Incidental Mutation 'R9571:Vmn2r97'
| ID |
722018 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R9571 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 19149919 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 436
(V436L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168710
AA Change: V436L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: V436L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
AA Change: V436L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020A23Rik |
A |
G |
2: 130,247,482 (GRCm39) |
D6G |
probably benign |
Het |
| Abl2 |
T |
G |
1: 156,469,084 (GRCm39) |
S783A |
probably damaging |
Het |
| Adamtsl1 |
A |
T |
4: 86,117,543 (GRCm39) |
T169S |
probably benign |
Het |
| Adcy9 |
A |
G |
16: 4,141,653 (GRCm39) |
V621A |
probably benign |
Het |
| Ahnak2 |
T |
C |
12: 112,742,510 (GRCm39) |
S521G |
possibly damaging |
Het |
| Ap2m1 |
G |
A |
16: 20,360,037 (GRCm39) |
G213R |
probably damaging |
Het |
| Apol11b |
C |
T |
15: 77,524,771 (GRCm39) |
E5K |
possibly damaging |
Het |
| Arl4d |
T |
C |
11: 101,558,032 (GRCm39) |
M186T |
possibly damaging |
Het |
| Cep192 |
A |
G |
18: 67,952,109 (GRCm39) |
D428G |
probably damaging |
Het |
| Ckap5 |
A |
C |
2: 91,387,953 (GRCm39) |
D266A |
probably damaging |
Het |
| Crls1 |
A |
T |
2: 132,691,793 (GRCm39) |
N106I |
probably damaging |
Het |
| Csmd3 |
T |
A |
15: 48,655,398 (GRCm39) |
|
probably benign |
Het |
| Csnk1a1 |
A |
G |
18: 61,704,969 (GRCm39) |
R161G |
possibly damaging |
Het |
| Cyp4f39 |
T |
A |
17: 32,702,196 (GRCm39) |
I231N |
probably damaging |
Het |
| Ddx31 |
T |
A |
2: 28,750,034 (GRCm39) |
V352D |
probably damaging |
Het |
| Dna2 |
A |
G |
10: 62,800,740 (GRCm39) |
D758G |
probably damaging |
Het |
| Duxf4 |
G |
A |
10: 58,071,378 (GRCm39) |
L279F |
possibly damaging |
Het |
| Gatad2a |
C |
A |
8: 70,370,381 (GRCm39) |
A172S |
probably benign |
Het |
| Ghsr |
G |
T |
3: 27,426,664 (GRCm39) |
R240L |
probably benign |
Het |
| Gli3 |
T |
A |
13: 15,900,858 (GRCm39) |
M1415K |
probably benign |
Het |
| Glo1 |
G |
A |
17: 30,816,835 (GRCm39) |
T107I |
possibly damaging |
Het |
| Gm10800 |
AAAGAAAACTGAA |
ACAAGAAAACTGAA |
2: 98,497,378 (GRCm39) |
|
probably null |
Het |
| Gm17334 |
C |
T |
11: 53,663,760 (GRCm39) |
V34M |
unknown |
Het |
| Habp4 |
T |
A |
13: 64,322,615 (GRCm39) |
M228K |
probably benign |
Het |
| Hacl1 |
A |
G |
14: 31,344,838 (GRCm39) |
V257A |
possibly damaging |
Het |
| Ift122 |
T |
G |
6: 115,857,628 (GRCm39) |
S125A |
possibly damaging |
Het |
| Iqce |
C |
T |
5: 140,651,862 (GRCm39) |
D704N |
possibly damaging |
Het |
| Jcad |
T |
A |
18: 4,673,252 (GRCm39) |
L338* |
probably null |
Het |
| Kcnj13 |
T |
C |
1: 87,316,849 (GRCm39) |
D88G |
probably damaging |
Het |
| Kif1b |
T |
C |
4: 149,305,098 (GRCm39) |
D942G |
probably damaging |
Het |
| Marchf8 |
T |
A |
6: 116,383,237 (GRCm39) |
S271T |
probably benign |
Het |
| Meis1 |
A |
G |
11: 18,961,378 (GRCm39) |
L165S |
probably damaging |
Het |
| Morc2b |
T |
A |
17: 33,355,178 (GRCm39) |
T865S |
probably benign |
Het |
| Morc3 |
T |
A |
16: 93,641,107 (GRCm39) |
N46K |
possibly damaging |
Het |
| Mpzl1 |
C |
T |
1: 165,429,374 (GRCm39) |
C219Y |
probably benign |
Het |
| Mup5 |
A |
G |
4: 61,750,787 (GRCm39) |
|
probably null |
Het |
| Ninl |
A |
T |
2: 150,791,803 (GRCm39) |
W907R |
probably benign |
Het |
| Nol6 |
A |
T |
4: 41,120,156 (GRCm39) |
S491T |
probably benign |
Het |
| Or4f53 |
A |
T |
2: 111,088,083 (GRCm39) |
I208F |
probably benign |
Het |
| Or51g1 |
A |
G |
7: 102,634,221 (GRCm39) |
V50A |
probably benign |
Het |
| Or5b121 |
T |
A |
19: 13,507,697 (GRCm39) |
I264N |
probably damaging |
Het |
| Or6c205 |
C |
A |
10: 129,087,182 (GRCm39) |
P260T |
possibly damaging |
Het |
| Osbpl6 |
T |
A |
2: 76,425,191 (GRCm39) |
M919K |
probably benign |
Het |
| Otogl |
A |
T |
10: 107,598,364 (GRCm39) |
V2262E |
possibly damaging |
Het |
| Pcbp2 |
A |
G |
15: 102,383,113 (GRCm39) |
D77G |
possibly damaging |
Het |
| Pcsk7 |
G |
A |
9: 45,820,907 (GRCm39) |
R113Q |
possibly damaging |
Het |
| Pds5b |
T |
C |
5: 150,645,971 (GRCm39) |
I143T |
probably damaging |
Het |
| Polr2m |
T |
C |
9: 71,386,710 (GRCm39) |
E357G |
possibly damaging |
Het |
| Prox2 |
G |
A |
12: 85,141,766 (GRCm39) |
Q146* |
probably null |
Het |
| Ptprt |
A |
G |
2: 161,395,732 (GRCm39) |
V1167A |
probably benign |
Het |
| Rbm11 |
G |
A |
16: 75,397,543 (GRCm39) |
E158K |
possibly damaging |
Het |
| Sall2 |
A |
T |
14: 52,551,830 (GRCm39) |
V455E |
probably damaging |
Het |
| Sar1b |
T |
A |
11: 51,680,064 (GRCm39) |
L130Q |
probably damaging |
Het |
| Slc35f6 |
A |
G |
5: 30,815,180 (GRCm39) |
N369S |
possibly damaging |
Het |
| Slc39a12 |
A |
T |
2: 14,412,380 (GRCm39) |
M351L |
probably benign |
Het |
| Taf15 |
T |
A |
11: 83,395,487 (GRCm39) |
Y397* |
probably null |
Het |
| Tmprss11e |
A |
T |
5: 86,875,149 (GRCm39) |
V39D |
probably damaging |
Het |
| Trim71 |
T |
C |
9: 114,342,359 (GRCm39) |
D641G |
probably damaging |
Het |
| Trpc3 |
T |
A |
3: 36,694,909 (GRCm39) |
T682S |
probably damaging |
Het |
| Tsen54 |
T |
C |
11: 115,707,933 (GRCm39) |
|
probably null |
Het |
| Usp6nl |
A |
G |
2: 6,445,960 (GRCm39) |
N646D |
possibly damaging |
Het |
| Vip |
T |
C |
10: 5,590,661 (GRCm39) |
F12L |
probably benign |
Het |
| Vmn1r39 |
A |
T |
6: 66,781,572 (GRCm39) |
F249I |
probably benign |
Het |
| Vmn2r106 |
A |
T |
17: 20,505,641 (GRCm39) |
S18T |
probably benign |
Het |
| Washc2 |
T |
C |
6: 116,237,631 (GRCm39) |
|
probably null |
Het |
| Ykt6 |
T |
C |
11: 5,914,613 (GRCm39) |
V171A |
possibly damaging |
Het |
| Zfp658 |
A |
G |
7: 43,222,139 (GRCm39) |
D138G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAAGTGCTCATTTTCTGACAC -3'
(R):5'- ACCTTGCCCATGATTTCAAAAC -3'
Sequencing Primer
(F):5'- CTGTCAAACCAATGCTTCTTTGGATG -3'
(R):5'- TGCCCATGATTTCAAAACATCATAC -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation