Incidental Mutation 'R9569:Duox1'
| ID |
721818 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
068966-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9569 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 122148971 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 82
(V82A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
[ENSMUST00000110537]
[ENSMUST00000147788]
[ENSMUST00000148417]
[ENSMUST00000154412]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099461
AA Change: V82A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: V82A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110537
|
| SMART Domains |
Protein: ENSMUSP00000106166
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
290 |
3.9e-128 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147788
|
| SMART Domains |
Protein: ENSMUSP00000116280
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
134 |
5.9e-57 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148417
|
| SMART Domains |
Protein: ENSMUSP00000116963
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
210 |
1.2e-99 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154412
|
| SMART Domains |
Protein: ENSMUSP00000116911
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
100 |
6.3e-37 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi2 |
T |
A |
1: 60,503,763 (GRCm39) |
V356D |
probably damaging |
Het |
| Adgrd1 |
T |
C |
5: 129,256,701 (GRCm39) |
V690A |
possibly damaging |
Het |
| Apba2 |
T |
C |
7: 64,393,138 (GRCm39) |
M553T |
possibly damaging |
Het |
| Apeh |
C |
T |
9: 107,971,609 (GRCm39) |
V13M |
unknown |
Het |
| Apol11b |
C |
T |
15: 77,524,771 (GRCm39) |
E5K |
possibly damaging |
Het |
| Apol7e |
C |
T |
15: 77,601,933 (GRCm39) |
T177I |
probably damaging |
Het |
| Bltp1 |
T |
C |
3: 37,066,770 (GRCm39) |
M211T |
|
Het |
| Bub1b |
T |
C |
2: 118,468,884 (GRCm39) |
I883T |
probably damaging |
Het |
| C9 |
T |
C |
15: 6,489,062 (GRCm39) |
S140P |
probably damaging |
Het |
| Cbfa2t2 |
T |
A |
2: 154,346,485 (GRCm39) |
I64N |
probably benign |
Het |
| Cd180 |
A |
T |
13: 102,842,486 (GRCm39) |
I511F |
possibly damaging |
Het |
| Cic |
T |
C |
7: 24,972,120 (GRCm39) |
V617A |
possibly damaging |
Het |
| Clca3a2 |
A |
C |
3: 144,513,075 (GRCm39) |
|
probably null |
Het |
| D5Ertd579e |
T |
C |
5: 36,759,979 (GRCm39) |
T1394A |
probably damaging |
Het |
| Dclk1 |
A |
T |
3: 55,387,852 (GRCm39) |
E422D |
probably benign |
Het |
| Depdc5 |
A |
T |
5: 33,025,321 (GRCm39) |
D21V |
probably damaging |
Het |
| Dis3l |
A |
G |
9: 64,236,829 (GRCm39) |
F40S |
unknown |
Het |
| Dus2 |
T |
C |
8: 106,771,507 (GRCm39) |
V211A |
probably damaging |
Het |
| Eif2ak4 |
G |
A |
2: 118,251,316 (GRCm39) |
S326N |
probably benign |
Het |
| Fat3 |
A |
C |
9: 15,830,495 (GRCm39) |
L153R |
|
Het |
| Gpx8 |
C |
T |
13: 113,182,125 (GRCm39) |
V103I |
probably damaging |
Het |
| Gtf2a1l |
A |
G |
17: 89,001,948 (GRCm39) |
D268G |
probably benign |
Het |
| Hc |
T |
C |
2: 34,926,359 (GRCm39) |
I342V |
probably benign |
Het |
| Hsp90ab1 |
T |
A |
17: 45,879,878 (GRCm39) |
D546V |
possibly damaging |
Het |
| Ifi206 |
T |
G |
1: 173,314,209 (GRCm39) |
D77A |
|
Het |
| Igfbp1 |
A |
G |
11: 7,147,881 (GRCm39) |
|
probably benign |
Het |
| Kdm3a |
T |
C |
6: 71,584,434 (GRCm39) |
D559G |
probably benign |
Het |
| Kif2a |
A |
G |
13: 107,105,246 (GRCm39) |
I565T |
probably benign |
Het |
| Krt1c |
T |
C |
15: 101,724,924 (GRCm39) |
T229A |
probably damaging |
Het |
| Lcmt2 |
G |
A |
2: 120,970,522 (GRCm39) |
A187V |
probably damaging |
Het |
| Mapk8ip1 |
A |
G |
2: 92,217,599 (GRCm39) |
M241T |
probably benign |
Het |
| Mup15 |
T |
C |
4: 61,357,875 (GRCm39) |
|
probably benign |
Het |
| Myo9b |
T |
C |
8: 71,811,629 (GRCm39) |
V1912A |
probably benign |
Het |
| Naip5 |
T |
A |
13: 100,356,338 (GRCm39) |
E1092D |
probably benign |
Het |
| Naip5 |
T |
C |
13: 100,359,821 (GRCm39) |
T472A |
probably benign |
Het |
| Net1 |
A |
G |
13: 3,938,518 (GRCm39) |
F123S |
probably benign |
Het |
| Or1j8 |
T |
C |
2: 36,191,946 (GRCm39) |
Y132H |
probably damaging |
Het |
| Or52n2 |
C |
T |
7: 104,542,525 (GRCm39) |
M103I |
possibly damaging |
Het |
| Or5h17 |
A |
G |
16: 58,820,228 (GRCm39) |
Y60C |
probably damaging |
Het |
| Pcdhb13 |
T |
C |
18: 37,576,153 (GRCm39) |
F177S |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,907,065 (GRCm39) |
|
probably null |
Het |
| Perm1 |
A |
G |
4: 156,303,039 (GRCm39) |
T528A |
probably benign |
Het |
| Pik3c2a |
C |
T |
7: 115,957,939 (GRCm39) |
A1116T |
possibly damaging |
Het |
| Prox2 |
G |
A |
12: 85,141,766 (GRCm39) |
Q146* |
probably null |
Het |
| Psd |
A |
T |
19: 46,308,717 (GRCm39) |
C639S |
possibly damaging |
Het |
| Rffl |
T |
A |
11: 82,703,264 (GRCm39) |
T220S |
probably benign |
Het |
| Scn2a |
A |
G |
2: 65,560,622 (GRCm39) |
D1284G |
probably damaging |
Het |
| Scube1 |
T |
C |
15: 83,513,605 (GRCm39) |
Y385C |
probably damaging |
Het |
| Sec14l3 |
A |
T |
11: 4,026,324 (GRCm39) |
D388V |
probably damaging |
Het |
| Slc26a1 |
G |
T |
5: 108,819,460 (GRCm39) |
Q596K |
probably benign |
Het |
| Slc6a19 |
T |
C |
13: 73,834,030 (GRCm39) |
T343A |
probably benign |
Het |
| Slc7a4 |
A |
G |
16: 17,393,262 (GRCm39) |
V179A |
|
Het |
| Sox14 |
T |
G |
9: 99,757,562 (GRCm39) |
D49A |
|
Het |
| Spata31g1 |
G |
C |
4: 42,971,740 (GRCm39) |
V358L |
probably benign |
Het |
| Timm22 |
A |
G |
11: 76,298,196 (GRCm39) |
S56G |
probably benign |
Het |
| Tmub2 |
G |
A |
11: 102,179,153 (GRCm39) |
W322* |
probably null |
Het |
| Tsc22d4 |
A |
G |
5: 137,756,428 (GRCm39) |
T8A |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,539,652 (GRCm39) |
I34445V |
probably benign |
Het |
| Tyms |
A |
T |
5: 30,268,360 (GRCm39) |
Y196* |
probably null |
Het |
| Ube2o |
G |
A |
11: 116,434,823 (GRCm39) |
T546M |
probably damaging |
Het |
| Umodl1 |
A |
G |
17: 31,217,143 (GRCm39) |
Y1125C |
probably damaging |
Het |
| Unc13b |
CGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGC |
CGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGC |
4: 43,177,312 (GRCm39) |
|
probably benign |
Het |
| Unk |
A |
T |
11: 115,950,035 (GRCm39) |
Q747L |
probably damaging |
Het |
| Vmn1r170 |
A |
G |
7: 23,306,294 (GRCm39) |
E232G |
probably benign |
Het |
| Vps41 |
A |
G |
13: 19,013,396 (GRCm39) |
Y338C |
possibly damaging |
Het |
| Washc5 |
T |
C |
15: 59,215,980 (GRCm39) |
M800V |
probably benign |
Het |
| Wt1 |
T |
A |
2: 104,993,711 (GRCm39) |
I348N |
possibly damaging |
Het |
| Xirp2 |
A |
G |
2: 67,341,242 (GRCm39) |
Y1161C |
probably damaging |
Het |
| Xpo7 |
A |
G |
14: 70,906,140 (GRCm39) |
M1001T |
possibly damaging |
Het |
| Yeats2 |
A |
T |
16: 19,972,902 (GRCm39) |
R19W |
probably damaging |
Het |
| Zfp142 |
T |
C |
1: 74,615,386 (GRCm39) |
T476A |
probably damaging |
Het |
| Zfp229 |
T |
C |
17: 21,964,573 (GRCm39) |
W268R |
possibly damaging |
Het |
| Zfp473 |
A |
G |
7: 44,388,971 (GRCm39) |
F50S |
probably damaging |
Het |
| Zfp975 |
A |
T |
7: 42,311,413 (GRCm39) |
M400K |
probably benign |
Het |
| Zkscan5 |
A |
G |
5: 145,144,419 (GRCm39) |
M150V |
probably benign |
Het |
| Znfx1 |
T |
A |
2: 166,897,875 (GRCm39) |
I350F |
|
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAGAACGCACTTGAGGTAC -3'
(R):5'- TCTGACTCCCACTGGCTAAG -3'
Sequencing Primer
(F):5'- GAGTACATGCTGCTCTTACCGAAG -3'
(R):5'- CCAAGGGCTGAGGTTTGC -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation