Incidental Mutation 'R9570:Vps8'
| ID |
721949 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9570 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 21462953 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Tyrosine
at position 1406
(F1406Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112937
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053336]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053336
|
| SMART Domains |
Protein: ENSMUSP00000062303
Gene: ENSMUSG00000043391
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0524
|
12 |
248 |
1e-133 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
AA Change: F1378Y
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: F1378Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115397
AA Change: F1408Y
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: F1408Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117598
AA Change: F1406Y
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: F1406Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118923
AA Change: F1378Y
PolyPhen 2
Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: F1378Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125487
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam39 |
C |
T |
8: 41,277,687 (GRCm39) |
T26I |
probably benign |
Het |
| Adgrg7 |
A |
G |
16: 56,570,813 (GRCm39) |
L405P |
probably damaging |
Het |
| Ankle1 |
A |
G |
8: 71,859,424 (GRCm39) |
D106G |
probably damaging |
Het |
| Ankrd17 |
G |
T |
5: 90,401,536 (GRCm39) |
D1609E |
|
Het |
| Anpep |
A |
G |
7: 79,476,661 (GRCm39) |
V772A |
probably benign |
Het |
| Anxa8 |
T |
C |
14: 33,814,509 (GRCm39) |
V115A |
possibly damaging |
Het |
| Aoc1 |
T |
C |
6: 48,882,772 (GRCm39) |
F216S |
probably damaging |
Het |
| Aplf |
T |
A |
6: 87,640,781 (GRCm39) |
E76V |
possibly damaging |
Het |
| Apol11b |
C |
T |
15: 77,524,771 (GRCm39) |
E5K |
possibly damaging |
Het |
| Arhgap42 |
T |
A |
9: 9,148,209 (GRCm39) |
Y120F |
|
Het |
| Atg2a |
T |
A |
19: 6,305,749 (GRCm39) |
H1316Q |
probably benign |
Het |
| Atp8b3 |
A |
G |
10: 80,361,822 (GRCm39) |
F743S |
probably benign |
Het |
| Best1 |
A |
T |
19: 9,970,331 (GRCm39) |
W94R |
probably damaging |
Het |
| Catsper3 |
T |
C |
13: 55,953,669 (GRCm39) |
|
probably null |
Het |
| Ccdc80 |
A |
T |
16: 44,915,449 (GRCm39) |
E68D |
probably benign |
Het |
| Col8a1 |
T |
A |
16: 57,448,539 (GRCm39) |
I324F |
unknown |
Het |
| Coro1c |
G |
A |
5: 114,003,816 (GRCm39) |
R68* |
probably null |
Het |
| Dennd4c |
A |
G |
4: 86,747,208 (GRCm39) |
D1464G |
possibly damaging |
Het |
| Dgat2 |
C |
T |
7: 98,818,926 (GRCm39) |
V77I |
possibly damaging |
Het |
| Ecpas |
G |
A |
4: 58,832,796 (GRCm39) |
R855* |
probably null |
Het |
| Ednra |
A |
C |
8: 78,393,961 (GRCm39) |
N378K |
possibly damaging |
Het |
| Eif1ad4 |
A |
G |
12: 87,862,534 (GRCm39) |
D132G |
unknown |
Het |
| Eml5 |
A |
T |
12: 98,782,243 (GRCm39) |
D178E |
probably benign |
Het |
| Ethe1 |
G |
T |
7: 24,293,236 (GRCm39) |
|
probably benign |
Het |
| Fgf21 |
C |
T |
7: 45,264,594 (GRCm39) |
R46Q |
probably damaging |
Het |
| Flt3 |
C |
T |
5: 147,309,424 (GRCm39) |
V198M |
possibly damaging |
Het |
| Fryl |
T |
C |
5: 73,179,498 (GRCm39) |
N2970D |
probably benign |
Het |
| Gtf2e2 |
T |
A |
8: 34,252,076 (GRCm39) |
D197E |
probably damaging |
Het |
| Gtf2i |
G |
A |
5: 134,294,627 (GRCm39) |
R362W |
probably damaging |
Het |
| Gtpbp10 |
C |
T |
5: 5,596,382 (GRCm39) |
G188R |
probably damaging |
Het |
| Gzmc |
A |
C |
14: 56,469,042 (GRCm39) |
S226A |
probably benign |
Het |
| Hhatl |
A |
T |
9: 121,613,282 (GRCm39) |
V471D |
possibly damaging |
Het |
| Hoxd11 |
T |
C |
2: 74,512,812 (GRCm39) |
S26P |
possibly damaging |
Het |
| Ighv1-85 |
A |
T |
12: 115,963,794 (GRCm39) |
W69R |
probably benign |
Het |
| Kcnk3 |
T |
C |
5: 30,779,433 (GRCm39) |
L161P |
possibly damaging |
Het |
| Klk6 |
A |
G |
7: 43,477,967 (GRCm39) |
D113G |
probably damaging |
Het |
| Map3k5 |
A |
G |
10: 19,876,314 (GRCm39) |
I158V |
probably benign |
Het |
| Marchf8 |
T |
A |
6: 116,382,639 (GRCm39) |
M434K |
probably benign |
Het |
| Mcc |
T |
C |
18: 44,578,925 (GRCm39) |
R828G |
probably damaging |
Het |
| Muc4 |
A |
T |
16: 32,569,695 (GRCm39) |
T252S |
possibly damaging |
Het |
| Naip5 |
T |
C |
13: 100,359,821 (GRCm39) |
T472A |
probably benign |
Het |
| Nme7 |
A |
G |
1: 164,206,961 (GRCm39) |
D282G |
probably benign |
Het |
| Npdc1 |
G |
T |
2: 25,298,312 (GRCm39) |
A228S |
probably benign |
Het |
| Nrbp1 |
T |
A |
5: 31,401,272 (GRCm39) |
S49R |
probably damaging |
Het |
| Ntan1 |
T |
C |
16: 13,637,248 (GRCm39) |
V10A |
possibly damaging |
Het |
| Or10a3 |
A |
G |
7: 108,480,504 (GRCm39) |
V103A |
possibly damaging |
Het |
| Or10b1 |
T |
C |
10: 78,356,084 (GRCm39) |
V214A |
probably benign |
Het |
| Or51b4 |
A |
G |
7: 103,530,856 (GRCm39) |
V198A |
probably benign |
Het |
| Pdcd2l |
T |
C |
7: 33,892,401 (GRCm39) |
D156G |
probably benign |
Het |
| Pde11a |
A |
G |
2: 75,877,157 (GRCm39) |
S771P |
probably damaging |
Het |
| Pilra |
T |
A |
5: 137,834,342 (GRCm39) |
M14L |
probably benign |
Het |
| Pkd1l1 |
T |
A |
11: 8,840,697 (GRCm39) |
E1237V |
|
Het |
| Pkp2 |
A |
T |
16: 16,078,278 (GRCm39) |
T507S |
possibly damaging |
Het |
| Polm |
A |
G |
11: 5,779,713 (GRCm39) |
Y362H |
probably damaging |
Het |
| Pramel12 |
A |
T |
4: 143,144,514 (GRCm39) |
M287L |
probably benign |
Het |
| Prcd |
C |
T |
11: 116,550,583 (GRCm39) |
S85F |
possibly damaging |
Het |
| Prox2 |
G |
A |
12: 85,141,766 (GRCm39) |
Q146* |
probably null |
Het |
| Ptger1 |
T |
C |
8: 84,395,461 (GRCm39) |
W313R |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,227,217 (GRCm39) |
E44G |
probably damaging |
Het |
| Rai1 |
A |
G |
11: 60,076,568 (GRCm39) |
T211A |
probably benign |
Het |
| Rgl1 |
C |
A |
1: 152,430,082 (GRCm39) |
D234Y |
possibly damaging |
Het |
| Rlf |
A |
G |
4: 121,007,087 (GRCm39) |
V741A |
possibly damaging |
Het |
| Rnaseh2b |
T |
C |
14: 62,597,978 (GRCm39) |
|
probably null |
Het |
| Selenon |
C |
T |
4: 134,270,055 (GRCm39) |
R383H |
probably benign |
Het |
| Sh3rf2 |
A |
T |
18: 42,272,620 (GRCm39) |
H368L |
possibly damaging |
Het |
| Slc9c1 |
A |
T |
16: 45,380,705 (GRCm39) |
I544L |
probably benign |
Het |
| Smarca4 |
A |
G |
9: 21,580,849 (GRCm39) |
E993G |
probably damaging |
Het |
| Stab1 |
T |
A |
14: 30,864,638 (GRCm39) |
I1966F |
probably benign |
Het |
| Stard9 |
G |
A |
2: 120,534,714 (GRCm39) |
S3657N |
probably benign |
Het |
| Tex15 |
G |
A |
8: 34,067,309 (GRCm39) |
M2246I |
probably damaging |
Het |
| Ttc41 |
A |
T |
10: 86,549,598 (GRCm39) |
N264I |
possibly damaging |
Het |
| Use1 |
T |
A |
8: 71,820,473 (GRCm39) |
M96K |
possibly damaging |
Het |
| Vmn1r201 |
T |
C |
13: 22,659,236 (GRCm39) |
I150T |
probably damaging |
Het |
| Vmn1r34 |
T |
C |
6: 66,614,718 (GRCm39) |
I7V |
probably benign |
Het |
| Zfp788 |
A |
T |
7: 41,300,006 (GRCm39) |
T881S |
possibly damaging |
Het |
| Zfp804a |
C |
T |
2: 82,088,844 (GRCm39) |
T891I |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAACACAGGGCTTTTCACTGC -3'
(R):5'- ATCTGCGGTCTGACCTGTAAC -3'
Sequencing Primer
(F):5'- GGCTTTTCACTGCCCTCTC -3'
(R):5'- CTGTAACAGGGAGAGTGCACTG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation