	13: 100,359,821 (GRCm39)	T472A	probably benign	Het
Naip5	T	A	13: 100,356,338 (GRCm39)	E1092D	probably benign	Het
Nyap1	C	T	5: 137,733,394 (GRCm39)	W546*	probably null	Het
Olfml3	T	G	3: 103,644,282 (GRCm39)	Y129S	possibly damaging	Het
Or4d5	A	T	9: 40,011,864 (GRCm39)	D307E	probably benign	Het
Or5h19	C	A	16: 58,856,213 (GRCm39)	V296F	probably damaging	Het
Or6z5	A	G	7: 6,477,334 (GRCm39)	E75G	probably damaging	Het
Or9k2b	T	A	10: 130,015,814 (GRCm39)	I312F	probably benign	Het
P2rx6	A	C	16: 17,385,300 (GRCm39)		probably null	Het
Plxnb2	A	T	15: 89,045,160 (GRCm39)	Y1095*	probably null	Het
Pmepa1	G	A	2: 173,069,794 (GRCm39)	R216C	probably damaging	Het
Prodh	A	G	16: 17,902,619 (GRCm39)		probably benign	Het
Ptch1	A	G	13: 63,689,987 (GRCm39)	Y389H	probably damaging	Het
Ptgs2	G	T	1: 149,976,842 (GRCm39)		probably null	Het
Rbm14	A	G	19: 4,861,464 (GRCm39)	Y25H	probably damaging	Het
Rfc2	T	C	5: 134,622,112 (GRCm39)	L197P	probably damaging	Het
Rnf19b	G	T	4: 128,967,397 (GRCm39)	W313L	probably damaging	Het
Sh3rf1	G	T	8: 61,825,585 (GRCm39)	A527S	probably benign	Het
Slc12a1	A	G	2: 125,032,218 (GRCm39)	Y623C	probably damaging	Het
Slc25a54	T	A	3: 109,005,932 (GRCm39)	W147R	probably damaging	Het
Slc4a1	A	G	11: 102,247,680 (GRCm39)	L401P	probably damaging	Het
Slc4a7	A	G	14: 14,796,073 (GRCm38)		probably null	Het
Stab2	A	G	10: 86,699,420 (GRCm39)	Y1933H	probably damaging	Het
Supt5	A	T	7: 28,014,688 (GRCm39)	V1037E	probably damaging	Het
Sv2b	A	T	7: 74,775,428 (GRCm39)	H466Q	probably benign	Het
Tmco5	G	A	2: 116,710,730 (GRCm39)	E17K	probably damaging	Het
Tmem69	G	A	4: 116,411,972 (GRCm39)	S12F	probably damaging	Het
Trp53	C	A	11: 69,478,392 (GRCm39)	Y100*	probably null	Het
Trpm7	A	T	2: 126,664,510 (GRCm39)	H956Q	probably benign	Het
Tsnaxip1	G	A	8: 106,569,135 (GRCm39)	R495H	probably benign	Het
Vmn1r237	A	T	17: 21,534,777 (GRCm39)	I167F	probably benign	Het
Vmn1r70	A	G	7: 10,368,292 (GRCm39)	D260G	probably benign	Het
Zbtb38	G	A	9: 96,570,944 (GRCm39)	H47Y	probably damaging	Het
Zfp184	G	T	13: 22,142,897 (GRCm39)	C201F	probably benign	Het
Zfp384	T	A	6: 125,001,796 (GRCm39)	I147N	possibly damaging	Het

Other mutations in Csmd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Csmd3	APN	15	48,150,891 (GRCm39)	missense	possibly damaging	0.61
IGL00591:Csmd3	APN	15	47,868,279 (GRCm39)	missense	probably damaging	1.00
IGL00668:Csmd3	APN	15	47,777,341 (GRCm39)	missense	probably damaging	1.00
IGL00753:Csmd3	APN	15	47,507,631 (GRCm39)	missense	probably damaging	1.00
IGL00773:Csmd3	APN	15	47,454,115 (GRCm39)	missense	probably damaging	0.96
IGL00926:Csmd3	APN	15	47,574,360 (GRCm39)	missense	possibly damaging	0.87
IGL00942:Csmd3	APN	15	47,710,502 (GRCm39)	critical splice donor site	probably null
IGL01080:Csmd3	APN	15	47,744,799 (GRCm39)	missense	probably benign	0.12
IGL01314:Csmd3	APN	15	47,713,151 (GRCm39)	missense	probably damaging	1.00
IGL01326:Csmd3	APN	15	47,713,181 (GRCm39)	missense	probably benign	0.06
IGL01393:Csmd3	APN	15	48,320,995 (GRCm39)	missense	possibly damaging	0.88
IGL01432:Csmd3	APN	15	47,596,895 (GRCm39)	missense	probably damaging	1.00
IGL01519:Csmd3	APN	15	47,460,246 (GRCm39)	missense	probably benign	0.31
IGL01530:Csmd3	APN	15	47,533,013 (GRCm39)	missense	probably damaging	1.00
IGL01530:Csmd3	APN	15	47,701,833 (GRCm39)	missense	possibly damaging	0.95
IGL01547:Csmd3	APN	15	47,747,013 (GRCm39)	missense	probably benign	0.41
IGL01594:Csmd3	APN	15	47,492,635 (GRCm39)	missense	probably benign	0.01
IGL01618:Csmd3	APN	15	47,874,479 (GRCm39)	missense	probably benign	0.05
IGL01670:Csmd3	APN	15	47,475,225 (GRCm39)	missense	probably damaging	1.00
IGL01680:Csmd3	APN	15	47,833,426 (GRCm39)	missense	probably damaging	1.00
IGL01734:Csmd3	APN	15	48,048,700 (GRCm39)	missense	probably damaging	1.00
IGL01777:Csmd3	APN	15	47,561,594 (GRCm39)	missense	probably benign	0.06
IGL01779:Csmd3	APN	15	47,721,290 (GRCm39)	missense	probably benign	0.10
IGL01820:Csmd3	APN	15	47,470,538 (GRCm39)	nonsense	probably null
IGL01843:Csmd3	APN	15	47,522,395 (GRCm39)	splice site	probably benign
IGL01919:Csmd3	APN	15	47,539,168 (GRCm39)	missense	possibly damaging	0.62
IGL01986:Csmd3	APN	15	47,522,591 (GRCm39)	missense	possibly damaging	0.82
IGL02049:Csmd3	APN	15	47,864,870 (GRCm39)	missense	possibly damaging	0.91
IGL02065:Csmd3	APN	15	47,530,024 (GRCm39)	missense	probably damaging	1.00
IGL02112:Csmd3	APN	15	48,177,265 (GRCm39)	missense	possibly damaging	0.95
IGL02133:Csmd3	APN	15	47,721,338 (GRCm39)	missense	possibly damaging	0.86
IGL02203:Csmd3	APN	15	47,713,073 (GRCm39)	splice site	probably null
IGL02215:Csmd3	APN	15	47,449,084 (GRCm39)	missense	probably damaging	1.00
IGL02234:Csmd3	APN	15	47,811,512 (GRCm39)	missense	probably damaging	1.00
IGL02326:Csmd3	APN	15	47,619,359 (GRCm39)	splice site	probably benign
IGL02478:Csmd3	APN	15	47,701,794 (GRCm39)	splice site	probably benign
IGL02491:Csmd3	APN	15	47,777,511 (GRCm39)	splice site	probably benign
IGL02598:Csmd3	APN	15	47,533,086 (GRCm39)	missense	probably damaging	0.98
IGL02626:Csmd3	APN	15	47,567,503 (GRCm39)	splice site	probably benign
IGL02696:Csmd3	APN	15	47,533,065 (GRCm39)	missense	probably benign	0.33
IGL02876:Csmd3	APN	15	47,469,492 (GRCm39)	splice site	probably benign
IGL02971:Csmd3	APN	15	47,777,325 (GRCm39)	splice site	probably benign
IGL03068:Csmd3	APN	15	47,710,517 (GRCm39)	missense	possibly damaging	0.69
IGL03087:Csmd3	APN	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
IGL03114:Csmd3	APN	15	47,683,847 (GRCm39)	missense	probably damaging	0.99
IGL03146:Csmd3	APN	15	47,744,873 (GRCm39)	missense	probably benign	0.25
IGL03193:Csmd3	APN	15	47,492,626 (GRCm39)	splice site	probably benign
IGL03274:Csmd3	APN	15	47,508,900 (GRCm39)	missense	probably damaging	1.00
R0040:Csmd3	UTSW	15	47,497,212 (GRCm39)	missense	probably damaging	1.00
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0119:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0124:Csmd3	UTSW	15	47,454,112 (GRCm39)	missense	probably damaging	1.00
R0127:Csmd3	UTSW	15	47,845,326 (GRCm39)	missense	probably benign	0.45
R0136:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0201:Csmd3	UTSW	15	47,483,125 (GRCm39)	splice site	probably benign
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0318:Csmd3	UTSW	15	47,522,549 (GRCm39)	missense	probably damaging	1.00
R0369:Csmd3	UTSW	15	47,833,543 (GRCm39)	missense	probably damaging	1.00
R0391:Csmd3	UTSW	15	47,520,969 (GRCm39)	missense	probably damaging	1.00
R0499:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0506:Csmd3	UTSW	15	48,320,907 (GRCm39)	missense	probably benign	0.00
R0606:Csmd3	UTSW	15	48,321,058 (GRCm39)	missense	probably benign
R0639:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0658:Csmd3	UTSW	15	47,874,543 (GRCm39)	missense	possibly damaging	0.66
R0673:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0689:Csmd3	UTSW	15	47,619,421 (GRCm39)	missense	probably benign	0.19
R0696:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R0799:Csmd3	UTSW	15	48,048,780 (GRCm39)	splice site	probably benign
R0834:Csmd3	UTSW	15	47,747,073 (GRCm39)	intron	probably benign
R0894:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R0926:Csmd3	UTSW	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
R0943:Csmd3	UTSW	15	47,539,135 (GRCm39)	missense	probably damaging	0.99
R0944:Csmd3	UTSW	15	47,475,227 (GRCm39)	missense	probably damaging	1.00
R0967:Csmd3	UTSW	15	47,721,227 (GRCm39)	missense	probably null	0.89
R0973:Csmd3	UTSW	15	47,522,485 (GRCm39)	missense	probably damaging	1.00
R1055:Csmd3	UTSW	15	47,744,933 (GRCm39)	missense	probably damaging	1.00
R1066:Csmd3	UTSW	15	47,777,361 (GRCm39)	missense	probably damaging	1.00
R1086:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	probably damaging	0.99
R1103:Csmd3	UTSW	15	47,811,402 (GRCm39)	missense	probably damaging	1.00
R1136:Csmd3	UTSW	15	47,539,213 (GRCm39)	missense	probably damaging	1.00
R1139:Csmd3	UTSW	15	47,559,232 (GRCm39)	missense	probably damaging	1.00
R1158:Csmd3	UTSW	15	48,156,170 (GRCm39)	splice site	probably null
R1215:Csmd3	UTSW	15	47,868,227 (GRCm39)	splice site	probably null
R1233:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R1271:Csmd3	UTSW	15	47,874,455 (GRCm39)	missense	probably benign	0.11
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1479:Csmd3	UTSW	15	47,721,282 (GRCm39)	missense	probably damaging	1.00
R1480:Csmd3	UTSW	15	47,595,325 (GRCm39)	missense	possibly damaging	0.90
R1526:Csmd3	UTSW	15	47,449,028 (GRCm39)	critical splice donor site	probably null
R1527:Csmd3	UTSW	15	47,811,483 (GRCm39)	missense	probably benign	0.08
R1539:Csmd3	UTSW	15	47,683,794 (GRCm39)	missense	probably benign	0.24
R1544:Csmd3	UTSW	15	47,475,294 (GRCm39)	splice site	probably null
R1548:Csmd3	UTSW	15	47,845,371 (GRCm39)	missense	possibly damaging	0.91
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1619:Csmd3	UTSW	15	47,813,346 (GRCm39)	missense	probably damaging	1.00
R1630:Csmd3	UTSW	15	47,701,918 (GRCm39)	missense	possibly damaging	0.66
R1665:Csmd3	UTSW	15	47,560,185 (GRCm39)	missense	probably damaging	1.00
R1680:Csmd3	UTSW	15	47,604,566 (GRCm39)	missense	probably damaging	1.00
R1725:Csmd3	UTSW	15	47,460,203 (GRCm39)	missense	probably damaging	1.00
R1743:Csmd3	UTSW	15	48,485,485 (GRCm39)	missense	probably damaging	1.00
R1749:Csmd3	UTSW	15	47,449,056 (GRCm39)	missense	probably damaging	1.00
R1752:Csmd3	UTSW	15	47,523,669 (GRCm39)	missense	probably benign	0.15
R1769:Csmd3	UTSW	15	47,567,505 (GRCm39)	splice site	probably benign
R1775:Csmd3	UTSW	15	47,763,135 (GRCm39)	missense	probably damaging	0.99
R1795:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R1819:Csmd3	UTSW	15	47,617,131 (GRCm39)	missense	possibly damaging	0.56
R1840:Csmd3	UTSW	15	47,470,560 (GRCm39)	missense	probably damaging	1.00
R1860:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1861:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1879:Csmd3	UTSW	15	47,520,915 (GRCm39)	missense	possibly damaging	0.90
R1958:Csmd3	UTSW	15	47,868,035 (GRCm39)	critical splice donor site	probably null
R1965:Csmd3	UTSW	15	47,713,144 (GRCm39)	missense	probably benign	0.15
R1970:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R2029:Csmd3	UTSW	15	47,701,975 (GRCm39)	missense	probably damaging	1.00
R2051:Csmd3	UTSW	15	48,485,389 (GRCm39)	critical splice donor site	probably null
R2108:Csmd3	UTSW	15	47,868,257 (GRCm39)	missense	possibly damaging	0.81
R2132:Csmd3	UTSW	15	48,320,899 (GRCm39)	missense	probably benign	0.06
R2146:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2147:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2148:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2157:Csmd3	UTSW	15	47,559,183 (GRCm39)	missense	probably damaging	0.99
R2159:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2160:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2161:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2162:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2164:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2213:Csmd3	UTSW	15	47,683,843 (GRCm39)	missense	possibly damaging	0.92
R2301:Csmd3	UTSW	15	47,595,394 (GRCm39)	missense	probably damaging	1.00
R2302:Csmd3	UTSW	15	48,177,447 (GRCm39)	missense	probably benign
R2355:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2497:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2509:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2566:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2567:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2568:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2570:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2571:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2907:Csmd3	UTSW	15	47,874,449 (GRCm39)	missense	probably damaging	0.99
R3116:Csmd3	UTSW	15	47,520,995 (GRCm39)	missense	probably damaging	1.00
R3423:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3425:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3508:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3746:Csmd3	UTSW	15	47,713,162 (GRCm39)	missense	probably benign	0.04
R3813:Csmd3	UTSW	15	48,655,209 (GRCm39)	missense	possibly damaging	0.82
R3832:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3959:Csmd3	UTSW	15	47,507,585 (GRCm39)	missense	probably benign	0.18
R4042:Csmd3	UTSW	15	47,477,480 (GRCm39)	missense	probably damaging	1.00
R4043:Csmd3	UTSW	15	47,619,362 (GRCm39)	critical splice donor site	probably null
R4191:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4192:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4419:Csmd3	UTSW	15	47,567,707 (GRCm39)	missense	probably damaging	1.00
R4426:Csmd3	UTSW	15	47,532,581 (GRCm39)	missense	possibly damaging	0.51
R4434:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4438:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4490:Csmd3	UTSW	15	48,177,429 (GRCm39)	missense	possibly damaging	0.83
R4562:Csmd3	UTSW	15	47,763,240 (GRCm39)	missense	probably benign	0.32
R4604:Csmd3	UTSW	15	47,868,211 (GRCm39)	missense	possibly damaging	0.90
R4620:Csmd3	UTSW	15	47,449,149 (GRCm39)	missense	probably benign	0.09
R4632:Csmd3	UTSW	15	47,874,605 (GRCm39)	missense	probably damaging	0.99
R4679:Csmd3	UTSW	15	48,024,479 (GRCm39)	nonsense	probably null
R4696:Csmd3	UTSW	15	47,777,364 (GRCm39)	missense	probably benign	0.24
R4718:Csmd3	UTSW	15	47,561,546 (GRCm39)	nonsense	probably null
R4723:Csmd3	UTSW	15	47,532,556 (GRCm39)	missense	probably benign	0.29
R4801:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4802:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4806:Csmd3	UTSW	15	48,177,464 (GRCm39)	missense	probably benign
R4816:Csmd3	UTSW	15	47,721,330 (GRCm39)	missense	possibly damaging	0.68
R4935:Csmd3	UTSW	15	48,024,480 (GRCm39)	missense	probably damaging	1.00
R4955:Csmd3	UTSW	15	48,536,914 (GRCm39)	missense	probably damaging	0.99
R4991:Csmd3	UTSW	15	47,864,874 (GRCm39)	missense	probably damaging	1.00
R5031:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R5034:Csmd3	UTSW	15	47,492,683 (GRCm39)	missense	possibly damaging	0.94
R5035:Csmd3	UTSW	15	47,454,175 (GRCm39)	missense	probably damaging	1.00
R5120:Csmd3	UTSW	15	48,536,891 (GRCm39)	nonsense	probably null
R5224:Csmd3	UTSW	15	47,752,080 (GRCm39)	missense	possibly damaging	0.91
R5235:Csmd3	UTSW	15	47,492,674 (GRCm39)	missense	probably benign	0.20
R5279:Csmd3	UTSW	15	48,655,340 (GRCm39)	splice site	probably null
R5360:Csmd3	UTSW	15	47,532,599 (GRCm39)	missense	probably damaging	0.99
R5365:Csmd3	UTSW	15	47,868,145 (GRCm39)	missense	possibly damaging	0.68
R5379:Csmd3	UTSW	15	47,499,846 (GRCm39)	nonsense	probably null
R5381:Csmd3	UTSW	15	47,604,611 (GRCm39)	missense	probably benign	0.21
R5393:Csmd3	UTSW	15	47,497,099 (GRCm39)	missense	probably damaging	1.00
R5413:Csmd3	UTSW	15	47,701,831 (GRCm39)	missense	probably damaging	1.00
R5549:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5550:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5551:Csmd3	UTSW	15	48,177,492 (GRCm39)	missense	probably benign	0.13
R5567:Csmd3	UTSW	15	47,508,864 (GRCm39)	missense	possibly damaging	0.92
R5621:Csmd3	UTSW	15	48,177,374 (GRCm39)	missense	possibly damaging	0.84
R5668:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	possibly damaging	0.48
R5677:Csmd3	UTSW	15	48,485,447 (GRCm39)	missense	probably damaging	0.98
R5701:Csmd3	UTSW	15	48,403,729 (GRCm39)	missense	probably damaging	0.99
R5701:Csmd3	UTSW	15	47,513,617 (GRCm39)	missense	probably damaging	1.00
R5871:Csmd3	UTSW	15	47,752,112 (GRCm39)	missense	probably damaging	0.98
R5872:Csmd3	UTSW	15	47,445,923 (GRCm39)	missense	probably damaging	1.00
R5874:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R5952:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense	probably damaging	0.98
R5956:Csmd3	UTSW	15	48,655,278 (GRCm39)	missense	possibly damaging	0.84
