Incidental Mutation 'R9574:Vmn2r67'
ID |
722195 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r67
|
Ensembl Gene |
ENSMUSG00000095664 |
Gene Name |
vomeronasal 2, receptor 67 |
Synonyms |
EG620672 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.111)
|
Stock # |
R9574 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 84786017 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 663
(I663V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
AlphaFold |
K7N6T2 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000168730
AA Change: I663V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000126007 Gene: ENSMUSG00000095664 AA Change: I663V
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 72 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9930111J21Rik1 |
T |
A |
11: 48,838,496 (GRCm39) |
E697V |
probably damaging |
Het |
Actn4 |
T |
C |
7: 28,594,864 (GRCm39) |
D805G |
probably benign |
Het |
Adam2 |
C |
T |
14: 66,275,071 (GRCm39) |
S554N |
probably benign |
Het |
Adra2b |
A |
G |
2: 127,206,283 (GRCm39) |
T267A |
probably benign |
Het |
Apobec4 |
A |
T |
1: 152,632,415 (GRCm39) |
T148S |
probably damaging |
Het |
B4galt1 |
T |
A |
4: 40,853,766 (GRCm39) |
M14L |
probably benign |
Het |
Bok |
C |
A |
1: 93,616,947 (GRCm39) |
Q98K |
probably benign |
Het |
Cacnb4 |
A |
T |
2: 52,327,016 (GRCm39) |
L394Q |
probably damaging |
Het |
Ccar2 |
T |
C |
14: 70,381,105 (GRCm39) |
K287E |
probably benign |
Het |
Cdyl2 |
T |
A |
8: 117,350,669 (GRCm39) |
E154V |
probably benign |
Het |
Cenpn |
T |
G |
8: 117,660,149 (GRCm39) |
Y160D |
probably damaging |
Het |
Cfap20 |
T |
C |
8: 96,149,514 (GRCm39) |
Y58C |
probably benign |
Het |
Creb5 |
T |
A |
6: 53,658,039 (GRCm39) |
L123Q |
unknown |
Het |
Cspg4 |
G |
A |
9: 56,797,342 (GRCm39) |
V1269M |
probably damaging |
Het |
Cyp2b19 |
G |
T |
7: 26,466,353 (GRCm39) |
K385N |
probably null |
Het |
Cyp2b19 |
A |
T |
7: 26,466,352 (GRCm39) |
K385M |
probably damaging |
Het |
Ercc2 |
C |
A |
7: 19,124,060 (GRCm39) |
D422E |
probably benign |
Het |
Fbxl12 |
A |
G |
9: 20,550,109 (GRCm39) |
V129A |
possibly damaging |
Het |
Fbxo11 |
T |
C |
17: 88,321,951 (GRCm39) |
E84G |
|
Het |
Fmn1 |
T |
C |
2: 113,425,402 (GRCm39) |
L1192S |
probably damaging |
Het |
Galk2 |
T |
C |
2: 125,824,979 (GRCm39) |
F392L |
probably benign |
Het |
Gas2l3 |
G |
A |
10: 89,258,135 (GRCm39) |
H153Y |
probably damaging |
Het |
Gcn1 |
A |
T |
5: 115,713,341 (GRCm39) |
K101N |
possibly damaging |
Het |
Gmfg |
C |
T |
7: 28,145,359 (GRCm39) |
Q101* |
probably null |
Het |
Gpr108 |
C |
T |
17: 57,545,039 (GRCm39) |
C309Y |
probably damaging |
Het |
H3c8 |
T |
C |
13: 23,719,761 (GRCm39) |
L49P |
probably damaging |
Het |
Hscb |
A |
T |
5: 110,982,595 (GRCm39) |
I164N |
probably damaging |
Het |
Kifc2 |
T |
C |
15: 76,546,397 (GRCm39) |
W260R |
probably damaging |
Het |
Lrp6 |
T |
A |
6: 134,447,662 (GRCm39) |
D995V |
possibly damaging |
Het |
Lrrc1 |
T |
A |
9: 77,358,708 (GRCm39) |
I308F |
probably damaging |
Het |
Map7 |
C |
T |
10: 20,153,966 (GRCm39) |
A694V |
unknown |
Het |
Mapre2 |
A |
G |
18: 23,965,993 (GRCm39) |
D68G |
probably benign |
Het |
Mertk |
A |
T |
2: 128,593,880 (GRCm39) |
I295F |
probably benign |
Het |
Mst1 |
T |
A |
9: 107,962,053 (GRCm39) |
C690* |
probably null |
Het |
Nde1 |
A |
G |
16: 13,988,345 (GRCm39) |
E76G |
probably damaging |
Het |
Nek5 |
T |
C |
8: 22,564,040 (GRCm39) |
T597A |
probably benign |
Het |
Nup210l |
T |
C |
3: 90,117,693 (GRCm39) |
F1800L |
probably benign |
Het |
Or5c1 |
A |
G |
2: 37,222,148 (GRCm39) |
I130V |
possibly damaging |
Het |
Pdpn |
T |
A |
4: 142,997,101 (GRCm39) |
D131V |
probably benign |
Het |
Pgap6 |
T |
C |
17: 26,337,861 (GRCm39) |
V415A |
probably damaging |
Het |
Pot1a |
T |
C |
6: 25,775,718 (GRCm39) |
T118A |
possibly damaging |
Het |
Prom1 |
A |
G |
5: 44,158,179 (GRCm39) |
I843T |
probably benign |
Het |
Prrt3 |
T |
C |
6: 113,474,587 (GRCm39) |
T212A |
probably benign |
Het |
Rabgap1 |
A |
G |
2: 37,433,246 (GRCm39) |
|
probably null |
Het |
Rarb |
A |
T |
14: 16,574,858 (GRCm38) |
S53T |
probably damaging |
Het |
Rnft2 |
A |
G |
5: 118,375,330 (GRCm39) |
S140P |
probably benign |
Het |
Rxfp1 |
T |
C |
3: 79,563,581 (GRCm39) |
M362V |
probably benign |
Het |
Sall2 |
G |
A |
14: 52,551,617 (GRCm39) |
T526M |
probably damaging |
Het |
Scube1 |
T |
C |
15: 83,501,000 (GRCm39) |
D598G |
|
Het |
Sema3f |
T |
A |
9: 107,566,972 (GRCm39) |
I186F |
possibly damaging |
Het |
Shank2 |
A |
G |
7: 143,622,462 (GRCm39) |
T199A |
possibly damaging |
Het |
Sipa1l2 |
T |
A |
8: 126,169,453 (GRCm39) |
M1427L |
probably benign |
Het |
Sis |
C |
T |
3: 72,828,490 (GRCm39) |
G1195D |
probably benign |
Het |
Slc25a39 |
A |
T |
11: 102,295,390 (GRCm39) |
H193Q |
probably benign |
Het |
Sprr2b |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
3: 92,224,826 (GRCm39) |
|
probably benign |
Het |
Srgn |
A |
C |
10: 62,343,444 (GRCm39) |
L17R |
probably damaging |
Het |
Stard5 |
A |
G |
7: 83,281,944 (GRCm39) |
N34D |
probably benign |
Het |
Syt8 |
A |
T |
7: 141,993,203 (GRCm39) |
D220V |
probably damaging |
Het |
Tex15 |
A |
G |
8: 34,064,509 (GRCm39) |
E1313G |
probably benign |
Het |
Tmem131l |
T |
C |
3: 83,868,911 (GRCm39) |
R155G |
probably damaging |
Het |
Tmem220 |
T |
C |
11: 66,916,093 (GRCm39) |
V30A |
probably damaging |
Het |
Tollip |
A |
G |
7: 141,445,731 (GRCm39) |
I119T |
probably damaging |
Het |
Treml4 |
G |
A |
17: 48,571,672 (GRCm39) |
G25D |
probably damaging |
Het |
Trim7 |
T |
C |
11: 48,728,460 (GRCm39) |
F36S |
probably damaging |
Het |
Txnrd3 |
T |
A |
6: 89,640,166 (GRCm39) |
C293* |
probably null |
Het |
Utp14b |
A |
G |
1: 78,643,482 (GRCm39) |
D460G |
probably benign |
Het |
Vmn2r41 |
T |
A |
7: 8,153,329 (GRCm39) |
N397Y |
probably benign |
Het |
Zfp292 |
T |
A |
4: 34,839,460 (GRCm39) |
H135L |
probably damaging |
Het |
Zfp420 |
C |
T |
7: 29,575,480 (GRCm39) |
R567* |
probably null |
Het |
Zfp518b |
C |
T |
5: 38,830,773 (GRCm39) |
V411M |
probably benign |
Het |
Zfp638 |
T |
A |
6: 83,956,680 (GRCm39) |
D1762E |
probably damaging |
Het |
Zfp691 |
T |
A |
4: 119,028,230 (GRCm39) |
M1L |
possibly damaging |
Het |
|
Other mutations in Vmn2r67 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
Predicted Primers |
PCR Primer
(F):5'- GCAATCACTGAACCTTTGTTGC -3'
(R):5'- ACTCTGCATCTTCTTGAAACACAG -3'
Sequencing Primer
(F):5'- GTGGCCATGTACCATGTATACATCAG -3'
(R):5'- TGCATCTTCTTGAAACACAGAGAAAC -3'
|
Posted On |
2022-08-09 |