R5966:Csmd3	UTSW	15	47,713,135 (GRCm39)	missense	probably damaging	0.96
R5969:Csmd3	UTSW	15	47,811,386 (GRCm39)	missense	probably damaging	1.00
R5989:Csmd3	UTSW	15	47,454,160 (GRCm39)	missense	possibly damaging	0.69
R6017:Csmd3	UTSW	15	48,177,408 (GRCm39)	missense	possibly damaging	0.95
R6057:Csmd3	UTSW	15	47,618,787 (GRCm39)	missense	probably damaging	1.00
R6127:Csmd3	UTSW	15	47,513,624 (GRCm39)	missense	probably damaging	1.00
R6178:Csmd3	UTSW	15	48,536,854 (GRCm39)	missense	probably damaging	1.00
R6198:Csmd3	UTSW	15	48,177,273 (GRCm39)	missense	probably benign	0.28
R6213:Csmd3	UTSW	15	47,492,656 (GRCm39)	missense	probably damaging	1.00
R6256:Csmd3	UTSW	15	47,533,125 (GRCm39)	missense	probably damaging	1.00
R6274:Csmd3	UTSW	15	47,484,833 (GRCm39)	missense	probably benign
R6327:Csmd3	UTSW	15	47,744,783 (GRCm39)	missense	probably damaging	1.00
R6354:Csmd3	UTSW	15	47,744,885 (GRCm39)	missense	probably damaging	1.00
R6405:Csmd3	UTSW	15	47,683,767 (GRCm39)	missense	probably damaging	0.99
R6410:Csmd3	UTSW	15	48,536,803 (GRCm39)	missense	probably damaging	1.00
R6416:Csmd3	UTSW	15	48,536,956 (GRCm39)	missense	probably damaging	1.00
R6463:Csmd3	UTSW	15	47,539,875 (GRCm39)	missense	probably damaging	1.00
R6536:Csmd3	UTSW	15	47,701,863 (GRCm39)	missense	probably damaging	1.00
R6625:Csmd3	UTSW	15	47,470,471 (GRCm39)	missense	probably benign	0.02
R6695:Csmd3	UTSW	15	47,721,230 (GRCm39)	missense	probably damaging	0.99
R6895:Csmd3	UTSW	15	47,529,910 (GRCm39)	splice site	probably null
R6906:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R6914:Csmd3	UTSW	15	47,874,534 (GRCm39)	missense	possibly damaging	0.53
R6920:Csmd3	UTSW	15	47,507,601 (GRCm39)	missense	probably damaging	1.00
R7024:Csmd3	UTSW	15	47,574,387 (GRCm39)	missense	probably damaging	1.00
R7178:Csmd3	UTSW	15	47,454,170 (GRCm39)	missense
R7192:Csmd3	UTSW	15	47,567,633 (GRCm39)	missense
R7220:Csmd3	UTSW	15	48,320,994 (GRCm39)	missense	probably damaging	0.99
R7362:Csmd3	UTSW	15	47,619,388 (GRCm39)	missense	possibly damaging	0.65
R7380:Csmd3	UTSW	15	47,450,361 (GRCm39)	missense
R7397:Csmd3	UTSW	15	47,559,130 (GRCm39)	missense
R7467:Csmd3	UTSW	15	47,492,640 (GRCm39)	missense
R7585:Csmd3	UTSW	15	48,485,471 (GRCm39)	missense	possibly damaging	0.76
R7623:Csmd3	UTSW	15	47,813,334 (GRCm39)	missense
R7649:Csmd3	UTSW	15	47,532,539 (GRCm39)	missense
R7691:Csmd3	UTSW	15	47,604,569 (GRCm39)	missense
R7695:Csmd3	UTSW	15	47,683,777 (GRCm39)	missense
R7759:Csmd3	UTSW	15	47,561,569 (GRCm39)	missense
R7817:Csmd3	UTSW	15	47,721,356 (GRCm39)	missense	probably damaging	0.99
R8052:Csmd3	UTSW	15	47,569,783 (GRCm39)	missense
R8089:Csmd3	UTSW	15	47,532,603 (GRCm39)	missense
R8110:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R8152:Csmd3	UTSW	15	47,532,860 (GRCm39)	splice site	probably null
R8323:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8341:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8353:Csmd3	UTSW	15	47,813,349 (GRCm39)	missense	probably damaging	1.00
R8364:Csmd3	UTSW	15	48,536,837 (GRCm39)	missense	probably damaging	1.00
R8405:Csmd3	UTSW	15	47,619,379 (GRCm39)	missense	probably damaging	1.00
R8412:Csmd3	UTSW	15	47,499,794 (GRCm39)	missense
R8436:Csmd3	UTSW	15	47,868,218 (GRCm39)	missense	probably damaging	0.97
R8516:Csmd3	UTSW	15	47,492,761 (GRCm39)	nonsense	probably null
R8553:Csmd3	UTSW	15	47,484,724 (GRCm39)	missense	possibly damaging	0.52
R8554:Csmd3	UTSW	15	47,507,538 (GRCm39)	missense	probably benign	0.32
R8678:Csmd3	UTSW	15	47,499,849 (GRCm39)	missense
R8751:Csmd3	UTSW	15	47,845,402 (GRCm39)	missense
R8758:Csmd3	UTSW	15	47,469,593 (GRCm39)	missense
R8768:Csmd3	UTSW	15	47,561,572 (GRCm39)	missense
R8785:Csmd3	UTSW	15	48,177,482 (GRCm39)	missense	probably benign	0.00
R8788:Csmd3	UTSW	15	47,470,513 (GRCm39)	missense
R8798:Csmd3	UTSW	15	47,595,382 (GRCm39)	missense
R8801:Csmd3	UTSW	15	48,321,024 (GRCm39)	missense	possibly damaging	0.70
R8811:Csmd3	UTSW	15	47,560,139 (GRCm39)	missense
R8844:Csmd3	UTSW	15	48,536,815 (GRCm39)	missense	probably damaging	0.98
R8844:Csmd3	UTSW	15	47,604,590 (GRCm39)	missense	probably damaging	0.96
R8892:Csmd3	UTSW	15	47,604,634 (GRCm39)	missense
R8897:Csmd3	UTSW	15	48,222,739 (GRCm39)	missense	probably benign	0.06
R9001:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense
R9007:Csmd3	UTSW	15	47,751,892 (GRCm39)	intron	probably benign
R9016:Csmd3	UTSW	15	47,522,438 (GRCm39)	missense
R9039:Csmd3	UTSW	15	47,483,308 (GRCm39)	splice site	probably benign
R9109:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9121:Csmd3	UTSW	15	47,683,774 (GRCm39)	missense
R9155:Csmd3	UTSW	15	47,449,051 (GRCm39)	missense
R9176:Csmd3	UTSW	15	47,864,937 (GRCm39)	missense
R9281:Csmd3	UTSW	15	47,460,272 (GRCm39)	missense
R9298:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9304:Csmd3	UTSW	15	47,569,805 (GRCm39)	missense
R9343:Csmd3	UTSW	15	48,015,001 (GRCm39)	missense	probably damaging	1.00
R9367:Csmd3	UTSW	15	47,567,564 (GRCm39)	missense
R9405:Csmd3	UTSW	15	47,539,187 (GRCm39)	missense
R9448:Csmd3	UTSW	15	47,460,315 (GRCm39)	missense
R9460:Csmd3	UTSW	15	47,617,130 (GRCm39)	missense
R9481:Csmd3	UTSW	15	47,470,459 (GRCm39)	missense
R9520:Csmd3	UTSW	15	47,561,608 (GRCm39)	missense
R9551:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9552:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9571:Csmd3	UTSW	15	48,655,398 (GRCm39)	start gained	probably benign
R9607:Csmd3	UTSW	15	47,618,811 (GRCm39)	missense	probably damaging	0.98
R9621:Csmd3	UTSW	15	47,713,116 (GRCm39)	missense
R9671:Csmd3	UTSW	15	47,845,299 (GRCm39)	missense
R9718:Csmd3	UTSW	15	47,560,083 (GRCm39)	missense
U24488:Csmd3	UTSW	15	47,573,795 (GRCm39)	missense	probably damaging	1.00
V8831:Csmd3	UTSW	15	48,321,092 (GRCm39)	missense	probably damaging	0.96
X0021:Csmd3	UTSW	15	47,833,489 (GRCm39)	nonsense	probably null
Z1088:Csmd3	UTSW	15	47,710,677 (GRCm39)	missense	probably damaging	0.98
Z1088:Csmd3	UTSW	15	47,499,789 (GRCm39)	missense	probably damaging	1.00
Z1177:Csmd3	UTSW	15	47,596,813 (GRCm39)	missense
Z1177:Csmd3	UTSW	15	47,539,130 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- CTGGCTTACATAGTTTGAGTTCAC -3'
(R):5'- TATCCAGTGTTGGTAGGTTATATCC -3'

Sequencing Primer
(F):5'- GTTTGAGTTCACTTAATACACATTCC -3'
(R):5'- AGTGTTGGTAGGTTATATCCAGATAG -3'

Posted On

2022-08-09